Edna Cukierman

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. ncbi request reprint Tumour development due to stroma permissiveness
    Edna Cukierman
    Basic Science Tumor Cell Biology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Biosci 30:551-2. 2005
  2. pmc The mesenchymal tumor microenvironment: a drug-resistant niche
    Edna Cukierman
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, USA
    Cell Adh Migr 6:285-96. 2012
  3. pmc Physico-mechanical aspects of extracellular matrix influences on tumorigenic behaviors
    Edna Cukierman
    Fox Chase Cancer Center, Cancer Biology, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    Semin Cancer Biol 20:139-45. 2010
  4. pmc The benefits and challenges associated with the use of drug delivery systems in cancer therapy
    Edna Cukierman
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    Biochem Pharmacol 80:762-70. 2010
  5. pmc Staged stromal extracellular 3D matrices differentially regulate breast cancer cell responses through PI3K and beta1-integrins
    Remedios Castelló-Cros
    Cancer Genetics and Signaling Program, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    BMC Cancer 9:94. 2009
  6. pmc Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis
    Daniel E Bassi
    Department of Pathology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Neoplasia 12:516-26. 2010
  7. pmc FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cells
    Hyung Ok Lee
    Department of Medical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111, USA
    BMC Cancer 11:245. 2011
  8. ncbi request reprint Stromagenesis: the changing face of fibroblastic microenvironments during tumor progression
    Dorothy A Beacham
    Fox Chase Cancer Center, Basic Science Tumor Cell Biology, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    Semin Cancer Biol 15:329-41. 2005
  9. ncbi request reprint Preparation of extracellular matrices produced by cultured and primary fibroblasts
    Dorothy A Beacham
    Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Curr Protoc Cell Biol . 2007
  10. pmc Stroma-derived three-dimensional matrices are necessary and sufficient to promote desmoplastic differentiation of normal fibroblasts
    Michael D Amatangelo
    Basic Science Tumor Cell Biology, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    Am J Pathol 167:475-88. 2005

Research Grants

Collaborators

  • Remedios Castelló-Cros
  • Erica Golemis
  • Margaret von Mehren
  • Claudia D Andl
  • Kimberly M Brown
  • Ekaterina G Shatalova
  • Wafik S El-Deiry
  • Hiroshi Nakagawa
  • Jonathan D Cheng
  • Tahseen Al-Saleem
  • Anil Rustgi
  • M Herlyn
  • Carmen Z Michaylira
  • Thomas H Bugge
  • Daniel E Bassi
  • Dorothy A Beacham
  • Kenneth M Yamada
  • Andres J P Klein-Szanto
  • Roumen Pankov
  • Michael D Amatangelo
  • Vivekanand Gupta
  • Hyung Ok Lee
  • Matthildi Valianou
  • Ralica Damianova
  • Ilya Serebriiskii
  • Roderick M Quiros
  • Jonathan Cenna
  • Samuel Litwin
  • Takaomi Okawa
  • Jay E Johnson
  • Margret B Einarson
  • Kazue Matsumoto
  • Miles B Zajaczkowski
  • Ben Zion Katz
  • Lars H Engelholm
  • Jeffrey D Simons
  • Karthik Devarajan
  • Janusz Franco-Barraza
  • Robert G Uzzo
  • Stefanie R Mullins
  • Jirong Zhang
  • Nadezhda Stefanova
  • Albena Momchilova
  • Andrew K Godwin
  • Youngjoo Kwon
  • Acacia Lamb
  • Jiri Kalabis
  • Cameron N Johnstone
  • Douglas B Stairs
  • Andres J Klein-Szanto
  • Robert J Varkonyi
  • Arthur Patchefsky
  • Masaru Araki
  • Ricardo Lopez De Cicco
  • Jaclyn Schwalm
  • Yukinori Endo
  • Sharona Even-Ram
  • Andres Klein-Szanto
  • Ryan Cragle
  • Katherine Clark
  • Dominique Broccoli
  • Duane A Compton
  • Benjamin Geiger
  • Hannah Aaronson
  • Lewis Romer
  • Shingo Miyamoto
  • David J Mitola
  • Lars Kjøller
  • Karin List
  • Henning Birkedal-Hansen
  • Sarah Netzel-Arnett
  • Niels Behrendt
  • Keld Danø
  • Tova Volberg
  • Catherine G Galbraith
  • Kenn Holmbeck
  • Dudley K Strickland
  • Jørgen K Larsen

