A G Knudson

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. ncbi request reprint Two genetic hits (more or less) to cancer
    A G Knudson
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Nat Rev Cancer 1:157-62. 2001
  2. ncbi request reprint Cancer genetics through a personal retrospectroscope
    Alfred G Knudson
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Genes Chromosomes Cancer 38:288-91. 2003
  3. ncbi request reprint Chasing the cancer demon
    A G Knudson
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Annu Rev Genet 34:1-19. 2000
  4. ncbi request reprint Cancer genetics
    Alfred G Knudson
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Am J Med Genet 111:96-102. 2002
  5. ncbi request reprint The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19
    R S Yeung
    Division of Medical Science, Fox Chase Cancer Center, Philadelphia, PA 19111
    Oncogene 8:3465-8. 1993
  6. ncbi request reprint Assignment of 22 loci in the rat by somatic hybrid and linkage analysis
    R S Yeung
    Fox Chase Cancer Center, Department of Surgical Oncology, Philadelphia, Pennsylvania 19111
    Mamm Genome 4:585-8. 1993
  7. pmc The ninth Gordon Hamilton-Fairley memorial lecture. Hereditary cancers: clues to mechanisms of carcinogenesis
    A G Knudson
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111
    Br J Cancer 59:661-6. 1989
  8. pmc Susceptibility to renal carcinoma in the Eker rat involves a tumor suppressor gene on chromosome 10
    R S Yeung
    Division of Medical Science, Fox Chase Cancer Center, Philadelphia, PA 19111
    Proc Natl Acad Sci U S A 90:8038-42. 1993
  9. ncbi request reprint A personal sixty-year tour of genetics and medicine
    Alfred G Knudson
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Annu Rev Genomics Hum Genet 6:1-14. 2005
  10. ncbi request reprint Knudson's hypothesis and the TP53 revolution
    Suzanne J Baker
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Genes Chromosomes Cancer 38:329. 2003

Detail Information

Publications16

  1. ncbi request reprint Two genetic hits (more or less) to cancer
    A G Knudson
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Nat Rev Cancer 1:157-62. 2001
    ..Evidence from the recent molecular era also indicates that cancers can arise from small numbers of events that affect common cell birth and death processes...
  2. ncbi request reprint Cancer genetics through a personal retrospectroscope
    Alfred G Knudson
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Genes Chromosomes Cancer 38:288-91. 2003
  3. ncbi request reprint Chasing the cancer demon
    A G Knudson
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Annu Rev Genet 34:1-19. 2000
    ..The common carcinomas are much more complex and are typically genetically unstable, owing either to mutational instability or chromosomal instability...
  4. ncbi request reprint Cancer genetics
    Alfred G Knudson
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Am J Med Genet 111:96-102. 2002
    ..The knowledge gained is stimulating new approaches to the treatment and prevention of cancer...
  5. ncbi request reprint The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19
    R S Yeung
    Division of Medical Science, Fox Chase Cancer Center, Philadelphia, PA 19111
    Oncogene 8:3465-8. 1993
    ..Deletions of chromosome 16q have been found in several human neoplasias (including breast, ovarian, hepatic, and prostatic cancers) which is in support of an involvement of RB2 in human cancer as a tumor suppressor gene...
  6. ncbi request reprint Assignment of 22 loci in the rat by somatic hybrid and linkage analysis
    R S Yeung
    Fox Chase Cancer Center, Department of Surgical Oncology, Philadelphia, Pennsylvania 19111
    Mamm Genome 4:585-8. 1993
    ..Results of this study further support the extensive conservation of synteny between the rat and mouse and, to a lesser degree, between rat and human...
  7. pmc The ninth Gordon Hamilton-Fairley memorial lecture. Hereditary cancers: clues to mechanisms of carcinogenesis
    A G Knudson
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111
    Br J Cancer 59:661-6. 1989
    ..For this tumour the recessive mechanism has been demonstrated by molecular means, and the gene has been cloned. The possibility has been suggested that gene (or gene product) replacement therapy could be accomplished...
  8. pmc Susceptibility to renal carcinoma in the Eker rat involves a tumor suppressor gene on chromosome 10
    R S Yeung
    Division of Medical Science, Fox Chase Cancer Center, Philadelphia, PA 19111
    Proc Natl Acad Sci U S A 90:8038-42. 1993
    ..Our result suggested that the human homolog of the RC gene may reside on human chromosome 16, not known to be altered commonly in human RC...
  9. ncbi request reprint A personal sixty-year tour of genetics and medicine
    Alfred G Knudson
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Annu Rev Genomics Hum Genet 6:1-14. 2005
    ....
  10. ncbi request reprint Knudson's hypothesis and the TP53 revolution
    Suzanne J Baker
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Genes Chromosomes Cancer 38:329. 2003
  11. ncbi request reprint A personal and professional memoir of Alfred Knudson
    Anna T Meadows
    The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Genes Chromosomes Cancer 38:300-1. 2003
  12. ncbi request reprint A tribute to Alfred G. Knudson
    Edward B Lewis
    Biology Division 156 29, California Institute of Technology, Pasadena, California, USA
    Genes Chromosomes Cancer 38:292-3. 2003
  13. ncbi request reprint Tumor suppressor genes and the two-hit model of recessive oncogenesis: celebrating Alfred Knudson's 80th birthday
    Joseph R Testa
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Genes Chromosomes Cancer 38:286-7. 2003
  14. pmc Endogenous DNA double-strand breaks: production, fidelity of repair, and induction of cancer
    Michael M Vilenchik
    The Sally Balin Medical Center, Media, PA 19063, USA
    Proc Natl Acad Sci U S A 100:12871-6. 2003
    ..We conclude that rates of production of EDSBs and of ensuing spontaneous mitotic recombination events can account for a substantial fraction of the earliest oncogenic events in human carcinomas...
  15. ncbi request reprint Improvements in tumor targeting, survivorship, and chemoprevention pioneered by tamoxifen. A personal perspective
    V Craig Jordan
    Medical Science Division, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Oncology (Williston Park) 20:553-62; discussion 567-8, 573, 577. 2006
    ..This knowledge would establish a practical approach to breast cancer chemoprevention for women at high risk (tamoxifen) and low risk (raloxifene)...