Massimo Cristofanilli

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. pmc Advancements in the Treatment of Metastatic Breast Cancer (MBC): The Role of Ixabepilone
    Massimo Cristofanilli
    Department of Medical Oncology, G Morris Dorrance Jr Endowed Chair in Medical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Room C315, Philadelphia, PA 19111 2497, USA
    J Oncol 2012:703858. 2012
  2. pmc Considerations in the development of circulating tumor cell technology for clinical use
    David R Parkinson
    New Enterprise Associates, Menlo Park, CA 94025, USA
    J Transl Med 10:138. 2012
  3. pmc A randomized phase II study of lapatinib + pazopanib versus lapatinib in patients with HER2+ inflammatory breast cancer
    Massimo Cristofanilli
    MD Anderson Cancer Center, Houston, TX, USA
    Breast Cancer Res Treat 137:471-82. 2013
  4. ncbi request reprint The nuclear transcription factor kappaB/bcl-2 pathway correlates with pathologic complete response to doxorubicin-based neoadjuvant chemotherapy in human breast cancer
    Thomas A Buchholz
    Department of Radiation Oncology, Breast Medical Oncology, Surgical Oncology, and Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 11:8398-402. 2005
  5. ncbi request reprint Inflammatory breast cancer (IBC) and patterns of recurrence: understanding the biology of a unique disease
    Massimo Cristofanilli
    Department of Breast Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 110:1436-44. 2007
  6. ncbi request reprint Prognostic value of pathologic complete response after primary chemotherapy in relation to hormone receptor status and other factors
    Valentina Guarneri
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1439, USA
    J Clin Oncol 24:1037-44. 2006
  7. ncbi request reprint Breast cancer molecular subtypes respond differently to preoperative chemotherapy
    Roman Rouzier
    Department of Breast Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Clin Cancer Res 11:5678-85. 2005
  8. ncbi request reprint Weekly paclitaxel improves pathologic complete remission in operable breast cancer when compared with paclitaxel once every 3 weeks
    Marjorie C Green
    The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 424, Houston, TX 77030, USA
    J Clin Oncol 23:5983-92. 2005
  9. doi request reprint Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer
    Cornelia Liedtke
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 1439, USA
    J Clin Oncol 26:1275-81. 2008
  10. ncbi request reprint Epidermal growth factor receptor expression correlates with poor survival in patients who have breast carcinoma treated with doxorubicin-based neoadjuvant chemotherapy
    Thomas A Buchholz
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 104:676-81. 2005

Collaborators

Detail Information

Publications86

  1. pmc Advancements in the Treatment of Metastatic Breast Cancer (MBC): The Role of Ixabepilone
    Massimo Cristofanilli
    Department of Medical Oncology, G Morris Dorrance Jr Endowed Chair in Medical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Room C315, Philadelphia, PA 19111 2497, USA
    J Oncol 2012:703858. 2012
    ..In this article, we review the efficacy and safety data of ixabepilone as a monotherapy and as a component of combination therapy for metastatic and primary breast cancer...
  2. pmc Considerations in the development of circulating tumor cell technology for clinical use
    David R Parkinson
    New Enterprise Associates, Menlo Park, CA 94025, USA
    J Transl Med 10:138. 2012
    ....
  3. pmc A randomized phase II study of lapatinib + pazopanib versus lapatinib in patients with HER2+ inflammatory breast cancer
    Massimo Cristofanilli
    MD Anderson Cancer Center, Houston, TX, USA
    Breast Cancer Res Treat 137:471-82. 2013
    ..The combination also had increased toxicity resulting in more dose reductions, modifications, and treatment delays. Activity with single-agent lapatinib was confirmed in this population...
  4. ncbi request reprint The nuclear transcription factor kappaB/bcl-2 pathway correlates with pathologic complete response to doxorubicin-based neoadjuvant chemotherapy in human breast cancer
    Thomas A Buchholz
    Department of Radiation Oncology, Breast Medical Oncology, Surgical Oncology, and Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 11:8398-402. 2005
    ....
