Brian L Egleston

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. pmc A comparison of perioperative outcomes of Video-Assisted Thoracic Surgical (VATS) Lobectomy with open thoracotomy and lobectomy: Results of an analysis using propensity score based weighting
    Walter J Scott
    Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Ann Surg Innov Res 4:1. 2010
  2. pmc The impact of misclassification due to survey response fatigue on estimation and identifiability of treatment effects
    Brian L Egleston
    Biostatistics and Bioinformatics Facility, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Stat Med 30:3560-72. 2011
  3. pmc Validity of estimating non-sex hormone-binding globulin bound testosterone and oestradiol from total hormone measurements in boys and girls
    Brian L Egleston
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19130, USA
    Ann Clin Biochem 47:233-41. 2010
  4. pmc On estimation of the survivor average causal effect in observational studies when important confounders are missing due to death
    Brian L Egleston
    Biostatistics Facility, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 2497, USA
    Biometrics 65:497-504. 2009
  5. pmc A tutorial on principal stratification-based sensitivity analysis: application to smoking cessation studies
    Brian L Egleston
    Fox Chase Cancer Center, Philadelphia, PA, USA
    Clin Trials 7:286-98. 2010
  6. pmc Sensitivity analysis to investigate the impact of a missing covariate on survival analyses using cancer registry data
    Brian L Egleston
    Biostatistics Facility, Fox Chase Cancer Center, Philadelphia, PA, USA
    Stat Med 28:1498-511. 2009
  7. ncbi request reprint Causal inference for non-mortality outcomes in the presence of death
    Brian L Egleston
    Biostatistics Facility, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Biostatistics 8:526-45. 2007
  8. pmc Preparing individuals to communicate genetic test results to their relatives: report of a randomized control trial
    Susan V Montgomery
    Department of Clinical Genetics, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, 19111, USA
    Fam Cancer 12:537-46. 2013
  9. pmc Anatomic features of enhancing renal masses predict malignant and high-grade pathology: a preoperative nomogram using the RENAL Nephrometry score
    Alexander Kutikov
    Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center Philadelphia, PA 19111, USA
    Eur Urol 60:241-8. 2011
  10. pmc Advanced imaging modalities in early stage breast cancer: preoperative use in the United States Medicare population
    Margaret L Crivello
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Ann Surg Oncol 20:102-10. 2013

Detail Information

Publications50

  1. pmc A comparison of perioperative outcomes of Video-Assisted Thoracic Surgical (VATS) Lobectomy with open thoracotomy and lobectomy: Results of an analysis using propensity score based weighting
    Walter J Scott
    Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Ann Surg Innov Res 4:1. 2010
    ....
  2. pmc The impact of misclassification due to survey response fatigue on estimation and identifiability of treatment effects
    Brian L Egleston
    Biostatistics and Bioinformatics Facility, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Stat Med 30:3560-72. 2011
    ..The results suggest that measures designed to reduce survey order effects might have unintended consequences. We present a data example that demonstrates the problem of survey order effects...
  3. pmc Validity of estimating non-sex hormone-binding globulin bound testosterone and oestradiol from total hormone measurements in boys and girls
    Brian L Egleston
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19130, USA
    Ann Clin Biochem 47:233-41. 2010
    ..However, assays to measure circulating hormone levels might not always be accessible. We sought to validate the empirical calculation of circulating bioavailable testosterone and oestradiol in children...
  4. pmc On estimation of the survivor average causal effect in observational studies when important confounders are missing due to death
    Brian L Egleston
    Biostatistics Facility, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 2497, USA
    Biometrics 65:497-504. 2009
    ..We apply our methodology to the evaluation of the effect of trauma center care on vitality outcomes using data from the National Study on Costs and Outcomes of Trauma Care...
  5. pmc A tutorial on principal stratification-based sensitivity analysis: application to smoking cessation studies
    Brian L Egleston
    Fox Chase Cancer Center, Philadelphia, PA, USA
    Clin Trials 7:286-98. 2010
    ..Those who enter a randomized trial but do not change smoking behavior might not experience withdrawal-related symptoms...
