Jose Russo

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. pmc Pregnancy-induced chromatin remodeling in the breast of postmenopausal women
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Cancer 131:1059-70. 2012
  2. ncbi request reprint Pattern of distribution of cells positive for estrogen receptor alpha and progesterone receptor in relation to proliferating cells in the mammary gland
    J Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Breast Cancer Res Treat 53:217-27. 1999
  3. ncbi request reprint Molecular basis of pregnancy-induced breast cancer protection
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Eur J Cancer Prev 15:306-42. 2006
  4. ncbi request reprint Difference in gene expression profile in breast epithelial cells from women with different reproductive history
    Shanchun Guo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Oncol 23:933-41. 2003
  5. ncbi request reprint Estrogen and its metabolites are carcinogenic agents in human breast epithelial cells
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    J Steroid Biochem Mol Biol 87:1-25. 2003
  6. ncbi request reprint Breast development, hormones and cancer
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Adv Exp Med Biol 630:52-6. 2008
  7. ncbi request reprint Genotoxicity of steroidal estrogens
    Jose Russo
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Trends Endocrinol Metab 15:211-4. 2004
  8. ncbi request reprint Development of the human breast
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Maturitas 49:2-15. 2004
  9. doi request reprint Full-term pregnancy induces a specific genomic signature in the human breast
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Cancer Epidemiol Biomarkers Prev 17:51-66. 2008
  10. ncbi request reprint The concept of stem cell in the mammary gland and its implication in morphogenesis, cancer and prevention
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Front Biosci 11:151-72. 2006

Collaborators

Detail Information

Publications78

  1. pmc Pregnancy-induced chromatin remodeling in the breast of postmenopausal women
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Cancer 131:1059-70. 2012
    ..These are indicative of a safeguard step that maintains the fidelity of the transcription process, becoming the ultimate mechanism mediating the protection of the breast conferred by full-term pregnancy...
  2. ncbi request reprint Pattern of distribution of cells positive for estrogen receptor alpha and progesterone receptor in relation to proliferating cells in the mammary gland
    J Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Breast Cancer Res Treat 53:217-27. 1999
    ....
  3. ncbi request reprint Molecular basis of pregnancy-induced breast cancer protection
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Eur J Cancer Prev 15:306-42. 2006
    ..This is a novel concept that challenges the current knowledge that a chemopreventive agent needs to be given for a long period to suppress a metabolic pathway or abrogate the function of an organ...
  4. ncbi request reprint Difference in gene expression profile in breast epithelial cells from women with different reproductive history
    Shanchun Guo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Oncol 23:933-41. 2003
    ..The results indicate that differentially expressed genes occur during normal human breast lobular differentiation and these changes might persistently modify the genomic signature of the breast epithelia...
  5. ncbi request reprint Estrogen and its metabolites are carcinogenic agents in human breast epithelial cells
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    J Steroid Biochem Mol Biol 87:1-25. 2003
    ....
  6. ncbi request reprint Breast development, hormones and cancer
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Adv Exp Med Biol 630:52-6. 2008
    ....
  7. ncbi request reprint Genotoxicity of steroidal estrogens
    Jose Russo
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Trends Endocrinol Metab 15:211-4. 2004
    ..In this article, we concentrate on discussing the role of estrogen receptors and the metabolic activation of 17beta-estradiol (E(2)) as mechanisms of breast cancer initiation...
  8. ncbi request reprint Development of the human breast
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Maturitas 49:2-15. 2004
    ..However, only when all the other components of milk, (such as lactose, alpha-lactalbumin, casein and milk fat) are coordinately synthesized within the appropriate structure can full differentiation of the mammary gland be acknowledged...
  9. doi request reprint Full-term pregnancy induces a specific genomic signature in the human breast
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Cancer Epidemiol Biomarkers Prev 17:51-66. 2008
    ..The signature that identifies those women in whom parity has been protective will serve as a molecular biomarker of differentiation for evaluating the potential use of preventive agents...
  10. ncbi request reprint The concept of stem cell in the mammary gland and its implication in morphogenesis, cancer and prevention
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Front Biosci 11:151-72. 2006
    ....