  5. ncbi request reprint Inflammatory breast cancer (IBC) and patterns of recurrence: understanding the biology of a unique disease
    Massimo Cristofanilli
    Department of Breast Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 110:1436-44. 2007
    ..The authors compared the prognostic features of IBC and non-IBC locally advanced breast cancer (LABC) to gain insight into the biology of this disease entity...
  6. ncbi request reprint Prognostic value of pathologic complete response after primary chemotherapy in relation to hormone receptor status and other factors
    Valentina Guarneri
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1439, USA
    J Clin Oncol 24:1037-44. 2006
    ..To evaluate whether hormonal receptor (HR) status can influence the prognostic significance of pathologic complete response (pCR)...
  7. ncbi request reprint Breast cancer molecular subtypes respond differently to preoperative chemotherapy
    Roman Rouzier
    Department of Breast Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Clin Cancer Res 11:5678-85. 2005
    ..The goal of this research was to determine if these different molecular subtypes of breast cancer also respond differently to preoperative chemotherapy...
  8. ncbi request reprint Weekly paclitaxel improves pathologic complete remission in operable breast cancer when compared with paclitaxel once every 3 weeks
    Marjorie C Green
    The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 424, Houston, TX 77030, USA
    J Clin Oncol 23:5983-92. 2005
    ....
  9. doi request reprint Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer
    Cornelia Liedtke
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 1439, USA
    J Clin Oncol 26:1275-81. 2008
    ..In this study, we compared response to neoadjuvant chemotherapy and survival between patients with TNBC and non-TNBC...
  10. ncbi request reprint Epidermal growth factor receptor expression correlates with poor survival in patients who have breast carcinoma treated with doxorubicin-based neoadjuvant chemotherapy
    Thomas A Buchholz
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 104:676-81. 2005
    ..To the authors' knowledge there are few data that correlate the expression of the epidermal growth factor receptor (EGFR) with the outcome of patients who have breast carcinoma and are treated with anthracycline chemotherapy...
  11. ncbi request reprint Predictors of systemic recurrence and disease-specific survival after ipsilateral breast tumor recurrence
    Jeannie Shen
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer 104:479-90. 2005
    ..Therefore, the management of isolated IBTR remains controversial. The objective of the current study was to identify determinants of systemic recurrence and DSS after IBTR...
  12. ncbi request reprint Kinetics of serum HER-2/neu changes in patients with HER-2-positive primary breast cancer after initiation of primary chemotherapy
    Chafika Mazouni
    Department of Breast Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77230 1439, USA
    Cancer 109:496-501. 2007
    ....
  13. doi request reprint Circulating tumor cells and [18F]fluorodeoxyglucose positron emission tomography/computed tomography for outcome prediction in metastatic breast cancer
    Ugo De Giorgi
    The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    J Clin Oncol 27:3303-11. 2009
    ..In this study, we compared the prognostic value of CTC and FDG-PET/CT monitoring during systemic therapy for metastatic breast cancer (MBC)...
  14. ncbi request reprint Downregulation of the cyclin-dependent kinase inhibitor p27kip1 might correlate with poor disease-free and overall survival in inflammatory breast cancer
    Ana Maria Gonzalez-Angulo
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77230 1439, USA
    Clin Breast Cancer 7:326-30. 2006
    ..The objective of this study was to evaluate whether p27kip1 downregulation is a prognostic factor in patients with inflammatory breast carcinoma (IBC)...
  15. doi request reprint Relationship between lymphocytopenia and circulating tumor cells as prognostic factors for overall survival in metastatic breast cancer
    Ugo De Giorgi
    Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Clin Breast Cancer 12:264-9. 2012
    ....
  16. ncbi request reprint Effective local control and long-term survival in patients with T4 locally advanced breast cancer treated with breast conservation therapy
    Jeannie Shen
    Department of Surgical Oncology, Unit 444, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Ann Surg Oncol 11:854-60. 2004
    ..This study was conducted to assess the outcome of a carefully selected group of patients who presented with breast cancer involving the skin and who had breast conservation therapy (BCT) following neoadjuvant chemotherapy...
  17. doi request reprint Prognostic value of initial clinical disease stage after achieving pathological complete response
    Shaheenah Dawood
    Department of Breast Medical Oncology, Unit 1354, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030 4009, USA
    Oncologist 13:6-15. 2008
    ..Overall, patients who achieved a pCR had a low rate of recurrence. However, higher clinical stage and IBC were associated with worse outcomes in breast cancer patients who achieved a pCR after PST...
