JONATHAN D CHERNOFF

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. pmc The evolutionary history of effectors downstream of Cdc42 and Rac
    Sophie Cotteret
    Fox Chase Cancer Center, 7701 Burholme Ave, Philadelphia, PA 19111, USA
    Genome Biol 3:REVIEWS0002. 2002
  2. pmc p21-Activated kinases are required for transformation in a cell-based model of neurofibromatosis type 2
    Hoi Yee Chow
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 5:e13791. 2010
  3. ncbi request reprint Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas)
    F Liu
    Chemistry Department, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Biol Chem 271:31290-5. 1996
  4. ncbi request reprint Protein tyrosine phosphatases as negative regulators of mitogenic signaling
    J Chernoff
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Cell Physiol 180:173-81. 1999
  5. pmc Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties
    Sophie Cotteret
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    Mol Cell Biol 26:3215-30. 2006

Research Grants

  1. A Growth-Regulating Protein Tyrosine Phosphatase
    Jonathan Chernoff; Fiscal Year: 2004
  2. TUMOR-SUPPRESSING PROTEIN TYROSINE PHOSPHATASE
    Jonathan Chernoff; Fiscal Year: 1993
  3. Signaling by p21-activated protein kinases
    Jonathan Chernoff; Fiscal Year: 2009
  4. TUMOR SUPPRESSING PROTEIN TYROSINE PHOSPHATASE
    Jonathan Chernoff; Fiscal Year: 2001
  5. A Growth-Regulating Protein Tyrosine Phosphatase
    Jonathan Chernoff; Fiscal Year: 2006
  6. REGULATION OF P21-ACTIVATED KINASES
    Jonathan Chernoff; Fiscal Year: 2001
  7. A Growth-Regulating Protein Tyrosine Phosphatase
    Jonathan Chernoff; Fiscal Year: 2005
  8. Signaling by p21-activated protein kinases
    Jonathan Chernoff; Fiscal Year: 2006
  9. REGULATION OF P21-ACTIVATED KINASES
    Jonathan Chernoff; Fiscal Year: 2000
  10. A Growth-Regulating Protein Tyrosine Phosphatase
    Jonathan Chernoff; Fiscal Year: 2007

Collaborators

  • F Liu
  • Sophie Cotteret
  • Hoi Yee Chow
  • Dina Stepanova
  • Jennifer Koch

Detail Information

Publications8

  1. pmc The evolutionary history of effectors downstream of Cdc42 and Rac
    Sophie Cotteret
    Fox Chase Cancer Center, 7701 Burholme Ave, Philadelphia, PA 19111, USA
    Genome Biol 3:REVIEWS0002. 2002
    ..Although dozens of proteins act downstream of these GTPases, a comparison of effector proteins from evolutionarily diverse organisms suggests that six groups of proteins serve as the core machinery for signaling from Cdc42 and Rac...
  2. pmc p21-Activated kinases are required for transformation in a cell-based model of neurofibromatosis type 2
    Hoi Yee Chow
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 5:e13791. 2010
    ..Here, we examine the effect of Pak inhibition on cells with diminished Merlin function...
  3. ncbi request reprint Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas)
    F Liu
    Chemistry Department, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Biol Chem 271:31290-5. 1996
    ..These results suggest that the proline-rich domain between amino acids 301 and 315 in PTP1B binds Src homology 3-containing proteins and that p130(Cas) may be a physiological target of this phosphatase in cells...
  4. ncbi request reprint Protein tyrosine phosphatases as negative regulators of mitogenic signaling
    J Chernoff
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Cell Physiol 180:173-81. 1999
    ..In this review, I will survey recent advances in the identification and regulation of protein tyrosine phosphatases that downregulate cell proliferation...
  5. pmc Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties
    Sophie Cotteret
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    Mol Cell Biol 26:3215-30. 2006
    ..These results show that Pak5 shuttles from mitochondria to the nucleus and that the mitochondrial localization of Pak5 is vital to its effects on cell survival...

