Research Topics
| Eric G MossSummaryAffiliation: Fox Chase Cancer Center Country: USA Publications
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Detail Information
Publications
MicroRNAs: something new under the sunEric G Moss
Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Curr Biol 12:R688-90. 2002..Although the targets of these miRNAs are still not known, excellent candidates have been identified based on sequence similarity to the miRNAs...- Silencing unhealthy alleles naturallyEric G Moss
Cell and Developmental Biology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Trends Biotechnol 21:185-7. 2003..Small RNA technology is both extremely versatile, because virtually any expressed gene can be inhibited, and effective, because it exploits natural cellular machinery that evolved to use small RNAs to regulate gene expression... - Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sitesEric G Moss
Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
Dev Biol 258:432-42. 2003..elegans lin-4 and let-7 microRNAs, suggesting that microRNA regulation is a conserved feature of the Lin-28 gene in diverse animals... - Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiationKathy Seggerson
Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
Dev Biol 243:215-25. 2002..The role of lin-4 may be to initiate or potentiate the lin-4-independent circuit. We speculate that a parallel lin-4-independent regulatory mechanism regulates the expression of lin-14... - RNA repair: damage controlAlfonso Bellacosa
Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Curr Biol 13:R482-4. 2003..RNA damage can induce apoptosis and may be exploited for anti-cancer chemotherapy. It is a surprise, however, to learn that cells may repair RNA damage, suggesting a far greater significance of RNA in genotoxic stress... - The C. elegans heterochronic gene lin-46 affects developmental timing at two larval stages and encodes a relative of the scaffolding protein gephyrinAnita S R Pepper
Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Development 131:2049-59. 2004..Our findings suggest that the LIN-46 protein acts as a scaffold for a multiprotein assembly that controls developmental timing, and expand the known roles of gephyrin-related proteins to development... - MicroRNAs: hidden in the genomeEric G Moss
Cell and Developmental Biology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Curr Biol 12:R138-40. 2002..Some of these microRNAs have been conserved through evolution, and many are expressed only at specific times or places. How they act is just beginning to be understood, but their importance to biology is likely to be great... - Temporally regulated expression of Lin-28 in diverse tissues of the developing mouseDong Hua Yang
Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
Gene Expr Patterns 3:719-26. 2003.... - Heterochronic genes and the nature of developmental timeEric G Moss
Department of Molecular Biology, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey 08084, USA
Curr Biol 17:R425-34. 2007..Homologs of certain heterochronic genes of vertebrates show temporally regulated expression patterns, and may ultimately reveal timing mechanisms not previously known to exist... 
Lin-28 binds IGF-2 mRNA and participates in skeletal myogenesis by increasing translation efficiencyAnna Polesskaya
Centre National de la Recherche Scientifique CNRS FRE 2944, Institut Andre Lwoff, Villejuif F 94801, France
Genes Dev 21:1125-38. 2007..Our results unravel novel mechanisms of translational regulation in skeletal muscle and suggest that Lin-28 performs the role of "translational enhancer" in embryonic and adult cells and tissues...- Small-interfering RNAs in the radar of the interferon systemEric G Moss
Nat Cell Biol 5:771-2. 2003 - Localization of the developmental timing regulator Lin28 to mRNP complexes, P-bodies and stress granulesErica Balzer
Department of Molecular Biology, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey 08084, USA
RNA Biol 4:16-25. 2007..These studies are consistent with a model in which Lin28 binds mRNAs in the nucleus and accompanies them to ribosomes and P-bodies. We propose that Lin28 influences the translation or stability of specific mRNAs during differentiation...