  18. ncbi request reprint Biologic markers in axillary node-negative breast cancer: differential expression in invasive ductal carcinoma versus invasive lobular carcinoma
    Ana Maria Gonzalez-Angulo
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Breast Cancer 7:396-400. 2006
    ....
  19. ncbi request reprint A nonreplicating adenoviral vector that contains the wild-type p53 transgene combined with chemotherapy for primary breast cancer: safety, efficacy, and biologic activity of a novel gene-therapy approach
    Massimo Cristofanilli
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77230, USA
    Cancer 107:935-44. 2006
    ....
  20. doi request reprint Circulating tumor cells in metastatic breast cancer: from prognostic stratification to modification of the staging system?
    Shaheenah Dawood
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 113:2422-30. 2008
    ..The aim of the current study was to assess the prognostic value of baseline circulating tumor cells (CTCs) in a large cohort of patients with newly diagnosed metastatic breast cancer (MBC)...
  21. ncbi request reprint Disease-free and overall survival after pathologic complete disease remission of cytologically proven inflammatory breast carcinoma axillary lymph node metastases after primary systemic chemotherapy
    Bryan T Hennessy
    Department of Breast Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 106:1000-6. 2006
    ..The purpose of the current study was to determine long-term outcome in patients achieving a pCR of cytologically proven inflammatory breast carcinoma ALN metastases after primary chemotherapy...
  22. doi request reprint Retrospective study of 18F-FDG PET/CT in the diagnosis of inflammatory breast cancer: preliminary data
    Selin Carkaci
    Department of Diagnostic Radiology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    J Nucl Med 50:231-8. 2009
    ..Our objective was to retrospectively evaluate 18F-FDG PET/CT in the initial staging of inflammatory breast cancer (IBC)...
  23. ncbi request reprint Factors predictive of distant metastases in patients with breast cancer who have a pathologic complete response after neoadjuvant chemotherapy
    Ana M Gonzalez-Angulo
    Department of Breast Medical Oncology, Unit 424, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Clin Oncol 23:7098-104. 2005
    ..To identify clinicopathological factors predictive of distant metastasis in patients who had a pathologic complete response (pCR) after neoadjuvant chemotherapy (NC)...
  24. ncbi request reprint Invasive lobular carcinoma classic type: response to primary chemotherapy and survival outcomes
    Massimo Cristofanilli
    Department of Breast Medical Oncology, Unit 424, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 4009, USA
    J Clin Oncol 23:41-8. 2005
    ..To investigate the impact of histologic type invasive lobular carcinoma (ILC) versus invasive ductal carcinoma (IDC) on response to primary chemotherapy (PC) and long-term outcome...
  25. pmc Prognostic value of HER2-positive circulating tumor cells in patients with metastatic breast cancer
    Naoki Hayashi
    Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Clin Oncol 17:96-104. 2012
    ..The presence of ≥5 circulating tumor cells (CTCs) in 7.5 ml blood is a poor prognostic marker in metastatic breast cancer (MBC). However, the role of human epidermal growth factor receptor 2 (HER2) status in CTCs is not known...
  26. doi request reprint Pre-clinical studies of Notch signaling inhibitor RO4929097 in inflammatory breast cancer cells
    Bisrat G Debeb
    Department of Radiation Oncology, Unit 1202, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Breast Cancer Res Treat 134:495-510. 2012
    ....
  27. ncbi request reprint Prognostic role of a multigene reverse transcriptase-PCR assay in patients with node-negative breast cancer not receiving adjuvant systemic therapy
    Francisco J Esteva
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 11:3315-9. 2005
    ..A secondary objective was to determine whether the quantitative RT-PCR data correlated with immunohistochemistry assay data regarding estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 status...
  28. ncbi request reprint Circulating tumor cells in metastatic breast cancer: biologic staging beyond tumor burden
    Massimo Cristofanilli
    Department of Breast Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Breast Cancer 7:471-9. 2007
    ..We compared the prognostic significance of CTCs with clinical and laboratory measures of tumor burden and phenotypic subtype of disease...
