G Freedman

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. ncbi request reprint Patients with early stage invasive cancer with close or positive margins treated with conservative surgery and radiation have an increased risk of breast recurrence that is delayed by adjuvant systemic therapy
    G Freedman
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Radiat Oncol Biol Phys 44:1005-15. 1999
  2. ncbi request reprint Phase I trial of preoperative hypofractionated intensity-modulated radiotherapy with incorporated boost and oral capecitabine in locally advanced rectal cancer
    Gary M Freedman
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19111, USA
    Int J Radiat Oncol Biol Phys 67:1389-93. 2007
  3. ncbi request reprint Intensity modulated radiation therapy (IMRT) decreases acute skin toxicity for women receiving radiation for breast cancer
    Gary M Freedman
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Am J Clin Oncol 29:66-70. 2006
  4. ncbi request reprint Pattern of local recurrence after conservative surgery and whole-breast irradiation
    Gary M Freedman
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Int J Radiat Oncol Biol Phys 61:1328-36. 2005
  5. ncbi request reprint Recursive partitioning identifies patients at high and low risk for ipsilateral tumor recurrence after breast-conserving surgery and radiation
    G M Freedman
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Clin Oncol 20:4015-21. 2002
  6. ncbi request reprint Should internal mammary lymph nodes in breast cancer be a target for the radiation oncologist?
    G M Freedman
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia PA 19111, USA
    Int J Radiat Oncol Biol Phys 46:805-14. 2000
  7. ncbi request reprint Internal mammary node irradiation neither decreases distant metastases nor improves survival in stage I and II breast cancer
    B Fowble
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Radiat Oncol Biol Phys 47:883-94. 2000
  8. ncbi request reprint Lobular carcinoma in situ increases the risk of local recurrence in selected patients with stages I and II breast carcinoma treated with conservative surgery and radiation
    A R Sasson
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19104, USA
    Cancer 91:1862-9. 2001
  9. ncbi request reprint Postmenopausal hormone replacement therapy: effect on diagnosis and outcome in early-stage invasive breast cancer treated with conservative surgery and radiation
    B Fowble
    Division of Population Science, Department of Biostatistics, and Departments of Radiation Oncology, Radiology, Pathology, and Surgery, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Clin Oncol 17:1680-8. 1999
  10. ncbi request reprint Second cancers after conservative surgery and radiation for stages I-II breast cancer: identifying a subset of women at increased risk
    B Fowble
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Radiat Oncol Biol Phys 51:679-90. 2001

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Patients with early stage invasive cancer with close or positive margins treated with conservative surgery and radiation have an increased risk of breast recurrence that is delayed by adjuvant systemic therapy
    G Freedman
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Radiat Oncol Biol Phys 44:1005-15. 1999
    ..This study examines the interaction between margin status, margin width, and adjuvant systemic therapy on the 5- and 10-year risk of IBTR after conservative surgery and radiation...
  2. ncbi request reprint Phase I trial of preoperative hypofractionated intensity-modulated radiotherapy with incorporated boost and oral capecitabine in locally advanced rectal cancer
    Gary M Freedman
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19111, USA
    Int J Radiat Oncol Biol Phys 67:1389-93. 2007
    ..To determine the safety and efficacy of preoperative hypofractionated radiotherapy using intensity-modulated radiotherapy (IMRT) and an incorporated boost with concurrent capecitabine in patients with locally advanced rectal cancer...
  3. ncbi request reprint Intensity modulated radiation therapy (IMRT) decreases acute skin toxicity for women receiving radiation for breast cancer
    Gary M Freedman
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Am J Clin Oncol 29:66-70. 2006
    ..Our hypothesis is that measures to decrease dose inhomogeneity within the breast and skin with IMRT will improve acute skin toxicity...
  4. ncbi request reprint Pattern of local recurrence after conservative surgery and whole-breast irradiation
    Gary M Freedman
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Int J Radiat Oncol Biol Phys 61:1328-36. 2005
    ..We analyzed the long-term risk of recurrence by area of the breast after whole-breast irradiation...
  5. ncbi request reprint Recursive partitioning identifies patients at high and low risk for ipsilateral tumor recurrence after breast-conserving surgery and radiation
    G M Freedman
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Clin Oncol 20:4015-21. 2002
    ....
  6. ncbi request reprint Should internal mammary lymph nodes in breast cancer be a target for the radiation oncologist?
    G M Freedman
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia PA 19111, USA
    Int J Radiat Oncol Biol Phys 46:805-14. 2000
    ..The purpose of this study is to critically review historical and new data regarding IMNs in breast cancer...
