Research Topics
Species | Kerry CampbellSummaryAffiliation: Fox Chase Cancer Center Country: USA Publications
Research Grants
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Detail Information
Publications
Structure/function of human killer cell immunoglobulin-like receptors: lessons from polymorphisms, evolution, crystal structures and mutationsKerry S Campbell
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Immunology 132:315-25. 2011....
NKp44 triggers NK cell activation through DAP12 association that is not influenced by a putative cytoplasmic inhibitory sequenceKerry S Campbell
Division of Basic Science, Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
J Immunol 172:899-906. 2004..In summary, all activating properties and surface expression of NKp44 are mediated through its association with DAP12, and the putative ITIM in the NKp44 cytoplasmic domain does not appear to attenuate activating function...- SHP-1- and phosphotyrosine-independent inhibitory signaling by a killer cell Ig-like receptor cytoplasmic domain in human NK cellsSei ichi Yusa
Division of Basic Science, Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
J Immunol 168:5047-57. 2002..These results reveal new aspects of the KIR-inhibitory pathway in human NK cells, which are SHP-1 and phosphotyrosine independent... - KIR2DL4 is an IL-2-regulated NK cell receptor that exhibits limited expression in humans but triggers strong IFN-gamma productionAkiko Kikuchi-Maki
Fox Chase Cancer Center, Division of Basic Science, Institute for Cancer Research, Philadelphia, PA 19111, USA
J Immunol 171:3415-25. 2003..1 and 2DL4(*) exhibited similar activation potential, indicating that the ITIM does not influence 2DL4.1 activating function. The unique activation properties of 2DL4 suggest linkage to a distinct signaling pathway... - KIR2DL5 can inhibit human NK cell activation via recruitment of Src homology region 2-containing protein tyrosine phosphatase-2 (SHP-2)Sei ichi Yusa
Division of Basic Science, Fox Chase Cancer Center, Institute for Cancer Research, 333 Cottman Avenue, Philadelphia, PA 19111, USA
J Immunol 172:7385-92. 2004..Therefore, the cytoplasmic domains of type II KIRs (2DL4 and 2DL5) exhibit distinct inhibitory capacities when compared with type I KIRs (3DL1), due to alterations in the canonical ITIM sequences... - Receptors and lytic mediators regulating anti-tumor activity by the leukemic killer T cell line TALL-104Clara Brando
The Wistar Institute, Philadelphia, PA, USA
J Leukoc Biol 78:359-71. 2005..The data demonstrate the ability of TALL-104 cells to recognize a wide variety of tumors with NK cell receptors and kill them with a broad arsenal of cytolytic effector mechanisms, including cytolytic granules and TNF family ligands... - Altered gene expression in morphologically normal epithelial cells from heterozygous carriers of BRCA1 or BRCA2 mutationsAlfonso Bellacosa
Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Cancer Prev Res (Phila) 3:48-61. 2010.... - Altered gene expression in phenotypically normal renal cells from carriers of tumor suppressor gene mutationsRadka Stoyanova
Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Cancer Biol Ther 3:1313-21. 2004..Detectable effects of "one-hit" represent early molecular changes in tumorigenesis that may serve as targets for chemopreventive intervention... - Cutting edge: KIR2DL4 transduces signals into human NK cells through association with the Fc receptor gamma proteinAkiko Kikuchi-Maki
Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, PA 19111, USA
J Immunol 174:3859-63. 2005..Selective association with gamma distinguishes 2DL4 from all other activating forms of the KIR family, which alternatively associate with DNAX-activating protein (DAP)12... - Immunotherapy of cancerHossein Borghaei
Department of Medical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
Eur J Pharmacol 625:41-54. 2009..Here, we examine some of these immunotherapeutic approaches currently in use or testing to treat cancer, and we examine available evidence with regards to mechanism and efficacy of these treatments... - KIR2DL4 differentially signals downstream functions in human NK cells through distinct structural modulesS M Shahjahan Miah
Fox Chase Cancer Center, Division of Basic Science, Institute for Cancer Research, Philadelphia, PA 19111, USA
J Immunol 180:2922-32. 2008.... - Src homology region 2-containing protein tyrosine phosphatase-2 (SHP-2) can play a direct role in the inhibitory function of killer cell Ig-like receptors in human NK cellsSei ichi Yusa
Division of Basic Science, Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, PA 19111, USA
