Davide Ruggero

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. ncbi The Akt of translational control
    Davide Ruggero
    Human Genetics Program, Fox Chase Cancer Center, PA 19111, USA
    Oncogene 24:7426-34. 2005
  2. ncbi Impaired control of IRES-mediated translation in X-linked dyskeratosis congenita
    Andrew Yoon
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Science 312:902-6. 2006
  3. ncbi Does the ribosome translate cancer?
    Davide Ruggero
    Molecular Biology Program, Department of Pathology, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Nat Rev Cancer 3:179-92. 2003
  4. ncbi Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification
    Davide Ruggero
    Molecular Biology Program, Department of Pathology, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Science 299:259-62. 2003

Research Grants

  1. Role of rRNA Modifications in Dyskeratosis Congenita and Translation Control
    Davide Ruggero; Fiscal Year: 2007

Collaborators

Detail Information

Publications4

  1. ncbi The Akt of translational control
    Davide Ruggero
    Human Genetics Program, Fox Chase Cancer Center, PA 19111, USA
    Oncogene 24:7426-34. 2005
    ..In this review, we highlight and discuss the emerging molecular and genetic evidence that support a model by which deregulation of specific or global protein synthesis contributes to cancer...
  2. ncbi Impaired control of IRES-mediated translation in X-linked dyskeratosis congenita
    Andrew Yoon
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Science 312:902-6. 2006
    ..Moreover, Dkc1(m) ribosomes were unable to direct translation from IRES elements present in viral messenger RNAs. These findings reveal a potential mechanism by which defective ribosome activity leads to disease and cancer...
  3. ncbi Does the ribosome translate cancer?
    Davide Ruggero
    Molecular Biology Program, Department of Pathology, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Nat Rev Cancer 3:179-92. 2003
    ..Although many studies have correlated deregulation of protein biosynthesis with cancer, it remains to be established whether this translates directly into an increase in cancer susceptibility, and under what circumstances...
  4. ncbi Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification
    Davide Ruggero
    Molecular Biology Program, Department of Pathology, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Science 299:259-62. 2003
    ..These results suggest that deregulated ribosome function is important in the initiation of DC, whereas telomere shortening may modify and/or exacerbate DC...

Research Grants2

  1. Role of rRNA Modifications in Dyskeratosis Congenita and Translation Control
    Davide Ruggero; Fiscal Year: 2007
    ....