Karthik Devarajan

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. pmc Nonnegative matrix factorization: an analytical and interpretive tool in computational biology
    Karthik Devarajan
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    PLoS Comput Biol 4:e1000029. 2008
  2. pmc A randomized comparison of print and web communication on colorectal cancer screening
    David S Weinberg
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    JAMA Intern Med 173:122-9. 2013
  3. pmc Identifying breast cancer risk loci by global differential allele-specific expression (DASE) analysis in mammary epithelial transcriptome
    Chuan Gao
    Cancer Epigenetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    BMC Genomics 13:570. 2012
  4. pmc Estrogen and cytochrome P450 1B1 contribute to both early- and late-stage head and neck carcinogenesis
    Ekaterina G Shatalova
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Prev Res (Phila) 4:107-15. 2011
  5. pmc Endoscopic imaging and size estimation of colorectal adenomas in the multiple intestinal neoplasia mouse
    Harvey H Hensley
    Divisions of Basic Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Gastrointest Endosc 69:742-9. 2009
  6. pmc Phase II trial of single agent cetuximab in patients with persistent or recurrent epithelial ovarian or primary peritoneal carcinoma with the potential for dose escalation to rash
    Russell J Schilder
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Gynecol Oncol 113:21-7. 2009
  7. doi request reprint 5-aminosalicylic acid inhibits colitis-associated colorectal dysplasias in the mouse model of azoxymethane/dextran sulfate sodium-induced colitis
    Margie L Clapper
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Inflamm Bowel Dis 14:1341-7. 2008
  8. pmc Early changes in gene expression induced by tobacco smoke: Evidence for the importance of estrogen within lung tissue
    Sibele I Meireles
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cancer Prev Res (Phila) 3:707-17. 2010
  9. pmc The mTOR pathway affects proliferation and chemosensitivity of urothelial carcinoma cells and is upregulated in a subset of human bladder cancers
    Igor Makhlin
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, USA
    BJU Int 108:E84-90. 2011
  10. pmc A prospective study of quality of life among women undergoing risk-reducing salpingo-oophorectomy versus gynecologic screening for ovarian cancer
    Carolyn Y Fang
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Gynecol Oncol 112:594-600. 2009

