William Mason

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. ncbi request reprint Lamivudine therapy of WHV-infected woodchucks
    W S Mason
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Virology 245:18-32. 1998
  2. pmc Immune selection during chronic hepadnavirus infection
    William S Mason
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, 19111, USA
    Hepatol Int 2:3-16. 2008
  3. pmc Detection of clonally expanded hepatocytes in chimpanzees with chronic hepatitis B virus infection
    William S Mason
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Virol 83:8396-408. 2009
  4. pmc The amount of hepatocyte turnover that occurred during resolution of transient hepadnavirus infections was lower when virus replication was inhibited with entecavir
    William S Mason
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Virol 83:1778-89. 2009
  5. pmc Clonal expansion of normal-appearing human hepatocytes during chronic hepatitis B virus infection
    William S Mason
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111, USA
    J Virol 84:8308-15. 2010
  6. pmc Clonal expansion of hepatocytes during chronic woodchuck hepatitis virus infection
    William S Mason
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 102:1139-44. 2005
  7. ncbi request reprint The competing roles of virus replication and hepatocyte death rates in the emergence of drug-resistant mutants: theoretical considerations
    Samuel Litwin
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Clin Virol 34:S96-S107. 2005
  8. pmc Mutations of the woodchuck hepatitis virus polymerase gene that confer resistance to lamivudine and 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil
    Toshiki Yamamoto
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Virol 76:1213-23. 2002
  9. ncbi request reprint Adenovirus-based gene therapy during clevudine treatment of woodchucks chronically infected with woodchuck hepatitis virus
    Yuao Zhu
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Virology 327:26-40. 2004
  10. pmc The liver of woodchucks chronically infected with the woodchuck hepatitis virus contains foci of virus core antigen-negative hepatocytes with both altered and normal morphology
    Chunxiao Xu
    Division of Basic Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Virology 359:283-94. 2007

Research Grants

  1. MOLECULAR BASIS FOR CHRONIC HEPADNAVIRAL INFECTIONS
    William Mason; Fiscal Year: 1993
  2. HEPADNAVIRUS INFECTIONS AND LIVER CANCER
    William Mason; Fiscal Year: 2004
  3. 2007 Molecular Biology of Hepatitis B Viruses Meeting
    William Mason; Fiscal Year: 2007
  4. HEPADNAVIRUS INFECTIONS AND LIVER CANCER
    William Mason; Fiscal Year: 1999
  5. HEPADNAVIRUS INFECTIONS AND LIVER CANCER
    William Mason; Fiscal Year: 2009