  11. ncbi request reprint Pathways of carcinogenesis and prevention in the human breast
    J Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Eur J Cancer 38:S31-2. 2002
  12. pmc The protective role of pregnancy in breast cancer
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Breast Cancer Res 7:131-42. 2005
    ....
  13. pmc The role of the basal stem cell of the human breast in normal development and cancer
    Jose Russo
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Adv Exp Med Biol 720:121-34. 2011
    ..This in vitro-in vivo model demonstrates the importance of the basal cell type as a stem cell that reconstitutes the branching pattern of the breast and that is also target of a carcinogenic insult leading to transformation and cancer...
  14. ncbi request reprint Cancer risk related to mammary gland structure and development
    J Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Microsc Res Tech 52:204-23. 2001
    ..Comparative studies of normal and neoplastic breast development have unraveled similarities with experimental models that validate the extrapolation of findings for testing hypotheses on the initiation and progression of breast cancer...
  15. ncbi request reprint Carcinogenicity of estrogens in human breast epithelial cells
    J Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadephila, PA 19111, USA
    APMIS 109:39-52. 2001
    ....
  16. pmc The role of estrogen in the initiation of breast cancer
    J Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Steroid Biochem Mol Biol 102:89-96. 2006
    ....
  17. ncbi request reprint Mammary gland architecture as a determining factor in the susceptibility of the human breast to cancer
    J Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Breast J 7:278-91. 2001
    ....
  18. ncbi request reprint Cellular basis of breast cancer susceptibility
    J Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Oncol Res 11:169-78. 1999
    ..The finding that cell proliferation is of importance for cancer initiation, whereas differentiation is a powerful inhibitor, provides novel tools for developing rational strategies for breast cancer prevention and control...
  19. ncbi request reprint 17-Beta-estradiol induces transformation and tumorigenesis in human breast epithelial cells
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, Pennsylvania 19111, USA
    FASEB J 20:1622-34. 2006
    ....
  20. ncbi request reprint Genomic signature induced by pregnancy in the human breast
    Gabriela A Balogh
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Oncol 28:399-410. 2006
    ....
  21. ncbi request reprint The estrogen antagonist ICI-182-780 does not inhibit the transformation phenotypes induced by 17-beta-estradiol and 4-OH estradiol in human breast epithelial cells
    Mohamed H Lareef
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Oncol 26:423-9. 2005
    ....
  22. ncbi request reprint Methodological approach to study the genomic profile of the human breast
    Gabriela A Balogh
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Oncol 31:253-60. 2007
    ....
  23. ncbi request reprint The breast of parous women without cancer has a different genomic profile compared to those with cancer
    Gabriela A Balogh
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Int J Oncol 31:1165-75. 2007
    ..This genomic signature induced by pregnancy could help to predict in which women parity is protective...
  24. doi request reprint Effect of prenatal exposure to the endocrine disruptor bisphenol A on mammary gland morphology and gene expression signature
    Raquel Moral
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111, USA
    J Endocrinol 196:101-12. 2008
    ..The increase of undifferentiated structures and the changes in the gene expression profile at different ages suggest that prenatal exposure to BPA can affect the susceptibility of the mammary gland to transformation...
  25. pmc Expression and DNA methylation changes in human breast epithelial cells after bisphenol A exposure
    Sandra V Fernandez
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Oncol 41:369-77. 2012
    ..These results suggest that the breast tissue of women with BRCA1 or BRCA2 mutations could be more susceptible to the effects of BPA...
  26. ncbi request reprint Breast differentiation and its implication in cancer prevention
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Clin Cancer Res 11:931s-6s. 2005
    ..This is a novel concept which challenges the current knowledge that a chemopreventive agent needs to be given for a long period of time to suppress a metabolic pathway or abrogate the function of an organ...
  27. pmc Defining the genomic signature of the parous breast
    Suraj Peri
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    BMC Med Genomics 5:46. 2012
    ..This phenomenon is thought to be associated with the development and differentiation of the breast during pregnancy...