Collaborators

Detail Information

Publications20

  1. pmc Nonnegative matrix factorization: an analytical and interpretive tool in computational biology
    Karthik Devarajan
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    PLoS Comput Biol 4:e1000029. 2008
    ..In this paper, we review this method as a data analytical and interpretive tool in computational biology with an emphasis on these applications...
  2. pmc A randomized comparison of print and web communication on colorectal cancer screening
    David S Weinberg
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    JAMA Intern Med 173:122-9. 2013
    ..Evidence supports the efficacy of health communications that are targeted and tailored to improve the uptake of recommendations...
  3. pmc Identifying breast cancer risk loci by global differential allele-specific expression (DASE) analysis in mammary epithelial transcriptome
    Chuan Gao
    Cancer Epigenetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    BMC Genomics 13:570. 2012
    ....
  4. pmc Estrogen and cytochrome P450 1B1 contribute to both early- and late-stage head and neck carcinogenesis
    Ekaterina G Shatalova
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Prev Res (Phila) 4:107-15. 2011
    ..024 and 0.008, respectively). These data provide novel insight into the mechanisms underlying head and neck carcinogenesis and facilitate the identification of new targets for chemopreventive intervention...
  5. pmc Endoscopic imaging and size estimation of colorectal adenomas in the multiple intestinal neoplasia mouse
    Harvey H Hensley
    Divisions of Basic Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Gastrointest Endosc 69:742-9. 2009
    ..The scientific potential of animal models of carcinogenesis has not been fully realized because of our limited ability to monitor tumor growth in vivo...
  6. pmc Phase II trial of single agent cetuximab in patients with persistent or recurrent epithelial ovarian or primary peritoneal carcinoma with the potential for dose escalation to rash
    Russell J Schilder
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Gynecol Oncol 113:21-7. 2009
    ..Determine if cetuximab dose escalation to induce grade 2 rash correlates with anti-tumor activity and if sera-based markers could predict likelihood of response...
  7. doi request reprint 5-aminosalicylic acid inhibits colitis-associated colorectal dysplasias in the mouse model of azoxymethane/dextran sulfate sodium-induced colitis
    Margie L Clapper
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Inflamm Bowel Dis 14:1341-7. 2008
    ..The chemopreventive activity of 5-ASA was evaluated in the Swiss Webster model of azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced colitis-associated neoplasia...
  8. pmc Early changes in gene expression induced by tobacco smoke: Evidence for the importance of estrogen within lung tissue
    Sibele I Meireles
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cancer Prev Res (Phila) 3:707-17. 2010
    ....
  9. pmc The mTOR pathway affects proliferation and chemosensitivity of urothelial carcinoma cells and is upregulated in a subset of human bladder cancers
    Igor Makhlin
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, USA
    BJU Int 108:E84-90. 2011
    ..To investigate whether mammalian target of rapamycin (mTOR) inhibition by rapamycin is therapeutically efficacious in combination with cisplatin for bladder cancer...
  10. pmc A prospective study of quality of life among women undergoing risk-reducing salpingo-oophorectomy versus gynecologic screening for ovarian cancer
    Carolyn Y Fang
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Gynecol Oncol 112:594-600. 2009
    ..The primary objective of the study was to prospectively assess quality of life (QOL) among women at increased risk of ovarian cancer who are undergoing risk-reducing salpingo-oophorectomy (RRSO) or serial screening...
  11. doi request reprint Familiarity and Self-Reported Compliance with American Urological Association Best Practice Recommendations for Use of Thromboembolic Prophylaxis among American Urological Association Members
    Steve Sterious
    Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Temple University School of Medicine, Philadelphia, Pennsylvania
    J Urol 190:992-8. 2013
    ....
  12. pmc Build it, and will they come? Unexpected findings from a study on a Web-based intervention to improve colorectal cancer screening
    Linda Fleisher
    Fox Chase Cancer Center, 510 Township Line Road, Cheltenham, PA 19012, USA
    J Health Commun 17:41-53. 2012
    ..004). Among true users, most (81%) logged on once only. These findings raise questions about how to increase use of important health communication interventions...
  13. pmc Synthetic lethal screen of an EGFR-centered network to improve targeted therapies
    Igor Astsaturov
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Sci Signal 3:ra67. 2010
    ..Such a focused approach can potentially improve the coherent design of combination cancer therapies...
  14. pmc The codon 72 polymorphism of p53 regulates interaction with NF-{kappa}B and transactivation of genes involved in immunity and inflammation
    Amanda K Frank
    Fox Chase Cancer Center, W209, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Mol Cell Biol 31:1201-13. 2011
    ..Consistent with this, we show that P72 mice have a markedly enhanced response to inflammatory challenge compared to that of R72 mice. Our data indicate that the codon 72 polymorphism impacts p53's role in inflammation...
  15. pmc Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair
    Salvatore Cortellino
    Cancer Biology Program and Epigenetics and Progenitor Cells Keystone Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cell 146:67-79. 2011
    ....
  16. pmc Elevated expression of stromal palladin predicts poor clinical outcome in renal cell carcinoma
    Vivekanand Gupta
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e21494. 2011
    ..The clinical value of assessing RCC stromal activation merits further study...
  17. pmc Detection of colorectal adenomas using a bioactivatable probe specific for matrix metalloproteinase activity
    Margie L Clapper
    Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Neoplasia 13:685-91. 2011
    ..Use of this fluorescent probe in combination with colonoscopy could aid in preventing colorectal neoplasias by providing new opportunities for early detection and therapeutic intervention...
  18. pmc Altered gene expression in morphologically normal epithelial cells from heterozygous carriers of BRCA1 or BRCA2 mutations
    Alfonso Bellacosa
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cancer Prev Res (Phila) 3:48-61. 2010
    ....
  19. ncbi request reprint A mouse model recapitulating molecular features of human mesothelioma
    Deborah A Altomare
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 65:8090-5. 2005
    ....
  20. ncbi request reprint Comparison of RNA amplification methods and chip platforms for microarray analysis of samples processed by laser capture microdissection
    Elena Caretti
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    J Cell Biochem 103:556-63. 2008
    ..986. The quicker NuGEN procedure, when coupled with X3P arrays, also yielded excellent results (correlation of 0.951). These observations will be useful for planning large-scale analyses of LCM-dissected clinical samples...