  6. pmc Sensitivity analysis to investigate the impact of a missing covariate on survival analyses using cancer registry data
    Brian L Egleston
    Biostatistics Facility, Fox Chase Cancer Center, Philadelphia, PA, USA
    Stat Med 28:1498-511. 2009
    ..We found that surgery was protective, but that the magnitude of the effect depended on assumptions about the relationship of grade with missingness...
  7. ncbi request reprint Causal inference for non-mortality outcomes in the presence of death
    Brian L Egleston
    Biostatistics Facility, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Biostatistics 8:526-45. 2007
    ..We apply our method using the first three rounds of survey data from the Salisbury Eye Evaluation, a population-based cohort study of older adults. We also present a simulation study that validates our method...
  8. pmc Preparing individuals to communicate genetic test results to their relatives: report of a randomized control trial
    Susan V Montgomery
    Department of Clinical Genetics, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, 19111, USA
    Fam Cancer 12:537-46. 2013
    ..Communication of test results is selective, with male relatives and parents less likely to be informed. Prevalent psychosocial factors play a role in the communication of genetic test results within families...
  9. pmc Anatomic features of enhancing renal masses predict malignant and high-grade pathology: a preoperative nomogram using the RENAL Nephrometry score
    Alexander Kutikov
    Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center Philadelphia, PA 19111, USA
    Eur Urol 60:241-8. 2011
    ..Counseling patients with enhancing renal mass currently occurs in the context of significant uncertainty regarding tumor pathology...
  10. pmc Advanced imaging modalities in early stage breast cancer: preoperative use in the United States Medicare population
    Margaret L Crivello
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Ann Surg Oncol 20:102-10. 2013
    ..Guidelines for breast cancer staging exist, but adherence remains unknown. This study evaluates patterns of imaging in early stage breast cancer usually reserved for advanced disease...
  11. doi request reprint Competing risks of death in patients with localized renal cell carcinoma: a comorbidity based model
    Alexander Kutikov
    Department of Urological Oncology, Fox Chase Cancer Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19111, USA
    J Urol 188:2077-83. 2012
    ..These factors must be considered against the benefits of treatment. We constructed a model of competing causes of death to help contextualize treatment trade-off analyses in patients with localized renal cell carcinoma...
  12. pmc Cancer patient preferences for quality and length of life
    Neal J Meropol
    Division of Medical Science and Population Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cancer 113:3459-66. 2008
    ..The objective of the current study was to describe cancer patient values regarding QOL and LOL and explore associations with communication preferences...
  13. doi request reprint Small renal masses progressing to metastases under active surveillance: a systematic review and pooled analysis
    Marc C Smaldone
    Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer 118:997-1006. 2012
    ..The authors systematically reviewed the literature and conducted a pooled analysis of studies on small renal masses who underwent active surveillance to identify the risk progression and the characteristics associated with metastases...
  14. pmc Physical activity among lung cancer survivors: changes across the cancer trajectory and associations with quality of life
    Elliot J Coups
    Cancer Prevention and Control Program, Fox Chase Cancer Center, Cheltenham, PA 19012, USA
    Cancer Epidemiol Biomarkers Prev 18:664-72. 2009
    ..The current study addressed this research gap and also examined the association between lung cancer survivors' physical activity and their QOL...
  15. pmc Evaluating overall survival and competing risks of death in patients with localized renal cell carcinoma using a comprehensive nomogram
    Alexander Kutikov
    Department of Urological Oncology, Fox Chase Cancer Center, Temple University School of Medicine, Philadelphia, PA 19111, USA
    J Clin Oncol 28:311-7. 2010
    ....
  16. pmc Comparison of prostate cancer diagnosis in patients receiving unrelated urological and non-urological cancer care
    Anthony T Corcoran
    Department of Urological Oncology, Fox Chase Cancer Center, Temple University School of Medicine, Philadelphia, PA 19111, USA
    BJU Int 112:161-8. 2013
    ..To evaluate prostate cancer diagnosis rates and survival outcomes in patients receiving unrelated (non-prostate) urological care with those in patients receiving non-urological care...
