Kyoko Hayakawa

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. ncbi request reprint Positive selection of natural autoreactive B cells
    K Hayakawa
    Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Science 285:113-6. 1999
  2. pmc Positive selection of anti-thy-1 autoreactive B-1 cells and natural serum autoantibody production independent from bone marrow B cell development
    Kyoko Hayakawa
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Exp Med 197:87-99. 2003
  3. ncbi request reprint Evidence of marginal-zone B cell-positive selection in spleen
    Lijun Wen
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Immunity 23:297-308. 2005
  4. doi request reprint Positive and negative selection of natural autoreactive B cells
    Richard R Hardy
    Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Adv Exp Med Biol 750:227-38. 2012
  5. ncbi request reprint Development of B cells producing natural autoantibodies to thymocytes and senescent erythrocytes
    Richard R Hardy
    Division of Basic Sciences, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA
    Springer Semin Immunopathol 26:363-75. 2005
  6. ncbi request reprint Association of B-1 B cells with follicular dendritic cells in spleen
    Lijun Wen
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Immunol 174:6918-26. 2005
  7. pmc Autoreactive B-1 B cells: constraints on natural autoantibody B cell antigen receptors
    Ben Rowley
    Division of Basic Science, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA
    J Autoimmun 29:236-45. 2007
  8. ncbi request reprint Selection during development of VH11+ B cells: a model for natural autoantibody-producing CD5+ B cells
    Richard R Hardy
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    Immunol Rev 197:60-74. 2004

Collaborators

  • D Allman
  • Richard Hardy
  • Lijun Wen
  • Ben Rowley
  • Susan A Shinton
  • Susan Shinton
  • Lingjuan Tang
  • Joni Brill-Dashoff
  • Masanao Asano

Detail Information

Publications8

  1. ncbi request reprint Positive selection of natural autoreactive B cells
    K Hayakawa
    Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Science 285:113-6. 1999
    ..Thus, B cells can be subject to positive selection, generated, and maintained on the basis of their autoreactivity...
  2. pmc Positive selection of anti-thy-1 autoreactive B-1 cells and natural serum autoantibody production independent from bone marrow B cell development
    Kyoko Hayakawa
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Exp Med 197:87-99. 2003
    ..These findings demonstrate that B-1 positive selection, resulting in the production of natural serum ATA, arises independently from the major pathway of BM B cell development and selection...
  3. ncbi request reprint Evidence of marginal-zone B cell-positive selection in spleen
    Lijun Wen
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Immunity 23:297-308. 2005
    ..These data indicate that positive selection can occur in developing B cells and that BCR signal strength is a key factor in deciding between two functionally distinct mature B cell compartments in the microenvironment of the spleen...
  4. doi request reprint Positive and negative selection of natural autoreactive B cells
    Richard R Hardy
    Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Adv Exp Med Biol 750:227-38. 2012
    ....
  5. ncbi request reprint Development of B cells producing natural autoantibodies to thymocytes and senescent erythrocytes
    Richard R Hardy
    Division of Basic Sciences, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA
    Springer Semin Immunopathol 26:363-75. 2005
    ....
  6. ncbi request reprint Association of B-1 B cells with follicular dendritic cells in spleen
    Lijun Wen
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Immunol 174:6918-26. 2005
    ..These results indicate that B-1 B cells are the first B cells to express fully mature levels of CXCR5, thereby promoting the development of FDC...
  7. pmc Autoreactive B-1 B cells: constraints on natural autoantibody B cell antigen receptors
    Ben Rowley
    Division of Basic Science, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA
    J Autoimmun 29:236-45. 2007
    ..Here, we examine another possible bottleneck to the B1 cell repertoire: light chain pairing with V(H)11 heavy chain, finding very significant preferences...
  8. ncbi request reprint Selection during development of VH11+ B cells: a model for natural autoantibody-producing CD5+ B cells
    Richard R Hardy
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    Immunol Rev 197:60-74. 2004
    ..Together, these constrain VH11 generation to fetal development and may favor production of B cells with the prototype VH11Vkappa9 BCR...