Kerry Campbell

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. pmc Natural killer cell biology: an update and future directions
    Kerry S Campbell
    Immune Cell Development and Host Defense Program, the Research Institute at Fox Chase Cancer Center, Philadelphia, PA, USA
    J Allergy Clin Immunol 132:536-44. 2013
  2. pmc Structure/function of human killer cell immunoglobulin-like receptors: lessons from polymorphisms, evolution, crystal structures and mutations
    Kerry S Campbell
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Immunology 132:315-25. 2011
  3. ncbi request reprint NKp44 triggers NK cell activation through DAP12 association that is not influenced by a putative cytoplasmic inhibitory sequence
    Kerry S Campbell
    Division of Basic Science, Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    J Immunol 172:899-906. 2004
  4. ncbi request reprint SHP-1- and phosphotyrosine-independent inhibitory signaling by a killer cell Ig-like receptor cytoplasmic domain in human NK cells
    Sei ichi Yusa
    Division of Basic Science, Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    J Immunol 168:5047-57. 2002
  5. ncbi request reprint KIR2DL4 is an IL-2-regulated NK cell receptor that exhibits limited expression in humans but triggers strong IFN-gamma production
    Akiko Kikuchi-Maki
    Fox Chase Cancer Center, Division of Basic Science, Institute for Cancer Research, Philadelphia, PA 19111, USA
    J Immunol 171:3415-25. 2003
  6. ncbi request reprint KIR2DL5 can inhibit human NK cell activation via recruitment of Src homology region 2-containing protein tyrosine phosphatase-2 (SHP-2)
    Sei ichi Yusa
    Division of Basic Science, Fox Chase Cancer Center, Institute for Cancer Research, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Immunol 172:7385-92. 2004
  7. ncbi request reprint Receptors and lytic mediators regulating anti-tumor activity by the leukemic killer T cell line TALL-104
    Clara Brando
    The Wistar Institute, Philadelphia, PA, USA
    J Leukoc Biol 78:359-71. 2005
  8. pmc Altered gene expression in morphologically normal epithelial cells from heterozygous carriers of BRCA1 or BRCA2 mutations
    Alfonso Bellacosa
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cancer Prev Res (Phila) 3:48-61. 2010
  9. pmc Immunotherapy of cancer
    Hossein Borghaei
    Department of Medical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Eur J Pharmacol 625:41-54. 2009
  10. ncbi request reprint Altered gene expression in phenotypically normal renal cells from carriers of tumor suppressor gene mutations
    Radka Stoyanova
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Biol Ther 3:1313-21. 2004

