MARGIE CLAPPER

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. pmc Detection of colorectal adenomas using a bioactivatable probe specific for matrix metalloproteinase activity
    Margie L Clapper
    Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Neoplasia 13:685-91. 2011
  2. doi request reprint 5-aminosalicylic acid inhibits colitis-associated colorectal dysplasias in the mouse model of azoxymethane/dextran sulfate sodium-induced colitis
    Margie L Clapper
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Inflamm Bowel Dis 14:1341-7. 2008
  3. ncbi request reprint Dextran sulfate sodium-induced colitis-associated neoplasia: a promising model for the development of chemopreventive interventions
    Margie Lee Clapper
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Acta Pharmacol Sin 28:1450-9. 2007
  4. ncbi request reprint beta-catenin-mediated signaling: a molecular target for early chemopreventive intervention
    Margie L Clapper
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Mutat Res 555:97-105. 2004
  5. ncbi request reprint Altered gene expression in phenotypically normal renal cells from carriers of tumor suppressor gene mutations
    Radka Stoyanova
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Biol Ther 3:1313-21. 2004
  6. pmc Altered gene expression in morphologically normal epithelial cells from heterozygous carriers of BRCA1 or BRCA2 mutations
    Alfonso Bellacosa
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cancer Prev Res (Phila) 3:48-61. 2010
  7. ncbi request reprint Loss of p53 enhances the induction of colitis-associated neoplasia by dextran sulfate sodium
    Wen Chi L Chang
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Carcinogenesis 28:2375-81. 2007
  8. ncbi request reprint Sulindac sulfone is most effective in modulating beta-catenin-mediated transcription in cells with mutant APC
    Wen Chi L Chang
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Ann N Y Acad Sci 1059:41-55. 2005
  9. ncbi request reprint Detection and volume determination of colonic tumors in Min mice by magnetic resonance micro-imaging
    Harvey H Hensley
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Magn Reson Med 52:524-9. 2004
  10. pmc Endoscopic imaging and size estimation of colorectal adenomas in the multiple intestinal neoplasia mouse
    Harvey H Hensley
    Divisions of Basic Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Gastrointest Endosc 69:742-9. 2009

