Magdalena Karbowniczek

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. ncbi request reprint mTOR is activated in the majority of malignant melanomas
    Magdalena Karbowniczek
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Invest Dermatol 128:980-7. 2008
  2. pmc The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development
    Magdalena Karbowniczek
    Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Clin Invest 120:93-102. 2010
  3. ncbi request reprint The role of tuberin in cellular differentiation: are B-Raf and MAPK involved?
    Magdalena Karbowniczek
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Ann N Y Acad Sci 1059:168-73. 2005
  4. ncbi request reprint Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization
    Magdalena Karbowniczek
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 281:25447-56. 2006
  5. ncbi request reprint Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent
    Magdalena Karbowniczek
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 279:29930-7. 2004
  6. pmc The TSC1/2 complex controls Drosophila pigmentation through TORC1-dependent regulation of catecholamine biosynthesis
    Diana Zitserman
    Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e48720. 2012
  7. pmc Renal angiomyolipomas from patients with sporadic lymphangiomyomatosis contain both neoplastic and non-neoplastic vascular structures
    Magdalena Karbowniczek
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Am J Pathol 162:491-500. 2003
  8. pmc Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells
    Jane J Yu
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 106:2635-40. 2009
  9. ncbi request reprint Recurrent lymphangiomyomatosis after transplantation: genetic analyses reveal a metastatic mechanism
    Magdalena Karbowniczek
    Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Am J Respir Crit Care Med 167:976-82. 2003
  10. ncbi request reprint Activation of the mTOR signaling pathway in renal clear cell carcinoma
    Victoria A Robb
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Urol 177:346-52. 2007

Collaborators

Detail Information

Publications12

  1. ncbi request reprint mTOR is activated in the majority of malignant melanomas
    Magdalena Karbowniczek
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Invest Dermatol 128:980-7. 2008
    ..Together, these data implicate activation of mTOR in the pathogenesis of melanoma, and suggest that Rheb and mTOR may be targets for melanoma therapy...
  2. pmc The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development
    Magdalena Karbowniczek
    Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Clin Invest 120:93-102. 2010
    ....
  3. ncbi request reprint The role of tuberin in cellular differentiation: are B-Raf and MAPK involved?
    Magdalena Karbowniczek
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Ann N Y Acad Sci 1059:168-73. 2005
    ..We hypothesize that aberrant B-Raf activity in angiomyolipomas leads to abnormal cellular differentiation and migration...
  4. ncbi request reprint Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization
    Magdalena Karbowniczek
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 281:25447-56. 2006
    ..In addition, we found that Rheb inhibits the association of B-Raf with H-Ras. Taken together, these results support a central role of Rheb in the regulation of the Ras/B-Raf/C-Raf/MEK signaling network...
  5. ncbi request reprint Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent
    Magdalena Karbowniczek
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 279:29930-7. 2004
    ..Taken together these data demonstrate that inhibition of B-Raf kinase via Rheb is an mTOR-independent function of tuberin...
  6. pmc The TSC1/2 complex controls Drosophila pigmentation through TORC1-dependent regulation of catecholamine biosynthesis
    Diana Zitserman
    Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e48720. 2012
    ....
  7. pmc Renal angiomyolipomas from patients with sporadic lymphangiomyomatosis contain both neoplastic and non-neoplastic vascular structures
    Magdalena Karbowniczek
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Am J Pathol 162:491-500. 2003
    ..Angiomyolipomas appear to reflect novel vascular mechanisms that may be the result of activation of cellular pathways involving S6 Kinase...
  8. pmc Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells
    Jane J Yu
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 106:2635-40. 2009
    ..Taken together these results reveal a new model for LAM pathogenesis in which activation of MEK-dependent pathways by E(2) leads to pulmonary metastasis via enhanced survival of detached tuberin-null cells...
  9. ncbi request reprint Recurrent lymphangiomyomatosis after transplantation: genetic analyses reveal a metastatic mechanism
    Magdalena Karbowniczek
    Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Am J Respir Crit Care Med 167:976-82. 2003
    ..In addition, the patient had no evidence of a renal angiomyolipoma at autopsy and therefore demonstrated for the first time that somatic TSC2 mutations cause LAM in patients without angiomyolipomas...
  10. ncbi request reprint Activation of the mTOR signaling pathway in renal clear cell carcinoma
    Victoria A Robb
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Urol 177:346-52. 2007
    ..We determined the frequency of mTOR/p70S6 kinase signaling pathway activation in clear cell renal cell carcinoma...
  11. ncbi request reprint Mutational analysis of the von hippel lindau gene in clear cell renal carcinomas from tuberous sclerosis complex patients
    Karen Duffy
    Medical Oncology Division, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mod Pathol 15:205-10. 2002
    ..These findings suggest that mutations in the TSC1 and TSC2 genes lead to clear cell renal carcinogenesis via an alternate pathway not involving VHL mutations...
  12. pmc Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53
    Chung Han Lee
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    EMBO J 26:4812-23. 2007
    ..Clinically, this also suggests that the efficacy of mTOR inhibitors in anti-neoplastic therapy may also depend on p53 status, and mTOR inhibitors may antagonize the effects of genotoxic chemotherapeutics...