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Lamivudine therapy of WHV-infected woodchucks
    W S Mason
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Virology 245:18-32. 1998
    ..The YMDD motif itself remained unchanged. Not unexpectedly, the lamivudine therapy did not have a impact on development of liver cancer...
  2. pmc Immune selection during chronic hepadnavirus infection
    William S Mason
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, 19111, USA
    Hepatol Int 2:3-16. 2008
    ..To gain insights into how these latter changes take place, we employed computer simulations of the chronically infected liver...
  3. pmc Detection of clonally expanded hepatocytes in chimpanzees with chronic hepatitis B virus infection
    William S Mason
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Virol 83:8396-408. 2009
    ..However, no obvious association between the extent of clonal expansion and the integration site was apparent. This suggests that the integration site per se is not responsible for the outgrowth of large clones of hepatocytes...
  4. pmc The amount of hepatocyte turnover that occurred during resolution of transient hepadnavirus infections was lower when virus replication was inhibited with entecavir
    William S Mason
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Virol 83:1778-89. 2009
    ..Computer modeling of the complexity data suggests that mechanisms in addition to hepatocyte death were responsible for elimination of cccDNA during recovery from transient infections...
  5. pmc Clonal expansion of normal-appearing human hepatocytes during chronic hepatitis B virus infection
    William S Mason
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111, USA
    J Virol 84:8308-15. 2010
    ..This analysis revealed that clonal expansion can occur among normal-appearing human hepatocytes...
  6. pmc Clonal expansion of hepatocytes during chronic woodchuck hepatitis virus infection
    William S Mason
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 102:1139-44. 2005
    ..The results provide evidence for a large amount of hepatocyte proliferation and selection having occurred during the period of chronic WHV infection ( approximately 1.5 years) in these animals...
  7. ncbi request reprint The competing roles of virus replication and hepatocyte death rates in the emergence of drug-resistant mutants: theoretical considerations
    Samuel Litwin
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Clin Virol 34:S96-S107. 2005
    ....
  8. pmc Mutations of the woodchuck hepatitis virus polymerase gene that confer resistance to lamivudine and 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil
    Toshiki Yamamoto
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Virol 76:1213-23. 2002
    ..However, their delayed emergence during therapy suggested replication efficiency in the presence of the drug that was still well below that of wild-type WHV in the absence of the drug...
  9. ncbi request reprint Adenovirus-based gene therapy during clevudine treatment of woodchucks chronically infected with woodchuck hepatitis virus
    Yuao Zhu
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Virology 327:26-40. 2004
    ....
  10. pmc The liver of woodchucks chronically infected with the woodchuck hepatitis virus contains foci of virus core antigen-negative hepatocytes with both altered and normal morphology
    Chunxiao Xu
    Division of Basic Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Virology 359:283-94. 2007
    ..We hypothesize that a common event is loss of the ability to express WHV, allowing these hepatocytes to escape immune mediated cell death and to undergo clonal expansion to form distinct foci...
  11. pmc Primary human hepatocytes are susceptible to infection by hepatitis delta virus assembled with envelope proteins of woodchuck hepatitis virus
    Severin Gudima
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    J Virol 82:7276-83. 2008
    ..One interpretation of these data is that host range specificity of HDV is determined entirely by pre-S1 and that the WHV and HBV pre-S1 proteins recognize different receptors on PHH...
  12. pmc Identification and characterization of avihepadnaviruses isolated from exotic anseriformes maintained in captivity
    Haitao Guo
    Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA
    J Virol 79:2729-42. 2005
    ..Despite this, all of the new isolates were infectious for primary cultures of Pekin duck hepatocytes, and infectivity in young Pekin ducks was demonstrated for all but the ashy-headed sheldgoose isolate...
  13. ncbi request reprint miR-122, a mammalian liver-specific microRNA, is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1
    Jinhong Chang
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 2497, USA
    RNA Biol 1:106-13. 2004
    ..In summary, these studies followed the accumulation during development of miR-122 from its mRNA precursor, hcr, through to identification of what may be a specific mRNA target, CAT-1...
  14. pmc Hepatocyte turnover during resolution of a transient hepadnaviral infection
    Jesse Summers
    Department of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, NM 87131, USA
    Proc Natl Acad Sci U S A 100:11652-9. 2003
    ..Our results indicated that during resolution of the transient infections a large fraction of the infected hepatocyte population was killed and replaced by hepatocyte cell division...
  15. ncbi request reprint Cellular and virological mechanisms of HBV drug resistance
    Stephen Locarnini
    Research and Molecular Development, Victorian Infectious Diseases Reference Laboratory, North Melbourne, Vic 3051, Australia
    J Hepatol 44:422-31. 2006
  16. pmc Residual integrated viral DNA after hepadnavirus clearance by nucleoside analog therapy
    Jesse Summers
    Department of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, NM 87131, USA
    Proc Natl Acad Sci U S A 101:638-40. 2004
    ..Our results indicate that genetic changes from this damage remain in the liver even while virus infection is cleared and argue for early antiviral intervention in chronic hepatitis...

Research Grants27

  1. MOLECULAR BASIS FOR CHRONIC HEPADNAVIRAL INFECTIONS
    William Mason; Fiscal Year: 1993
    ....
  2. HEPADNAVIRUS INFECTIONS AND LIVER CANCER
    William Mason; Fiscal Year: 2004
    ..There is an absolute requirement for the X gene product of viral reproduction in vivo, making it an ideal therapeutic target. Experiments are described to determine where in the virus life cycle X is required. ..
  3. 2007 Molecular Biology of Hepatitis B Viruses Meeting
    William Mason; Fiscal Year: 2007
    ..Limited support for meeting materials and organizational functions is also needed. ..
  4. HEPADNAVIRUS INFECTIONS AND LIVER CANCER
    William Mason; Fiscal Year: 1999
    ..These objectives will be pursued using cell culture systems as well as woodchucks infected with woodchuck hepatitis virus and ducks infected with duck hepatitis B virus. ..
  5. HEPADNAVIRUS INFECTIONS AND LIVER CANCER
    William Mason; Fiscal Year: 2009
    ..abstract_text> ..