Remedios Castelló-Cros

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. pmc Staged stromal extracellular 3D matrices differentially regulate breast cancer cell responses through PI3K and beta1-integrins
    Remedios Castelló-Cros
    Cancer Genetics and Signaling Program, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    BMC Cancer 9:94. 2009
  2. ncbi Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling
    Gemma Migneco
    Department of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 9:2412-22. 2010
  3. pmc Matrix remodeling stimulates stromal autophagy, "fueling" cancer cell mitochondrial metabolism and metastasis
    Remedios Castelló-Cros
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 10:2021-34. 2011
  4. pmc The milk protein α-casein functions as a tumor suppressor via activation of STAT1 signaling, effectively preventing breast cancer tumor growth and metastasis
    Gloria Bonuccelli
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Department of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 11:3972-82. 2012
  5. pmc Genetic ablation of Cav1 differentially affects melanoma tumor growth and metastasis in mice: role of Cav1 in Shh heterotypic signaling and transendothelial migration
    Franco Capozza
    Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Cancer Res 72:2262-74. 2012
  6. ncbi The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts
    Gloria Bonuccelli
    Department of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 9:1960-71. 2010
  7. pmc Scleroderma-like properties of skin from caveolin-1-deficient mice: implications for new treatment strategies in patients with fibrosis and systemic sclerosis
    Remedios Castelló-Cros
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 10:2140-50. 2011
  8. ncbi The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
    Stephanos Pavlides
    Department of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 8:3984-4001. 2009
  9. pmc Stromagenesis during tumorigenesis: characterization of tumor-associated fibroblasts and stroma-derived 3D matrices
    Remedios Castelló-Cros
    Fox Chase Cancer Center, Philadelphia, PA, USA
    Methods Mol Biol 522:275-305. 2009
  10. pmc Fibroblast-derived 3D matrix differentially regulates the growth and drug-responsiveness of human cancer cells
    Ilya Serebriiskii
    Division of Basic Science Tumor Cell Biology, Fox Chase Cancer Center, Philadelphia, PA 19111, United States
    Matrix Biol 27:573-85. 2008

Collaborators

Detail Information

Publications10

  1. pmc Staged stromal extracellular 3D matrices differentially regulate breast cancer cell responses through PI3K and beta1-integrins
    Remedios Castelló-Cros
    Cancer Genetics and Signaling Program, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    BMC Cancer 9:94. 2009
    ..The goal of this study was to analyze the direct effects of staged stroma-derived extracellular matrices on breast cancer cell behavior...
  2. ncbi Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling
    Gemma Migneco
    Department of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 9:2412-22. 2010
    ....
  3. pmc Matrix remodeling stimulates stromal autophagy, "fueling" cancer cell mitochondrial metabolism and metastasis
    Remedios Castelló-Cros
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 10:2021-34. 2011
    ..Thus, the secretion and remodeling of extracellular matrix components (such as PAI-1/2) can directly regulate both (1) autophagy in stromal fibroblasts and (2) epithelial tumor cell mitochondrial metabolism...
  4. pmc The milk protein α-casein functions as a tumor suppressor via activation of STAT1 signaling, effectively preventing breast cancer tumor growth and metastasis
    Gloria Bonuccelli
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Department of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 11:3972-82. 2012
    ..Thus, we conclude that a lactation-based therapeutic strategy using recombinant α-casein would provide a more natural and non-toxic approach to the development of novel anticancer therapies...
  5. pmc Genetic ablation of Cav1 differentially affects melanoma tumor growth and metastasis in mice: role of Cav1 in Shh heterotypic signaling and transendothelial migration
    Franco Capozza
    Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Cancer Res 72:2262-74. 2012
    ..Together, our findings show that Cav1 may regulate different mechanisms during primary melanoma tumor growth and metastatic dissemination...
  6. ncbi The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts
    Gloria Bonuccelli
    Department of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 9:1960-71. 2010
    ..We also identify the stromal expression of PKM2 and LDH-B as new candidate biomarkers for the "Reverse Warburg Effect" or "Stromal-Epithelial Metabolic Coupling" in human breast cancers...
  7. pmc Scleroderma-like properties of skin from caveolin-1-deficient mice: implications for new treatment strategies in patients with fibrosis and systemic sclerosis
    Remedios Castelló-Cros
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 10:2140-50. 2011
    ..Finally, Cav-1 (-/-) null mice are also a pre-clinical model for a "lethal" tumor micro-environment, possibly explaining the link between fibrosis, tumor progression, and cancer metastasis...
  8. ncbi The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
    Stephanos Pavlides
    Department of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 8:3984-4001. 2009
    ..Thus, an absence of stromal Cav-1 may be a biomarker for the "Reverse Warburg Effect," explaining its powerful predictive value...
  9. pmc Stromagenesis during tumorigenesis: characterization of tumor-associated fibroblasts and stroma-derived 3D matrices
    Remedios Castelló-Cros
    Fox Chase Cancer Center, Philadelphia, PA, USA
    Methods Mol Biol 522:275-305. 2009
    ..It describes how to produce and characterize fibroblast-derived 3D matrices. Finally, it describes how to test matrix permissiveness by analyzing the morphology of cancer cells cultured within various 3D matrices...
  10. pmc Fibroblast-derived 3D matrix differentially regulates the growth and drug-responsiveness of human cancer cells
    Ilya Serebriiskii
    Division of Basic Science Tumor Cell Biology, Fox Chase Cancer Center, Philadelphia, PA 19111, United States
    Matrix Biol 27:573-85. 2008
    ..Based on these results, we propose that these matrices potentially have value as in vitro drug screening platforms...