  7. ncbi request reprint Internal mammary node irradiation neither decreases distant metastases nor improves survival in stage I and II breast cancer
    B Fowble
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Radiat Oncol Biol Phys 47:883-94. 2000
    ....
  8. ncbi request reprint Lobular carcinoma in situ increases the risk of local recurrence in selected patients with stages I and II breast carcinoma treated with conservative surgery and radiation
    A R Sasson
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19104, USA
    Cancer 91:1862-9. 2001
    ..The risk of local recurrence appears to be modified by the use of tamoxifen. Further studies are needed to address this issue...
  9. ncbi request reprint Postmenopausal hormone replacement therapy: effect on diagnosis and outcome in early-stage invasive breast cancer treated with conservative surgery and radiation
    B Fowble
    Division of Population Science, Department of Biostatistics, and Departments of Radiation Oncology, Radiology, Pathology, and Surgery, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Clin Oncol 17:1680-8. 1999
    ....
  10. ncbi request reprint Second cancers after conservative surgery and radiation for stages I-II breast cancer: identifying a subset of women at increased risk
    B Fowble
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Radiat Oncol Biol Phys 51:679-90. 2001
    ..Long-term follow-up is important to document the risk and patterns of second cancer, and knowledge of this risk and the patterns will influence surveillance and prevention strategies...
  11. ncbi request reprint Trimodality therapy for advanced gallbladder cancer
    A R Sasson
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Am Surg 67:277-83; discussion 284. 2001
    ..8 months (range 4-28 months). We conclude that trimodality therapy in selected patients with stage III, IV, or recurrent carcinoma of the gallbladder is possible and may result in prolonged survival...
  12. ncbi request reprint Effect of preoperative chemoradiotherapy on surgical margin status of resected adenocarcinoma of the head of the pancreas
    J F Pingpank
    Department of Suregery, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Gastrointest Surg 5:121-30. 2001
    ..06) and vein (P = 0.04) margins. However, this has not yet resulted in a significant increase in disease-free or overall survival for patients receiving preoperative therapy (P = 0.07)...
  13. ncbi request reprint The effect of multiple reexcisions on the risk of local recurrence after breast conserving surgery
    T Li
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    Ann Surg Oncol 14:3133-40. 2007
    ..This study examined the effect of multiple reexcisions on local recurrence (LR) and identified factors predictive of the need for multiple reexcisions...
  14. doi request reprint Radiation therapy for operable breast cancer: sixty years of progress as seen through the articles published in the journal Cancer
    G M Freedman
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA19111, USA
    Cancer 113:1779-800. 2008
    ....
  15. ncbi request reprint Clinical implementation of intensity-modulated tangential beam irradiation for breast cancer
    J S Li
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Med Phys 31:1023-31. 2004
    ..The IMRT technique has been proven practical for breast treatment clinically. The results showed that tangential IMRT improved the dose homogeneity in the breast and reduced the dose to the lung and heart...
  16. ncbi request reprint To move or not to move: measurements of prostate motion by urethrography using MRI
    D Mah
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Radiat Oncol Biol Phys 50:947-51. 2001
    ..Sagittal MRI scans were acquired immediately before and after a localization urethrogram to determine the extent of displacement...
  17. ncbi request reprint Optimization of combined electron and photon beams for breast cancer
    W Xiong
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Phys Med Biol 49:1973-89. 2004
    ..It is concluded that combined photon and electron beam therapy may be advantageous for treating breast cancer compared to conventional treatment techniques using tangential wedged photon beams followed by a boost electron field...
  18. ncbi request reprint TH-E-BRA-03: Clinical Experience at Fox Chase Cancer Center for Treatment of Bone Metastases Using ExAblate 2000 with MR Guidance
    L Chen
    Fox Chase Cancer Center, Philadelphia, PA
    Med Phys 39:4012. 2012
    ..Conclusions: A comprehensive QA program has been developed for the MRgFUS system. Our data suggest that MRgFUS is a safe, effective and noninvasive treatment modality for palliation of bone metastases...
  19. ncbi request reprint Routine mammography is associated with earlier stage disease and greater eligibility for breast conservation in breast carcinoma patients age 40 years and older
    Gary M Freedman
    Department of Radiation Oncology, the Breast Evaluation Center, Fox Chase Cancer Center, Philadelphia, PA, USA
    Cancer 98:918-25. 2003
    ..The current study analyzed the impact of mammography in the staging and treatment of breast carcinoma...
  20. ncbi request reprint Multi-institutional review of repeat irradiation of chest wall and breast for recurrent breast cancer
    Andrew O Wahl
    Department of Radiation Oncology, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Int J Radiat Oncol Biol Phys 70:477-84. 2008
    ..To review the toxicity and clinical outcomes for patients who underwent repeat chest wall or breast irradiation (RT) after local recurrence...