  17. pmc Knowledge and perceptions of familial and genetic risks for breast cancer risk in adolescent girls
    Angela R Bradbury
    Division of Hematology Oncology, Department of Medicine, University of Pennsylvania, 3 West Perelman Center 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA
    Breast Cancer Res Treat 136:749-57. 2012
    ..Research evaluating the impact of awareness and perceptions of breast cancer risk on psychosocial, health, and risk behaviors is needed to develop strategies to optimize responses to cancer risk...
  18. doi request reprint Percutaneous vs surgical cryoablation of the small renal mass: is efficacy compromised?
    Christopher J Long
    Departments of Urological Oncology and Biostatistics, Fox Chase Cancer Center, Temple University School of Medicine, Philadelphia, PA, USA
    BJU Int 107:1376-80. 2011
    ..To review and analyse the cumulative literature to compare surgical and percutaneous cryoablation of small renal masses (SRMs)...
  19. pmc Use of systemic therapy and factors affecting survival for patients undergoing cytoreductive nephrectomy
    Alexander Kutikov
    Department of Urological Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    BJU Int 106:218-23. 2010
    ....
  20. ncbi request reprint Nephron-sparing management vs radical nephroureterectomy for low- or moderate-grade, low-stage upper tract urothelial carcinoma
    Jay Simhan
    Division of Urologic Oncology, Departments of Surgical Oncology, Philadelphia, PA, USA
    BJU Int 114:216-20. 2014
    ..To compare overall and cancer-specific outcomes between patients with upper tract urothelial carcinoma (UTUC) managed with either radical nephroureterectomy (RNU) or nephron-sparing measures (NSM) using a large population-based dataset...
  21. pmc Preoperative delays in the US Medicare population with breast cancer
    Richard J Bleicher
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Clin Oncol 30:4485-92. 2012
    ....
  22. pmc Age, tumor size and relative survival of patients with localized renal cell carcinoma: a surveillance, epidemiology and end results analysis
    Benjamin J Scoll
    Department of Urologic Oncology, Fox Chase Cancer Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19111, USA
    J Urol 181:506-11. 2009
    ..We analyzed data from the SEER (Surveillance, Epidemiology and End Results) database to evaluate the relative survival of patients treated surgically for localized renal cell carcinoma as related to tumor size and patient age...
  23. pmc Cancer genetic risk assessment and referral patterns in primary care
    Hetal S Vig
    Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Genet Test Mol Biomarkers 13:735-41. 2009
    ..This study was undertaken to describe cancer risk assessment practices among primary care providers (PCPs)...
  24. pmc Prospective case-control study of serum mullerian inhibiting substance and breast cancer risk
    Joanne F Dorgan
    Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA
    J Natl Cancer Inst 101:1501-9. 2009
    ..The objective of this study was to determine whether serum MIS levels are associated with breast cancer risk...
  25. pmc Assay reproducibility and within-person variation of Müllerian inhibiting substance
    Joanne F Dorgan
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19012, USA
    Fertil Steril 94:301-4. 2010
    ..To assess reproducibility of a commercial müllerian inhibiting substance (MIS) assay and evaluate within-person variation in serum MIS levels...
  26. pmc Depressive symptoms and serum lipid levels in young adult women
    Carolyn Y Fang
    Cancer Prevention and Control Program, Fox Chase Cancer Center, Robert C Young Pavilion, 4th Floor, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Behav Med 36:143-52. 2013
    ..The present findings suggest that depressive symptoms are inversely associated with serum LDL-C levels in young adult women, but that these associations are not likely mediated by adverse lifestyle behaviors...
  27. pmc Cancer patients' trade-offs among efficacy, toxicity, and out-of-pocket cost in the curative and noncurative setting
    Yu Ning Wong
    Fox Chase Cancer Center, Temple Health System, Philadelphia, PA 19111, USA
    Med Care 51:838-45. 2013
    ..When making treatment decisions, cancer patients must make trade-offs among efficacy, toxicity, and cost. However, little is known about what patient characteristics may influence these trade-offs...
