Mary B Daly

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. pmc Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers
    Antonis C Antoniou
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Worts Causeway, Cambridge CB1 8RN, UK
    Breast Cancer Res 14:R33. 2012
  2. pmc Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2
    Anna Marie Mulligan
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Worts Causeway, Cambridge, CB1 8RN, UK
    Breast Cancer Res 13:R110. 2011
  3. pmc Rare variants in the ATM gene and risk of breast cancer
    David E Goldgar
    Department of Dermatology, University of Utah School of Medicine, 30 N 1900 E, Salt Lake City, UT 84132 2101, USA
    Breast Cancer Res 13:R73. 2011
  4. pmc Exploring the link between MORF4L1 and risk of breast cancer
    Griselda Martrat
    Translational Research Laboratory, Catalan Institute of Oncology, Bellvitge Institute for Biomedical Research IDIBELL, Gran Via 199, L Hospitalet del Llobregat 08908, Spain
    Breast Cancer Res 13:R40. 2011
  5. pmc Contribution of large genomic BRCA1 alterations to early-onset breast cancer selected for family history and tumour morphology: a report from The Breast Cancer Family Registry
    Letitia D Smith
    Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Melbourne, Victoria 3010, Australia
    Breast Cancer Res 13:R14. 2011
  6. pmc Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers
    Susan L Neuhausen
    Department of Epidemiology, University of California Irvine, 224 Irvine Hall, Irvine, CA 92697, USA
    Breast Cancer Res 11:R76. 2009
  7. pmc The impact of social roles on the experience of men in BRCA1/2 families: implications for counseling
    Mary B Daly
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Genet Couns 18:42-8. 2009
  8. ncbi request reprint How to establish a high-risk cancer genetics clinic: limitations and successes
    Mary B Daly
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    Curr Oncol Rep 7:469-74. 2005
  9. pmc Occult ovarian cancers identified at risk-reducing salpingo-oophorectomy in a prospective cohort of BRCA1/2 mutation carriers
    Susan M Domchek
    Abramson Cancer Center, The University of Pennsylvania School of Medicine, 3W Perelman Center, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA
    Breast Cancer Res Treat 124:195-203. 2010
  10. pmc Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality
    Susan M Domchek
    Abramson Cancer Center and Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    JAMA 304:967-75. 2010

Detail Information

Publications62

  1. pmc Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers
    Antonis C Antoniou
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Worts Causeway, Cambridge CB1 8RN, UK
    Breast Cancer Res 14:R33. 2012
    ..2)...
  2. pmc Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2
    Anna Marie Mulligan
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Worts Causeway, Cambridge, CB1 8RN, UK
    Breast Cancer Res 13:R110. 2011
    ..It is currently unknown how these alleles are associated with different breast cancer subtypes in BRCA1 and BRCA2 mutation carriers defined by estrogen (ER) or progesterone receptor (PR) status of the tumour...
  3. pmc Rare variants in the ATM gene and risk of breast cancer
    David E Goldgar
    Department of Dermatology, University of Utah School of Medicine, 30 N 1900 E, Salt Lake City, UT 84132 2101, USA
    Breast Cancer Res 13:R73. 2011
    ..However, the magnitude of risk and the subset of variants that are pathogenic for breast cancer remain unresolved...
  4. pmc Exploring the link between MORF4L1 and risk of breast cancer
    Griselda Martrat
    Translational Research Laboratory, Catalan Institute of Oncology, Bellvitge Institute for Biomedical Research IDIBELL, Gran Via 199, L Hospitalet del Llobregat 08908, Spain
    Breast Cancer Res 13:R40. 2011
    ..To gain deeper insight into this pathway and its influence on cancer risk, we searched for novel components through protein physical interaction screens...
  5. pmc Contribution of large genomic BRCA1 alterations to early-onset breast cancer selected for family history and tumour morphology: a report from The Breast Cancer Family Registry
    Letitia D Smith
    Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Melbourne, Victoria 3010, Australia
    Breast Cancer Res 13:R14. 2011
    ..We sought to test the value of selecting women for BRCA1 mutation testing on the basis of family history and/or breast tumour morphology criteria as well as the value of testing for large genomic alterations in BRCA1...
