M L Clapper

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. ncbi Genetic polymorphism and cancer risk
    M L Clapper
    Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Curr Oncol Rep 2:251-6. 2000
  2. ncbi Chemoprevention of colorectal cancer
    M L Clapper
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Curr Opin Oncol 13:307-13. 2001
  3. ncbi Depletion of colonic detoxication enzyme activity in mice with dextran sulphate sodium-induced colitis
    M L Clapper
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, PA, USA
    Aliment Pharmacol Ther 13:389-96. 1999
  4. ncbi Chronic dosing of oltipraz in people at increased risk for colorectal cancer
    C E Szarka
    Fox Chase Cancer Center, Department of Population Science, Philadelphia, PA 19111, USA
    Cancer Detect Prev 25:352-61. 2001
  5. ncbi The role of mutant Apc in the development of dysplasia and cancer in the mouse model of dextran sulfate sodium-induced colitis
    H S Cooper
    Department of Pathology, Division of Medical Science, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Gastroenterology 121:1407-16. 2001
  6. ncbi Gender differences in genetic susceptibility for lung cancer
    C M Dresler
    Department of Surgical Onccology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Lung Cancer 30:153-60. 2000
  7. ncbi Sulindac sulfone is most effective in modulating beta-catenin-mediated transcription in cells with mutant APC
    Wen Chi L Chang
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Ann N Y Acad Sci 1059:41-55. 2005
  8. ncbi beta-catenin-mediated signaling: a molecular target for early chemopreventive intervention
    Margie L Clapper
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Mutat Res 555:97-105. 2004
  9. ncbi Loss of p53 enhances the induction of colitis-associated neoplasia by dextran sulfate sodium
    Wen Chi L Chang
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Carcinogenesis 28:2375-81. 2007
  10. ncbi Detection and volume determination of colonic tumors in Min mice by magnetic resonance micro-imaging
    Harvey H Hensley
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Magn Reson Med 52:524-9. 2004

Research Grants

  1. Disruption of Glutathione S-Transferase M1 in Mice
    MARGIE CLAPPER; Fiscal Year: 2006
  2. Colonoscopic Analysis of Response of Murine Colon Lesions to Drug Intervention
    MARGIE CLAPPER; Fiscal Year: 2007

