Sandra V Fernandez

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. pmc Expression and DNA methylation changes in human breast epithelial cells after bisphenol A exposure
    Sandra V Fernandez
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Oncol 41:369-77. 2012
  2. pmc DNA methylation changes in a human cell model of breast cancer progression
    Sandra V Fernandez
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Mutat Res 688:28-35. 2010
  3. ncbi request reprint 17-Beta-estradiol induces transformation and tumorigenesis in human breast epithelial cells
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, Pennsylvania 19111, USA
    FASEB J 20:1622-34. 2006
  4. ncbi request reprint Estradiol and its metabolites 4-hydroxyestradiol and 2-hydroxyestradiol induce mutations in human breast epithelial cells
    Sandra V Fernandez
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Cancer 118:1862-8. 2006
  5. pmc Human chorionic gonadotropin (hCG) prevents the transformed phenotypes induced by 17 beta-estradiol in human breast epithelial cells
    Hilal Kocdor
    Fox Chase Cancer Center, Breast Cancer Research Laboratory, Philadelphia, PA 19111, USA
    Cell Biol Int 33:1135-43. 2009
  6. ncbi request reprint The concept of stem cell in the mammary gland and its implication in morphogenesis, cancer and prevention
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Front Biosci 11:151-72. 2006
  7. ncbi request reprint Epithelial mesenchymal transition during the neoplastic transformation of human breast epithelial cells by estrogen
    Daniel G Tiezzi
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Oncol 31:823-7. 2007
  8. ncbi request reprint Comparative genomic hybridization of human breast epithelial cells transformed by estrogen and its metabolites
    Sandra V Fernandez
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA, USA
    Int J Oncol 26:691-5. 2005
  9. ncbi request reprint Sodium/potassium ATPase (Na+, K+-ATPase) and ouabain/related cardiac glycosides: A new paradigm for development of anti- breast cancer drugs?
    Jin Qiang Chen
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Breast Cancer Res Treat 96:1-15. 2006
  10. doi request reprint Inflammatory breast cancer (IBC): clues for targeted therapies
    Sandra V Fernandez
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Breast Cancer Res Treat 140:23-33. 2013

Detail Information

Publications10

  1. pmc Expression and DNA methylation changes in human breast epithelial cells after bisphenol A exposure
    Sandra V Fernandez
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Oncol 41:369-77. 2012
    ..These results suggest that the breast tissue of women with BRCA1 or BRCA2 mutations could be more susceptible to the effects of BPA...
  2. pmc DNA methylation changes in a human cell model of breast cancer progression
    Sandra V Fernandez
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Mutat Res 688:28-35. 2010
    ..Furthermore, NRG1 exon 1 was partially methylated in 9 out of 14 (64.3%) morphologically normal tissue samples adjacent to invasive carcinomas...
  3. ncbi request reprint 17-Beta-estradiol induces transformation and tumorigenesis in human breast epithelial cells
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, Pennsylvania 19111, USA
    FASEB J 20:1622-34. 2006
    ....
  4. ncbi request reprint Estradiol and its metabolites 4-hydroxyestradiol and 2-hydroxyestradiol induce mutations in human breast epithelial cells
    Sandra V Fernandez
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Cancer 118:1862-8. 2006
    ..ICI182780 did not prevent these mutations, indicating that the carcinogenic effect of E2 is mainly through its reactive metabolites 4-OHE2 and 2-OHE2, with 4-OHE2 and E2 being mutagenic at lower doses than 2-OHE2...
  5. pmc Human chorionic gonadotropin (hCG) prevents the transformed phenotypes induced by 17 beta-estradiol in human breast epithelial cells
    Hilal Kocdor
    Fox Chase Cancer Center, Breast Cancer Research Laboratory, Philadelphia, PA 19111, USA
    Cell Biol Int 33:1135-43. 2009
    ....
  6. ncbi request reprint The concept of stem cell in the mammary gland and its implication in morphogenesis, cancer and prevention
    Jose Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Front Biosci 11:151-72. 2006
    ....
  7. ncbi request reprint Epithelial mesenchymal transition during the neoplastic transformation of human breast epithelial cells by estrogen
    Daniel G Tiezzi
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Oncol 31:823-7. 2007
    ....
  8. ncbi request reprint Comparative genomic hybridization of human breast epithelial cells transformed by estrogen and its metabolites
    Sandra V Fernandez
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA, USA
    Int J Oncol 26:691-5. 2005
    ..Whereas no aneuploidy was observed in any of the transformed cells, the CGH revealed instead that only cells treated with 4-OH-E2 at the highest concentration (3.6 microM) exhibited DNA gains at 8q24, 9q34 and 20q13 and losses at 13q21...
  9. ncbi request reprint Sodium/potassium ATPase (Na+, K+-ATPase) and ouabain/related cardiac glycosides: A new paradigm for development of anti- breast cancer drugs?
    Jin Qiang Chen
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Breast Cancer Res Treat 96:1-15. 2006
    ..Modulators, e.g. ouabain and related digitalis could be useful to develop valuable anti-breast cancer drugs as both Na+, K+-ATPase inhibitors and ER antagonists...
  10. doi request reprint Inflammatory breast cancer (IBC): clues for targeted therapies
    Sandra V Fernandez
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Breast Cancer Res Treat 140:23-33. 2013
    ..Additionally, FC-IBC02 showed amplification of ALK and NOTCH3. These results indicate that MYC, ATAD2, CD44, NOTCH3, ALK and/or FAK1 may be used as potential targeted therapies against IBC. ..