  6. pmc Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers
    Susan L Neuhausen
    Department of Epidemiology, University of California Irvine, 224 Irvine Hall, Irvine, CA 92697, USA
    Breast Cancer Res 11:R76. 2009
    ..In this study, we investigate the association of variants in genes involved in IGF signaling and risk of breast cancer in women who carry deleterious BRCA1 and BRCA2 mutations...
  7. pmc The impact of social roles on the experience of men in BRCA1/2 families: implications for counseling
    Mary B Daly
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Genet Couns 18:42-8. 2009
    ..Genetic counselors are in a position to inform at-risk males of their genetic risk, and to help them explore their personal health options...
  8. ncbi request reprint How to establish a high-risk cancer genetics clinic: limitations and successes
    Mary B Daly
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    Curr Oncol Rep 7:469-74. 2005
    ..The societal benefits include a more educated public armed with the information needed to make health decisions appropriate for the individual level of risk...
  9. pmc Occult ovarian cancers identified at risk-reducing salpingo-oophorectomy in a prospective cohort of BRCA1/2 mutation carriers
    Susan M Domchek
    Abramson Cancer Center, The University of Pennsylvania School of Medicine, 3W Perelman Center, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA
    Breast Cancer Res Treat 124:195-203. 2010
    ..An unacceptably high proportion of pathologic examinations did not adequately examine ovaries and fallopian tubes obtained at RRSO...
  10. pmc Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality
    Susan M Domchek
    Abramson Cancer Center and Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    JAMA 304:967-75. 2010
    ..Mastectomy and salpingo-oophorectomy are widely used by carriers of BRCA1 or BRCA2 mutations to reduce their risks of breast and ovarian cancer...
  11. doi request reprint Bilateral prophylactic oophorectomy and bilateral prophylactic mastectomy in a prospective cohort of unaffected BRCA1 and BRCA2 mutation carriers
    Tara M Friebel
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Clin Breast Cancer 7:875-82. 2007
    ..The availability of these risk-reduction strategies is an important consideration in the decision to undergo genetic testing...
  12. pmc Breast and ovarian cancer risk and risk reduction in Jewish BRCA1/2 mutation carriers
    Brian S Finkelman
    Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    J Clin Oncol 30:1321-8. 2012
    ..Three mutations in these genes (185delAG, 5382insC, and 6174delT) occur at high frequency in Ashkenazi Jews. We evaluated how these common Jewish mutations (CJMs) affect cancer risks and risk reduction...
  13. ncbi request reprint Mortality after bilateral salpingo-oophorectomy in BRCA1 and BRCA2 mutation carriers: a prospective cohort study
    Susan M Domchek
    Abramson Cancer Centre, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Lancet Oncol 7:223-9. 2006
    ..However, the reduction in mortality after this surgery is unclear. We aimed to assess whether BPSO improves overall mortality or cancer-specific mortality in BRCA1 and BRCA2 mutation carriers...
  14. ncbi request reprint Effect of short-term hormone replacement therapy on breast cancer risk reduction after bilateral prophylactic oophorectomy in BRCA1 and BRCA2 mutation carriers: the PROSE Study Group
    Timothy R Rebbeck
    Center for Clinical Epidemiology and Biostatistics, The University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Clin Oncol 23:7804-10. 2005
    ..Thus, we evaluated whether the breast cancer risk reduction conferred by BPO in BRCA1/2 mutation carriers is altered by use of post-BPO HRT...
  15. doi request reprint Allelic imbalance in BRCA1 and BRCA2 gene expression is associated with an increased breast cancer risk
    Xiaowei Chen
    Medical Science Division, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    Hum Mol Genet 17:1336-48. 2008
    ..02 and P < 0.02, respectively). In conclusion, we have found that AI affecting BRCA1 and to a lesser extent BRCA2 may contribute to both familial and non-familial forms of breast cancer...
