Irma H Russo

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. pmc Human chorionic gonadotropin (hCG) prevents the transformed phenotypes induced by 17 beta-estradiol in human breast epithelial cells
    Hilal Kocdor
    Fox Chase Cancer Center, Breast Cancer Research Laboratory, Philadelphia, PA 19111, USA
    Cell Biol Int 33:1135-43. 2009
  2. ncbi request reprint Role of hormones in mammary cancer initiation and progression
    I H Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Mammary Gland Biol Neoplasia 3:49-61. 1998
  3. ncbi request reprint Cigarette smoking and risk of breast cancer in women
    Irma H Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Lancet 360:1033-4. 2002
  4. ncbi request reprint Neoplastic transformation of human breast epithelial cells by estrogens and chemical carcinogens
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Environ Mol Mutagen 39:254-63. 2002
  5. ncbi request reprint Molecular basis of pregnancy-induced breast cancer protection
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Eur J Cancer Prev 15:306-42. 2006
  6. ncbi request reprint The concept of stem cell in the mammary gland and its implication in morphogenesis, cancer and prevention
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Front Biosci 11:151-72. 2006
  7. ncbi request reprint Genomic signature induced by pregnancy in the human breast
    Gabriela A Balogh
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Oncol 28:399-410. 2006
  8. doi request reprint Effect of prenatal exposure to the endocrine disruptor bisphenol A on mammary gland morphology and gene expression signature
    Raquel Moral
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111, USA
    J Endocrinol 196:101-12. 2008
  9. ncbi request reprint 17-Beta-estradiol induces transformation and tumorigenesis in human breast epithelial cells
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, Pennsylvania 19111, USA
    FASEB J 20:1622-34. 2006
  10. ncbi request reprint The breast of parous women without cancer has a different genomic profile compared to those with cancer
    Gabriela A Balogh
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Int J Oncol 31:1165-75. 2007

Collaborators

Detail Information

Publications46

  1. pmc Human chorionic gonadotropin (hCG) prevents the transformed phenotypes induced by 17 beta-estradiol in human breast epithelial cells
    Hilal Kocdor
    Fox Chase Cancer Center, Breast Cancer Research Laboratory, Philadelphia, PA 19111, USA
    Cell Biol Int 33:1135-43. 2009
    ....
  2. ncbi request reprint Role of hormones in mammary cancer initiation and progression
    I H Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Mammary Gland Biol Neoplasia 3:49-61. 1998
    ..Understanding of such mechanisms is indispensable for developing a rational basis for its prevention and control...
  3. ncbi request reprint Cigarette smoking and risk of breast cancer in women
    Irma H Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Lancet 360:1033-4. 2002
  4. ncbi request reprint Neoplastic transformation of human breast epithelial cells by estrogens and chemical carcinogens
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Environ Mol Mutagen 39:254-63. 2002
    ..2. The relevance of these findings is highlighted by the observation that E(2)- and B[a]P-induced genomic alterations in the same loci found in ductal hyperplasia, ductal carcinoma in situ, and invasive ductal carcinoma of the breast...
  5. ncbi request reprint Molecular basis of pregnancy-induced breast cancer protection
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Eur J Cancer Prev 15:306-42. 2006
    ..This is a novel concept that challenges the current knowledge that a chemopreventive agent needs to be given for a long period to suppress a metabolic pathway or abrogate the function of an organ...
  6. ncbi request reprint The concept of stem cell in the mammary gland and its implication in morphogenesis, cancer and prevention
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Front Biosci 11:151-72. 2006
    ....
  7. ncbi request reprint Genomic signature induced by pregnancy in the human breast
    Gabriela A Balogh
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Oncol 28:399-410. 2006
    ....
  8. doi request reprint Effect of prenatal exposure to the endocrine disruptor bisphenol A on mammary gland morphology and gene expression signature
    Raquel Moral
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111, USA
    J Endocrinol 196:101-12. 2008
    ..The increase of undifferentiated structures and the changes in the gene expression profile at different ages suggest that prenatal exposure to BPA can affect the susceptibility of the mammary gland to transformation...