Collaborators

Detail Information

Publications17

  1. ncbi Genetic polymorphism and cancer risk
    M L Clapper
    Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Curr Oncol Rep 2:251-6. 2000
    ....
  2. ncbi Chemoprevention of colorectal cancer
    M L Clapper
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Curr Opin Oncol 13:307-13. 2001
    ....
  3. ncbi Depletion of colonic detoxication enzyme activity in mice with dextran sulphate sodium-induced colitis
    M L Clapper
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, PA, USA
    Aliment Pharmacol Ther 13:389-96. 1999
    ..The increased risk of colonic malignancies in individuals with ulcerative colitis has prompted a search for early biomarkers of disease progression...
  4. ncbi Chronic dosing of oltipraz in people at increased risk for colorectal cancer
    C E Szarka
    Fox Chase Cancer Center, Department of Population Science, Philadelphia, PA 19111, USA
    Cancer Detect Prev 25:352-61. 2001
    ..Phase II trials evaluating a tolerable regimen of oltipraz (as demonstrated in this study) and other possible mechanisms that may be responsible for the protective activity of oltipraz should be pursued...
  5. ncbi The role of mutant Apc in the development of dysplasia and cancer in the mouse model of dextran sulfate sodium-induced colitis
    H S Cooper
    Department of Pathology, Division of Medical Science, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Gastroenterology 121:1407-16. 2001
    ....
  6. ncbi Gender differences in genetic susceptibility for lung cancer
    C M Dresler
    Department of Surgical Onccology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Lung Cancer 30:153-60. 2000
    ..54 for lung cancer in women versus 2.36 for men, independent of age or smoking history. These data suggest that polymorphisms in CYP1A1 and GSTM1 contribute to the increased risk of females for lung cancer...
  7. ncbi Sulindac sulfone is most effective in modulating beta-catenin-mediated transcription in cells with mutant APC
    Wen Chi L Chang
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Ann N Y Acad Sci 1059:41-55. 2005
    ..These data demonstrate that sulindac sulfone can modulate the APC/beta-catenin pathway in vitro and that its efficacy is dependent upon the mutational status of APC and beta-catenin...
  8. ncbi beta-catenin-mediated signaling: a molecular target for early chemopreventive intervention
    Margie L Clapper
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Mutat Res 555:97-105. 2004
    ..The common role of beta-catenin in both Wnt signaling and cell adhesion provides a unique opportunity to develop chemopreventive therapies that both prevent the development of cancer and delay tumor progression...
  9. ncbi Loss of p53 enhances the induction of colitis-associated neoplasia by dextran sulfate sodium
    Wen Chi L Chang
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Carcinogenesis 28:2375-81. 2007
    ..As observed in humans, p53 plays a protective role in colitis-associated neoplasia in the DSS model...
  10. ncbi Detection and volume determination of colonic tumors in Min mice by magnetic resonance micro-imaging
    Harvey H Hensley
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Magn Reson Med 52:524-9. 2004
    ..942, and a P-value of 0.008, based on Spearman's test. These data show that MRI can be used to accurately monitor tumor growth in mouse models of colorectal carcinogenesis...
  11. ncbi Hemin potentiates nitric oxide-mediated nitrosation of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) to 2-nitrosoamino-3-methylimidazo[4,5-f]quinoline
    Vijaya M Lakshmi
    VA Medical Center, Division of Geriatric Medicine and Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, St. Louis, Missouri 63125, USA
    Chem Res Toxicol 18:528-35. 2005
    ....
  12. ncbi Generation of a unique strain of multiple intestinal neoplasia (Apc(+/Min-FCCC)) mice with significantly increased numbers of colorectal adenomas
    Harry S Cooper
    Department of Pathology, Division of Medical Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Mol Carcinog 44:31-41. 2005
    ..4) The Apc(+/Min-FCCC) strain is highly suited for the investigation of colorectal neoplastic disease and chemoprevention studies...
  13. ncbi The chemopreventive agent oltipraz possesses potent antiangiogenic activity in vitro, ex vivo, and in vivo and inhibits tumor xenograft growth
    Bruce A Ruggeri
    Division of Oncology, Cephalon, Inc, West Chester, Pennsylvania 19380, USA
    Clin Cancer Res 8:267-74. 2002
    ..These data suggest that the chemopreventive agent oltipraz may be effective in the treatment of advanced stage cancers and metastases, in part, because of its antiangiogenic activity in vivo...
  14. ncbi Successful application of microarray technology to microdissected formalin-fixed, paraffin-embedded tissue
    Renata A Coudry
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA
    J Mol Diagn 9:70-9. 2007
    ..97. The presence of ribosomal RNA peaks in FFPE-derived RNA was reflected by a high correlation with paired frozen samples. A set of practical recommendations for evaluating the RNA integrity and quality in FFPE samples is reported...
  15. ncbi Searchable high-resolution 2D gel proteome of the human colon crypt
    Bhavinkumar B Patel
    Division of Basic Science, Medical Science, and Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Proteome Res 6:2232-8. 2007
    ..These interactive, searchable, hyperlink-enabled proteome maps and gene ontology analyses will facilitate future studies to discover the earliest markers and intervention targets during progression to colon cancer...
  16. ncbi Comparison of RNA amplification methods and chip platforms for microarray analysis of samples processed by laser capture microdissection
    Elena Caretti
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    J Cell Biochem 103:556-63. 2008
    ..986. The quicker NuGEN procedure, when coupled with X3P arrays, also yielded excellent results (correlation of 0.951). These observations will be useful for planning large-scale analyses of LCM-dissected clinical samples...
  17. ncbi Optimized procedures for microarray analysis of histological specimens processed by laser capture microdissection
    John J Upson
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Cell Physiol 201:366-73. 2004
    ..Taken together, these results demonstrate that LCM-derived tissue from histological specimens can generate abundant amounts of high-quality aRNA for subsequent microarray analysis...

Research Grants4

  1. Disruption of Glutathione S-Transferase M1 in Mice
    MARGIE CLAPPER; Fiscal Year: 2006
    ..abstract_text> ..
  2. Colonoscopic Analysis of Response of Murine Colon Lesions to Drug Intervention
    MARGIE CLAPPER; Fiscal Year: 2007
    ..These results could lead to the establishment of the first accepted therapy for the prevention of colon cancer. ..