  28. ncbi request reprint Comparative genomic hybridization of human breast epithelial cells transformed by estrogen and its metabolites
    Sandra V Fernandez
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA, USA
    Int J Oncol 26:691-5. 2005
    ..Whereas no aneuploidy was observed in any of the transformed cells, the CGH revealed instead that only cells treated with 4-OH-E2 at the highest concentration (3.6 microM) exhibited DNA gains at 8q24, 9q34 and 20q13 and losses at 13q21...
  29. ncbi request reprint ERbeta shifts from mitochondria to nucleus during estrogen-induced neoplastic transformation of human breast epithelial cells and is involved in estrogen-induced synthesis of mitochondrial respiratory chain proteins
    Jin Qiang Chen
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    Biochim Biophys Acta 1773:1732-46. 2007
    ..Our findings provide a new insight into one of the potential roles of ERbeta in human breast cancer...
  30. ncbi request reprint Epithelial mesenchymal transition during the neoplastic transformation of human breast epithelial cells by estrogen
    Daniel G Tiezzi
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Oncol 31:823-7. 2007
    ....
  31. ncbi request reprint The genomic signature of breast cancer prevention
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Recent Results Cancer Res 174:131-50. 2007
    ....
  32. ncbi request reprint 17Beta-estradiol is carcinogenic in human breast epithelial cells
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    J Steroid Biochem Mol Biol 80:149-62. 2002
    ..3 and 11q24.2-25, respectively These results also indicate that E(2), like the chemical carcinogen BP, induces in HBEC phenotypes indicative of neoplastic transformation...
  33. pmc Human chorionic gonadotropin (hCG) prevents the transformed phenotypes induced by 17 beta-estradiol in human breast epithelial cells
    Hilal Kocdor
    Fox Chase Cancer Center, Breast Cancer Research Laboratory, Philadelphia, PA 19111, USA
    Cell Biol Int 33:1135-43. 2009
    ....
  34. ncbi request reprint Neoplastic transformation of human breast epithelial cells by estrogens and chemical carcinogens
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Environ Mol Mutagen 39:254-63. 2002
    ..2. The relevance of these findings is highlighted by the observation that E(2)- and B[a]P-induced genomic alterations in the same loci found in ductal hyperplasia, ductal carcinoma in situ, and invasive ductal carcinoma of the breast...
  35. ncbi request reprint Estradiol and its metabolites 4-hydroxyestradiol and 2-hydroxyestradiol induce mutations in human breast epithelial cells
    Sandra V Fernandez
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Cancer 118:1862-8. 2006
    ..ICI182780 did not prevent these mutations, indicating that the carcinogenic effect of E2 is mainly through its reactive metabolites 4-OHE2 and 2-OHE2, with 4-OHE2 and E2 being mutagenic at lower doses than 2-OHE2...
  36. pmc In utero exposure to butyl benzyl phthalate induces modifications in the morphology and the gene expression profile of the mammary gland: an experimental study in rats
    Raquel Moral
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Environ Health 10:5. 2011
    ..The aim of this study was to elucidate the effect of prenatal exposure to BBP on the morphology, proliferative index, and genomic signature of the rat mammary gland at different ages...
  37. pmc The plasticizer butyl benzyl phthalate induces genomic changes in rat mammary gland after neonatal/prepubertal exposure
    Raquel Moral
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    BMC Genomics 8:453. 2007
    ....
  38. ncbi request reprint Truncation of the mismatch repair protein PMS2 during the neoplastic transformation of human breast epithelial cells in vitro
    Gabriela A Balogh
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Oncol 25:381-7. 2004
    ..Our results indicate that a protein-truncating mutation in the hPMS2 gene had occurred during the process of cell transformation and tumorigenesis and that truncation is related to a lack of function of this gene...
  39. ncbi request reprint Mutations in mismatch repair genes are involved in the neoplastic transformation of human breast epithelial cells
    Gabriela A Balogh
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Oncol 23:411-9. 2003
    ..This is the first report demonstrating mutations of MMR genes during the neoplastic transformation of human breast epithelial cells...
  40. ncbi request reprint Chromosome 17p13.2 transfer reverts transformation phenotypes and Fas-mediated apoptosis in breast epithelial cells
    Mohamed H Lareef
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Mol Carcinog 39:234-46. 2004
    ....