  9. ncbi request reprint 17-Beta-estradiol induces transformation and tumorigenesis in human breast epithelial cells
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, Pennsylvania 19111, USA
    FASEB J 20:1622-34. 2006
    ....
  10. ncbi request reprint The breast of parous women without cancer has a different genomic profile compared to those with cancer
    Gabriela A Balogh
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Int J Oncol 31:1165-75. 2007
    ..This genomic signature induced by pregnancy could help to predict in which women parity is protective...
  11. pmc Defining the genomic signature of the parous breast
    Suraj Peri
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    BMC Med Genomics 5:46. 2012
    ..This phenomenon is thought to be associated with the development and differentiation of the breast during pregnancy...
  12. pmc Pregnancy-induced chromatin remodeling in the breast of postmenopausal women
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Cancer 131:1059-70. 2012
    ..These are indicative of a safeguard step that maintains the fidelity of the transcription process, becoming the ultimate mechanism mediating the protection of the breast conferred by full-term pregnancy...
  13. ncbi request reprint The genomic signature of breast cancer prevention
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Recent Results Cancer Res 174:131-50. 2007
    ....
  14. ncbi request reprint Comparative genomic hybridization of human breast epithelial cells transformed by estrogen and its metabolites
    Sandra V Fernandez
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA, USA
    Int J Oncol 26:691-5. 2005
    ..Whereas no aneuploidy was observed in any of the transformed cells, the CGH revealed instead that only cells treated with 4-OH-E2 at the highest concentration (3.6 microM) exhibited DNA gains at 8q24, 9q34 and 20q13 and losses at 13q21...
  15. pmc The protective role of pregnancy in breast cancer
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Breast Cancer Res 7:131-42. 2005
    ....
  16. ncbi request reprint 17Beta-estradiol is carcinogenic in human breast epithelial cells
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    J Steroid Biochem Mol Biol 80:149-62. 2002
    ..3 and 11q24.2-25, respectively These results also indicate that E(2), like the chemical carcinogen BP, induces in HBEC phenotypes indicative of neoplastic transformation...
  17. ncbi request reprint Breast differentiation and its implication in cancer prevention
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Clin Cancer Res 11:931s-6s. 2005
    ..This is a novel concept which challenges the current knowledge that a chemopreventive agent needs to be given for a long period of time to suppress a metabolic pathway or abrogate the function of an organ...
  18. ncbi request reprint The estrogen antagonist ICI-182-780 does not inhibit the transformation phenotypes induced by 17-beta-estradiol and 4-OH estradiol in human breast epithelial cells
    Mohamed H Lareef
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Oncol 26:423-9. 2005
    ....
  19. ncbi request reprint Truncation of the mismatch repair protein PMS2 during the neoplastic transformation of human breast epithelial cells in vitro
    Gabriela A Balogh
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Oncol 25:381-7. 2004
    ..Our results indicate that a protein-truncating mutation in the hPMS2 gene had occurred during the process of cell transformation and tumorigenesis and that truncation is related to a lack of function of this gene...
  20. ncbi request reprint Estradiol and its metabolites 4-hydroxyestradiol and 2-hydroxyestradiol induce mutations in human breast epithelial cells
    Sandra V Fernandez
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Cancer 118:1862-8. 2006
    ..ICI182780 did not prevent these mutations, indicating that the carcinogenic effect of E2 is mainly through its reactive metabolites 4-OHE2 and 2-OHE2, with 4-OHE2 and E2 being mutagenic at lower doses than 2-OHE2...
  21. pmc The plasticizer butyl benzyl phthalate induces genomic changes in rat mammary gland after neonatal/prepubertal exposure
    Raquel Moral
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    BMC Genomics 8:453. 2007
    ....
  22. doi request reprint Full-term pregnancy induces a specific genomic signature in the human breast
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Cancer Epidemiol Biomarkers Prev 17:51-66. 2008
    ..The signature that identifies those women in whom parity has been protective will serve as a molecular biomarker of differentiation for evaluating the potential use of preventive agents...