Research Grants

Collaborators

Detail Information

Publications20

  1. pmc Detection of colorectal adenomas using a bioactivatable probe specific for matrix metalloproteinase activity
    Margie L Clapper
    Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Neoplasia 13:685-91. 2011
    ..Use of this fluorescent probe in combination with colonoscopy could aid in preventing colorectal neoplasias by providing new opportunities for early detection and therapeutic intervention...
  2. doi request reprint 5-aminosalicylic acid inhibits colitis-associated colorectal dysplasias in the mouse model of azoxymethane/dextran sulfate sodium-induced colitis
    Margie L Clapper
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Inflamm Bowel Dis 14:1341-7. 2008
    ..The chemopreventive activity of 5-ASA was evaluated in the Swiss Webster model of azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced colitis-associated neoplasia...
  3. ncbi request reprint Dextran sulfate sodium-induced colitis-associated neoplasia: a promising model for the development of chemopreventive interventions
    Margie Lee Clapper
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Acta Pharmacol Sin 28:1450-9. 2007
    ..Emerging data from chemopreventive intervention studies document the efficacy of several agents in inhibiting DSS-induced neoplasia and provide great promise that colitis-associated colorectal neoplasia is a preventable disease...
  4. ncbi request reprint beta-catenin-mediated signaling: a molecular target for early chemopreventive intervention
    Margie L Clapper
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Mutat Res 555:97-105. 2004
    ..The common role of beta-catenin in both Wnt signaling and cell adhesion provides a unique opportunity to develop chemopreventive therapies that both prevent the development of cancer and delay tumor progression...
  5. ncbi request reprint Altered gene expression in phenotypically normal renal cells from carriers of tumor suppressor gene mutations
    Radka Stoyanova
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Biol Ther 3:1313-21. 2004
    ..The inherently complex signaling networks of tumors result from genetic and epigenetic alterations that occur during cancer initiation and progression...
  6. pmc Altered gene expression in morphologically normal epithelial cells from heterozygous carriers of BRCA1 or BRCA2 mutations
    Alfonso Bellacosa
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cancer Prev Res (Phila) 3:48-61. 2010
    ....
  7. ncbi request reprint Loss of p53 enhances the induction of colitis-associated neoplasia by dextran sulfate sodium
    Wen Chi L Chang
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Carcinogenesis 28:2375-81. 2007
    ..As observed in humans, p53 plays a protective role in colitis-associated neoplasia in the DSS model...
  8. ncbi request reprint Sulindac sulfone is most effective in modulating beta-catenin-mediated transcription in cells with mutant APC
    Wen Chi L Chang
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Ann N Y Acad Sci 1059:41-55. 2005
    ..These data demonstrate that sulindac sulfone can modulate the APC/beta-catenin pathway in vitro and that its efficacy is dependent upon the mutational status of APC and beta-catenin...
  9. ncbi request reprint Detection and volume determination of colonic tumors in Min mice by magnetic resonance micro-imaging
    Harvey H Hensley
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Magn Reson Med 52:524-9. 2004
    ..942, and a P-value of 0.008, based on Spearman's test. These data show that MRI can be used to accurately monitor tumor growth in mouse models of colorectal carcinogenesis...
  10. pmc Endoscopic imaging and size estimation of colorectal adenomas in the multiple intestinal neoplasia mouse
    Harvey H Hensley
    Divisions of Basic Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Gastrointest Endosc 69:742-9. 2009
    ..The scientific potential of animal models of carcinogenesis has not been fully realized because of our limited ability to monitor tumor growth in vivo...
  11. ncbi request reprint Optimized procedures for microarray analysis of histological specimens processed by laser capture microdissection
    John J Upson
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Cell Physiol 201:366-73. 2004
    ..Taken together, these results demonstrate that LCM-derived tissue from histological specimens can generate abundant amounts of high-quality aRNA for subsequent microarray analysis...
  12. pmc Successful application of microarray technology to microdissected formalin-fixed, paraffin-embedded tissue
    Renata A Coudry
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA
    J Mol Diagn 9:70-9. 2007
    ..97. The presence of ribosomal RNA peaks in FFPE-derived RNA was reflected by a high correlation with paired frozen samples. A set of practical recommendations for evaluating the RNA integrity and quality in FFPE samples is reported...
  13. pmc Early changes in gene expression induced by tobacco smoke: Evidence for the importance of estrogen within lung tissue
    Sibele I Meireles
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cancer Prev Res (Phila) 3:707-17. 2010
    ....
  14. ncbi request reprint Generation of a unique strain of multiple intestinal neoplasia (Apc(+/Min-FCCC)) mice with significantly increased numbers of colorectal adenomas
    Harry S Cooper
    Department of Pathology, Division of Medical Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Mol Carcinog 44:31-41. 2005
    ..4) The Apc(+/Min-FCCC) strain is highly suited for the investigation of colorectal neoplastic disease and chemoprevention studies...
  15. ncbi request reprint Comparison of RNA amplification methods and chip platforms for microarray analysis of samples processed by laser capture microdissection
    Elena Caretti
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    J Cell Biochem 103:556-63. 2008
    ..986. The quicker NuGEN procedure, when coupled with X3P arrays, also yielded excellent results (correlation of 0.951). These observations will be useful for planning large-scale analyses of LCM-dissected clinical samples...
  16. ncbi request reprint Searchable high-resolution 2D gel proteome of the human colon crypt
    Bhavinkumar B Patel
    Division of Basic Science, Medical Science, and Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Proteome Res 6:2232-8. 2007
    ..These interactive, searchable, hyperlink-enabled proteome maps and gene ontology analyses will facilitate future studies to discover the earliest markers and intervention targets during progression to colon cancer...
  17. ncbi request reprint Use of RNA amplification in the optimal characterization of global gene expression using cDNA microarrays
    Radka Stoyanova
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    J Cell Physiol 201:359-65. 2004
    ..This study indicates that high quality microarray data can be generated from small amounts of RNA, including those extracted from limiting clinical samples and microdissected histological specimens...
  18. pmc Estrogen and cytochrome P450 1B1 contribute to both early- and late-stage head and neck carcinogenesis
    Ekaterina G Shatalova
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Prev Res (Phila) 4:107-15. 2011
    ..024 and 0.008, respectively). These data provide novel insight into the mechanisms underlying head and neck carcinogenesis and facilitate the identification of new targets for chemopreventive intervention...
  19. ncbi request reprint Hemin potentiates nitric oxide-mediated nitrosation of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) to 2-nitrosoamino-3-methylimidazo[4,5-f]quinoline
    Vijaya M Lakshmi
    VA Medical Center, Division of Geriatric Medicine and Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, St Louis, Missouri 63125, USA
    Chem Res Toxicol 18:528-35. 2005
    ....
  20. ncbi request reprint The chemopreventive agent oltipraz possesses potent antiangiogenic activity in vitro, ex vivo, and in vivo and inhibits tumor xenograft growth
    Bruce A Ruggeri
    Division of Oncology, Cephalon, Inc, West Chester, Pennsylvania 19380, USA
    Clin Cancer Res 8:267-74. 2002
    ..These data suggest that the chemopreventive agent oltipraz may be effective in the treatment of advanced stage cancers and metastases, in part, because of its antiangiogenic activity in vivo...

Research Grants8

  1. Analysis of the Chemopreventive Activity of FGN 1
    MARGIE CLAPPER; Fiscal Year: 2004
    ....
  2. Chemoprevention of Colitis-Associated Neoplasia by 5-ASA
    MARGIE CLAPPER; Fiscal Year: 2009
    ..Findings from the proposed mouse studies could lead to the use of 5-ASA for cancer prevention and significantly impact the establishment of future guidelines for the clinical management of patients with inflammatory bowel disease. ..
  3. Chemoprevention of Colitis-Associated Neoplasia by 5-ASA
    Margie L Clapper; Fiscal Year: 2010
    ..Findings from the proposed mouse studies could lead to the use of 5-ASA for cancer prevention and significantly impact the establishment of future guidelines for the clinical management of patients with inflammatory bowel disease. ..
  4. Chemoprevention of Colitis-Associated Neoplasia by 5-ASA
    MARGIE CLAPPER; Fiscal Year: 2009
    ..Findings from the proposed mouse studies could lead to the use of 5-ASA for cancer prevention and significantly impact the establishment of future guidelines for the clinical management of patients with inflammatory bowel disease. ..