  29. ncbi request reprint Significantly higher pathologic complete remission rate after neoadjuvant therapy with trastuzumab, paclitaxel, and epirubicin chemotherapy: results of a randomized trial in human epidermal growth factor receptor 2-positive operable breast cancer
    Aman U Buzdar
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 424, Houston, TX 77030, USA
    J Clin Oncol 23:3676-85. 2005
    ....
  30. ncbi request reprint Trends for inflammatory breast cancer: is survival improving?
    Ana M Gonzalez-Angulo
    Department of Breast Medical Oncology, Unit 1354, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030 4009, USA
    Oncologist 12:904-12. 2007
    ..Clinical trials focusing on the management of this aggressive disease are warranted. Disclosure of potential conflicts of interest is found at the end of this article...
  31. doi request reprint Inflammatory breast cancer: the disease, the biology, the treatment
    Fredika M Robertson
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    CA Cancer J Clin 60:351-75. 2010
    ..This review examines IBC's unique clinical presentation, pathology, epidemiology, imaging, and biology and details current multidisciplinary management of the disease, which comprises systemic therapy, surgery, and radiation therapy...
  32. pmc Circulating tumor cells as prognostic and predictive markers in metastatic breast cancer patients receiving first-line systemic treatment
    Mario Giuliano
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Breast Cancer Res 13:R67. 2011
    ..We assessed the prognostic impact of CTCs according to different first-line systemic treatments, and explored their potential predictive value in MBC patients...
  33. doi request reprint Prognostic significance of HER-2 status in women with inflammatory breast cancer
    Shaheenah Dawood
    Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Cancer 112:1905-11. 2008
    ..The purpose of this study was to define the prognostic impact of HER-2 status on survival outcomes of patients with IBC...
  34. ncbi request reprint p53 expression as a prognostic marker in inflammatory breast cancer
    Ana M Gonzalez-Angulo
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 10:6215-21. 2004
    ..We retrospectively analyze the expression of p53 as a prognostic marker to predict pathological complete response and survival in patients with IBC...
  35. ncbi request reprint Circulating tumor cells: a novel prognostic factor for newly diagnosed metastatic breast cancer
    Massimo Cristofanilli
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 424, Houston, TX 77030, USA
    J Clin Oncol 23:1420-30. 2005
    ....
  36. ncbi request reprint CD44 expression is associated with increased survival in node-negative invasive breast carcinoma
    Leslie K Diaz
    Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 11:3309-14. 2005
    ..The purpose of this study was to evaluate the prognostic significance of CD44 isoforms in early-stage, lymph node-negative invasive breast carcinoma...
  37. doi request reprint Prognostic value of body mass index in locally advanced breast cancer
    Shaheenah Dawood
    Department of Breast Medical Oncology, Division of Quantitative Sciences, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 14:1718-25. 2008
    ..The analysis includes the subsets of inflammatory (IBC) and noninflammatory (non-IBC LABC) breast cancer...
  38. ncbi request reprint Suberoylanilide hydroxamic acid blocks self-renewal and homotypic aggregation of inflammatory breast cancer spheroids
    Fredika M Robertson
    The Morgan Welch Inflammatory Breast Cancer Research Program, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 116:2760-7. 2010
    ....
  39. pmc Serum HER2 levels determined by two methods in patients with metastatic breast cancer
    Naoki Hayashi
    Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Clin Oncol 17:55-62. 2012
    ..We prospectively assessed the prognostic value of serum HER2 levels in MBC using two methods, enzyme immunoassay (EIA) and chemiluminescence immunoassay (CLIA)...
  40. doi request reprint HER2 status predicts the presence of circulating tumor cells in patients with operable breast cancer
    Julie E Lang
    Department of Surgical Oncology, MD Anderson Cancer Center, Advanced Research Center for Microscopic Disease, The University of Texas, Houston, TX 77030, USA
    Breast Cancer Res Treat 113:501-7. 2009
    ..We hypothesized that primary tumor characteristics would predict the likelihood of identifying CTCs in patients with operable breast cancer...