  41. ncbi request reprint Effect of human chorionic gonadotropin in the gene expression profile of MCF-7 cells
    Shanchun Guo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Oncol 24:399-407. 2004
    ..The results obtained in this study demonstrated that genes regulating cell proliferation, apoptosis, cell trafficking, and DNA repair are significantly affected by hCG in human breast cancer cells in vitro...
  42. pmc Fish oil alters tamoxifen-modulated expression of mRNAs that encode genes related to differentiation, proliferation, metastasis, and immune response in rat mammary tumors
    Lucas Tadeu Bidinotto
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Nutr Cancer 64:991-9. 2012
    ..Supplemental materials are available for this article. Go to the publisher's online edition of Nutrition and Cancer to view the supplemental file...
  43. ncbi request reprint The mismatch repair gene hPMS2 is mutated in primary breast cancer
    Gabriela A Balogh
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Mol Med 18:853-7. 2006
    ....
  44. pmc ERalpha-negative and triple negative breast cancer: molecular features and potential therapeutic approaches
    Jin Qiang Chen
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Biochim Biophys Acta 1796:162-75. 2009
    ..Gaining better insights into these molecular pathways in TNBC may lead to identification of novel biomarkers and targets for development of diagnostic and therapeutic approaches for prevention and treatment of TNBC...
  45. pmc DNA methylation changes in a human cell model of breast cancer progression
    Sandra V Fernandez
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Mutat Res 688:28-35. 2010
    ..Furthermore, NRG1 exon 1 was partially methylated in 9 out of 14 (64.3%) morphologically normal tissue samples adjacent to invasive carcinomas...
  46. ncbi request reprint Sodium/potassium ATPase (Na+, K+-ATPase) and ouabain/related cardiac glycosides: A new paradigm for development of anti- breast cancer drugs?
    Jin Qiang Chen
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Breast Cancer Res Treat 96:1-15. 2006
    ..Modulators, e.g. ouabain and related digitalis could be useful to develop valuable anti-breast cancer drugs as both Na+, K+-ATPase inhibitors and ER antagonists...
  47. pmc MMTV Env encodes an ITAM responsible for transformation of mammary epithelial cells in three-dimensional culture
    Elad Katz
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Exp Med 201:431-9. 2005
    ..Therefore, these data suggest a heretofore unappreciated potential mechanism for the initiation of breast cancer and identify MMTV Env and ITAM-containing proteins in human breast tumors as probable oncoproteins...
  48. ncbi request reprint Alternately spliced luteinizing hormone/human chorionic gonadotropin receptor mRNA in human breast epithelial cells
    Xiaoshan Jiang
    Breast Cancer Resarch Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Oncol 20:735-8. 2002
    ..This difference in the expression of alternate splicing of LH/hCG receptor mRNA among the MCF-10F, MCF-7 and MDA-MB-231 cells, may explain the divergent response of these cells to HOXA1 activation by hCG...
  49. ncbi request reprint Primary prevention of breast cancer by hormone-induced differentiation
    Irma H Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Recent Results Cancer Res 174:111-30. 2007
    ....
  50. ncbi request reprint Human chorionic gonadotropin and inhibin induce histone acetylation in human breast epithelial cells
    Xiaoshan Jiang
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Oncol 20:77-9. 2002
    ..Slight induction of acetylated histone H4 was detected only in the cells treated with inhibin at 100 ng/ml for 12 and 24 h. This study is the first one to demonstrate that these hormones increase the acetylation of histones...
  51. ncbi request reprint Pregnancy-induced changes in breast cancer risk
    Irma H Russo
    Molecular Endocrinology Section, Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Mammary Gland Biol Neoplasia 16:221-33. 2011
    ..This signature is indicative of a reduced breast cancer risk and serves as a molecular biomarker of differentiation for evaluating the potential use of chemopreventive agents...
