RICHARD ALAN KATZ

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. ncbi High-frequency epigenetic repression and silencing of retroviruses can be antagonized by histone deacetylase inhibitors and transcriptional activators, but uniform reactivation in cell clones is restricted by additional mechanisms
    Richard A Katz
    Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Virol 81:2592-604. 2007
  2. ncbi Evidence that stable retroviral transduction and cell survival following DNA integration depend on components of the nonhomologous end joining repair pathway
    Rene Daniel
    Fox Chase Cancer Center, Institute for Cancer Research, 333 Cottman Ave, Philadelphia, PA 19111 2497, USA
    J Virol 78:8573-81. 2004
  3. ncbi Identification of a functional network of human epigenetic silencing factors
    Andrey Poleshko
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 285:422-33. 2010
  4. ncbi Transduction of terminally differentiated neurons by avian sarcoma virus
    James G Greger
    Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, Pennsylvania 19111-2497, USA
    J Virol 78:4902-6. 2004
  5. ncbi Identification of cellular proteins that maintain retroviral epigenetic silencing: evidence for an antiviral response
    Andrey Poleshko
    Fox Chase Cancer Center, Institute for Cancer Research, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Virol 82:2313-23. 2008
  6. ncbi The cellular protein daxx interacts with avian sarcoma virus integrase and viral DNA to repress viral transcription
    James G Greger
    Fox Chase Cancer Center, Institute for Cancer Research, 333 Cottman Ave, Philadelphia, PA 19111 2497, USA
    J Virol 79:4610-8. 2005
  7. ncbi Transduction of interphase cells by avian sarcoma virus
    Richard A Katz
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Virol 76:5422-34. 2002
  8. ncbi Integrase-specific enhancement and suppression of retroviral DNA integration by compacted chromatin structure in vitro
    Konstantin D Taganov
    Fox Chase Cancer Center, Institute for Cancer Research, 333 Cottman Ave, Philadelphia, PA 19111-2497, USA
    J Virol 78:5848-55. 2004
  9. ncbi Human immunodeficiency virus type 1 DNA nuclear import and integration are mitosis independent in cycling cells
    Richard A Katz
    Institute for Cancer Research, Fox Chase Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19111, USA
    J Virol 77:13412-7. 2003
  10. ncbi Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response
    Rene Daniel
    Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 100:4778-83. 2003

Research Grants

  1. GFP-Based Assays to Probe Transcriptional Controls(RMI)
    Richard Katz; Fiscal Year: 2005
  2. Discovery of Epigenetic Marks in Human Cells by High Throughput siRNA Screening
    RICHARD ALAN KATZ; Fiscal Year: 2010
  3. Discovery of Epigenetic Marks in Human Cells by High Throughput siRNA Screening
    Richard Katz; Fiscal Year: 2009