  41. ncbi request reprint Thyroid hormone and breast carcinoma. Primary hypothyroidism is associated with a reduced incidence of primary breast carcinoma
    Massimo Cristofanilli
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 103:1122-8. 2005
    ....
  42. ncbi request reprint Feasibility and utility of using chromosomal aneusomy to further define the cytologic categories in nipple aspirate fluid specimens: a preliminary study
    Savitri Krishnamurthy
    Department of Cytopathology, Unit 53, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer 102:322-7. 2004
    ....
  43. ncbi request reprint Central nervous system metastases in patients with high-risk breast carcinoma after multimodality treatment
    Ana M Gonzalez-Angulo
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 101:1760-6. 2004
    ..D. Anderson Cancer Center (Houston, TX)...
  44. pmc Locoregional treatment outcomes after multimodality management of inflammatory breast cancer
    Ian J Bristol
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 72:474-84. 2008
    ....
  45. ncbi request reprint A Phase II study of intravenous exatecan mesylate (DX-8951f) administered daily for 5 days every 3 weeks to patients with metastatic breast carcinoma
    Francisco J Esteva
    Department of Breast Medical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 424, Houston, TX 77030, USA
    Cancer 98:900-7. 2003
    ..The objective of the current study was to determine the antitumor activity, safety, and pharmacokinetic (PK) profile of exatecan mesylate in patients with anthracycline-resistant and taxane-resistant, metastatic breast carcinoma...
  46. ncbi request reprint A Phase I study of docetaxel plus cyclophosphamide in solid tumors followed by a Phase II study as first-line therapy in metastatic breast cancer
    Jonathan C Trent
    Departments of Sarcoma Medical Oncology, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 9:2426-34. 2003
    ..For Phase II, the purpose was to determine the safety and efficacy of this combination as first-line treatment in patients with metastatic breast cancer (MBC)...
  47. ncbi request reprint Beta4 integrin subunit gene expression correlates with tumor size and nuclear grade in early breast cancer
    Leslie K Diaz
    Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 18:1165-75. 2005
    ....
  48. ncbi request reprint Nipple aspirate fluid cytology in breast carcinoma
    Savitri Krishnamurthy
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 99:97-104. 2003
    ..Cytologic-histologic correlations of NAF were performed in only a few studies...
  49. ncbi request reprint Phase I/II study of G3139 (Bcl-2 antisense oligonucleotide) in combination with doxorubicin and docetaxel in breast cancer
    Stacy L Moulder
    Department of Breast Medical Oncology, Pathology, Surgical Oncology, Radiation Oncology and Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 14:7909-16. 2008
    ..We evaluated the efficacy and safety of a Bcl-2 antisense oligonucleotide, G3139, in combination with doxorubicin (A) and docetaxel (T) in patients with locally advanced breast cancer (LABC)...
  50. doi request reprint Polycomb group protein EZH2 is frequently expressed in inflammatory breast cancer and is predictive of worse clinical outcome
    Yun Gong
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 117:5476-84. 2011
    ..In this retrospective study, the authors examined EZH2 expression in IBC tumors and evaluated the relation between EZH2 expression and patient survival...
  51. pmc Epithelial-mesenchymal transition and stem cell markers in patients with HER2-positive metastatic breast cancer
    Antonio Giordano
    Department of Hematopathology, Unit 0054, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA
    Mol Cancer Ther 11:2526-34. 2012
    ..Moreover, an enrichment of CSCs was found in CD326(-)CD45(-) cells. Additional studies are needed to determine whether EMT-CTCs and CSCs have prognostic value in patients with HER2(+) MBCs treated with trastuzumab-based therapy...
  52. doi request reprint Characterization of metastatic breast cancer patients with nondetectable circulating tumor cells
    Michal Mego
    Departments of Hematopathology, The Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, University of Texas, MD Anderson Cancer Center, Houston, TX, USA
    Int J Cancer 129:417-23. 2011
    ..We showed that some important metastatic disease characteristics are predictive of undetectable CTC status in MBC...
  53. ncbi request reprint Systemic treatments for inflammatory breast cancer
    Charles H Yang
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Breast Dis 22:55-65. 2005
    ..In this review, we discuss some recent developments in the use of systemic therapies for inflammatory breast cancer...