Research Grants

Collaborators

Detail Information

Publications25

  1. pmc Natural killer cell biology: an update and future directions
    Kerry S Campbell
    Immune Cell Development and Host Defense Program, the Research Institute at Fox Chase Cancer Center, Philadelphia, PA, USA
    J Allergy Clin Immunol 132:536-44. 2013
    ..As our molecular understanding improves, these and future immunotherapies should continue to provide promising strategies to exploit the unique functions of NK cells to treat cancer, infections, and other pathologic conditions...
  2. pmc Structure/function of human killer cell immunoglobulin-like receptors: lessons from polymorphisms, evolution, crystal structures and mutations
    Kerry S Campbell
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Immunology 132:315-25. 2011
    ....
  3. ncbi request reprint NKp44 triggers NK cell activation through DAP12 association that is not influenced by a putative cytoplasmic inhibitory sequence
    Kerry S Campbell
    Division of Basic Science, Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    J Immunol 172:899-906. 2004
    ..In summary, all activating properties and surface expression of NKp44 are mediated through its association with DAP12, and the putative ITIM in the NKp44 cytoplasmic domain does not appear to attenuate activating function...
  4. ncbi request reprint SHP-1- and phosphotyrosine-independent inhibitory signaling by a killer cell Ig-like receptor cytoplasmic domain in human NK cells
    Sei ichi Yusa
    Division of Basic Science, Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    J Immunol 168:5047-57. 2002
    ..These results reveal new aspects of the KIR-inhibitory pathway in human NK cells, which are SHP-1 and phosphotyrosine independent...
  5. ncbi request reprint KIR2DL4 is an IL-2-regulated NK cell receptor that exhibits limited expression in humans but triggers strong IFN-gamma production
    Akiko Kikuchi-Maki
    Fox Chase Cancer Center, Division of Basic Science, Institute for Cancer Research, Philadelphia, PA 19111, USA
    J Immunol 171:3415-25. 2003
    ..1 and 2DL4(*) exhibited similar activation potential, indicating that the ITIM does not influence 2DL4.1 activating function. The unique activation properties of 2DL4 suggest linkage to a distinct signaling pathway...
  6. ncbi request reprint KIR2DL5 can inhibit human NK cell activation via recruitment of Src homology region 2-containing protein tyrosine phosphatase-2 (SHP-2)
    Sei ichi Yusa
    Division of Basic Science, Fox Chase Cancer Center, Institute for Cancer Research, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Immunol 172:7385-92. 2004
    ..Therefore, the cytoplasmic domains of type II KIRs (2DL4 and 2DL5) exhibit distinct inhibitory capacities when compared with type I KIRs (3DL1), due to alterations in the canonical ITIM sequences...
  7. ncbi request reprint Receptors and lytic mediators regulating anti-tumor activity by the leukemic killer T cell line TALL-104
    Clara Brando
    The Wistar Institute, Philadelphia, PA, USA
    J Leukoc Biol 78:359-71. 2005
    ..The data demonstrate the ability of TALL-104 cells to recognize a wide variety of tumors with NK cell receptors and kill them with a broad arsenal of cytolytic effector mechanisms, including cytolytic granules and TNF family ligands...
  8. pmc Altered gene expression in morphologically normal epithelial cells from heterozygous carriers of BRCA1 or BRCA2 mutations
    Alfonso Bellacosa
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cancer Prev Res (Phila) 3:48-61. 2010
    ....
  9. pmc Immunotherapy of cancer
    Hossein Borghaei
    Department of Medical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Eur J Pharmacol 625:41-54. 2009
    ..Here, we examine some of these immunotherapeutic approaches currently in use or testing to treat cancer, and we examine available evidence with regards to mechanism and efficacy of these treatments...
  10. ncbi request reprint Altered gene expression in phenotypically normal renal cells from carriers of tumor suppressor gene mutations
    Radka Stoyanova
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Biol Ther 3:1313-21. 2004
    ..The inherently complex signaling networks of tumors result from genetic and epigenetic alterations that occur during cancer initiation and progression...
  11. ncbi request reprint Cutting edge: KIR2DL4 transduces signals into human NK cells through association with the Fc receptor gamma protein
    Akiko Kikuchi-Maki
    Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, PA 19111, USA
    J Immunol 174:3859-63. 2005
    ..Selective association with gamma distinguishes 2DL4 from all other activating forms of the KIR family, which alternatively associate with DNAX-activating protein (DAP)12...
  12. ncbi request reprint KIR2DL4 differentially signals downstream functions in human NK cells through distinct structural modules
    S M Shahjahan Miah
    Fox Chase Cancer Center, Division of Basic Science, Institute for Cancer Research, Philadelphia, PA 19111, USA
    J Immunol 180:2922-32. 2008
    ....
  13. ncbi request reprint Protein kinase C regulates expression and function of inhibitory killer cell Ig-like receptors in NK cells
    Diana A Alvarez-Arias
    Division of Basic Science, Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Immunol 179:5281-90. 2007