Collaborators

Detail Information

Publications13

  1. ncbi High-frequency epigenetic repression and silencing of retroviruses can be antagonized by histone deacetylase inhibitors and transcriptional activators, but uniform reactivation in cell clones is restricted by additional mechanisms
    Richard A Katz
    Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Virol 81:2592-604. 2007
    ..We conclude that HDACs can act rapidly to initiate and maintain promoter-independent retroviral epigenetic repression and silencing but that reactivation can be restricted by additional mechanisms...
  2. ncbi Evidence that stable retroviral transduction and cell survival following DNA integration depend on components of the nonhomologous end joining repair pathway
    Rene Daniel
    Fox Chase Cancer Center, Institute for Cancer Research, 333 Cottman Ave, Philadelphia, PA 19111 2497, USA
    J Virol 78:8573-81. 2004
    ..Results presented in this study lend further support to a general role for the NHEJ DNA repair pathway in completion of the retroviral DNA integration process...
  3. ncbi Identification of a functional network of human epigenetic silencing factors
    Andrey Poleshko
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 285:422-33. 2010
    ..These results reveal how functionally diverse factors may cooperate to maintain gene silencing during normal development or in disease. Furthermore, the findings suggest an avenue for discovery of new targets for epigenetic therapies...
  4. ncbi Transduction of terminally differentiated neurons by avian sarcoma virus
    James G Greger
    Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, Pennsylvania 19111-2497, USA
    J Virol 78:4902-6. 2004
    ..The transduction efficiency of the ASV vector was found to be intermediate between the relatively high and low efficiencies obtained with human immunodeficiency virus type 1 and murine leukemia virus vectors, respectively...
  5. ncbi Identification of cellular proteins that maintain retroviral epigenetic silencing: evidence for an antiviral response
    Andrey Poleshko
    Fox Chase Cancer Center, Institute for Cancer Research, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Virol 82:2313-23. 2008
    ..Furthermore, our results indicate that siRNAs can be used as specific reagents to interrupt the maintenance of epigenetic silencing...
  6. ncbi The cellular protein daxx interacts with avian sarcoma virus integrase and viral DNA to repress viral transcription
    James G Greger
    Fox Chase Cancer Center, Institute for Cancer Research, 333 Cottman Ave, Philadelphia, PA 19111 2497, USA
    J Virol 79:4610-8. 2005
    ..Our findings provide a novel example of cellular immunity against viral replication in which viral transcription is repressed via the recruitment of antiviral proteins to the viral DNA...
  7. ncbi Transduction of interphase cells by avian sarcoma virus
    Richard A Katz
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Virol 76:5422-34. 2002
    ..Lastly, we observed that ASV can transduce postmitotic mouse neurons. These results support an active nuclear import mechanism for the oncoretrovirus ASV and suggest that this mechanism can operate in both nondividing and dividing cells...
  8. ncbi Integrase-specific enhancement and suppression of retroviral DNA integration by compacted chromatin structure in vitro
    Konstantin D Taganov
    Fox Chase Cancer Center, Institute for Cancer Research, 333 Cottman Ave, Philadelphia, PA 19111-2497, USA
    J Virol 78:5848-55. 2004
    ..These distinct properties of integrases may also affect target site selection in vivo, resulting in an important bias against or in favor of integration into actively transcribed host DNA...
  9. ncbi Human immunodeficiency virus type 1 DNA nuclear import and integration are mitosis independent in cycling cells
    Richard A Katz
    Institute for Cancer Research, Fox Chase Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19111, USA
    J Virol 77:13412-7. 2003
    ..We conclude that efficient nuclear entry can occur independently of mitotic nuclear disassembly in cycling cells...
  10. ncbi Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response
    Rene Daniel
    Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 100:4778-83. 2003
    ..Components of the cellular DNA damage repair response may represent potential targets for antiretroviral drug development...
  11. ncbi Genome-wide analyses of avian sarcoma virus integration sites
    Anna Narezkina
    Fox Chase Cancer Center, Institute for Cancer Research, 333 Cottman Ave, Philadelphia, PA 19111-2497, USA
    J Virol 78:11656-63. 2004
    ..Such differences may be relevant to viral pathogenesis and provide utility in retroviral vector design...
  12. ncbi Histone H2AX is phosphorylated at sites of retroviral DNA integration but is dispensable for postintegration repair
    Rene Daniel
    Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, Pennsylvania 19111 2497, USA
    J Biol Chem 279:45810-4. 2004
    ..These observations provide independent support for an anchoring model for the function of gammaH2AX in chromatin repair...
  13. ncbi Effects of cell cycle status on early events in retroviral replication
    Richard A Katz
    Fox Chase Cancer Center, Institute for Cancer Research, 333 Cottman Avenue, Philadelphia, PA 19111-2497, USA
    J Cell Biochem 94:880-9. 2005
    ..However, all retroviruses are subject to a variety of cell cycle restrictions. Here, we discuss such restrictions, and how they may block retroviral replication, be tolerated, or overcome...

Research Grants5

  1. GFP-Based Assays to Probe Transcriptional Controls(RMI)
    Richard Katz; Fiscal Year: 2005
    ..The assays have the potential to reveal new lead compounds, as well as new gene targets for therapeutics. ..
  2. Discovery of Epigenetic Marks in Human Cells by High Throughput siRNA Screening
    RICHARD ALAN KATZ; Fiscal Year: 2010
    ..This process, termed "epigenetic silencing," is reversible, and the goal of the proposed research is to identify novel cellular processes that cause epigenetic silencing such that new therapies can be devised. ..
  3. Discovery of Epigenetic Marks in Human Cells by High Throughput siRNA Screening
    Richard Katz; Fiscal Year: 2009
    ..This process, termed "epigenetic silencing," is reversible, and the goal of the proposed research is to identify novel cellular processes that cause epigenetic silencing such that new therapies can be devised. ..