  23. ncbi request reprint ERbeta shifts from mitochondria to nucleus during estrogen-induced neoplastic transformation of human breast epithelial cells and is involved in estrogen-induced synthesis of mitochondrial respiratory chain proteins
    Jin Qiang Chen
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    Biochim Biophys Acta 1773:1732-46. 2007
    ..Our findings provide a new insight into one of the potential roles of ERbeta in human breast cancer...
  24. pmc In utero exposure to butyl benzyl phthalate induces modifications in the morphology and the gene expression profile of the mammary gland: an experimental study in rats
    Raquel Moral
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Environ Health 10:5. 2011
    ..The aim of this study was to elucidate the effect of prenatal exposure to BBP on the morphology, proliferative index, and genomic signature of the rat mammary gland at different ages...
  25. ncbi request reprint Chromosome 17p13.2 transfer reverts transformation phenotypes and Fas-mediated apoptosis in breast epithelial cells
    Mohamed H Lareef
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Mol Carcinog 39:234-46. 2004
    ....
  26. ncbi request reprint Mutations in mismatch repair genes are involved in the neoplastic transformation of human breast epithelial cells
    Gabriela A Balogh
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Oncol 23:411-9. 2003
    ..This is the first report demonstrating mutations of MMR genes during the neoplastic transformation of human breast epithelial cells...
  27. pmc The role of estrogen in the initiation of breast cancer
    J Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Steroid Biochem Mol Biol 102:89-96. 2006
    ....
  28. ncbi request reprint Estrogen and its metabolites are carcinogenic agents in human breast epithelial cells
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    J Steroid Biochem Mol Biol 87:1-25. 2003
    ....
  29. pmc Fish oil alters tamoxifen-modulated expression of mRNAs that encode genes related to differentiation, proliferation, metastasis, and immune response in rat mammary tumors
    Lucas Tadeu Bidinotto
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Nutr Cancer 64:991-9. 2012
    ..Supplemental materials are available for this article. Go to the publisher's online edition of Nutrition and Cancer to view the supplemental file...
  30. ncbi request reprint Effect of human chorionic gonadotropin in the gene expression profile of MCF-7 cells
    Shanchun Guo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Oncol 24:399-407. 2004
    ..The results obtained in this study demonstrated that genes regulating cell proliferation, apoptosis, cell trafficking, and DNA repair are significantly affected by hCG in human breast cancer cells in vitro...
  31. pmc DNA methylation changes in a human cell model of breast cancer progression
    Sandra V Fernandez
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Mutat Res 688:28-35. 2010
    ..Furthermore, NRG1 exon 1 was partially methylated in 9 out of 14 (64.3%) morphologically normal tissue samples adjacent to invasive carcinomas...
  32. pmc The role of the basal stem cell of the human breast in normal development and cancer
    Jose Russo
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Adv Exp Med Biol 720:121-34. 2011
    ..This in vitro-in vivo model demonstrates the importance of the basal cell type as a stem cell that reconstitutes the branching pattern of the breast and that is also target of a carcinogenic insult leading to transformation and cancer...
  33. ncbi request reprint Primary prevention of breast cancer by hormone-induced differentiation
    Irma H Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Recent Results Cancer Res 174:111-30. 2007
    ....
  34. ncbi request reprint Sodium/potassium ATPase (Na+, K+-ATPase) and ouabain/related cardiac glycosides: A new paradigm for development of anti- breast cancer drugs?
    Jin Qiang Chen
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Breast Cancer Res Treat 96:1-15. 2006
    ..Modulators, e.g. ouabain and related digitalis could be useful to develop valuable anti-breast cancer drugs as both Na+, K+-ATPase inhibitors and ER antagonists...
  35. ncbi request reprint Alternately spliced luteinizing hormone/human chorionic gonadotropin receptor mRNA in human breast epithelial cells
    Xiaoshan Jiang
    Breast Cancer Resarch Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Oncol 20:735-8. 2002
    ..This difference in the expression of alternate splicing of LH/hCG receptor mRNA among the MCF-10F, MCF-7 and MDA-MB-231 cells, may explain the divergent response of these cells to HOXA1 activation by hCG...