    ..Our results provide evidence that serine/threonine phosphorylation is an important regulatory mechanism of KIR function...
  14. ncbi request reprint Src homology region 2-containing protein tyrosine phosphatase-2 (SHP-2) can play a direct role in the inhibitory function of killer cell Ig-like receptors in human NK cells
    Sei ichi Yusa
    Division of Basic Science, Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, PA 19111, USA
    J Immunol 170:4539-47. 2003
    ..These results strongly indicate that SHP-2 catalytic activity plays a direct role in inhibitory KIR functions, and SHP-2 inhibits NK cell activation in concert with SHP-1...
  15. pmc Blocking NK cell inhibitory self-recognition promotes antibody-dependent cellular cytotoxicity in a model of anti-lymphoma therapy
    Liat Binyamin
    Department of Medical Oncology and Division of Basic Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Immunol 180:6392-401. 2008
    ..This method provides an alternative approach to potentiate the therapeutic benefit of antitumor Abs that mediate ADCC...
  16. ncbi request reprint Prostaglandin D2 suppresses human NK cell function via signaling through D prostanoid receptor
    Yingying Chen
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Immunol 179:2766-73. 2007
    ..Together, these data uncover a novel mechanism by which PGD(2) functions through DP to suppress type 1 and cytolytic functions of human NK cells, thus contributing to the promotion of a type 2 immune response...
  17. pmc SHP-2 expression negatively regulates NK cell function
    Amanda K Purdy
    Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, PA 19111, USA
    J Immunol 183:7234-43. 2009
    ..This suppression of activation impacts microtubule organizing center-based cytoskeletal rearrangement and granule release...
  18. pmc Enhanced NK-cell development and function in BCAP-deficient mice
    Alexander W MacFarlane
    Fox Chase Cancer Center, Division of Basic Science, Institute for Cancer Research, Philadelphia, PA 19111 2497, USA
    Blood 112:131-40. 2008
    ..Our data support a model in which blunting of BCAP-mediated activation signaling in developing NK cells promotes functionality, terminal maturation, and long-term survival...
  19. pmc Expression of cDNAs in human Natural Killer cell lines by retroviral transduction
    S M Shahjahan Miah
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA, USA
    Methods Mol Biol 612:199-208. 2010
    ..Using this method, the sorted/selected cells uniformly express the gene of interest and the expression is stable for many weeks of culture...
  20. pmc Natural killer cells and cancer: regulation by the killer cell Ig-like receptors (KIR)
    Amanda K Purdy
    Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, PA, USA
    Cancer Biol Ther 8:2211-20. 2009
    ....
  21. pmc Measuring intracellular calcium signaling in murine NK cells by flow cytometry
    Alexander W MacFarlane
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA, USA
    Methods Mol Biol 612:149-57. 2010
    ..The increase in intracellular calcium is quantified by measuring a shift in the indo-1 emission spectrum that takes place when the dye becomes bound to calcium...
  22. pmc Introduction of shRNAs into human NK-like cell lines with retrovirus
    Amanda K Purdy
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA, USA
    Methods Mol Biol 612:223-31. 2010
    ..With this method, protein expression can be stably decreased to less than 10% of wild-type levels...
  23. ncbi request reprint Characterization of the recognition of tumor cells by the natural cytotoxicity receptor, NKp44
    Oren Hershkovitz
    The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences, and the Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Biochemistry 46:7426-36. 2007
    ..Thus, we suggest that heparan sulfate epitope(s) are ligands/co-ligands of NKp44 and are involved in its tumor recognition ability...
  24. ncbi request reprint Parallel purification of three catalytic subunits of the protein serine/threonine phosphatase 2A family (PP2A(C), PP4(C), and PP6(C)) and analysis of the interaction of PP2A(C) with alpha4 protein
    Susanne Kloeker
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Protein Expr Purif 31:19-33. 2003
    ..Together, these findings increase our understanding of the biochemistry of alpha4/phosphatase complexes and suggest that the alpha4 binding site within PP2A may include the phosphatase catalytic domain...

Research Grants14

  1. Negative Signalling by Killer Ig-like Receptors
    Kerry Campbell; Fiscal Year: 2007
    ..Characterization of the kinetics of SHP-1 and SHP-2 recruitment to KIR 2) Establishment of the functional roles for SHP-1 and SHP-2 in KIR inhibition 3) Characterization of the roles of kinases in KIR inhibitory function ..
  2. Mechanisms of NK Cell Activation by the KIR2DL4 Receptor
    Kerry Campbell; Fiscal Year: 2007
    ..What are the molecular mechanisms by which KIR2DL4 transduces unique activation signals inhuman NK cells? ..
  3. NEGATIVE SIGNALLING BY KILLER CELL INHIBITORY RECEPTORS
    Kerry Campbell; Fiscal Year: 2002
    ..abstract_text> ..
  4. Molecular Regulation of Inhibitory Killer Cell Ig-like Receptors
    Kerry S Campbell; Fiscal Year: 2010
    ....