M A Sells

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. pmc p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts
    M A Sells
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Cell Biol 145:837-49. 1999
  2. ncbi request reprint Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells
    M A Sells
    Fox Chase Cancer Centre, 7701 Burholme Avenue, Philadelphia, Pennsylvania 19111, USA
    Curr Biol 7:202-10. 1997
  3. ncbi request reprint Characterization of Pak2p, a pleckstrin homology domain-containing, p21-activated protein kinase from fission yeast
    M A Sells
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 273:18490-8. 1998
  4. pmc Transformation suppression by protein tyrosine phosphatase 1B requires a functional SH3 ligand
    F Liu
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Cell Biol 18:250-9. 1998
  5. ncbi request reprint Interaction of the Nck adapter protein with p21-activated kinase (PAK1)
    G M Bokoch
    Department of Immunology and Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 271:25746-9. 1996
  6. pmc Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating
    S Ottilie
    Molecular Biology and Virology Laboratory, Salk Institute, San Diego, CA 92186, USA
    EMBO J 14:5908-19. 1995
  7. pmc p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis
    A Schurmann
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakulät, Rheinisch Westfälische Technische Hochschule Aachen, D52057 Aachen, Germany
    Mol Cell Biol 20:453-61. 2000

Collaborators

Detail Information

Publications7

  1. pmc p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts
    M A Sells
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Cell Biol 145:837-49. 1999
    ..These results suggest that Pak1 affects the phosphorylation state of MLC, thus linking this kinase to a molecule that directly affects cell movement...
  2. ncbi request reprint Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells
    M A Sells
    Fox Chase Cancer Centre, 7701 Burholme Avenue, Philadelphia, Pennsylvania 19111, USA
    Curr Biol 7:202-10. 1997
    ..This kinase is therefore a candidate effector for the changes in cell shape induced by growth factors...
  3. ncbi request reprint Characterization of Pak2p, a pleckstrin homology domain-containing, p21-activated protein kinase from fission yeast
    M A Sells
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 273:18490-8. 1998
    ..pombe encodes at least two pak genes with distinct functions and suggest that the membrane localization of Pak2p, directed by its interactions with membrane lipids and Cdc42p, is critical to its biological activity...
  4. pmc Transformation suppression by protein tyrosine phosphatase 1B requires a functional SH3 ligand
    F Liu
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Cell Biol 18:250-9. 1998
    ..These data show that transformation suppression by PTP1B requires a functional SH3 ligand and suggest that p130Cas may represent an important physiological target of PTP1B in cells...
  5. ncbi request reprint Interaction of the Nck adapter protein with p21-activated kinase (PAK1)
    G M Bokoch
    Department of Immunology and Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 271:25746-9. 1996
    ..The interaction of active PAK1 with Nck leads to the phosphorylation of Nck at multiple sites. Association of Nck with PAK1 may serve to link this important regulatory kinase to cell activation by growth factor receptors...
  6. pmc Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating
    S Ottilie
    Molecular Biology and Virology Laboratory, Salk Institute, San Diego, CA 92186, USA
    EMBO J 14:5908-19. 1995
    ..These results indicate that the Pak1 protein is likely to be an effector for Cdc42p or a related GTPase, and suggest that Pak1p is involved in the maintenance of cell polarity and in mating...
  7. pmc p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis
    A Schurmann
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakulät, Rheinisch Westfälische Technische Hochschule Aachen, D52057 Aachen, Germany
    Mol Cell Biol 20:453-61. 2000
    ..Our findings indicate that PAK inhibits the proapoptotic effects of Bad by direct phosphorylation and that PAK may play an important role in cell survival pathways...