  21. ncbi request reprint Parity confers better prognosis in older women with early-stage breast cancer treated with breast-conserving therapy
    Penny R Anderson
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Clin Breast Cancer 5:225-31. 2004
    ..Parity can be considered a prognostic factor in elderly patients with early-stage breast cancer, and therefore may be used as a tool for identifying patients who may benefit from a more aggressive treatment approach...
  22. pmc Presence of lobular carcinoma in situ does not increase local recurrence in patients treated with breast-conserving therapy
    Robin M Ciocca
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Ann Surg Oncol 15:2263-71. 2008
    ..We hypothesized that, if LCIS were a precursor, its presence in the lumpectomy specimen, particularly at the margin, could increase local recurrence (LR) after breast-conserving therapy (BCT)...
  23. ncbi request reprint Low complication rates are achievable after postmastectomy breast reconstruction and radiation therapy
    Penny R Anderson
    Department of Radiation Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Int J Radiat Oncol Biol Phys 59:1080-7. 2004
    ..To report our institution's experience of complications and cosmetic results among patients who underwent modified radical mastectomy followed by reconstruction and radiation therapy (RT)...
  24. ncbi request reprint Four-week course of radiation for breast cancer using hypofractionated intensity modulated radiation therapy with an incorporated boost
    Gary M Freedman
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Radiat Oncol Biol Phys 68:347-53. 2007
    ..This is an inconvenience to many women, and for some a barrier for breast conservation. We present the acute toxicity of a 4-week course of hypofractionated radiation...
  25. ncbi request reprint A multi-institutional phase II trial of preoperative full-dose gemcitabine and concurrent radiation for patients with potentially resectable pancreatic carcinoma
    Mark S Talamonti
    Division of Surgical Oncology, Feinberg School of Medicine, Northwestern University, 201 E Huron, Galter 10 105, Chicago, Illinois 60611, USA
    Ann Surg Oncol 13:150-8. 2006
    ..We report the results of a multi-institutional phase II trial that used preoperative full-dose gemcitabine and radiotherapy for patients with potentially resectable pancreatic carcinoma...
  26. ncbi request reprint Identifying breast cancer patients most likely to benefit from aromatase inhibitor therapy after adjuvant radiation and tamoxifen
    Gary M Freedman
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Cancer 107:2552-8. 2006
    ..The purpose of the current study was to examine patient selection for an aromatase inhibitor in breast cancer patients who were free from adverse events 5 years after treatment with tamoxifen...
  27. ncbi request reprint Re-excision of margins before breast radiation-diagnostic or therapeutic?
    Derek B Chism
    Department of Radiation Oncology, North Shore Medical Center, Peabody, MA, USA
    Int J Radiat Oncol Biol Phys 65:1416-21. 2006
    ..To identify factors in breast cancer patients that predict the pathologic results of re-excision for close or positive margins and to determine the effect on local control...
  28. doi request reprint Full-dose gemcitabine with concurrent radiation therapy in patients with nonmetastatic pancreatic cancer: a multicenter phase II trial
    William Small
    Robert H Lurie Comprehensive Cancer Center of Northwestern University, 251 East Huron St, LC 178, Chicago, IL 60611, USA
    J Clin Oncol 26:942-7. 2008
    ..This study assessed safety and efficacy of full-dose gemcitabine administered before and during concurrent three-dimensional conformal radiation (3D-CRT) in patients with nonmetastatic pancreatic cancer...
  29. ncbi request reprint Resection of isolated pelvic recurrences after colorectal surgery: long-term results and predictors of improved clinical outcome
    Leonard R Henry
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Ann Surg Oncol 14:2000-9. 2007
    ..Resection offers the only reasonable probability for cure, but at the cost of perioperative morbidity and potential mortality. Clinical decision making remains difficult...
  30. ncbi request reprint Importance of physical examination in the absence of a mammographic abnormality for the detection of early-stage breast cancer
    Hasmik Diratzouian
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Clin Breast Cancer 6:330-3. 2005
    ..A recent trial called into question the efficacy of breast self-examination. We studied the characteristics and outcome of women in whom physical examination (PE) was their sole method of breast cancer detection...
  31. ncbi request reprint Resection of isolated pelvic recurrences after colorectal surgery: long-term results and predictors of improved clinical outcome
    Leonard R Henry
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Ann Surg Oncol 14:1081-91. 2007
    ..Resection offers the only reasonable probability for cure, but at the cost of marked perioperative morbidity and potential mortality. Clinical decision making remains difficult...