  16. pmc Modification of BRCA1-Associated Breast and Ovarian Cancer Risk by BRCA1-Interacting Genes
    Timothy R Rebbeck
    Abramson Cancer Center, Center for Clinical Epidemiology and Biostatistics, and Department of Medicine, The University of Pennsylvania Perleman School of Medicine, Philadelphia, Pennsylvania, USA
    Cancer Res 71:5792-805. 2011
    ..Overall, the data suggest that genomic variation at multiple loci that encode proteins that interact biologically with BRCA1 are associated with modified breast cancer and ovarian cancer risk in women who carry BRCA1 mutations...
  17. doi request reprint Intention to communicate BRCA1/BRCA2 genetic test results to the family
    Andrea M Barsevick
    Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    J Fam Psychol 22:303-12. 2008
    ..These results extend the theory of planned behavior by showing that gender and generation influence intention when the relative's opinion is unknown...
  18. ncbi request reprint The joint effect of smoking and AIB1 on breast cancer risk in BRCA1 mutation carriers
    Susan Colilla
    Department of Biostatistics and Epidemiology and Medicine and Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Carcinogenesis 27:599-605. 2006
    ....
  19. pmc Dietary intake and breast density in high-risk women: a cross-sectional study
    Marilyn Tseng
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Breast Cancer Res 9:R72. 2007
    ..The objective of the present study was to determine whether diet, a modifiable risk factor, is related to breast density among women at high genetic risk for breast cancer...
  20. ncbi request reprint Age-dependent morphological alterations of human ovaries from populations with and without BRCA mutations
    Kathy Qi Cai
    Ovarian Cancer Program and Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Gynecol Oncol 103:719-28. 2006
    ....
  21. ncbi request reprint Enhanced counseling for women undergoing BRCA1/2 testing: impact on subsequent decision making about risk reduction behaviors
    Suzanne M Miller
    Fox Chase Cancer Center, Philadelphia, Pennsylvania, PA 19111, USA
    Health Educ Behav 32:654-67. 2005
    ..The results indicate that the use of enhanced counseling can play an important role in decision making about risk reduction behaviors following BRCA1/2 testing...
  22. ncbi request reprint Focus on epithelial ovarian cancer
    Robert F Ozols
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cancer Cell 5:19-24. 2004
  23. pmc Identifying breast cancer risk loci by global differential allele-specific expression (DASE) analysis in mammary epithelial transcriptome
    Chuan Gao
    Cancer Epigenetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    BMC Genomics 13:570. 2012
    ....
  24. pmc Knowledge and perceptions of familial and genetic risks for breast cancer risk in adolescent girls
    Angela R Bradbury
    Division of Hematology Oncology, Department of Medicine, University of Pennsylvania, 3 West Perelman Center 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA
    Breast Cancer Res Treat 136:749-57. 2012
    ..Research evaluating the impact of awareness and perceptions of breast cancer risk on psychosocial, health, and risk behaviors is needed to develop strategies to optimize responses to cancer risk...
  25. pmc Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicenter cohort of BRCA1/2 mutation carriers
    Timothy R Rebbeck
    Abramson Cancer Center, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Cancer Res 69:5801-10. 2009
    ..026). Variants in genes that interact biologically withBRCA1 and/or BRCA2 may be associated with modified ovarian cancer risk in women who carry BRCA1/2 mutations...
  26. ncbi request reprint Genetic/familial high-risk assessment: breast and ovarian
    Mary B Daly
    Fox Chase Cancer Center, Philadelphia, PA, USA
    J Natl Compr Canc Netw 4:156-76. 2006
  27. pmc New strategies in ovarian cancer: uptake and experience of women at high risk of ovarian cancer who are considering risk-reducing salpingo-oophorectomy
    Suzanne M Miller
    Psychosocial and Biobehavioral Medicine Program, Fox Chase Cancer Center, Cheltenham, Pennsylvania 19012, USA
    Clin Cancer Res 16:5094-106. 2010
    ..These findings indicate that when designing decision aids, demographic, medical history, and psychosocial variables need to be addressed in order to facilitate quality decision making...
  28. pmc A prospective study of quality of life among women undergoing risk-reducing salpingo-oophorectomy versus gynecologic screening for ovarian cancer
    Carolyn Y Fang
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Gynecol Oncol 112:594-600. 2009
    ..The primary objective of the study was to prospectively assess quality of life (QOL) among women at increased risk of ovarian cancer who are undergoing risk-reducing salpingo-oophorectomy (RRSO) or serial screening...
