Peter Makhov

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. pmc Transcriptional regulation of the major zinc uptake protein hZip1 in prostate cancer cells
    Peter Makhov
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Gene 431:39-46. 2009
  2. pmc Reversal of epigenetic silencing of AP-2alpha results in increased zinc uptake in DU-145 and LNCaP prostate cancer cells
    Peter B Makhov
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Carcinogenesis 32:1773-81. 2011
  3. pmc Depletion of intracellular zinc increases expression of tumorigenic cytokines VEGF, IL-6 and IL-8 in prostate cancer cells via NF-kappaB-dependent pathway
    Konstantin Golovine
    Department of Urological Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Prostate 68:1443-9. 2008
  4. ncbi request reprint Vitamin E succinate inhibits NF-kappaB and prevents the development of a metastatic phenotype in prostate cancer cells: implications for chemoprevention
    Paul L Crispen
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Prostate 67:582-90. 2007
  5. pmc Overexpression of the zinc uptake transporter hZIP1 inhibits nuclear factor-kappaB and reduces the malignant potential of prostate cancer cells in vitro and in vivo
    Konstantin Golovine
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 10111, USA
    Clin Cancer Res 14:5376-84. 2008
  6. pmc The effect of 5-aminolevulinic acid and its derivatives on protoporphyrin IX accumulation and apoptotic cell death in castrate-resistant prostate cancer cells
    Ervin Teper
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Urology 80:1391.e1-7. 2012
  7. pmc Interleukin-6: a potential biomarker of resistance to multitargeted receptor tyrosine kinase inhibitors in castration-resistant prostate cancer
    Alexander Kutikov
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Urology 78:968.e7-11. 2011
  8. pmc Docetaxel-mediated apoptosis in myeloid progenitor TF-1 cells is mitigated by zinc: potential implication for prostate cancer therapy
    Peter Makhov
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Prostate 71:1413-9. 2011
  9. pmc Co-administration of piperine and docetaxel results in improved anti-tumor efficacy via inhibition of CYP3A4 activity
    Peter Makhov
    Department of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Prostate 72:661-7. 2012
  10. pmc Cadmium down-regulates expression of XIAP at the post-transcriptional level in prostate cancer cells through an NF-kappaB-independent, proteasome-mediated mechanism
    Konstantin Golovine
    Division of Urological Oncology, Department of Surgery, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Mol Cancer 9:183. 2010

Collaborators

Detail Information

Publications12

  1. pmc Transcriptional regulation of the major zinc uptake protein hZip1 in prostate cancer cells
    Peter Makhov
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Gene 431:39-46. 2009
    ..Our experiments identified the core promoter region responsible for constitutive expression of hZip1 and demonstrated critical roles for SP1 and CREB1 in transcriptional regulation of the hZip1 gene in prostate cancer cells...
  2. pmc Reversal of epigenetic silencing of AP-2alpha results in increased zinc uptake in DU-145 and LNCaP prostate cancer cells
    Peter B Makhov
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Carcinogenesis 32:1773-81. 2011
    ....
  3. pmc Depletion of intracellular zinc increases expression of tumorigenic cytokines VEGF, IL-6 and IL-8 in prostate cancer cells via NF-kappaB-dependent pathway
    Konstantin Golovine
    Department of Urological Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Prostate 68:1443-9. 2008
    ....
  4. ncbi request reprint Vitamin E succinate inhibits NF-kappaB and prevents the development of a metastatic phenotype in prostate cancer cells: implications for chemoprevention
    Paul L Crispen
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Prostate 67:582-90. 2007
    ..NF-kappaB and AP-1 transcriptional factors contribute to the development and progression of prostate malignancy by regulating the expression of genes involved in proliferation, apoptosis, angiogenesis, and metastasis...
  5. pmc Overexpression of the zinc uptake transporter hZIP1 inhibits nuclear factor-kappaB and reduces the malignant potential of prostate cancer cells in vitro and in vivo
    Konstantin Golovine
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 10111, USA
    Clin Cancer Res 14:5376-84. 2008
    ..In this study, we investigate the functional effect of hZIP1 overexpression on NF-kappaB activity and tumorigenic potential in human prostate cancer cells in vitro and in vivo...
  6. pmc The effect of 5-aminolevulinic acid and its derivatives on protoporphyrin IX accumulation and apoptotic cell death in castrate-resistant prostate cancer cells
    Ervin Teper
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Urology 80:1391.e1-7. 2012
    ....
  7. pmc Interleukin-6: a potential biomarker of resistance to multitargeted receptor tyrosine kinase inhibitors in castration-resistant prostate cancer
    Alexander Kutikov
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Urology 78:968.e7-11. 2011
    ..As such, we investigated whether cellular IL-6 production can predict TKI response in both in vitro and in vivo models...
  8. pmc Docetaxel-mediated apoptosis in myeloid progenitor TF-1 cells is mitigated by zinc: potential implication for prostate cancer therapy
    Peter Makhov
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Prostate 71:1413-9. 2011
    ..Induction of pre-mitotic arrest protects cells against docetaxel-mediated toxicity and affords therapeutic opportunities...
  9. pmc Co-administration of piperine and docetaxel results in improved anti-tumor efficacy via inhibition of CYP3A4 activity
    Peter Makhov
    Department of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Prostate 72:661-7. 2012
    ..Thus, we investigated whether the co-administration of piperine and docetaxel could increase docetaxel's pharmacokinetic activity in vitro and in vivo...
  10. pmc Cadmium down-regulates expression of XIAP at the post-transcriptional level in prostate cancer cells through an NF-kappaB-independent, proteasome-mediated mechanism
    Konstantin Golovine
    Division of Urological Oncology, Department of Surgery, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Mol Cancer 9:183. 2010
    ..The prostate is one of the organs with highest levels of cadmium accumulation. Importantly, patients with prostate cancer appear to have higher levels of cadmium both in the circulation and in prostatic tissues...
  11. ncbi request reprint Diverse effects of zinc on NF-kappaB and AP-1 transcription factors: implications for prostate cancer progression
    Robert G Uzzo
    Department of Urological Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Carcinogenesis 27:1980-90. 2006
    ..Upregulation of intracellular zinc levels may have important implications for inhibiting the angiogenic and metastatic potentials of malignant cells, predominantly through suppression of NF-kappaB signaling...
  12. ncbi request reprint Methylseleninic acid sensitizes prostate cancer cells to TRAIL-mediated apoptosis
    Kenya Yamaguchi
    Department of Urological Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Oncogene 24:5868-77. 2005
    ..These results suggest that selenium-based dietary compounds may help to overcome resistance to TRAIL-mediated apoptosis in prostate cancer cells...