Chang W, Everley L, Pfeiffer G, Cooper H, Barusevicius A, Clapper M. Sulindac sulfone is most effective in modulating beta-catenin-mediated transcription in cells with mutant APC. Ann N Y Acad Sci. 2005;1059:41-55 pubmed
..These data demonstrate that sulindac sulfone can modulate the APC/beta-catenin pathway in vitro and that its efficacy is dependent upon the mutational status of APC and beta-catenin. ..
Chang W, Coudry R, Clapper M, Zhang X, Williams K, Spittle C, et al. Loss of p53 enhances the induction of colitis-associated neoplasia by dextran sulfate sodium. Carcinogenesis. 2007;28:2375-81 pubmed
..As observed in humans, p53 plays a protective role in colitis-associated neoplasia in the DSS model. ..