Vladimir M Kolenko

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. pmc Zinc and zinc transporters in prostate carcinogenesis
    Vladimir Kolenko
    Fox Chase Cancer Center, Department of Surgical Oncology, Philadelphia, PA 19111 2497, USA
    Nat Rev Urol 10:219-26. 2013
  2. pmc Modulation of Akt/mTOR signaling overcomes sunitinib resistance in renal and prostate cancer cells
    Peter B Makhov
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Cancer Ther 11:1510-7. 2012
  3. pmc Interleukin-6: a potential biomarker of resistance to multitargeted receptor tyrosine kinase inhibitors in castration-resistant prostate cancer
    Alexander Kutikov
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Urology 78:968.e7-11. 2011
  4. pmc Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells
    Konstantin V Golovine
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania
    Prostate 73:23-30. 2013
  5. ncbi request reprint Vitamin E succinate inhibits NF-kappaB and prevents the development of a metastatic phenotype in prostate cancer cells: implications for chemoprevention
    Paul L Crispen
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Prostate 67:582-90. 2007
  6. pmc Depletion of intracellular zinc increases expression of tumorigenic cytokines VEGF, IL-6 and IL-8 in prostate cancer cells via NF-kappaB-dependent pathway
    Konstantin Golovine
    Department of Urological Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Prostate 68:1443-9. 2008
  7. pmc The effect of 5-aminolevulinic acid and its derivatives on protoporphyrin IX accumulation and apoptotic cell death in castrate-resistant prostate cancer cells
    Ervin Teper
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Urology 80:1391.e1-7. 2012
  8. pmc Overexpression of the zinc uptake transporter hZIP1 inhibits nuclear factor-kappaB and reduces the malignant potential of prostate cancer cells in vitro and in vivo
    Konstantin Golovine
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 10111, USA
    Clin Cancer Res 14:5376-84. 2008
  9. pmc Transcriptional regulation of the major zinc uptake protein hZip1 in prostate cancer cells
    Peter Makhov
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Gene 431:39-46. 2009
  10. pmc Piperlongumine inhibits NF-κB activity and attenuates aggressive growth characteristics of prostate cancer cells
    Serge Ginzburg
    Department of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, PA
    Prostate 74:177-86. 2014