  28. pmc When parents disclose BRCA1/2 test results: their communication and perceptions of offspring response
    Angela R Bradbury
    Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 2497, USA
    Cancer 118:3417-25. 2012
    ..Little is known about the prevalence and predictors of parent communication to offspring and how offspring respond to this communication...
  29. pmc Population-based trends in lung cancer incidence in women
    Brian L Egleston
    Biostatistics and Bioinformatics Facility, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Semin Oncol 36:506-15. 2009
    ..This review aims to discuss the epidemiology of lung cancer in women, as well as the incidence of second primaries, and presents current opinions on the myriad of causes...
  30. pmc Enhanced genetic instability and dasatinib sensitivity in mammary tumor cells lacking NEDD9
    Mahendra K Singh
    Departments of Developmental Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 70:8907-16. 2010
    ..These studies identify NEDD9 as a complex modulator of different aspects of mammary tumor growth...
  31. doi request reprint Patterns of nodal staging during breast conservation surgery in the medicare patient: will the ACOSOG Z0011 trial change the pattern of care?
    Catherine E Loveland-Jones
    Department of Surgery, Temple University School of Medicine, Philadelphia, PA, USA
    Breast Cancer Res Treat 143:571-7. 2014
    ..Future changes in the use of AD or axillary irradiation may yet modify that impact substantially...
  32. pmc A preliminary investigation of the predictors of tanning dependence
    Carolyn J Heckman
    Population Science, Fox Chase Cancer Center, Cheltenham, PA 19012, USA
    Am J Health Behav 32:451-64. 2008
    ..To investigate possible predictors of tanning dependence including demographic variables, exposure and protective behaviors, and other health-related behaviors...
  33. pmc Serum amino acid levels as a biomarker for renal cell carcinoma
    Aladdin Mustafa
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Urol 186:1206-12. 2011
    ..Therefore, we investigated whether serum amino acid profiles are a potentially useful biomarker in patients with renal cell carcinoma...
  34. pmc Psychological reactivity to laboratory stress is associated with hormonal responses in postmenopausal women
    Carolyn Y Fang
    Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA, USA
    J Int Med Res 42:444-56. 2014
    ..The present study examined associations between psychological reactivity and hormonal responses to a standardized laboratory stressor (Trier Social Stress Test, TSST) in postmenopausal women...
  35. pmc Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation
    Anna Sukhanova
    Program in Developmental Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Discov 3:96-111. 2013
    ..Analysis of Nsdhl-deficient Bpa(1H/+) mice confirmed dramatic and selective loss of internalized platelet-derived growth factor receptor in fibroblasts, and reduced activation of EGFR and its effectors in regions of skin lacking NSDHL...
  36. pmc Using health communication best practices to develop a web-based provider-patient communication aid: the CONNECT study
    Linda Fleisher
    Fox Chase Cancer Center, Philadelphia, PA 19012, United States
    Patient Educ Couns 71:378-87. 2008
    ..This paper highlights the development of a theory-guided, web-based communication aid (CONNECT), designed to facilitate treatment decision-making among patients with advanced cancer...
  37. pmc Evaluation of the Prostate Cancer Prevention Trial Risk calculator in a high-risk screening population
    David J Kaplan
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, USA
    BJU Int 105:334-7. 2010
    ..Study Type - Diagnostic (exploratory cohort) Level of Evidence 2b...
  38. pmc Efficacy of motivational interviewing for smoking cessation: a systematic review and meta-analysis
    Carolyn J Heckman
    Fox Chase Cancer Center, 510 Township Line Road, First Floor, Philadelphia, PA 19012, USA
    Tob Control 19:410-6. 2010
    ..A systematic review and meta-analysis to investigate the efficacy of interventions incorporating motivational interviewing for smoking cessation and identify correlates of treatment effects...
  39. pmc Symptom distress in older adults following cancer surgery
    Janet H Van Cleave
    College of Nursing, New York University, NY 10003, USA
    Cancer Nurs 36:292-300. 2013
    ..Understanding factors influencing older adults' symptom distress may lead to early identification and interventions, decreasing morbidity and improving outcomes...
