JONATHAN D CHERNOFF

..Although dozens of proteins act downstream of these GTPases, a comparison of effector proteins from evolutionarily diverse organisms suggests that six groups of proteins serve as the core machinery for signaling from Cdc42 and Rac...

..These results suggest that the proline-rich domain between amino acids 301 and 315 in PTP1B binds Src homology 3-containing proteins and that p130(Cas) may be a physiological target of this phosphatase in cells...

..In this review, I will survey recent advances in the identification and regulation of protein tyrosine phosphatases that downregulate cell proliferation...

..These results show that Pak5 shuttles from mitochondria to the nucleus and that the mitochondrial localization of Pak5 is vital to its effects on cell survival...

..Understanding the molecular basis for this regulation is not only of intrinsic scientific interest but is also likely to be relevant to important human diseases such as metastatic cancer. ..

..Importantly, it also may point the way to the development of new therapeutic agents for diseases such as diabetes and cancer. ..

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..The 8 oral sessions and 4 poster sessions will be enhanced by informal interactions at the conference site to develop new ideas and collaborative relationships. ..

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..The results of the proposed experiments may also pinpoint key elements, from among the myriad changes in cellular physiology that occur as the result of oncogene expression, that are required for neoplastic transformation. ..

..The results of the proposed experiments may also elucidate which key elements among the myriad changes in cellular physiology that occur as the result of PTK oncogene expression are required for the transformation process...

..Understanding the molecular basis for this phenomenon is not only of intrinsic scientific interest but is also likely to be relevant to important human diseases such as metastatic cancer. ..

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