Research Topics
Genomes and Genes | Gary D KruhSummaryAffiliation: Fox Chase Cancer Center Country: USA Publications
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ABCC10, ABCC11, and ABCC12Gary D Kruh
Medical Science Division, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Pflugers Arch 453:675-84. 2007..The functional characteristics of MRP9 are currently unknown...- MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenineYanping Guo
Medical Science Division, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
J Biol Chem 278:29509-14. 2003..We conclude that MRP8 is an amphipathic anion transporter that is able to efflux cAMP and cGMP and to function as a resistance factor for commonly employed purine and pyrimidine nucleotide analogs... - Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11)Zhe Sheng Chen
Medical Science Division, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA
Mol Pharmacol 67:545-57. 2005..These results suggest that MRP8 participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides and indicate that the pump has complex interactions with its substrates... - Transport of methotrexate, methotrexate polyglutamates, and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2: effects of acquired mutations at R482 on methotrexate transportZhe Sheng Chen
Medical Science Division, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Cancer Res 63:4048-54. 2003..In addition, it is demonstrated that R482 mutations observed in drug-resistant cell lines have profound effects on the in vitro transport properties of the pump... - Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): resistance to docetaxelElizabeth Hopper-Borge
Medical Science Division, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Cancer Res 64:4927-30. 2004..These results indicate that MRP7, unlike other MRPs, is a resistance factor for taxanes... - Multidrug resistance protein 4 protects bone marrow, thymus, spleen, and intestine from nucleotide analogue-induced damageMartin G Belinsky
Medical Science Division, Department of Pathology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
Cancer Res 67:262-8. 2007..This is the first demonstration that an ATP-binding cassette transporter can affect in vivo tissue sensitivity towards this class of agents... 
Expression of ABCC-type nucleotide exporters in blasts of adult acute myeloid leukemia: relation to long-term survivalYanping Guo
Medical Science Division, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
Clin Cancer Res 15:1762-9. 2009..g., cyclic adenosine 3', 5'-monophosphate and cyclic guanosine 3',5'-monophosphate) and nucleoside analogues. The nucleoside analogue cytosine arabinoside (AraC) is administered to all patients with AML...- Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10)Zhe Sheng Chen
Medical Sciences Division, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Mol Pharmacol 63:351-8. 2003..The determination that MRP7 has the facility for mediating the transport of conjugates such as E(2)17betaG indicates that it is a lipophilic anion transporter involved in phase III (cellular extrusion) of detoxification... - Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 as determined from recent studies on gene-disrupted miceGary D Kruh
Medical Science Division, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Cancer Metastasis Rev 26:5-14. 2007..This review will discuss insights into the physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 afforded by investigations of these new mouse models... 
Contribution of Abcc10 (Mrp7) to in vivo paclitaxel resistance as assessed in Abcc10(-/-) miceElizabeth A Hopper-Borge
Program in Developmental Therapeutics, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Cancer Res 71:3649-57. 2011..This is the first demonstration that an ATP-binding cassette transporter other than P-glycoprotein can affect in vivo tissue sensitivity toward taxanes...- Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6)Martin G Belinsky
Medical Science Division, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Cancer Res 62:6172-7. 2002..These results indicate that MRP6 is a glutathione conjugate pump that is able to confer low levels of resistance to certain anticancer agents... - Human multidrug resistance protein 7 (ABCC10) is a resistance factor for nucleoside analogues and epothilone BElizabeth Hopper-Borge
Medical and Basic Science Divisions, Fox Chase Cancer Center, Philadelphia, Pennsylvania
Cancer Res 69:178-84. 2009.... - Targeted ablation of Abcc1 or Abcc3 in Abcc6(-/-) mice does not modify the ectopic mineralization processQiaoli Li
Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
Exp Dermatol 16:853-9. 2007.... - Determination of methotrexate and its major metabolite 7-hydroxymethotrexate in mouse plasma and brain tissue by liquid chromatography-tandem mass spectrometryPing Guo
School of Pharmacy, Temple University, Philadelphia, PA 19140, USA
J Pharm Biomed Anal 43:1789-95. 2007..The method has the advantages of low sample volume, rapid clean-up, and the simultaneous measurement of MTX and 7-OH MTX in plasma and brain tissues allowing detailed PK studies to be completed in individual mice... - Analysis of the in vivo functions of Mrp3Martin G Belinsky
Medical Science Division, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
Mol Pharmacol 68:160-8. 2005.... - Dose-dependent disposition of methotrexate in Abcc2 and Abcc3 gene knockout murine modelsZhan Wang