Collaborators

Detail Information

Publications19

  1. pmc Zinc and zinc transporters in prostate carcinogenesis
    Vladimir Kolenko
    Fox Chase Cancer Center, Department of Surgical Oncology, Philadelphia, PA 19111 2497, USA
    Nat Rev Urol 10:219-26. 2013
    ..Only then can the potential of zinc and zinc transport proteins be harnessed in the diagnosis and treatment of men with prostate cancer...
  2. pmc Modulation of Akt/mTOR signaling overcomes sunitinib resistance in renal and prostate cancer cells
    Peter B Makhov
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Cancer Ther 11:1510-7. 2012
    ..Our findings underscore the importance of PTEN expression in relation to sunitinib resistance and imply a direct cytotoxic effect by sunitinib on tumor cells in addition to its antiangiogenic actions...
  3. pmc Interleukin-6: a potential biomarker of resistance to multitargeted receptor tyrosine kinase inhibitors in castration-resistant prostate cancer
    Alexander Kutikov
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Urology 78:968.e7-11. 2011
    ..As such, we investigated whether cellular IL-6 production can predict TKI response in both in vitro and in vivo models...
  4. pmc Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells
    Konstantin V Golovine
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania
    Prostate 73:23-30. 2013
    ..In this study, we investigate the functional impact of piperlongumine (PL), a naturally occurring alkaloid present in the Long pepper (Piper longum), on AR expression in PC cells and delineate its mechanism of action...
  5. ncbi request reprint Vitamin E succinate inhibits NF-kappaB and prevents the development of a metastatic phenotype in prostate cancer cells: implications for chemoprevention
    Paul L Crispen
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Prostate 67:582-90. 2007
    ..NF-kappaB and AP-1 transcriptional factors contribute to the development and progression of prostate malignancy by regulating the expression of genes involved in proliferation, apoptosis, angiogenesis, and metastasis...
  6. pmc Depletion of intracellular zinc increases expression of tumorigenic cytokines VEGF, IL-6 and IL-8 in prostate cancer cells via NF-kappaB-dependent pathway
    Konstantin Golovine
    Department of Urological Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Prostate 68:1443-9. 2008
    ....
  7. pmc The effect of 5-aminolevulinic acid and its derivatives on protoporphyrin IX accumulation and apoptotic cell death in castrate-resistant prostate cancer cells
    Ervin Teper
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Urology 80:1391.e1-7. 2012
    ....
  8. pmc Overexpression of the zinc uptake transporter hZIP1 inhibits nuclear factor-kappaB and reduces the malignant potential of prostate cancer cells in vitro and in vivo
    Konstantin Golovine
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 10111, USA
    Clin Cancer Res 14:5376-84. 2008
    ..In this study, we investigate the functional effect of hZIP1 overexpression on NF-kappaB activity and tumorigenic potential in human prostate cancer cells in vitro and in vivo...
  9. pmc Transcriptional regulation of the major zinc uptake protein hZip1 in prostate cancer cells
    Peter Makhov
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Gene 431:39-46. 2009
    ..Our experiments identified the core promoter region responsible for constitutive expression of hZip1 and demonstrated critical roles for SP1 and CREB1 in transcriptional regulation of the hZip1 gene in prostate cancer cells...
  10. pmc Piperlongumine inhibits NF-κB activity and attenuates aggressive growth characteristics of prostate cancer cells
    Serge Ginzburg
    Department of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, PA
    Prostate 74:177-86. 2014
    ..We look at the effects of piperlongumine (PL), a biologically active alkaloid/amide present in piper longum plant, on the NF-κB pathway in androgen-independent prostate cancer cells...
  11. pmc Co-administration of piperine and docetaxel results in improved anti-tumor efficacy via inhibition of CYP3A4 activity
    Peter Makhov
    Department of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Prostate 72:661-7. 2012
    ..Thus, we investigated whether the co-administration of piperine and docetaxel could increase docetaxel's pharmacokinetic activity in vitro and in vivo...
  12. ncbi request reprint Diverse effects of zinc on NF-kappaB and AP-1 transcription factors: implications for prostate cancer progression
    Robert G Uzzo
    Department of Urological Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Carcinogenesis 27:1980-90. 2006
    ..Upregulation of intracellular zinc levels may have important implications for inhibiting the angiogenic and metastatic potentials of malignant cells, predominantly through suppression of NF-kappaB signaling...
  13. pmc Reversal of epigenetic silencing of AP-2alpha results in increased zinc uptake in DU-145 and LNCaP prostate cancer cells
    Peter B Makhov
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Carcinogenesis 32:1773-81. 2011
    ....
  14. pmc Docetaxel-mediated apoptosis in myeloid progenitor TF-1 cells is mitigated by zinc: potential implication for prostate cancer therapy
    Peter Makhov
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Prostate 71:1413-9. 2011
    ..Induction of pre-mitotic arrest protects cells against docetaxel-mediated toxicity and affords therapeutic opportunities...
  15. ncbi request reprint Methylseleninic acid sensitizes prostate cancer cells to TRAIL-mediated apoptosis
    Kenya Yamaguchi
    Department of Urological Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Oncogene 24:5868-77. 2005
    ..These results suggest that selenium-based dietary compounds may help to overcome resistance to TRAIL-mediated apoptosis in prostate cancer cells...
  16. pmc Cadmium down-regulates expression of XIAP at the post-transcriptional level in prostate cancer cells through an NF-kappaB-independent, proteasome-mediated mechanism
    Konstantin Golovine
    Division of Urological Oncology, Department of Surgery, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Mol Cancer 9:183. 2010
    ..The prostate is one of the organs with highest levels of cadmium accumulation. Importantly, patients with prostate cancer appear to have higher levels of cadmium both in the circulation and in prostatic tissues...
  17. pmc Are all multi-targeted tyrosine kinase inhibitors created equal? An in vitro study of sunitinib and pazopanib in renal cell carcinoma cell lines
    Daniel Canter
    Division of Urologic Oncology, Department of Surgery, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Can J Urol 18:5819-25. 2011
    ..We examined the in vitro cellular effects of the multi-targeted receptor tyrosine kinase inhibitors (TKIs) sunitinib and pazopanib on a series of human renal cell carcinoma (RCC) cell lines...
  18. doi request reprint Mechanisms of apoptosis resistance and treatment strategies to overcome them in hormone-refractory prostate cancer
    Robert G Uzzo
    Division of Urology, Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer 112:1660-71. 2008
    ..In this review, the authors focused on the established aberrations of apoptosis in hormone-refractory prostate cancer, and they have described novel treatment strategies to overcome apoptosis resistance...
  19. ncbi request reprint Zinc inhibits nuclear factor-kappa B activation and sensitizes prostate cancer cells to cytotoxic agents
    Robert G Uzzo
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Clin Cancer Res 8:3579-83. 2002
    ..These results suggest one possible mechanism for the inhibitory effect of zinc on the development and progression of prostate malignancy and might have important consequences for the prevention and treatment of prostate cancer...