  29. pmc When parents disclose BRCA1/2 test results: their communication and perceptions of offspring response
    Angela R Bradbury
    Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 2497, USA
    Cancer 118:3417-25. 2012
    ..Little is known about the prevalence and predictors of parent communication to offspring and how offspring respond to this communication...
  30. ncbi request reprint Bilateral prophylactic mastectomy reduces breast cancer risk in BRCA1 and BRCA2 mutation carriers: the PROSE Study Group
    Timothy R Rebbeck
    Center for Clinical Epidemiology and Biostatistics, Abramson Family Cancer Research Institute, The University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    J Clin Oncol 22:1055-62. 2004
    ..Thus, we estimated the degree of breast cancer risk reduction after surgery in women who carry these mutations...
  31. doi request reprint Mentoring nurses in familial cancer risk assessment and counseling: lessons learned from a formative evaluation
    Agnes Masny
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Genet Couns 17:196-207. 2008
    ....
  32. ncbi request reprint Correlates of soy food consumption in women at increased risk for breast cancer
    Carolyn Y Fang
    Division of Population Science, Fox Chase Cancer Center, Cheltenham, PA 19012, USA
    J Am Diet Assoc 105:1552-8. 2005
    ....
  33. pmc Cancer genetic risk assessment and referral patterns in primary care
    Hetal S Vig
    Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Genet Test Mol Biomarkers 13:735-41. 2009
    ..This study was undertaken to describe cancer risk assessment practices among primary care providers (PCPs)...
  34. ncbi request reprint Psychosocial correlates of intention to undergo prophylactic oophorectomy among women with a family history of ovarian cancer
    Carolyn Y Fang
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Prev Med 37:424-31. 2003
    ..The purpose of this study was to examine sociodemographic and psychosocial correlates of intention to undergo prophylactic oophorectomy among women with a family history of ovarian cancer...
  35. ncbi request reprint Intronic alterations in BRCA1 and BRCA2: effect on mRNA splicing fidelity and expression
    Xiaowei Chen
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Hum Mutat 27:427-35. 2006
    ..Our studies help to clarify the aberrant splicing in BRCA1 and BRCA2 as well as provide information that can be used clinically to help counsel breast/ovarian cancer prone families...
  36. doi request reprint Food frequency questionnaires and overnight urines are valid indicators of daidzein and genistein intake in U.S. women relative to multiple 24-h urine samples
    Marilyn Tseng
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19130, USA
    Nutr Cancer 60:619-26. 2008
    ..We conclude that targeted soy food questionnaires, comprehensive FFQs, and multiple overnight urines are all reasonable options for assessing isoflavone intake in epidemiologic studies...
  37. ncbi request reprint Coping with ovarian cancer risk: the moderating effects of perceived control on coping and adjustment
    Carolyn Y Fang
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, PA 19012, USA
    Br J Health Psychol 11:561-80. 2006
    ..The present study was a longitudinal study of the effects of perceived control and problem-focused coping on changes in psychological adjustment and behavioural outcomes among women at increased risk for ovarian cancer...
  38. ncbi request reprint The search for predictive patterns in ovarian cancer: proteomics meets bioinformatics
    Mary B Daly
    Division of Population Science, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Cancer Cell 1:111-2. 2002
    ..Proteomic patterns in serum that discriminate between malignant and benign ovaries may provide a powerful tool for screening in high risk women...
  39. ncbi request reprint Acculturation and breast density in foreign-born, U.S. Chinese women
    Marilyn Tseng
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cancer Epidemiol Biomarkers Prev 15:1301-5. 2006
    ..Future longitudinal research will examine whether the association is due to early-life factors, postmigration lifestyle changes, or perimenopausal exposures...