Department of Pharmaceutical Sciences, Temple University, Philadelphia, Pennsylvania, USA
Drug Metab Dispos 39:2155-61. 2011..The findings confirmed that both Abcc2 and Abcc3 significantly influenced the PK properties of MTX, and depending on the MTX dose and strain, alternate elimination pathways were elicited and saturable... - Ins and outs of taxanesGary D Kruh
Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Cancer Biol Ther 4:1030-2. 2005 - The MRP family of drug efflux pumpsGary D Kruh
Medical Science Division, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Oncogene 22:7537-52. 2003..The review will describe the biochemical properties, drug resistance activities and potential in vivo functions of these unusual pumps... - Predicting human tumor drug concentrations from a preclinical pharmacokinetic model of temozolomide brain dispositionQingyu Zhou
Department of Pharmaceutical Sciences, School of Pharmacy, Temple University, Philadelphia, PA 19140, USA
Clin Cancer Res 13:4271-9. 2007..Our goal was to show how the latter could be achieved for temozolomide, an agent used in the treatment of brain tumors, using an orthotopic brain tumor model in rats... - Introduction to resistance to anticancer agentsGary D Kruh
Medical Science Division, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Oncogene 22:7262-4. 2003 - Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux systemZhe-Sheng Chen
Medical Science Division, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
Cancer Res 62:3144-50. 2002.... - The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasisAnuradha Rao
Department of Internal Medicine, Section on Gastroenterology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Proc Natl Acad Sci U S A 105:3891-6. 2008..Unlike a block in intestinal apical bile acid uptake, genetic ablation of basolateral bile acid export disrupts the classical homeostatic control of hepatic bile acid biosynthesis... - Evaluation of the role of multidrug resistance-associated protein (Mrp) 3 and Mrp4 in hepatic basolateral excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in Abcc3-/- and Abcc4-/- miceMaciej J Zamek-Gliszczynski
University of North Carolina, School of Pharmacy, Kerr Hall, CB 7360, Chapel Hill, NC 27599 7360, USA
J Pharmacol Exp Ther 319:1485-91. 2006..In addition, they reveal that Mrp3 mediates the hepatic basolateral excretion of diverse glucuronide conjugates... - Up-regulation of MRP4 and down-regulation of influx transporters in human leukemic cells with acquired resistance to 6-mercaptopurineXing Xiang Peng
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, NY 11439, United States
Leuk Res 32:799-809. 2008..Taken together these results showed that up-regulation of MRP4 and down-regulation of influx transporters played a major role in 6-MP resistance of CEM-MP5 cells... - Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cellsGergely Szakacs
Laboratory of Cell Biology, Center for Cancer Research, NCI, NIH, Bethesda, MD, 20892, USA
Cancer Cell 6:129-37. 2004..Unexpectedly, we also found and validated compounds whose activity is potentiated, rather than antagonized, by the MDR1 multidrug transporter. Such compounds may serve as leads for development... - ABCC11 expression is regulated by estrogen in MCF7 cells, correlated with estrogen receptor alpha expression in postmenopausal breast tumors and overexpressed in tamoxifen-resistant breast cancer cellsMylène Honorat
Universite de Lyon, Lyon1, ISPB, Lyon, France
Endocr Relat Cancer 15:125-38. 2008..ABCC11 may be a potential predictive tool in the choice of anticancer therapies in ER-positive breast cancers resistant to TAM... - Characterization of a 67Ga/68Ga radiopharmaceutical for SPECT and PET of MDR1 P-glycoprotein transport activity in vivo: validation in multidrug-resistant tumors and at the blood-brain barrierVijay Sharma
Molecular Imaging Center, Mallinckrodt Institute of Radiology, St. Louis, Missouri, USA
J Nucl Med 46:354-64. 2005..These Pgp-directed properties of the radiopharmaceutical may also translate favorably to myocardial perfusion imaging... - ArgBP2gamma interacts with Akt and p21-activated kinase-1 and promotes cell survivalZeng Qiang Yuan
Department of Pathology, University of South Florida College of Medicine and H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
J Biol Chem 280:21483-90. 2005..These data indicate that ArgBP2gamma is a physiological substrate of Akt, functions as an adaptor for Akt and PAK1, and plays a role in Akt/PAK1 cell survival pathway... - Comparative study of the importance of multidrug resistance-associated protein 1 and P-glycoprotein to drug sensitivity in immortalized mouse embryonic fibroblastsZ Ping Lin
Department of Pharmacology, Developmental Therapeutics Program, Cancer Center, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
Mol Cancer Ther 1:1105-14. 2002..They also suggest the existence of a compensatory mechanism by which the loss of one transporter can be functionally offset by the other in the transport of common drug substrates... - Impact of basolateral multidrug resistance-associated protein (Mrp) 3 and Mrp4 on the hepatobiliary disposition of fexofenadine in perfused mouse liversXianbin Tian
School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7360, USA
Drug Metab Dispos 36:911-5. 2008..In addition to Mrp2 and Mrp3, other transport proteins play an important role in the biliary and hepatic basolateral excretion of this zwitterionic drug...