Wen Chi L Chang

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. ncbi Sulindac sulfone is most effective in modulating beta-catenin-mediated transcription in cells with mutant APC
    Wen Chi L Chang
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Ann N Y Acad Sci 1059:41-55. 2005
  2. ncbi Loss of p53 enhances the induction of colitis-associated neoplasia by dextran sulfate sodium
    Wen Chi L Chang
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Carcinogenesis 28:2375-81. 2007
  3. ncbi 5-aminosalicylic acid inhibits colitis-associated colorectal dysplasias in the mouse model of azoxymethane/dextran sulfate sodium-induced colitis
    Margie L Clapper
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Inflamm Bowel Dis 14:1341-7. 2008
  4. ncbi Generation of a unique strain of multiple intestinal neoplasia (Apc(+/Min-FCCC)) mice with significantly increased numbers of colorectal adenomas
    Harry S Cooper
    Department of Pathology, Division of Medical Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Mol Carcinog 44:31-41. 2005
  5. ncbi Detection of colorectal adenomas using a bioactivatable probe specific for matrix metalloproteinase activity
    Margie L Clapper
    Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Neoplasia 13:685-91. 2011
  6. ncbi Detection and volume determination of colonic tumors in Min mice by magnetic resonance micro-imaging
    Harvey H Hensley
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Magn Reson Med 52:524-9. 2004
  7. ncbi beta-catenin-mediated signaling: a molecular target for early chemopreventive intervention
    Margie L Clapper
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Mutat Res 555:97-105. 2004
  8. ncbi Endoscopic imaging and size estimation of colorectal adenomas in the multiple intestinal neoplasia mouse
    Harvey H Hensley
    Divisions of Basic Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Gastrointest Endosc 69:742-9. 2009
  9. ncbi Perillyl alcohol-mediated inhibition of lung cancer cell line proliferation: potential mechanisms for its chemotherapeutic effects
    Mian Xu
    Department of Cancer Biology, Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1082, USA
    Toxicol Appl Pharmacol 195:232-46. 2004

Research Grants

  1. Early Events in Colitis-Associated Colorectal Cancer
    Wen Chi Chang; Fiscal Year: 2003
  2. APC PATHWAY--A TARGET FOR CHEMOPREVENTIVE INTERVENTION
    Wen Chi Chang; Fiscal Year: 2005
  3. Restoration of beta-catenin signaling by perillyl alcoh*
    Wen Chi Chang; Fiscal Year: 2005

Collaborators

Detail Information

Publications9

  1. ncbi Sulindac sulfone is most effective in modulating beta-catenin-mediated transcription in cells with mutant APC
    Wen Chi L Chang
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Ann N Y Acad Sci 1059:41-55. 2005
    ..These data demonstrate that sulindac sulfone can modulate the APC/beta-catenin pathway in vitro and that its efficacy is dependent upon the mutational status of APC and beta-catenin...
  2. ncbi Loss of p53 enhances the induction of colitis-associated neoplasia by dextran sulfate sodium
    Wen Chi L Chang
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Carcinogenesis 28:2375-81. 2007
    ..As observed in humans, p53 plays a protective role in colitis-associated neoplasia in the DSS model...
  3. ncbi 5-aminosalicylic acid inhibits colitis-associated colorectal dysplasias in the mouse model of azoxymethane/dextran sulfate sodium-induced colitis
    Margie L Clapper
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Inflamm Bowel Dis 14:1341-7. 2008
    ..The chemopreventive activity of 5-ASA was evaluated in the Swiss Webster model of azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced colitis-associated neoplasia...
  4. ncbi Generation of a unique strain of multiple intestinal neoplasia (Apc(+/Min-FCCC)) mice with significantly increased numbers of colorectal adenomas
    Harry S Cooper
    Department of Pathology, Division of Medical Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Mol Carcinog 44:31-41. 2005
    ..4) The Apc(+/Min-FCCC) strain is highly suited for the investigation of colorectal neoplastic disease and chemoprevention studies...
  5. ncbi Detection of colorectal adenomas using a bioactivatable probe specific for matrix metalloproteinase activity
    Margie L Clapper
    Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Neoplasia 13:685-91. 2011
    ..Use of this fluorescent probe in combination with colonoscopy could aid in preventing colorectal neoplasias by providing new opportunities for early detection and therapeutic intervention...
  6. ncbi Detection and volume determination of colonic tumors in Min mice by magnetic resonance micro-imaging
    Harvey H Hensley
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Magn Reson Med 52:524-9. 2004
    ..942, and a P-value of 0.008, based on Spearman's test. These data show that MRI can be used to accurately monitor tumor growth in mouse models of colorectal carcinogenesis...
  7. ncbi beta-catenin-mediated signaling: a molecular target for early chemopreventive intervention
    Margie L Clapper
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Mutat Res 555:97-105. 2004
    ..The common role of beta-catenin in both Wnt signaling and cell adhesion provides a unique opportunity to develop chemopreventive therapies that both prevent the development of cancer and delay tumor progression...
  8. ncbi Endoscopic imaging and size estimation of colorectal adenomas in the multiple intestinal neoplasia mouse
    Harvey H Hensley
    Divisions of Basic Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Gastrointest Endosc 69:742-9. 2009
    ..The scientific potential of animal models of carcinogenesis has not been fully realized because of our limited ability to monitor tumor growth in vivo...
  9. ncbi Perillyl alcohol-mediated inhibition of lung cancer cell line proliferation: potential mechanisms for its chemotherapeutic effects
    Mian Xu
    Department of Cancer Biology, Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1082, USA
    Toxicol Appl Pharmacol 195:232-46. 2004
    ..Our results suggest that POH may have potential use as an anticancer drug that stimulates or sensitizes lung tumor cells to apoptosis, and this effect may depend on genetic lesions present in tumor cells...

Research Grants3

  1. Early Events in Colitis-Associated Colorectal Cancer
    Wen Chi Chang; Fiscal Year: 2003
    ..abstract_text> ..
  2. APC PATHWAY--A TARGET FOR CHEMOPREVENTIVE INTERVENTION
    Wen Chi Chang; Fiscal Year: 2005
    ..in nutritional biochemistry when combined with the proposed training in cancer prevention and molecular genetics will provide her with the unique ability to develop both natural and synthetic compounds as clinical chemopreventive agents ..
  3. Restoration of beta-catenin signaling by perillyl alcoh*
    Wen Chi Chang; Fiscal Year: 2005
    ..Results from the proposed research will determine the feasibility of developing POH as a chemopreventive agent for patients with colorectal cancer and provide the basis for future R01 funding. ..