  40. ncbi request reprint A mechanism for cox-2 inhibitor anti-inflammatory activity in chemoprevention of epithelial cancers
    Elizabeth R Smith
    Ovarian Cancer Program, Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Cancer Epidemiol Biomarkers Prev 13:144-5. 2004
  41. ncbi request reprint Communication of BRCA1 and BRCA2 results to at-risk relatives: a cancer risk assessment program's experience
    Josephine Wagner Costalas
    Population Science Division, Family Risk Assessment Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Am J Med Genet C Semin Med Genet 119:11-8. 2003
    ..001). Individuals are disclosing their test results to their relatives. Probands who are BRCA1- or BRCA2-positive are more likely to experience difficulty and distress with the communication of their test results to family members...
  42. ncbi request reprint Loss of surface and cyst epithelial basement membranes and preneoplastic morphologic changes in prophylactic oophorectomies
    Isabelle H Roland
    Ovarian Cancer Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer 98:2607-23. 2003
    ..The authors speculated that the purging of the basement membrane may be similar to the proteolysis during gonadotropin-stimulated ovulation, a cyclooxygenase 2 (Cox-2)-mediated process...
  43. pmc Understanding the needs of women considering risk-reducing salpingo-oophorectomy
    Carol Cherry
    Women s Cancer, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Nurs 36:E33-8. 2013
    ..Significant time is often spent by nurses trained in genetics providing counseling to improve the decision-making process. The decision to undergo surgery is complex and laden with several sources of uncertainty...
  44. ncbi request reprint Tamoxifen in ductal carcinoma in situ
    Mary B Daly
    Department of Population Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Semin Oncol 33:647-9. 2006
    ..Tamoxifen should be considered as an adjunct to treatment for women undergoing breast-conserving surgery for ER-positive DCIS...
  45. pmc The Breast Cancer Family Registry: an infrastructure for cooperative multinational, interdisciplinary and translational studies of the genetic epidemiology of breast cancer
    Esther M John
    Clinical and Genetic Epidemiology Research Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA
    Breast Cancer Res 6:R375-89. 2004
    ....
  46. pmc Risk-reducing salpingo-oophorectomy for the prevention of BRCA1- and BRCA2-associated breast and gynecologic cancer: a multicenter, prospective study
    Noah D Kauff
    Clinical Genetics and Gynecology Services, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 192, New York, NY 10021, USA
    J Clin Oncol 26:1331-7. 2008
    ....
  47. ncbi request reprint Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations
    Timothy R Rebbeck
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    N Engl J Med 346:1616-22. 2002
    ..We investigated whether this procedure reduces the risk of cancers of the coelomic epithelium and breast in women who carry such mutations...
  48. ncbi request reprint Tailoring breast cancer treatment to genetic status: the challenges ahead
    Mary B Daly
    J Clin Oncol 22:1776-7. 2004
  49. ncbi request reprint The AIB1 polyglutamine repeat does not modify breast cancer risk in BRCA1 and BRCA2 mutation carriers
    Amanda B Spurdle
    The Queensland Institute of Medical Research, Brisbane, Australia
    Cancer Epidemiol Biomarkers Prev 15:76-9. 2006
    ..Given the large sample size, with more than adequate power to detect previously reported effects, we conclude that the AIB1 glutamine repeat does not substantially modify risk of breast cancer in BRCA1 and BRCA2 mutation carriers...
  50. ncbi request reprint Breast cancer screening and diagnosis
    Therese B Bevers
    University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Compr Canc Netw 4:480-508. 2006
  51. ncbi request reprint Determinants of preferences for genetic counselling in Jewish women
    Carmel Apicella
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, Australia
    Fam Cancer 5:159-67. 2006
    ..Cancer genetic services are relatively new, and little is known about clients' preferences. We sought to determine clients' preferences for genetic service delivery, and to identify factors that predict those preferences...
  52. pmc Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers
    Antonis C Antoniou
    Cancer Research UK, Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK
    Am J Hum Genet 82:937-48. 2008
    ....
  53. pmc Genetic and functional analysis of CHEK2 (CHK2) variants in multiethnic cohorts
    Daphne W Bell
    Massachusetts General Hospital Cancer Center, Charlestown, MA, USA
    Int J Cancer 121:2661-7. 2007
    ....
  54. pmc AURKA F31I polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a consortium of investigators of modifiers of BRCA1/2 study
    Fergus J Couch
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 16:1416-21. 2007
    ..In summary, the F31I polymorphism in AURKA is not associated with a modified risk of breast cancer in BRCA1 and BRCA2 carriers...