  52. ncbi request reprint DNA content and cell number determination in microdissected samples of breast carcinoma in situ
    Robert Blumenstein
    DeSales University, Center Valley, PA, USA
    Int J Oncol 21:447-50. 2002
    ..9995). These results represent a novel contribution for a more precise correlation between phenotypic and genotypic diversity in cancer cells studied from microdissected paraffin-embedded tissue...
  53. ncbi request reprint Regulation of mitochondrial respiratory chain structure and function by estrogens/estrogen receptors and potential physiological/pathophysiological implications
    Jin Qiang Chen
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Biochim Biophys Acta 1746:1-17. 2005
    ....
  54. doi request reprint Dysregulation of glucose transport, glycolysis, TCA cycle and glutaminolysis by oncogenes and tumor suppressors in cancer cells
    Jin Qiang Chen
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Biochim Biophys Acta 1826:370-84. 2012
    ....
  55. pmc Regulation of energy metabolism pathways by estrogens and estrogenic chemicals and potential implications in obesity associated with increased exposure to endocrine disruptors
    Jin Qiang Chen
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA
    Biochim Biophys Acta 1793:1128-43. 2009
    ..A better understanding of the cellular and molecular mechanisms underlying obesogen-associated obesity will lead to new approaches for slow down and/or prevention of the increased trend of obesity associated with exposure to obesogens...
  56. doi request reprint Chemoprevention of breast cancer by fish oil in preclinical models: trials and tribulations
    Carina Signori
    Department of Medicine, Penn State University College of Medicine, Milton S Hershey Medical Center, Hershey, Pennsylvania, USA
    Cancer Res 71:6091-6. 2011
    ....
  57. ncbi request reprint Reducing cancer disparities for minorities: a multidisciplinary research agenda to improve patient access to health systems, clinical trials, and effective cancer therapy
    Deborah Watkins Bruner
    University of Pennsylvania School of Nursing, Philadelphia, PA, 19104 6096, USA
    J Clin Oncol 24:2209-15. 2006
    ..These programs are offered as models for improving minority recruitment to cancer-control and -treatment trials, and minority access to cancer treatment in general...
  58. ncbi request reprint 17 beta -estradiol-mediated vessel assembly and stabilization in tumor angiogenesis requires TGF beta and EGFR crosstalk
    Raquel Soares
    IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    Angiogenesis 6:271-81. 2003
    ..Our data suggest that estrogen mediates endothelial cell stabilization and vessel assembly. These vessel protective effects involve TGF beta 1 and EGFR signaling transduction pathways...
  59. ncbi request reprint Cell death evaluation in benzo[a]pyrene-transformed human breast epithelial cells after microcell-mediated transfer of chromosomes 11 and 17
    Maria Luiza S Mello
    Department of Cell Biology, Institute of Biology, UNICAMP, 13084 971 Campinas SP, Brazil
    Mutat Res 546:39-43. 2004
    ....
  60. ncbi request reprint DNA content, chromatin texture and nuclear morphology in benzo[a]pyrene-transformed human breast epithelial cells after microcell-mediated transfer of chromosomes 11 and 17
    Maria Luiza S Mello
    Department of Cell Biology, Institute of Biology, UNICAMP, Campinas, Sao Paolo, Brazil
    Cytometry A 52:70-6. 2003
    ....
  61. ncbi request reprint Role of the estrogen antagonist ICI 182,780 in vessel assembly and apoptosis of endothelial cells
    Raquel Soares
    IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, R Roberto Frias, S N, 4200 Porto, Portugal
    Ultrastruct Pathol 27:33-9. 2003
    ....
  62. doi request reprint SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis
    Hye Jung Han
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
    Nature 452:187-93. 2008
    ..SATB1 reprogrammes chromatin organization and the transcription profiles of breast tumours to promote growth and metastasis; this is a new mechanism of tumour progression...
  63. pmc Image analysis of the AgNOR response in ras-transformed human breast epithelial cells
    Maria Luiza S Mello
    Department of Cell Biology, Institute of Biology, State University of Campinas UNICAMP, 13083 863 Campinas, Brazil
    Acta Histochem 110:210-6. 2008
    ..Based on data in the literature, it is also hypothesized that a decreased wild-type p53 level, possibly promoted by the ras transformation, may be associated with the increased AgNOR response...