  54. ncbi request reprint Different gene expressions are associated with the different molecular subtypes of inflammatory breast cancer
    Takayuki Iwamoto
    Breast Cancer Translational Research Laboratory, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Breast Cancer Res Treat 125:785-95. 2011
    ..IBC tumors can be divided into molecular and clinical subtypes similar to those of non-IBC. Clinical subtypes of IBC show molecular differences compared with similar subtypes of non-IBC...
  55. pmc Primary breast cancer patients with high risk clinicopathologic features have high percentages of bone marrow epithelial cells with ALDH activity and CD44⁺CD24lo cancer stem cell phenotype
    James M Reuben
    Department of Hematopathology, Unit 54, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Eur J Cancer 47:1527-36. 2011
    ..Therefore, we assessed the presence of Aldefluor(+) epithelial (CD326(+)CD45(dim)) cells for the presence of the CD44(+)CD24(lo) phenotype in BM of patients with primary breast cancer (PBC)...
  56. pmc Expression of epithelial-mesenchymal transition-inducing transcription factors in primary breast cancer: The effect of neoadjuvant therapy
    Michal Mego
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Int J Cancer 130:808-16. 2012
    ..In summary, our results demonstrate that CTCs with EMT phenotype may occur in the peripheral circulation of patients with PBC and that NAT is unable to eliminate CTCs undergoing EMT...
  57. ncbi request reprint Evaluation of a CXCR4 antagonist in a xenograft mouse model of inflammatory breast cancer
    Balraj Singh
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Exp Metastasis 27:233-40. 2010
    ..05). However, CTCE-9908 as a single therapy inhibited organ-specific metastasis to leg (P < 0.05 by chi-squared test and by two-sample t-test)...
  58. pmc Differential regulation of the aggressive phenotype of inflammatory breast cancer cells by prostanoid receptors EP3 and EP4
    Fredika M Robertson
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 116:2806-14. 2010
    ....
  59. pmc Establishment and validation of circulating tumor cell-based prognostic nomograms in first-line metastatic breast cancer patients
    Antonio Giordano
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 19:1596-602. 2013
    ..The objective here was to develop and validate nomograms that combined baseline CTC counts and the other prognostic factors to assess the outcome of individual patients starting first-line treatment for MBC...
  60. doi request reprint 18F-FDG PET/CT findings and circulating tumor cell counts in the monitoring of systemic therapies for bone metastases from breast cancer
    Ugo De Giorgi
    Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Nucl Med 51:1213-8. 2010
    ..Our objective was to compare the predictive significance of (18)F-FDG PET/CT findings and circulating tumor cell (CTC) count in patients with bone metastases from breast cancer treated with standard systemic therapy...
  61. pmc Triple-negative subtype predicts poor overall survival and high locoregional relapse in inflammatory breast cancer
    Jing Li
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Oncologist 16:1675-83. 2011
    ..However, these findings have not been confirmed for inflammatory breast cancer (IBC), which has different biological features than non-IBC...
  62. doi request reprint Detection of minimal residual disease in blood and bone marrow in early stage breast cancer
    Savitri Krishnamurthy
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 116:3330-7. 2010
    ..In this study, the authors investigated the occurrence of CTCs and DTCs in women with early stage breast cancer and evaluated the correlation of their presence with other prognostic markers...
  63. ncbi request reprint Inflammatory breast cancer (IBC): clues for targeted therapies
    Sandra V Fernandez
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Breast Cancer Res Treat 140:23-33. 2013
    ..Additionally, FC-IBC02 showed amplification of ALK and NOTCH3. These results indicate that MYC, ATAD2, CD44, NOTCH3, ALK and/or FAK1 may be used as potential targeted therapies against IBC. ..
  64. pmc Genomic and expression analysis of microdissected inflammatory breast cancer
    Wendy A Woodward
    Departments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Breast Cancer Res Treat 138:761-72. 2013
    ..Inflammatory breast cancer comparative genomic hybridization data are presented, but a validated genomic data set that identifies IBC is not demonstrated...