J Immunol 170:4539-47. 2003..These results strongly indicate that SHP-2 catalytic activity plays a direct role in inhibitory KIR functions, and SHP-2 inhibits NK cell activation in concert with SHP-1... - Protein kinase C regulates expression and function of inhibitory killer cell Ig-like receptors in NK cellsDiana A Alvarez Arias
Division of Basic Science, Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
J Immunol 179:5281-90. 2007..Our results provide evidence that serine/threonine phosphorylation is an important regulatory mechanism of KIR function... - Blocking NK cell inhibitory self-recognition promotes antibody-dependent cellular cytotoxicity in a model of anti-lymphoma therapyLiat Binyamin
Department of Medical Oncology and Division of Basic Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
J Immunol 180:6392-401. 2008..This method provides an alternative approach to potentiate the therapeutic benefit of antitumor Abs that mediate ADCC... - SHP-2 expression negatively regulates NK cell functionAmanda K Purdy
Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, PA 19111, USA
J Immunol 183:7234-43. 2009..This suppression of activation impacts microtubule organizing center-based cytoskeletal rearrangement and granule release... - Enhanced NK-cell development and function in BCAP-deficient miceAlexander W MacFarlane
Fox Chase Cancer Center, Division of Basic Science, Institute for Cancer Research, Philadelphia, PA 19111 2497, USA
Blood 112:131-40. 2008..Our data support a model in which blunting of BCAP-mediated activation signaling in developing NK cells promotes functionality, terminal maturation, and long-term survival... - Prostaglandin D2 suppresses human NK cell function via signaling through D prostanoid receptorYingying Chen
Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
J Immunol 179:2766-73. 2007..Together, these data uncover a novel mechanism by which PGD(2) functions through DP to suppress type 1 and cytolytic functions of human NK cells, thus contributing to the promotion of a type 2 immune response... - Natural killer cells and cancer: regulation by the killer cell Ig-like receptors (KIR)Amanda K Purdy
Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, PA, USA
Cancer Biol Ther 8:2211-20. 2009.... - Expression of cDNAs in human Natural Killer cell lines by retroviral transductionS M Shahjahan Miah
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA, USA
Methods Mol Biol 612:199-208. 2010..Using this method, the sorted/selected cells uniformly express the gene of interest and the expression is stable for many weeks of culture... - Measuring intracellular calcium signaling in murine NK cells by flow cytometryAlexander W MacFarlane
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA, USA
Methods Mol Biol 612:149-57. 2010..The increase in intracellular calcium is quantified by measuring a shift in the indo-1 emission spectrum that takes place when the dye becomes bound to calcium... - Introduction of shRNAs into human NK-like cell lines with retrovirusAmanda K Purdy
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA, USA
Methods Mol Biol 612:223-31. 2010..With this method, protein expression can be stably decreased to less than 10% of wild-type levels... - Characterization of the recognition of tumor cells by the natural cytotoxicity receptor, NKp44Oren Hershkovitz
The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences, and the Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
Biochemistry 46:7426-36. 2007..Thus, we suggest that heparan sulfate epitope(s) are ligands/co-ligands of NKp44 and are involved in its tumor recognition ability... - Parallel purification of three catalytic subunits of the protein serine/threonine phosphatase 2A family (PP2A(C), PP4(C), and PP6(C)) and analysis of the interaction of PP2A(C) with alpha4 proteinSusanne Kloeker
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Protein Expr Purif 31:19-33. 2003..Together, these findings increase our understanding of the biochemistry of alpha4/phosphatase complexes and suggest that the alpha4 binding site within PP2A may include the phosphatase catalytic domain...
Research Grants
- Negative Signalling by Killer Ig-like ReceptorsKerry Campbell; Fiscal Year: 2007..Characterization of the kinetics of SHP-1 and SHP-2 recruitment to KIR 2) Establishment of the functional roles for SHP-1 and SHP-2 in KIR inhibition 3) Characterization of the roles of kinases in KIR inhibitory function ..
- Mechanisms of NK Cell Activation by the KIR2DL4 ReceptorKerry Campbell; Fiscal Year: 2007..What are the molecular mechanisms by which KIR2DL4 transduces unique activation signals inhuman NK cells? ..
- NEGATIVE SIGNALLING BY KILLER CELL INHIBITORY RECEPTORSKerry Campbell; Fiscal Year: 2002..abstract_text> ..
- Molecular Regulation of Inhibitory Killer Cell Ig-like ReceptorsKerry S Campbell; Fiscal Year: 2010....