  64. ncbi request reprint Expression pattern of a homeotic gene, HOXA5, in normal breast and in breast tumors
    Gregory S Henderson
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell Oncol 28:305-13. 2006
    ..As homeotic genes play a pivotal role in development, we sought to decipher the expression pattern in both normal breast tissues and in breast carcinomas...
  65. pmc DNA content and chromatin texture of human breast epithelial cells transformed with 17-beta-estradiol and the estrogen antagonist ICI 182,780 as assessed by image analysis
    Maria Luiza S Mello
    Department of Cell Biology, Institute of Biology, UNICAMP, 13083 863 Campinas, SP, Brazil
    Mutat Res 617:1-7. 2007
    ..The changes produced by ICI 182,780 alone were attributed to effects other than its well-known anti-estrogenic activity...
  66. ncbi request reprint S-phase reduction in T47D human breast cancer epithelial cells induced by an S100P antisense-retroviral construct
    Bettina Beissel
    Centro de Química e Meio Ambiente, IPEN CNEN SP, 04039 032 Sao Paulo, SP, Brazil
    Oncol Rep 17:611-5. 2007
    ..The results showed here seem to further classify S100P as a protein that might be involved in the cell cycle imbalance observed during breast carcinogenesis...
  67. ncbi request reprint Histologic changes in the breast with menopausal hormone therapy use: correlation with breast density, estrogen receptor, progesterone receptor, and proliferation indices
    Jennifer A Harvey
    Department of Radiology, University of Virginia, Charlottesville, VA 22908, USA
    Menopause 15:67-73. 2008
    ..This retrospective study systematically compared mammographic density with histology in women receiving or not receiving menopausal hormone therapy (HT)...
  68. ncbi request reprint Catechol estrogen quinones as initiators of breast and other human cancers: implications for biomarkers of susceptibility and cancer prevention
    Ercole Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Biochim Biophys Acta 1766:63-78. 2006
    ..Initiated cells may be promoted by a number of processes, including hormone receptor stimulated proliferation. These results lay the groundwork for assessing risk and preventing disease...
  69. ncbi request reprint Genetic identification of distinct loci controlling mammary tumor multiplicity, latency, and aggressiveness in the rat
    Xiaojiang Quan
    Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, Rue Profs Jeener and Brachet, 12, Gosselies, B 6041, Belgium
    Mamm Genome 17:310-21. 2006
    ....
  70. ncbi request reprint S100P calcium-binding protein expression is associated with high-risk proliferative lesions of the breast
    Ana Paula Torres Schor
    Pathology Division of Clinical Hospital, Sao Paulo University, Brazil
    Oncol Rep 15:3-6. 2006
    ..The strong association between S100P and ER expression highlights the hypothesis about the possible role played by S100P in the very early stages of breast carcinogenesis...
  71. ncbi request reprint 17-beta-estradiol affects nuclear image properties in MCF-10F human breast epithelial cells with tumorigenesis
    Maria Luiza S Mello
    Department of Cell Biology, Institute of Biology, UNICAMP, 13083 863 Campinas SP, Brazil
    Oncol Rep 18:1475-81. 2007
    ..Studies on epigenetic mechanisms involving DNA methylation and/or the histone code would contribute to a better interpretation of the chromatin supraorganization changes reported herein...
  72. ncbi request reprint Epithelial to mesenchymal transition in human breast epithelial cells transformed by 17beta-estradiol
    Yong Huang
    W Harry Feinstone Center for Genomic Research, University of Memphis, Memphis, Tennessee, USA
    Cancer Res 67:11147-57. 2007
    ..The phenotypic and genomic changes triggered by estrogen exposure that lead normal cells to tumorigenesis confirm the role of this steroid hormone in cancer initiation...
  73. ncbi request reprint Breast carcinoma malignancy grading by Bloom-Richardson system vs proliferation index: reproducibility of grade and advantages of proliferation index
    John S Meyer
    St Luke s Hospital, Chesterfield, MO 63017, USA
    Mod Pathol 18:1067-78. 2005
    ..Measurement of proliferation index by immunohistochemically detectable markers will probably give superior prognostic results in comparison to grade...