  55. ncbi request reprint No increased risk of breast cancer associated with alcohol consumption among carriers of BRCA1 and BRCA2 mutations ages <50 years
    Valerie McGuire
    Department of Health Research and Policy, Stanford University School of Medicine, Health Research and Stanford, CA 94305 5405, USA
    Cancer Epidemiol Biomarkers Prev 15:1565-7. 2006
  56. ncbi request reprint BRCA2 mutation-associated breast cancers exhibit a distinguishing phenotype based on morphology and molecular profiles from tissue microarrays
    Anita L Bane
    Department of Pathology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Toronto, Ontario, Canada
    Am J Surg Pathol 31:121-8. 2007
    ....
  57. ncbi request reprint Symptoms of ovarian cancer--where to set the bar?
    Mary B Daly
    JAMA 291:2755-6. 2004
  58. ncbi request reprint Genetic linkage of prostate cancer risk to the chromosome 3 region bearing FHIT
    Garry P Larson
    Division of Molecular Medicine, Beckman Research Institute, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010 3000, USA
    Cancer Res 65:805-14. 2005
    ..54, df = 1, P = 0.0035). Our results strongly suggest involvement of germline variations of FHIT in prostate cancer risk...
  59. ncbi request reprint Breast cancer risk reduction
    Therese B Bevers
    National Comprehensive Cancer Network
    J Natl Compr Canc Netw 5:676-701. 2007
  60. pmc Evaluation of linkage of breast cancer to the putative BRCA3 locus on chromosome 13q21 in 128 multiple case families from the Breast Cancer Linkage Consortium
    Deborah Thompson
    CRC Genetic Epidemiology Unit, Strangeways Research Laboratories, University of Cambridge, Cambridge CB1 4RN, United Kingdom
    Proc Natl Acad Sci U S A 99:827-31. 2002
    ..65 was -11.0]. We conclude that, if a susceptibility gene does exist at this locus, it can only account for a small proportion of non-BRCA1/2 families with multiple cases of early-onset breast cancer...
  61. ncbi request reprint Specific keynote: chemoprevention of ovarian cancer: the journey begins
    Robert F Ozols
    Fox Chase Cancer Center
    Gynecol Oncol 88:S59-66; discussion S67-70. 2003
  62. ncbi request reprint Prospective multicenter trial to determine the feasibility of collection and predictive ability of breast fluid analysis in postmenopausal women receiving SERMs
    Edward R Sauter
    Department of Surgery, University of Missouri Columbia, One Hospital Drive, Rm N510, Columbia, MO 65212, USA
    Breast 16:489-94. 2007
    ..Multiinstitutional clinical trials in postmenopausal women using NAF biomarkers as the primary endpoints are feasible...

Research Grants13

  1. COMMUNICATING GENETIC TEST RESULTS TO THE FAMILY
    Mary Daly; Fiscal Year: 2007
    ..Our long-term goal is both to advance the field of cancer communication science and to create a bridge to the development of practice guidelines and the diffusion of best practice to the genetic counseling community. ..
  2. Benign Breast Disease: A New Frontier for Prevention
    Mary Daly; Fiscal Year: 2007
    ..The award will also facilitate my efforts to formalize a novel clinical genetics training rotation within the medical oncology fellowship, and will afford more opportunities to mentor students at all levels of training. ..
  3. ADVANCED CANCER RISK COUNSELING TRAINING FOR NURSES
    Mary Daly; Fiscal Year: 2006
    ..Course and mentoring evaluations will assess if this continuing education format is an effective method for preparing nurses skilled in the delivery of cancer genetic risk assessment and management. ..
  4. Benign Breast Registry to Assess Valid Endpoints
    Mary Daly; Fiscal Year: 2005
    ..If promising, this work would lead to a larger prospective clinical research project to validate the findings of the pilot study and explore mechanisms of action. ..
  5. COMMUNICATING GENETIC TEST RESULTS TO THE FAMILY
    Mary Daly; Fiscal Year: 2002
    ..If effective, this protocol will provide a model for risk communication within families facing genetic risk for a wide range of diseases. ..