Research Topics
| Paul CairnsSummaryAffiliation: Fox Chase Cancer Center Country: USA Publications
Research Grants
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Detail Information
Publications
Clipped wings: epigenetic inactivation of APCPaul Cairns
Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Cancer Biol Ther 3:965-6. 2004- Gene methylation and early detection of genitourinary cancer: the road aheadPaul Cairns
Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Nat Rev Cancer 7:531-43. 2007..The challenges of, and strategies for, advancing gene-methylation-based detection are relevant to all types of cancer... - Global reactivation of epigenetically silenced genes in prostate cancerIlsiya Ibragimova
Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
Cancer Prev Res (Phila) 3:1084-92. 2010..Further study of the hypermethylome will provide insight into the biology of the disease and facilitate translational studies in prostate cancer... - Promoter hypermethylation profile of kidney cancerEssel Dulaimi
Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
Clin Cancer Res 10:3972-9. 2004..To gain insight into the role of epigenetic silencing of tumor suppressor and cancer genes in kidney tumorigenesis, we determined a hypermethylation profile of kidney cancer... - Detection of bladder cancer in urine by a tumor suppressor gene hypermethylation panelEssel Dulaimi
Departments of Surgical Oncology and Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Clin Cancer Res 10:1887-93. 2004..Hypermethylation was detected in the urine DNA from 39 of 45 (87%) patients, including cases of early-stage disease amenable to cure. MSP may enhance early detection of bladder cancer using a noninvasive urine test... - Promoter hypermethylation of the PALB2 susceptibility gene in inherited and sporadic breast and ovarian cancerAnna Potapova
Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Cancer Res 68:998-1002. 2008.... - Identification of novel target genes by an epigenetic reactivation screen of renal cancerInmaculada Ibanez de Caceres
Departments of Surgical Oncology and Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Cancer Res 66:5021-8. 2006.... - Tumor suppressor gene promoter hypermethylation in serum of breast cancer patientsEssel Dulaimi
Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Clin Cancer Res 10:6189-93. 2004..If confirmed in additional studies, hypermethylation-based screening of serum, a readily accessible bodily fluid, may enhance early detection of breast cancer... - Tumor cell-specific BRCA1 and RASSF1A hypermethylation in serum, plasma, and peritoneal fluid from ovarian cancer patientsInmaculada Ibanez de Caceres
Department of Surgical Oncology and Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Cancer Res 64:6476-81. 2004..Analysis of tumor-specific hypermethylation in serum DNA may enhance early detection of ovarian cancer... - Detection of breast cancer in nipple aspirate fluid by CpG island hypermethylationRachel Krassenstein
Departments of Surgical Oncology and Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
Clin Cancer Res 10:28-32. 2004..Promoter hypermethylation represents a promising marker, and larger studies may lead to its useful application in breast cancer diagnosis and management... - 5'-azacytidine expression arraysPaul Cairns
Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
Methods Mol Biol 507:165-74. 2009..The potential of this approach for the identification of new hypermethylated genes and pathways has been demonstrated in bladder, colorectal, esophageal, and most other cancer types... - The genetics of renal oncocytosis: a possible model for neoplastic progressionTahseen Al-Saleem
Department of Pathology, Medical Science Division, Human Genetics Program, Populations Sciences Division, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
Cancer Genet Cytogenet 152:23-8. 2004..To our knowledge, this is the first report of the genetic and cytogenetic findings in oncocytosis not related to BDH syndrome and may suggest a possible model of progression from oncocytoma to chromophobe renal cell carcinoma... - Assays for hypermethylation of the BRCA1 gene promoter in tumor cells to predict sensitivity to PARP-inhibitor therapyIlsiya Ibragimova
Department of Surgical Oncolog, Fox Chase Cancer Center, Philadelphia, PA, USA
Methods Mol Biol 780:277-91. 2011..Here, we describe the four optimal technologies for assaying the promoter methylation status of BRCA1 and/or other genes... - Detection of promoter hypermethylation of tumor suppressor genes in urine from kidney cancer patientsPaul Cairns
Fox Chase Cancer Center, Surgical Oncology and Pathology, Philadelphia, Pennsylvania 19111, USA
Ann N Y Acad Sci 1022:40-3. 2004..We conclude that promoter hypermethylation is a common and early event in kidney tumorigenesis and can be detected in the urine DNA from patients with organ-confined renal cancer of all histologic types... - The basic biology and immunobiology of renal cell carcinoma: considerations for the clinicianRobert G Uzzo
