Research Topics
| Dietmar KappesSummaryAffiliation: Fox Chase Cancer Center Country: USA Publications
Research Grants
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Detail Information
Publications
Expanding roles for ThPOK in thymic developmentDietmar J Kappes
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Immunol Rev 238:182-94. 2010..The developmental consequences of ThPOK expression vary according to cell type, which may partly reflect differences in ThPOK levels and/or in transcriptional networks between cell types...
CD4 and CD8: hogging all the LckDietmar J Kappes
Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Immunity 27:691-3. 2007..Van Laethem et al. (2007) propose that the sequestration of the kinase Lck by coreceptors prevents the selection of non-MHC-reactive TCRs...
CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locusXi He
Fox Chase Cancer Center, 7701 Burholme Ave, Philadelphia, PA 19111, USA
Immunity 28:346-58. 2008..We propose a silencer-dependent model of lineage choice, whereby inactivation of the DRE silencer by a strong TCR signal leads to CD4 commitment, whereas continued silencer activity leads to CD8 commitment...- The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitmentXiao He
Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, Pennsylvania 19111, USA
Nature 433:826-33. 2005.... - CD4/CD8 lineage commitment: light at the end of the tunnel?Xiao He
Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
Curr Opin Immunol 18:135-42. 2006..The presence of this factor directs positively selected thymocytes to the CD4 lineage, whereas its absence causes default development to the CD8 lineage... - Role of the transcription factor Th-POK in CD4:CD8 lineage commitmentDietmar J Kappes
Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Immunol Rev 209:237-52. 2006..Here, we review data leading to the identification and characterization of this factor and discuss the implications of these studies in the context of current models of lineage commitment... - Recent insights into the signals that control alphabeta/gammadelta-lineage fateJens Peter H Lauritsen
Fox Chase Cancer Center, Division of Basic Sciences, Immunobiology Working Group, Philadelphia, PA 19111, USA
Immunol Rev 209:176-90. 2006..These findings will be placed in context of previous analyses in an effort to more precisely define the signals that control T-lineage fate during thymocyte development... - CD4-CD8 lineage commitment: an inside viewDietmar J Kappes
Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Nat Immunol 6:761-6. 2005..Finally, identification of the transcription factor Th-POK as a central component of the CD4 lineage-determining pathway has provided a new starting point from which to unravel this intriguing process 'from the inside out'... - TCR-mediated ThPOK induction promotes development of mature (CD24-) gammadelta thymocytesKyewon Park
Blood Cell Development and Cancer Keystone Program, Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, PA, USA
EMBO J 29:2329-41. 2010.... - Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independentJens Peter Holst Lauritsen
Blood Cell Development and Cancer Keystone, Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
Immunity 31:565-75. 2009..Taken together, these findings identify Id3 as a central player that controls both adoption of the gammadelta fate and its maturation in the thymus... - The role of ThPOK in control of CD4/CD8 lineage commitmentXi He
Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Annu Rev Immunol 28:295-320. 2010..Given the central role of ThPOK in lineage commitment, understanding its upstream regulation and downstream gene targets is expected to reveal further important aspects of the molecular machinery underlying lineage commitment... - Attenuation of gammadeltaTCR signaling efficiently diverts thymocytes to the alphabeta lineageMariëlle C Haks
Division of Basic Sciences, Immunobiology Working Group, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Immunity 22:595-606. 2005..Our data support a model whereby gammadelta versus alphabeta lineage commitment is controlled by TCR signal strength, which depends critically on the ERK MAPK-Egr pathway... - Towards a molecular understanding of the differential signals regulating alphabeta/gammadelta T lineage choiceSang Yun Lee
Immune Cell Development and Host Defense Program, Blood Cell Development and Cancer Keystone, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
Semin Immunol 22:237-46. 2010.... - CCR7 expression in developing thymocytes is linked to the CD4 versus CD8 lineage decisionXinye Yin
Department of Molecular and Cell Biology, Division of Immunology, University of California, Berkeley, CA 94720, USA
J Immunol 179:7358-64. 2007..These findings suggest that the timing of CCR7 expression relative to coreceptor down-regulation is regulated by lineage commitment signals... - Activation-induced modification in the CD3 complex of the gammadelta T cell receptorSandra M Hayes
Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 196:1355-61. 2002....
Research Grants
- Role of CD3 Delta in Developing and Mature T CellsDietmar Kappes; Fiscal Year: 2006..homologous CD3delta and gamma ITAMs collectively essential for particular signaling pathways and developmental processes? b) Is the CD3delta ITAM individually sufficient to supply all ITAM-mediated functions essential for development? ..
- CONTROL OF LINEAGE COMMITMENT IN DEVELOPING THYMOCYTESDietmar Kappes; Fiscal Year: 2006..2) To determine how cKrox activity is differentially regulated in class I- versus class II-specific thymocytes. 3) To functionally dissect the roles of the zinc finger and BTB/POZ domains of cKrox in lineage commitment. ..
- CONTROL OF LINEAGE COMMITMENT IN DEVELOPING THYMOCYTESDietmar Kappes; Fiscal Year: 2007..2) To determine how cKrox activity is differentially regulated in class I- versus class II-specific thymocytes. 3) To functionally dissect the roles of the zinc finger and BTB/POZ domains of cKrox in lineage commitment. ..
- Transcriptional Control of Th-POK, a Key Regulator of Lineage ControlDietmar J Kappes; Fiscal Year: 2010..Hence understanding the control of ThPOK expression is also directly relevant to the mechanism of lymphomagenesis. ..
- Molecular Triggers of T Helper Lineage ChoiceDietmar J Kappes; Fiscal Year: 2010..These experiments should provide insights into the molecular basis of alternate TCR signaling and the mechanism of lineage commitment. ..
- CD3 DELTA AND DEVELOPING AND MATURE T CELLSDietmar Kappes; Fiscal Year: 2001..This will be addressed for CTL by engineering a transgenic mouse in which CD3delta is expressed during development but specifically silenced in the CD8+ lineage. ..
- CONTROL OF LINEAGE COMMITMENT IN DEVELOPING THYMOCYTESDietmar Kappes; Fiscal Year: 2003..abstract_text> ..
- CONTROL OF LINEAGE COMMITMENT IN DEVELOPING THYMOCYTESDietmar J Kappes; Fiscal Year: 2010..How ThPOK controls this process is unknown and the subject of this proposal. Unregulated expression of ThPOK causes blood cell cancer, so that understanding its function is of direct relevance to health. ..