Rene Daniel

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. pmc Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response
    Rene Daniel
    Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 100:4778-83. 2003
  2. pmc Evidence that stable retroviral transduction and cell survival following DNA integration depend on components of the nonhomologous end joining repair pathway
    Rene Daniel
    Fox Chase Cancer Center, Institute for Cancer Research, 333 Cottman Ave, Philadelphia, PA 19111 2497, USA
    J Virol 78:8573-81. 2004
  3. pmc Integrase-specific enhancement and suppression of retroviral DNA integration by compacted chromatin structure in vitro
    Konstantin D Taganov
    Fox Chase Cancer Center, Institute for Cancer Research, 333 Cottman Ave, Philadelphia, PA 19111 2497, USA
    J Virol 78:5848-55. 2004
  4. ncbi request reprint Inhibition of HIV-1 replication by caffeine and caffeine-related methylxanthines
    Giuseppe Nunnari
    The Dorrance H Hamilton Laboratories, Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Virology 335:177-84. 2005
  5. pmc Evidence that the Nijmegen breakage syndrome protein, an early sensor of double-strand DNA breaks (DSB), is involved in HIV-1 post-integration repair by recruiting the ataxia telangiectasia-mutated kinase in a process similar to, but distinct from, cellul
    Johanna A Smith
    Division of Infectious Diseases Center for Human Virology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Virol J 5:11. 2008
  6. ncbi request reprint Histone H2AX is phosphorylated at sites of retroviral DNA integration but is dispensable for postintegration repair
    Rene Daniel
    Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, Pennsylvania 19111 2497, USA
    J Biol Chem 279:45810-4. 2004
  7. pmc A role for the histone deacetylase HDAC4 in the life-cycle of HIV-1-based vectors
    Johanna A Smith
    Division of Infectious Diseases Center for Human Virology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Virol J 7:237. 2010
  8. ncbi request reprint Pentoxifylline suppresses transduction by HIV-1-based vectors
    Johanna A Smith
    Division of Infectious Diseases, Center for Human Virology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Intervirology 50:377-86. 2007
  9. pmc Caffeine inhibits human immunodeficiency virus type 1 transduction of nondividing cells
    Rene Daniel
    Thomas Jefferson University, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, JAH Suite 321, 1020 Locust St, Philadelphia, PA 19107, USA
    J Virol 79:2058-65. 2005
  10. ncbi request reprint HIV-1 integration site preferences in pluripotent cells
    Janet L Markman
    Division of Infectious Diseases Center for Human Virology, Thomas Jefferson University, Philadelphia, PA, USA
    Front Biosci (Elite Ed) 3:453-62. 2011