  74. ncbi request reprint Identification of cripto-1 as a novel serologic marker for breast and colon cancer
    Caterina Bianco
    Tumor Growth Factor Section, Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 12:5158-64. 2006
    ..We evaluated whether CR-1 is present in the plasma of patients with breast and colon cancer, and if it can represent a new biomarker for these malignancies...
  75. ncbi request reprint Proceedings of the Fourth International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: conference summary statement
    Steven E Come
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Clin Cancer Res 11:861s-4s. 2005
  76. ncbi request reprint Soluble fragment of P-cadherin adhesion protein found in human milk
    Alejandro Peralta Soler
    The Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, Pennsylvania 19096, USA
    J Cell Biochem 85:180-4. 2002
    ..This is in contrast to the non-lactating mammary gland where P-cadherin is restricted to myoepithelial cells, and is present at sites of cell-cell contact...
  77. ncbi request reprint Formation of depurinating N3Adenine and N7Guanine adducts by MCF-10F cells cultured in the presence of 4-hydroxyestradiol
    Muhammad Saeed
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE, USA
    Int J Cancer 120:1821-4. 2007
    ..This DNA damage can play an important role in the 4-OHE2-induced mutations and transformation of MCF-10F cells to malignant cells...
  78. pmc CYP1B1 is not a major determinant of the disposition of aromatase inhibitors in epithelial cells of invasive ductal carcinoma
    Mostafizur Rahman
    W Harry Feinstone Center for Genomic Research, University of Memphis, 201 Life Sciences Building, Memphis, TN 38152, USA
    Drug Metab Dispos 36:963-70. 2008
    ..Thus, although both CYP19 and CYP1B1 are expressed in a high percentage of breast cancers, CYP1B1 is not a major determinant of the disposition of AIs...

Research Grants18

  1. Genomic Basis of Reproductive History on Breast Cancer
    Jose Russo; Fiscal Year: 2002
    ..abstract_text> ..
  2. Fox Chase Cancer Center Breast Cancer Tissue Resources
    Jose Russo; Fiscal Year: 2007
    ..abstract_text> ..
  3. Genomic Markers of Breast Cancer Prevention Induced by hCG in Women at High Risk
    Jose Russo; Fiscal Year: 2007
    ..This knowledge will serve as the basis for establishing novel genomic signatures as intermediate biomarkers for larger preventive clinical trials at the completion of this project. ..
  4. Epigenetic Changes Induced by Estrogens and Xenoestrogens in Breast Cancer
    Jose Russo; Fiscal Year: 2007
    ....
  5. Center for Environment and Mammary Gland Development
    Jose Russo; Fiscal Year: 2007
    ..The mission of the Center will be accomplished through interactive meetings among the participants of the Center, and other centers participating in this consortium. ..
  6. Genomic Basis of Reproductive History on Breast Cancer
    Jose Russo; Fiscal Year: 2006
    ..abstract_text> ..
  7. Genomic Basis of Reproductive History on Breast Cancer
    Jose Russo; Fiscal Year: 2005
    ..abstract_text> ..
  8. Fox Chase Cancer Center Breast Cancer Tissue Resources
    Jose Russo; Fiscal Year: 2005
    ..abstract_text> ..
  9. 4-Hydroxyestradiol Receptor in Breast Cancer
    Jose Russo; Fiscal Year: 2005
    ..This plan is in line with goals 1 and 3 of the Breast Cancer Progress Review Group to better understand the biology of the normal mammary gland and of precancerous lesions. ..
  10. Genomic Basis of Reproductive History on Breast Cancer
    Jose Russo; Fiscal Year: 2004
    ..abstract_text> ..
  11. Genomic Basis of Reproductive History on Breast Cancer
    Jose Russo; Fiscal Year: 2003
    ..abstract_text> ..
  12. ROLE OF MICROSATELLITE INSTABILITY IN BREAST CANCER
    Jose Russo; Fiscal Year: 2002
    ..The knowledge gained through this exploratory work will establish the basis for more in dept studies in the role of mismatch repair in breast cancer. ..