  40. pmc Academic ranking score: a publication-based reproducible metric of thought leadership in urology
    Alexander Kutikov
    Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Eur Urol 61:435-9. 2012
    ..Hospital rankings have become integral to the marketing strategies of many health care systems. Methodology used in compiling these lists appears highly flawed...
  41. pmc Association of routine pretreatment magnetic resonance imaging with time to surgery, mastectomy rate, and margin status
    Richard J Bleicher
    Department of Surgical Oncology, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA19111, USA
    J Am Coll Surg 209:180-7; quiz 294-5. 2009
    ..This study characterizes those receiving MRI versus those who did not, and reports on their short-term surgical outcomes, including time to operation, margin status, and mastectomy rate...
  42. pmc Family cohesion moderates the relation between free testosterone and delinquent behaviors in adolescent boys and girls
    Carolyn Y Fang
    Fox Chase Cancer Center, 510 Township Line Road, Cheltenham, PA 19012, USA
    J Adolesc Health 44:590-7. 2009
    ..This study examined the associations of free testosterone and family environment with delinquent and aggressive behaviors among adolescent boys and girls with elevated low-density lipoprotein (LDL)-cholesterol levels...
  43. ncbi request reprint Psychosocial functioning and vascular endothelial growth factor in patients with head and neck cancer
    Carolyn Y Fang
    Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania
    Head Neck 36:1113-9. 2014
    ..This study examined whether psychosocial functioning in patients with head and neck squamous cell carcinoma (HNSCC) is associated with tumor VEGF expression, a protein that stimulates angiogenesis and is associated with poor prognosis...
  44. pmc Inhibiting the HSP90 chaperone slows cyst growth in a mouse model of autosomal dominant polycystic kidney disease
    Tamina Seeger-Nukpezah
    Program in Developmental Therapeutics, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 110:12786-91. 2013
    ..These results provide an initial justification for evaluating HSP90 inhibitors as therapeutic agents for ADPKD. ..
  45. pmc Correlates of physical activity among lung cancer survivors
    Elliot J Coups
    Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA 19012, USA
    Psychooncology 18:395-404. 2009
    ..However, little is known regarding correlates of physical activity in this survivor population. The current study addressed this research gap...
  46. pmc A novel Cas family member, HEPL, regulates FAK and cell spreading
    Mahendra K Singh
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Mol Biol Cell 19:1627-36. 2008
    ..Better understanding of the complete protein family should help inform prediction of cancer incidence and prognosis...
  47. pmc Factors affecting recovery of functional status in older adults after cancer surgery
    Janet H Van Cleave
    NewCourtland Center for Transitions and Health, School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Am Geriatr Soc 59:34-43. 2011
    ..To explore factors influencing functional status over time after cancer surgery in adults aged 65 and older...
  48. doi request reprint Intention to communicate BRCA1/BRCA2 genetic test results to the family
    Andrea M Barsevick
    Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    J Fam Psychol 22:303-12. 2008
    ..These results extend the theory of planned behavior by showing that gender and generation influence intention when the relative's opinion is unknown...
  49. doi request reprint Excise, ablate or observe: the small renal mass dilemma--a meta-analysis and review
    David A Kunkle
    Department of Urologic Oncology, Fox Chase Cancer Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19111, USA
    J Urol 179:1227-33; discussion 1233-4. 2008
    ..We performed a meta-analysis of published data evaluating nephron sparing surgery, cryoablation, radio frequency ablation and observation for small renal masses to define the current data...
  50. ncbi request reprint Visual acuity change and mortality in older adults
    Ellen E Freeman
    Dana Center for Preventive Ophthalmology, Wilmer Eye Institute, Baltimore, MD 21250, USA
    Invest Ophthalmol Vis Sci 46:4040-5. 2005
    ..The goals of this study are to determine whether visual acuity loss increases the risk of dying and to examine whether depressive symptoms act as a mediator in this relationship...