Collaborators

Detail Information

Publications21

  1. pmc Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response
    Rene Daniel
    Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 100:4778-83. 2003
    ..Components of the cellular DNA damage repair response may represent potential targets for antiretroviral drug development...
  2. pmc Evidence that stable retroviral transduction and cell survival following DNA integration depend on components of the nonhomologous end joining repair pathway
    Rene Daniel
    Fox Chase Cancer Center, Institute for Cancer Research, 333 Cottman Ave, Philadelphia, PA 19111 2497, USA
    J Virol 78:8573-81. 2004
    ..Results presented in this study lend further support to a general role for the NHEJ DNA repair pathway in completion of the retroviral DNA integration process...
  3. pmc Integrase-specific enhancement and suppression of retroviral DNA integration by compacted chromatin structure in vitro
    Konstantin D Taganov
    Fox Chase Cancer Center, Institute for Cancer Research, 333 Cottman Ave, Philadelphia, PA 19111 2497, USA
    J Virol 78:5848-55. 2004
    ..These distinct properties of integrases may also affect target site selection in vivo, resulting in an important bias against or in favor of integration into actively transcribed host DNA...
  4. ncbi request reprint Inhibition of HIV-1 replication by caffeine and caffeine-related methylxanthines
    Giuseppe Nunnari
    The Dorrance H Hamilton Laboratories, Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Virology 335:177-84. 2005
    ..These data reveal the feasibility of therapeutic approaches targeting host cell proteins and further support the hypothesis that ATR and ATM proteins are involved in retroviral DNA integration...
  5. pmc Evidence that the Nijmegen breakage syndrome protein, an early sensor of double-strand DNA breaks (DSB), is involved in HIV-1 post-integration repair by recruiting the ataxia telangiectasia-mutated kinase in a process similar to, but distinct from, cellul
    Johanna A Smith
    Division of Infectious Diseases Center for Human Virology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Virol J 5:11. 2008
    ..A model is proposed emphasizing similarities and differences between PIR and DSB repair. Differences between the pathways may eventually allow strategies to block PIR while still allowing DSB repair...
  6. ncbi request reprint Histone H2AX is phosphorylated at sites of retroviral DNA integration but is dispensable for postintegration repair
    Rene Daniel
    Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, Pennsylvania 19111 2497, USA
    J Biol Chem 279:45810-4. 2004
    ..These observations provide independent support for an anchoring model for the function of gammaH2AX in chromatin repair...
  7. pmc A role for the histone deacetylase HDAC4 in the life-cycle of HIV-1-based vectors
    Johanna A Smith
    Division of Infectious Diseases Center for Human Virology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Virol J 7:237. 2010
    ..We conclude that HDAC4 is likely involved in PIR...
  8. ncbi request reprint Pentoxifylline suppresses transduction by HIV-1-based vectors
    Johanna A Smith
    Division of Infectious Diseases, Center for Human Virology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Intervirology 50:377-86. 2007
    ....
  9. pmc Caffeine inhibits human immunodeficiency virus type 1 transduction of nondividing cells
    Rene Daniel
    Thomas Jefferson University, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, JAH Suite 321, 1020 Locust St, Philadelphia, PA 19107, USA
    J Virol 79:2058-65. 2005
    ..Taken together, these data suggest that the effect(s) of caffeine on HIV-1 transduction is mediated at least partly by the inhibition of the ATR pathway but is not dependent on the caffeine-mediated inhibition of cell cycle checkpoints...
  10. ncbi request reprint HIV-1 integration site preferences in pluripotent cells
    Janet L Markman
    Division of Infectious Diseases Center for Human Virology, Thomas Jefferson University, Philadelphia, PA, USA
    Front Biosci (Elite Ed) 3:453-62. 2011
    ..We conclude that pluripotent cells may contain distinct cellular cofactors that participate in integration targeting and that are not present in somatic cells...
  11. pmc Modification of integration site preferences of an HIV-1-based vector by expression of a novel synthetic protein
    Robert M Silvers
    Division of Infectious Diseases, Center for Human Virology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Hum Gene Ther 21:337-49. 2010
    ..These data provide a novel approach to address the problem of the tendency of retroviral vectors to integrate at undesirable sites of the human genome...
  12. doi request reprint Abnormal cytokinesis after X-irradiation in tumor cells that override the G2 DNA damage checkpoint
    Haomin Huang
    Fox Chase Cancer Center, Department of Pathology, Children s Hospital of Philadelphia, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Cancer Res 68:3724-32. 2008
    ..Chromatin bridges that interfere with cytokinesis are likely to contribute to the replication failure and clonogenic death of cells exposed to irradiation...
  13. pmc A role for the Werner syndrome protein in epigenetic inactivation of the pluripotency factor Oct4
    Johanna A Smith
    Division of Infectious Diseases, Thomas Jefferson University, Philadelphia, USA
    Aging Cell 9:580-91. 2010
    ..The presented results reveal a novel function of WRNp and demonstrate that WRNp controls a key step in pluripotent stem cell differentiation...
  14. pmc Integration site selection by retroviral vectors: molecular mechanism and clinical consequences
    Rene Daniel
    Division of Infectious Diseases, Center for Human Virology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Hum Gene Ther 19:557-68. 2008
    ....
  15. ncbi request reprint Following the path of the virus: the exploitation of host DNA repair mechanisms by retroviruses
    Johanna A Smith
    Division of Infectious Diseases Center for Human Virology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, Pennsylvania 19107, USA
    ACS Chem Biol 1:217-26. 2006
    ....
  16. pmc The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity
    Salvatore Cortellino
    Program in Human Genetics, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 100:15071-6. 2003
    ..MED1 defects (much like MMR defects) may impair cell cycle arrest and apoptosis induced by DNA damage...
  17. ncbi request reprint Exogenous IL-7 induces Fas-mediated human neuronal apoptosis: potential effects during human immunodeficiency virus type 1 infection
    Giuseppe Nunnari
    Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Neurovirol 11:319-28. 2005
    ....
  18. doi request reprint Up-regulation of HIV-1 transduction in nondividing cells by double-strand DNA break-inducing agents
    Johanna A Smith
    Division of Infectious Diseases, Department of Medicine, Center for Human Virology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Biotechnol Lett 33:243-52. 2011
    ..The presented data support the hypothesis that DSB repair proteins are involved in the early steps of the retroviral life-cycle...
  19. pmc Proliferating cell nuclear antigen is required for loading of the SMCX/KMD5C histone demethylase onto chromatin
    Zhihui Liang
    Division of Infectious Diseases Center for Human Virology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Epigenetics Chromatin 4:18. 2011
    ..abstract:..
  20. pmc Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth
    Barbara Chiavarina
    Departments of Stem Cell Biology and Regenerative Medicine and Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cancer Biol Ther 12:1101-13. 2011
    ..As such, this subgroup of patients may benefit therapeutically from potent inhibitors targeting glycolysis, autophagy and/or mitochondrial activity (such as metformin)...
  21. pmc Stem cells and aging: a chicken-or-the-egg issue?
    Johanna A Smith
    Division of Infectious Diseases Center for Human Virology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Aging Dis 3:260-8. 2012
    ..Finally, we discuss new evidence from progeroid syndromes that supports the stem cell hypothesis of aging...