Detail Information

Publications27

  1. ncbi request reprint Tumour development due to stroma permissiveness
    Edna Cukierman
    Basic Science Tumor Cell Biology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Biosci 30:551-2. 2005
  2. pmc The mesenchymal tumor microenvironment: a drug-resistant niche
    Edna Cukierman
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, USA
    Cell Adh Migr 6:285-96. 2012
    ..Special emphasis is given to environment-mediated drug resistance in general and to cell adhesion-mediated drug resistance in particular...
  3. pmc Physico-mechanical aspects of extracellular matrix influences on tumorigenic behaviors
    Edna Cukierman
    Fox Chase Cancer Center, Cancer Biology, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    Semin Cancer Biol 20:139-45. 2010
    ..In this review we describe some of the physico-mechanical characteristics of tumor-associated ECMs believed to play important roles in regulating epithelial tumorigenic behaviors...
  4. pmc The benefits and challenges associated with the use of drug delivery systems in cancer therapy
    Edna Cukierman
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    Biochem Pharmacol 80:762-70. 2010
    ....
  5. pmc Staged stromal extracellular 3D matrices differentially regulate breast cancer cell responses through PI3K and beta1-integrins
    Remedios Castelló-Cros
    Cancer Genetics and Signaling Program, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    BMC Cancer 9:94. 2009
    ..The goal of this study was to analyze the direct effects of staged stroma-derived extracellular matrices on breast cancer cell behavior...
  6. pmc Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis
    Daniel E Bassi
    Department of Pathology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Neoplasia 12:516-26. 2010
    ..These results identify PACE4, together with other PCs, as suitable targets to slow down or block tumor progression, suggesting that PC inhibition is a potential approach for therapy for solid tumors...
  7. pmc FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cells
    Hyung Ok Lee
    Department of Medical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111, USA
    BMC Cancer 11:245. 2011
    ..We tested the hypothesis that FAP enzymatic activity locally modifies stromal ECM (extracellular matrix) components thus facilitating the formation of a permissive microenvironment promoting tumor invasion in human pancreatic cancer...
  8. ncbi request reprint Stromagenesis: the changing face of fibroblastic microenvironments during tumor progression
    Dorothy A Beacham
    Fox Chase Cancer Center, Basic Science Tumor Cell Biology, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    Semin Cancer Biol 15:329-41. 2005
    ..These systems provide unique experimental tools to identify early alterations in stromagenesis that are supportive of tumor progression with the ultimate goal of blocking neoplastic permissiveness and restoring normal phenotypes...
  9. ncbi request reprint Preparation of extracellular matrices produced by cultured and primary fibroblasts
    Dorothy A Beacham
    Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Curr Protoc Cell Biol . 2007
    ..Cell adhesion and spreading are normal on these matrices. This matrix can also be compressed into a two-dimensional matrix and solubilized to study the matrix biochemically...
  10. pmc Stroma-derived three-dimensional matrices are necessary and sufficient to promote desmoplastic differentiation of normal fibroblasts
    Michael D Amatangelo
    Basic Science Tumor Cell Biology, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    Am J Pathol 167:475-88. 2005
    ..In this study, we demonstrate that in vivo-like three-dimensional matrices appear to have the necessary topographical and molecular information sufficient to induce desmoplastic stroma differentiation of normal fibroblasts...
  11. pmc Estrogen and cytochrome P450 1B1 contribute to both early- and late-stage head and neck carcinogenesis
    Ekaterina G Shatalova
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Prev Res (Phila) 4:107-15. 2011
    ..024 and 0.008, respectively). These data provide novel insight into the mechanisms underlying head and neck carcinogenesis and facilitate the identification of new targets for chemopreventive intervention...
  12. pmc Stromagenesis during tumorigenesis: characterization of tumor-associated fibroblasts and stroma-derived 3D matrices
    Remedios Castelló-Cros
    Fox Chase Cancer Center, Philadelphia, PA, USA
    Methods Mol Biol 522:275-305. 2009
    ..It describes how to produce and characterize fibroblast-derived 3D matrices. Finally, it describes how to test matrix permissiveness by analyzing the morphology of cancer cells cultured within various 3D matrices...
  13. pmc Fibroblast-derived 3D matrix differentially regulates the growth and drug-responsiveness of human cancer cells
    Ilya Serebriiskii
    Division of Basic Science Tumor Cell Biology, Fox Chase Cancer Center, Philadelphia, PA 19111, United States
    Matrix Biol 27:573-85. 2008
    ..Based on these results, we propose that these matrices potentially have value as in vitro drug screening platforms...
  14. pmc Ovarian normal and tumor-associated fibroblasts retain in vivo stromal characteristics in a 3-D matrix-dependent manner
    Roderick M Quiros
    Basic Science, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    Gynecol Oncol 110:99-109. 2008