Department of Surgical Oncology, Division of Urology, Fox Chase Cancer Center, Temple University School of Medicine, 7701 Burholme Avenue, Room C308, Philadelphia, PA 19111, USA
Urol Clin North Am 30:423-36. 2003..These studies must be correlated in a rigorous fashion to clinical parameters and outcomes. Progress against this elusive tumor will require a continuous translational dialogue between laboratory and clinical investigators... - VILIP-1 downregulation in non-small cell lung carcinomas: mechanisms and prediction of survivalJian Fu
Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
PLoS ONE 3:e1698. 2008.... - Telomerase is frequently activated in tumors with microsatellite instabilityInmaculada Ibanez de Caceres
Department of Surgical Oncology, Philadelphia, Pennsylvania, USA
Cancer Biol Ther 3:289-92. 2004..We found similarly frequent activation of telomerase in tumors with and without MMR mutation, suggesting that human tumors with MMR mutation may respond favorably to treatment with telomerase inhibitors... - Wnt5a suppresses epithelial ovarian cancer by promoting cellular senescenceBenjamin G Bitler
Women s Cancer Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Cancer Res 71:6184-94. 2011..We suggest that strategies to drive senescence in EOC cells by reconstituting Wnt5a signaling may offer an effective new strategy for EOC therapy... - Promoter hypermethylation of tumor suppressor genes in urine from kidney cancer patientsCristina Battagli
Departments of Surgical Oncology and. Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Cancer Res 63:8695-9. 2003..Methylation-specific PCR may enhance early detection of renal cancer using a noninvasive urine test... - Translational application of epigenetic alterations: ovarian cancer as a modelMarie E Maradeo
SPORE in Ovarian Cancer Program, Fox Chase Cancer Center, Philadelphia, USA
FEBS Lett 585:2112-20. 2011..In this review, we discuss the rationale, studies to date, and issues in the translational application of epigenetics using epithelial ovarian cancer as a specific example of all types of cancer... - LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancerAbbas Abdollahi
Ovarian Cancer Program, Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
J Biol Chem 278:6041-9. 2003.... - Signaling pathways in renal cell carcinomaGowrishankar Banumathy
Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
Cancer Biol Ther 10:658-64. 2010..This review summarizes the state of knowledge about signaling pathways in RCC and discusses the known genetic and epigenetic alterations that underlie dysregulation of these pathways... - Epigenetics of kidney cancer and bladder cancerAmanda M Hoffman
Departments of Surgical Oncology and Pathology, W350, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
Epigenomics 3:19-34. 2011..These clinical problems are the basis for the translational application of gene hypermethylation in the diagnosis and prognosis of kidney and bladder cancer... - Towards Clinical Application of Methylated DNA Sequences as Cancer Biomarkers: A Joint NCI's EDRN and NIST Workshop on Standards, Methods, Assays, Reagents and ToolsJacob Kagan
Cancer Biomarkers Research Group, Division of Cancer Prevention, National Cancer Institute, NIH, Bethesda, Maryland, USA
Cancer Res 67:4545-9. 2007.... - Induction of the estrogen receptor by ablation of DNMT1 in ER-negative breast cancer cellsPeter D Adams
Fox Chase Cancer Center; Philadelphia, Pennsylvania USA
Cancer Biol Ther 2:557-8. 2003 - Molecular genetics and histopathologic features of adult distal nephron tumorsThomas J Polascik
Division of Urologic Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
Urology 60:941-6. 2002 - Reduction of Pax9 gene dosage in an allelic series of mouse mutants causes hypodontia and oligodontiaRalf Kist
Institute of Human Genetics, University of Newcastle upon Tyne, International Centre for Life, UK
Hum Mol Genet 14:3605-17. 2005.... - Genome-wide genetic characterization of bladder cancer: a comparison of high-density single-nucleotide polymorphism arrays and PCR-based microsatellite analysisMohammad Obaidul Hoque
Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205-2196, USA
Cancer Res 63:2216-22. 2003..Moreover, SNP analysis raises the possibility of individual tumor genome-wide allelotyping with potential prognostic and diagnostic applications...
Research Grants
- Molecular Detection of Prostate Cancer in UrinePaul Cairns; Fiscal Year: 2005..We will test this further in two clinically problematic populations in need of better diagnosis. ..
- Methylation & Proteomics-Based Detection of Renal CancerPaul Cairns; Fiscal Year: 2007..We have preliminary evidence which indicates that a sensitive and specific molecular test providing diagnosis of early renal cancer is feasible from a simple urine specimen. We will test this further. ..