  65. pmc A phase 1 study of weekly everolimus (RAD001) in combination with docetaxel in patients with metastatic breast cancer
    Stacy Moulder
    Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 118:2378-84. 2012
    ..Inhibition of mammalian target of rapamycin with everolimus may improve the efficacy of taxanes. Everolimus and docetaxel are both metabolized by CYP3A4, which could result in a pharmacokinetic (PK) interaction...
  66. doi request reprint Differences in survival among women with stage III inflammatory and noninflammatory locally advanced breast cancer appear early: a large population-based study
    Shaheenah Dawood
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 117:1819-26. 2011
    ....
  67. ncbi request reprint Novel targeted therapies in inflammatory breast cancer
    Massimo Cristofanilli
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 116:2837-9. 2010
    ..Further investigation is needed to confirm the efficacy of lapatinib...
  68. pmc Epidermal growth factor receptor tyrosine kinase inhibitor reverses mesenchymal to epithelial phenotype and inhibits metastasis in inflammatory breast cancer
    Dongwei Zhang
    Breast Cancer Translational Research Laboratory, Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 15:6639-48. 2009
    ..Epidermal growth factor receptor (EGFR) expression is an independent poor prognostic factor in IBC. The purpose of this study was to determine the effect on IBC tumorigenicity and metastasis of blocking the EGFR pathway...
  69. pmc Characterizing cancer cells with cancer stem cell-like features in 293T human embryonic kidney cells
    Bisrat G Debeb
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Mol Cancer 9:180. 2010
    ..Herein we fully characterize cancer stem cell-like features in 293T human embryonic kidney cells...
  70. ncbi request reprint Artificial neural network analysis of circulating tumor cells in metastatic breast cancer patients
    Antonio Giordano
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA
    Breast Cancer Res Treat 129:451-8. 2011
    ..This study may support the concept that the number of CTCs, along with the biologic characteristics, needs to be carefully taken into account in future analysis...
  71. doi request reprint Phase 2 trial of primary systemic therapy with doxorubicin and docetaxel followed by surgery, radiotherapy, and adjuvant chemotherapy with cyclophosphamide, methotrexate, and 5-fluorouracil based on clinical and pathologic response in patients with stage
    Ricardo H Alvarez
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Cancer 116:1210-7. 2010
    ....
  72. doi request reprint Molecular anatomy of breast cancer stroma and its prognostic value in estrogen receptor-positive and -negative cancers
    Giampaolo Bianchini
    Department of Breast Medical Oncology, Unit 1354, The University of Texas M D Anderson Cancer Center, PO Box 301439, Houston, TX 77230 1439, USA
    J Clin Oncol 28:4316-23. 2010
    ....
  73. doi request reprint Chromosome 17 polysomy in circulating tumor cells in patients with metastatic breast cancer: a case series
    Naoki Hayashi
    Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Clin Oncol 16:596-600. 2011
    ..In summary, polysomy 17 in CTCs was observed in only a small population of patients with MBC. We should prospectively evaluate its prognostic value in both HER2-positive and -negative metastatic breast cancer...
  74. doi request reprint Circulating tumor cells and PET
    Jian Q Yu
    Department of Radiology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    J Nucl Med 52:1501-4. 2011
    ..Moreover, molecular characterization of circulating tumor cells holds promise for furthering the care of cancer patients...
  75. ncbi request reprint The class I HDAC inhibitor Romidepsin targets inflammatory breast cancer tumor emboli and synergizes with paclitaxel to inhibit metastasis
    Fredika M Robertson
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Ther Oncol 10:219-33. 2013
    ..Furthermore, Romidepsin, in combination with a taxane, warrants evaluation as a therapeutic strategy that may effectively target the skin involvement and rapid metastasis that are hallmarks of IBC...
  76. pmc AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor (EGFR), HER2, and HER3: preclinical activity in HER2 non-amplified inflammatory breast cancer models
    Zhaomei Mu
    Department of Medical Oncology, Thomas Jefferson University and Kimmel Cancer Center, Philadelphia, PA 19107, USA
    J Exp Clin Cancer Res 33:47. 2014
    ..In this study, we investigated the antitumor activity of AZD8931 alone or in combination with paclitaxel using preclinical models of EGFR-overexpressed and HER2 non-amplified IBC cells...