    ..Here, we introduce an in vivo-like 3-D system of mesenchymal stromal progression during ovarian tumorigenesis to support the study of stroma permissiveness in human ovarian neoplasias...
  15. ncbi request reprint PACE4 expression in mouse basal keratinocytes results in basement membrane disruption and acceleration of tumor progression
    Daniel E Bassi
    Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 65:7310-9. 2005
    ..PACE4 overexpression resulted in enhanced susceptibility to carcinogenesis and tumor progression pointing to a new target for blocking tumor cell invasiveness...
  16. pmc The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation
    Takaomi Okawa
    Division of Gastroenterology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 21:2788-803. 2007
    ....
  17. ncbi request reprint A visual-quantitative analysis of fibroblastic stromagenesis in breast cancer progression
    Edna Cukierman
    Division of Basic Science Tumor Cell Biology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 2497, USA
    J Mammary Gland Biol Neoplasia 9:311-24. 2004
    ..Here we review stromagenic stages, experimental 3D systems, and discuss digital imaging analyses suitable for uncovering the mechanisms behind fibroblastic breast stromagenesis...
  18. pmc Elevated expression of stromal palladin predicts poor clinical outcome in renal cell carcinoma
    Vivekanand Gupta
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e21494. 2011
    ..The clinical value of assessing RCC stromal activation merits further study...
  19. ncbi request reprint Multiple mechanisms of telomere maintenance exist in liposarcomas
    Jay E Johnson
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Clin Cancer Res 11:5347-55. 2005
    ..Recent data suggest that constitutive telomere maintenance may not be required in all tumor types. Here we assess the role and requirement of telomere maintenance in liposarcoma...
  20. ncbi request reprint Cell migration analyses within fibroblast-derived 3-D matrices
    Edna Cukierman
    Tumor Cell Biology, Basic Science, Fox Chase Cancer Center, Philadelphia, PA, USA
    Methods Mol Biol 294:79-93. 2005
    ..Here we show how to measure the rates and directionality of fibroblasts motility within physiologically relevant in vivo-like cell-derived three-dimensional matrices...
  21. pmc Human enhancer of invasion-cluster, a coiled-coil protein required for passage through mitosis
    Margret B Einarson
    Division of Basic Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Cell Biol 24:3957-71. 2004
    ..These results place HEI-C as a novel regulator of spindle function and integrity during the metaphase-anaphase transition...
  22. ncbi request reprint Three-dimensional matrix induces sustained activation of ERK1/2 via Src/Ras/Raf signaling pathway
    Ralica Damianova
    Department of Cytology, Histology and Embryology, Biological Faculty, Sofia University St Kliment Ohridski, 1164 Sofia, Bulgaria
    Cell Biol Int 32:229-34. 2008
    ..These observations suggest that within in vivo-like conditions Src may have a leading role in the induction of sustained ERK1/2 activation...
  23. pmc A Rac switch regulates random versus directionally persistent cell migration
    Roumen Pankov
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 170:793-802. 2005
    ..Total Rac1 activity can therefore provide a regulatory switch between patterns of cell migration by a mechanism distinct from chemotaxis...
  24. ncbi request reprint Cell-matrix adhesions on poly(vinyl alcohol) hydrogels
    Miles B Zajaczkowski
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Tissue Eng 9:525-33. 2003
    ..Furthermore, they imply that bioactive polymers can selectively induce specific cell-matrix adhesions, a characteristic that may have consequences in various tissue-engineering applications...
  25. ncbi request reprint Targeting membrane-localized focal adhesion kinase to focal adhesions: roles of tyrosine phosphorylation and SRC family kinases
    Ben Zion Katz
    Craniofacial Developmental Biology and Regeneration Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:29115-20. 2003
    ..We propose here a molecular model for the tyrosine phosphorylation-dependent regulation of focal adhesion kinase organization involving Src kinases and an inhibitory phosphorylation of the C-terminal (Tyr-925) tyrosine residue...
  26. pmc uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion
    Lars H Engelholm
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 160:1009-15. 2003
    ..These studies identify a central function of uPARAP/Endo180 in cellular collagen interactions...
  27. ncbi request reprint Cell interactions with three-dimensional matrices
    Edna Cukierman
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4370, USA
    Curr Opin Cell Biol 14:633-9. 2002
    ..These three-dimensional systems are illuminating mechanisms of cell-matrix interactions in living organisms...

Research Grants6

  1. Primed Stroma: A Tumor Permissive Microenvironment
    Edna Cukierman; Fiscal Year: 2005
    ..Developing therapeutic approaches focusing on containing cancer as a chronic and innocuous disease is our ultimate goal. ..
  2. 3D-adhesion stromagenesis in cancer permissiveness
    Edna Cukierman; Fiscal Year: 2007
    ..Ultimately, our long-term goal is to target the tumor-associated stroma thus maintaining cancer as an innocuous chronic disease. ..
  3. 3D-adhesion stromagenesis in cancer permissiveness
    Edna Cukierman; Fiscal Year: 2010
    ..Ultimately, our long-term goal is to target the tumor-associated stroma thus maintaining cancer as an innocuous chronic disease. ..