Research Grants31

  1. A Growth-Regulating Protein Tyrosine Phosphatase
    Jonathan Chernoff; Fiscal Year: 2004
    ..Importantly, it also may point the way to the development of new therapeutic agents for diseases such as diabetes and cancer. ..
  2. TUMOR-SUPPRESSING PROTEIN TYROSINE PHOSPHATASE
    Jonathan Chernoff; Fiscal Year: 1993
    ..The results of the proposed experiments may also elucidate which key elements among the myriad changes in cellular physiology that occur as the result of PTK oncogene expression are required for the transformation process...
  3. Signaling by p21-activated protein kinases
    Jonathan Chernoff; Fiscal Year: 2009
    ....
  4. TUMOR SUPPRESSING PROTEIN TYROSINE PHOSPHATASE
    Jonathan Chernoff; Fiscal Year: 2001
    ..The results of the proposed experiments may also pinpoint key elements, from among the myriad changes in cellular physiology that occur as the result of oncogene expression, that are required for neoplastic transformation. ..
  5. A Growth-Regulating Protein Tyrosine Phosphatase
    Jonathan Chernoff; Fiscal Year: 2006
    ..Importantly, it also may point the way to the development of new therapeutic agents for diseases such as diabetes and cancer. ..
  6. REGULATION OF P21-ACTIVATED KINASES
    Jonathan Chernoff; Fiscal Year: 2001
    ..Understanding the molecular basis for this regulation is not only of intrinsic scientific interest but is also likely to be relevant to important human diseases such as metastatic cancer. ..
  7. A Growth-Regulating Protein Tyrosine Phosphatase
    Jonathan Chernoff; Fiscal Year: 2005
    ..Importantly, it also may point the way to the development of new therapeutic agents for diseases such as diabetes and cancer. ..
  8. Signaling by p21-activated protein kinases
    Jonathan Chernoff; Fiscal Year: 2006
    ....
  9. REGULATION OF P21-ACTIVATED KINASES
    Jonathan Chernoff; Fiscal Year: 2000
    ..Understanding the molecular basis for this phenomenon is not only of intrinsic scientific interest but is also likely to be relevant to important human diseases such as metastatic cancer. ..
  10. A Growth-Regulating Protein Tyrosine Phosphatase
    Jonathan Chernoff; Fiscal Year: 2007
    ..Importantly, it also may point the way to the development of new therapeutic agents for diseases such as diabetes and cancer. ..
  11. REGULATION OF P21-ACTIVATED KINASES
    Jonathan Chernoff; Fiscal Year: 2003
    ..Understanding the molecular basis for this regulation is not only of intrinsic scientific interest but is also likely to be relevant to important human diseases such as metastatic cancer. ..
  12. TUMOR SUPPRESSING PROTEIN TYROSINE PHOSPHATASE
    Jonathan Chernoff; Fiscal Year: 1999
    ..The results of the proposed experiments may also pinpoint key elements, from among the myriad changes in cellular physiology that occur as the result of oncogene expression, that are required for neoplastic transformation. ..
  13. REGULATION OF P21-ACTIVATED KINASES
    Jonathan Chernoff; Fiscal Year: 2002
    ..Understanding the molecular basis for this regulation is not only of intrinsic scientific interest but is also likely to be relevant to important human diseases such as metastatic cancer. ..
  14. 2007 Mechanisms of Cell Signalling Gordon Research Conference
    Jonathan Chernoff; Fiscal Year: 2007
    ..The 8 oral sessions and 4 poster sessions will be enhanced by informal interactions at the conference site to develop new ideas and collaborative relationships. ..
  15. Signaling by p21-activated protein kinases
    JONATHAN D CHERNOFF; Fiscal Year: 2010
    ....
  16. REGULATION OF P21-ACTIVATED KINASES
    Jonathan Chernoff; Fiscal Year: 1999
    ..Understanding the molecular basis for this phenomenon is not only of intrinsic scientific interest but is also likely to be relevant to important human diseases such as metastatic cancer. ..
  17. A Growth-Regulating Protein Tyrosine Phosphatase
    Jonathan Chernoff; Fiscal Year: 2003
    ..Importantly, it also may point the way to the development of new therapeutic agents for diseases such as diabetes and cancer. ..
  18. p21-Activated Kinases as New Therapeutic Targets in Neurofibromatosis Type 1
    JONATHAN D CHERNOFF; Fiscal Year: 2010
    ....
  19. TUMOR SUPPRESSING PROTEIN TYROSINE PHOSPHATASE
    Jonathan Chernoff; Fiscal Year: 2000
    ..The results of the proposed experiments may also pinpoint key elements, from among the myriad changes in cellular physiology that occur as the result of oncogene expression, that are required for neoplastic transformation. ..
  20. REGULATION OF P21-ACTIVATED KINASES
    Jonathan Chernoff; Fiscal Year: 2004
    ..Understanding the molecular basis for this regulation is not only of intrinsic scientific interest but is also likely to be relevant to important human diseases such as metastatic cancer. ..
  21. Signaling by p21-activated protein kinases
    Jonathan Chernoff; Fiscal Year: 2007
    ....
  22. TUMOR SUPPRESSING PROTEIN TYROSINE PHOSPHATASE
    Jonathan Chernoff; Fiscal Year: 2002
    ..The results of the proposed experiments may also pinpoint key elements, from among the myriad changes in cellular physiology that occur as the result of oncogene expression, that are required for neoplastic transformation. ..