  77. doi request reprint The role of circulating tumor cells in breast cancer diagnosis and prediction of therapy response
    James M Reuben
    University of Texas MD Anderson Cancer Center, Department of Hematopathology, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Expert Opin Med Diagn 2:339-48. 2008
    ....
  78. doi request reprint CTCs in metastatic breast cancer
    Antonio Giordano
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Recent Results Cancer Res 195:193-201. 2012
    ..Theoretically, the phenotypic analysis of CTCs can represent a "liquid" biopsy of breast tumor that is able to identify a new potential target against the metastatic disease...
  79. pmc Emergence of constitutively active estrogen receptor-α mutations in pretreated advanced estrogen receptor-positive breast cancer
    Rinath Jeselsohn
    Authors Affiliations Center for Functional Cancer Epigenetics, Department of Medical Oncology, Dana Farber Cancer Institute Department of Medicine, Brigham and Women s Hospital Departments of Pathology and Breast Medical Oncology Program, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston Foundation Medicine, Cambridge, Massachusetts Departments of Investigational Cancer Therapeutics, Surgical Oncology, and Systems Biology and Breast Medical Oncology, The University of MD Anderson Cancer Center, Houston, Texas Fundacion de Investigacion INCLIVA Institute for Health Research Departments of Hematology Oncology, Hospital Clinico Universitario de Valencia, Valencia, Spain Jefferson Breast Care Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania Instituto Nacional de Enfermedades Neoplásicas INEN, Lima, Perú Breast Cancer Program, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee Teva Pharmaceuticals, Petach Tikva Oncology Division, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel and Section of Breast Medical Oncology, Yale School of Medicine, New Haven, Connecticut
    Clin Cancer Res 20:1757-67. 2014
    ....
  80. pmc Circulating tumor cells in breast cancer: a tool whose time has come of age
    Ramona F Swaby
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    BMC Med 9:43. 2011
    ..We will also introduce their utility in pharmacodynamic monitoring for rational selection of molecularly targeted therapies and briefly address how they can help elucidate the biology of cancer metastasis...
  81. ncbi request reprint Inflammatory breast cancer
    Holly Dushkin
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Natl Compr Canc Netw 9:233-40; quiz 241. 2011
    ..Moreover, the current research in IBC is briefly described, which experts hope will further improve systemic therapies...
  82. doi request reprint The biological information obtainable from circulating tumor cells
    Massimo Cristofanilli
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230, USA
    Breast 18:S38-40. 2009
    ..Those data suggest interesting observations in the biology of those cells and indicate the possibility to evaluate targeted therapies based on the genomic profiling of CTCs, particularly with regards to HER-2 determination...
  83. doi request reprint Imaging and analysis of 3D tumor spheroids enriched for a cancer stem cell phenotype
    Fredika M Robertson
    The Department of Experimental Therapeutics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Biomol Screen 15:820-9. 2010
    ....
  84. doi request reprint MRI features of inflammatory breast cancer
    Huong T Le-Petross
    Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 57, Houston, TX 77030, USA
    AJR Am J Roentgenol 197:W769-76. 2011
    ..The aim of this study was to evaluate the features of inflammatory breast carcinoma (IBC) on MRI compared with mammography and ultrasound and to better define the role of MRI in patients with this aggressive disease...
  85. doi request reprint Clinical outcomes of patients with breast cancer in a phase I clinic: the M. D. Anderson cancer center experience
    Jennifer Wheler
    Department of Investigational Cancer Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1402, USA
    Clin Breast Cancer 10:46-51. 2010
    ..Patients with metastatic breast cancer (MBC) refractory to standard therapy have a poor prognosis. We assessed prognostic factors and clinical outcomes for patients with MBC referred to a phase I clinic focused primarily on targeted agents...
  86. doi request reprint Phase II, randomized trial to compare anastrozole combined with gefitinib or placebo in postmenopausal women with hormone receptor-positive metastatic breast cancer
    Massimo Cristofanilli
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 1439, USA
    Clin Cancer Res 16:1904-14. 2010
    ..This phase II randomized trial evaluated the efficacy and tolerability of anastrozole combined with gefitinib or anastrozole with placebo in women with hormone receptor-positive metastatic breast cancer (MBC)...