R A Katz

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. pmc Transduction of interphase cells by avian sarcoma virus
    Richard A Katz
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Virol 76:5422-34. 2002
  2. pmc Human immunodeficiency virus type 1 DNA nuclear import and integration are mitosis independent in cycling cells
    Richard A Katz
    Institute for Cancer Research, Fox Chase Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19111, USA
    J Virol 77:13412-7. 2003
  3. ncbi request reprint Effects of cell cycle status on early events in retroviral replication
    Richard A Katz
    Fox Chase Cancer Center, Institute for Cancer Research, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    J Cell Biochem 94:880-9. 2005
  4. pmc High-frequency epigenetic repression and silencing of retroviruses can be antagonized by histone deacetylase inhibitors and transcriptional activators, but uniform reactivation in cell clones is restricted by additional mechanisms
    Richard A Katz
    Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Virol 81:2592-604. 2007
  5. ncbi request reprint A preferred target DNA structure for retroviral integrase in vitro
    R A Katz
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 273:24190-5. 1998
  6. ncbi request reprint Role of DNA end distortion in catalysis by avian sarcoma virus integrase
    R A Katz
    Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 276:34213-20. 2001
  7. pmc Wortmannin potentiates integrase-mediated killing of lymphocytes and reduces the efficiency of stable transduction by retroviruses
    R Daniel
    Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, Pennsylvania 19111, USA
    Mol Cell Biol 21:1164-72. 2001
  8. ncbi request reprint Retroviral DNA integration and the DNA damage response
    A M Skalka
    Fox Chase Cancer Center, Institute for Cancer Research, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    Cell Death Differ 12:971-8. 2005
  9. ncbi request reprint The avian retroviral IN protein is both necessary and sufficient for integrative recombination in vitro
    R A Katz
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111
    Cell 63:87-95. 1990
  10. pmc Computational analysis of retrovirus-induced scid cell death
    R Daniel
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Virol 75:3121-8. 2001