  36. ncbi request reprint Breast development, hormones and cancer
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Adv Exp Med Biol 630:52-6. 2008
    ....
  37. ncbi request reprint Development of the human breast
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Maturitas 49:2-15. 2004
    ..However, only when all the other components of milk, (such as lactose, alpha-lactalbumin, casein and milk fat) are coordinately synthesized within the appropriate structure can full differentiation of the mammary gland be acknowledged...
  38. ncbi request reprint Genotoxicity of steroidal estrogens
    Jose Russo
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Trends Endocrinol Metab 15:211-4. 2004
    ..In this article, we concentrate on discussing the role of estrogen receptors and the metabolic activation of 17beta-estradiol (E(2)) as mechanisms of breast cancer initiation...
  39. ncbi request reprint Difference in gene expression profile in breast epithelial cells from women with different reproductive history
    Shanchun Guo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Oncol 23:933-41. 2003
    ..The results indicate that differentially expressed genes occur during normal human breast lobular differentiation and these changes might persistently modify the genomic signature of the breast epithelia...
  40. doi request reprint Pregnancy-induced changes in breast cancer risk
    Irma H Russo
    Molecular Endocrinology Section, Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Mammary Gland Biol Neoplasia 16:221-33. 2011
    ..This signature is indicative of a reduced breast cancer risk and serves as a molecular biomarker of differentiation for evaluating the potential use of chemopreventive agents...
  41. ncbi request reprint The cyclooxygenase-2 inhibitor, celecoxib, prevents the development of mammary tumors in Her-2/neu mice
    Susan Lanza-Jacoby
    Department of Surgery, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    Cancer Epidemiol Biomarkers Prev 12:1486-91. 2003
    ..Our findings provide additional preclinical evidence to support the clinical studies to investigate the potential effectiveness of COX-2 inhibitors in protecting woman who are at high risk for breast cancer...
  42. ncbi request reprint Human chorionic gonadotropin and inhibin induce histone acetylation in human breast epithelial cells
    Xiaoshan Jiang
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Oncol 20:77-9. 2002
    ..Slight induction of acetylated histone H4 was detected only in the cells treated with inhibin at 100 ng/ml for 12 and 24 h. This study is the first one to demonstrate that these hormones increase the acetylation of histones...
  43. pmc DNA content and chromatin texture of human breast epithelial cells transformed with 17-beta-estradiol and the estrogen antagonist ICI 182,780 as assessed by image analysis
    Maria Luiza S Mello
    Department of Cell Biology, Institute of Biology, UNICAMP, 13083 863 Campinas, SP, Brazil
    Mutat Res 617:1-7. 2007
    ..The changes produced by ICI 182,780 alone were attributed to effects other than its well-known anti-estrogenic activity...
  44. ncbi request reprint Epithelial to mesenchymal transition in human breast epithelial cells transformed by 17beta-estradiol
    Yong Huang
    W Harry Feinstone Center for Genomic Research, University of Memphis, Memphis, Tennessee, USA
    Cancer Res 67:11147-57. 2007
    ..The phenotypic and genomic changes triggered by estrogen exposure that lead normal cells to tumorigenesis confirm the role of this steroid hormone in cancer initiation...
  45. ncbi request reprint Soluble fragment of P-cadherin adhesion protein found in human milk
    Alejandro Peralta Soler
    The Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, Pennsylvania 19096, USA
    J Cell Biochem 85:180-4. 2002
    ..This is in contrast to the non-lactating mammary gland where P-cadherin is restricted to myoepithelial cells, and is present at sites of cell-cell contact...
  46. ncbi request reprint DNA content and cell number determination in microdissected samples of breast carcinoma in situ
    Robert Blumenstein
    DeSales University, Center Valley, PA, USA
    Int J Oncol 21:447-50. 2002
    ..9995). These results represent a novel contribution for a more precise correlation between phenotypic and genotypic diversity in cancer cells studied from microdissected paraffin-embedded tissue...