Collaborators

Detail Information

Publications22

  1. pmc Transduction of interphase cells by avian sarcoma virus
    Richard A Katz
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Virol 76:5422-34. 2002
    ..Lastly, we observed that ASV can transduce postmitotic mouse neurons. These results support an active nuclear import mechanism for the oncoretrovirus ASV and suggest that this mechanism can operate in both nondividing and dividing cells...
  2. pmc Human immunodeficiency virus type 1 DNA nuclear import and integration are mitosis independent in cycling cells
    Richard A Katz
    Institute for Cancer Research, Fox Chase Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19111, USA
    J Virol 77:13412-7. 2003
    ..We conclude that efficient nuclear entry can occur independently of mitotic nuclear disassembly in cycling cells...
  3. ncbi request reprint Effects of cell cycle status on early events in retroviral replication
    Richard A Katz
    Fox Chase Cancer Center, Institute for Cancer Research, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    J Cell Biochem 94:880-9. 2005
    ..However, all retroviruses are subject to a variety of cell cycle restrictions. Here, we discuss such restrictions, and how they may block retroviral replication, be tolerated, or overcome...
  4. pmc High-frequency epigenetic repression and silencing of retroviruses can be antagonized by histone deacetylase inhibitors and transcriptional activators, but uniform reactivation in cell clones is restricted by additional mechanisms
    Richard A Katz
    Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Virol 81:2592-604. 2007
    ..We conclude that HDACs can act rapidly to initiate and maintain promoter-independent retroviral epigenetic repression and silencing but that reactivation can be restricted by additional mechanisms...
  5. ncbi request reprint A preferred target DNA structure for retroviral integrase in vitro
    R A Katz
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 273:24190-5. 1998
    ..From these results we propose that such unpairing may enhance both the processing and the joining steps in the integration reaction, and perhaps other cellular recombination reactions as well...
  6. ncbi request reprint Role of DNA end distortion in catalysis by avian sarcoma virus integrase
    R A Katz
    Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 276:34213-20. 2001
    ..Furthermore, these results are consistent with our previous observations indicating that unpairing of target DNA promotes the joining reaction...
  7. pmc Wortmannin potentiates integrase-mediated killing of lymphocytes and reduces the efficiency of stable transduction by retroviruses
    R Daniel
    Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, Pennsylvania 19111, USA
    Mol Cell Biol 21:1164-72. 2001
    ..The studies also suggest that cells can be sensitized to such killing and stable retroviral DNA integration blocked by drugs that inhibit cellular DNA repair pathways...
  8. ncbi request reprint Retroviral DNA integration and the DNA damage response
    A M Skalka
    Fox Chase Cancer Center, Institute for Cancer Research, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    Cell Death Differ 12:971-8. 2005
    ..Here, we review these findings and discuss other ways that retroviral DNA intermediates may interact with the host DNA damage signaling and repair pathways...
  9. ncbi request reprint The avian retroviral IN protein is both necessary and sufficient for integrative recombination in vitro
    R A Katz
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111
    Cell 63:87-95. 1990
    ..In this paper, using two independent assays, we demonstrate that IN, alone, is sufficient to carry out the second step: cleavage and joining to the target DNA. These results demonstrate that the retroviral IN protein is an integrase...
  10. pmc Computational analysis of retrovirus-induced scid cell death
    R Daniel
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Virol 75:3121-8. 2001
    ....
  11. pmc Characterization of retrovirus-host DNA junctions in cells deficient in nonhomologous-end joining
    K Taganov
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Virol 75:9549-52. 2001
    ..These results indicate that the DNA repair pathway which compensates for loss of NHEJ in these transductants does not introduce any gross abnormalities at the provirus-host DNA junctions...
  12. ncbi request reprint A role for DNA-PK in retroviral DNA integration
    R Daniel
    Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Science 284:644-7. 1999
    ..These results suggest that the initial events in retroviral integration are detected as DNA damage by the host cell and that completion of the integration process requires the DNA-PK-mediated repair pathway...
  13. pmc cis-acting intron mutations that affect the efficiency of avian retroviral RNA splicing: implication for mechanisms of control
    R A Katz
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111
    J Virol 62:2686-95. 1988
    ..Furthermore, this retroviral system provides a powerful genetic method for selection and analysis of mutations that affect splicing control...
  14. ncbi request reprint Avian retroviral protease and cellular aspartic proteases are distinguished by activities on peptide substrates
    M Kotler
    Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, Pennsylvania 19111
    J Biol Chem 264:3428-35. 1989
    ..Furthermore pepstatin, a strong inhibitor of pepsin, renin, and cathepsin-D has little effect on PR...
  15. pmc The cellular protein daxx interacts with avian sarcoma virus integrase and viral DNA to repress viral transcription
    James G Greger
    Fox Chase Cancer Center, Institute for Cancer Research, 333 Cottman Ave, Philadelphia, PA 19111 2497, USA
    J Virol 79:4610-8. 2005
    ..Our findings provide a novel example of cellular immunity against viral replication in which viral transcription is repressed via the recruitment of antiviral proteins to the viral DNA...
  16. pmc Genome-wide analyses of avian sarcoma virus integration sites
    Anna Narezkina
    Fox Chase Cancer Center, Institute for Cancer Research, 333 Cottman Ave, Philadelphia, PA 19111 2497, USA
    J Virol 78:11656-63. 2004
    ..Such differences may be relevant to viral pathogenesis and provide utility in retroviral vector design...
  17. ncbi request reprint Histone H2AX is phosphorylated at sites of retroviral DNA integration but is dispensable for postintegration repair
    Rene Daniel
    Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, Pennsylvania 19111 2497, USA
    J Biol Chem 279:45810-4. 2004
    ..These observations provide independent support for an anchoring model for the function of gammaH2AX in chromatin repair...
  18. pmc Evidence that stable retroviral transduction and cell survival following DNA integration depend on components of the nonhomologous end joining repair pathway
    Rene Daniel
    Fox Chase Cancer Center, Institute for Cancer Research, 333 Cottman Ave, Philadelphia, PA 19111 2497, USA
    J Virol 78:8573-81. 2004
    ..Results presented in this study lend further support to a general role for the NHEJ DNA repair pathway in completion of the retroviral DNA integration process...
  19. pmc Integrase-specific enhancement and suppression of retroviral DNA integration by compacted chromatin structure in vitro
    Konstantin D Taganov
    Fox Chase Cancer Center, Institute for Cancer Research, 333 Cottman Ave, Philadelphia, PA 19111 2497, USA
    J Virol 78:5848-55. 2004
    ..These distinct properties of integrases may also affect target site selection in vivo, resulting in an important bias against or in favor of integration into actively transcribed host DNA...
  20. pmc Transduction of terminally differentiated neurons by avian sarcoma virus
    James G Greger
    Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, Pennsylvania 19111 2497, USA
    J Virol 78:4902-6. 2004
    ..The transduction efficiency of the ASV vector was found to be intermediate between the relatively high and low efficiencies obtained with human immunodeficiency virus type 1 and murine leukemia virus vectors, respectively...
  21. pmc Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response
    Rene Daniel
    Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 100:4778-83. 2003
    ..Components of the cellular DNA damage repair response may represent potential targets for antiretroviral drug development...
  22. pmc Identification of cellular proteins that maintain retroviral epigenetic silencing: evidence for an antiviral response
    Andrey Poleshko
    Fox Chase Cancer Center, Institute for Cancer Research, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Virol 82:2313-23. 2008
    ..Furthermore, our results indicate that siRNAs can be used as specific reagents to interrupt the maintenance of epigenetic silencing...