Paul Cairns

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. ncbi request reprint Clipped wings: epigenetic inactivation of APC
    Paul Cairns
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Biol Ther 3:965-6. 2004
  2. ncbi request reprint Gene methylation and early detection of genitourinary cancer: the road ahead
    Paul Cairns
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Nat Rev Cancer 7:531-43. 2007
  3. pmc Global reactivation of epigenetically silenced genes in prostate cancer
    Ilsiya Ibragimova
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Cancer Prev Res (Phila) 3:1084-92. 2010
  4. ncbi request reprint Promoter hypermethylation profile of kidney cancer
    Essel Dulaimi
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Clin Cancer Res 10:3972-9. 2004
  5. ncbi request reprint Detection of bladder cancer in urine by a tumor suppressor gene hypermethylation panel
    Essel Dulaimi
    Departments of Surgical Oncology and Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Clin Cancer Res 10:1887-93. 2004
  6. pmc Aberrant promoter hypermethylation of PBRM1, BAP1, SETD2, KDM6A and other chromatin-modifying genes is absent or rare in clear cell RCC
    Ilsiya Ibragimova
    Cancer Epigenetics Program and Kidney Keystone Program, Fox Chase Cancer Center, Philadelphia, PA, USA
    Epigenetics 8:486-93. 2013
  7. doi request reprint Promoter hypermethylation of the PALB2 susceptibility gene in inherited and sporadic breast and ovarian cancer
    Anna Potapova
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 68:998-1002. 2008
  8. ncbi request reprint Tumor suppressor gene promoter hypermethylation in serum of breast cancer patients
    Essel Dulaimi
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Clin Cancer Res 10:6189-93. 2004
  9. ncbi request reprint Identification of novel target genes by an epigenetic reactivation screen of renal cancer
    Inmaculada Ibanez de Caceres
    Departments of Surgical Oncology and Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 66:5021-8. 2006
  10. pmc ALDH1A1 is a novel EZH2 target gene in epithelial ovarian cancer identified by genome-wide approaches
    Hua Li
    Women s Cancer Program and Epigenetics and Progenitor Cell Keystone Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cancer Prev Res (Phila) 5:484-91. 2012

Research Grants

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Clipped wings: epigenetic inactivation of APC
    Paul Cairns
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Biol Ther 3:965-6. 2004
  2. ncbi request reprint Gene methylation and early detection of genitourinary cancer: the road ahead
    Paul Cairns
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Nat Rev Cancer 7:531-43. 2007
    ..The challenges of, and strategies for, advancing gene-methylation-based detection are relevant to all types of cancer...
  3. pmc Global reactivation of epigenetically silenced genes in prostate cancer
    Ilsiya Ibragimova
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Cancer Prev Res (Phila) 3:1084-92. 2010
    ..Further study of the hypermethylome will provide insight into the biology of the disease and facilitate translational studies in prostate cancer...
  4. ncbi request reprint Promoter hypermethylation profile of kidney cancer
    Essel Dulaimi
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Clin Cancer Res 10:3972-9. 2004
    ..To gain insight into the role of epigenetic silencing of tumor suppressor and cancer genes in kidney tumorigenesis, we determined a hypermethylation profile of kidney cancer...
  5. ncbi request reprint Detection of bladder cancer in urine by a tumor suppressor gene hypermethylation panel
    Essel Dulaimi
    Departments of Surgical Oncology and Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Clin Cancer Res 10:1887-93. 2004
    ....
  6. pmc Aberrant promoter hypermethylation of PBRM1, BAP1, SETD2, KDM6A and other chromatin-modifying genes is absent or rare in clear cell RCC
    Ilsiya Ibragimova
    Cancer Epigenetics Program and Kidney Keystone Program, Fox Chase Cancer Center, Philadelphia, PA, USA
    Epigenetics 8:486-93. 2013
    ..KDM5C and ARID1A were unmethylated in the TCGA 219 ccRCC and 119 adjacent normal specimens. Aberrant promoter hypermethylation of PBRM1, BAP1 and the other chromatin-modifying genes examined here is therefore absent or rare in ccRCC. ..
  7. doi request reprint Promoter hypermethylation of the PALB2 susceptibility gene in inherited and sporadic breast and ovarian cancer
    Anna Potapova
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 68:998-1002. 2008
    ....
  8. ncbi request reprint Tumor suppressor gene promoter hypermethylation in serum of breast cancer patients
    Essel Dulaimi
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Clin Cancer Res 10:6189-93. 2004
    ..In this study, we examine serum, a more readily accessible bodily fluid known to contain neoplastic DNA from individuals with cancer, for methylation-based detection of breast neoplasia...
  9. ncbi request reprint Identification of novel target genes by an epigenetic reactivation screen of renal cancer
    Inmaculada Ibanez de Caceres
    Departments of Surgical Oncology and Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 66:5021-8. 2006
    ....
  10. pmc ALDH1A1 is a novel EZH2 target gene in epithelial ovarian cancer identified by genome-wide approaches
    Hua Li
    Women s Cancer Program and Epigenetics and Progenitor Cell Keystone Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cancer Prev Res (Phila) 5:484-91. 2012
    ..Thus, we identified a list of 60 EZH2 target genes and established that ALDH1A1 is a novel EZH2 target gene in EOC cells. Our results suggest a role for EZH2 in regulating EOC stem cell equilibrium via regulation of ALDH1A1 expression...
  11. ncbi request reprint Tumor cell-specific BRCA1 and RASSF1A hypermethylation in serum, plasma, and peritoneal fluid from ovarian cancer patients
    Inmaculada Ibanez de Caceres
    Department of Surgical Oncology and Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 64:6476-81. 2004
    ..Analysis of tumor-specific hypermethylation in serum DNA may enhance early detection of ovarian cancer...
  12. ncbi request reprint Detection of breast cancer in nipple aspirate fluid by CpG island hypermethylation
    Rachel Krassenstein
    Departments of Surgical Oncology and Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Clin Cancer Res 10:28-32. 2004
    ....
  13. doi request reprint 5'-azacytidine expression arrays
    Paul Cairns
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Methods Mol Biol 507:165-74. 2009
    ..The potential of this approach for the identification of new hypermethylated genes and pathways has been demonstrated in bladder, colorectal, esophageal, and most other cancer types...
  14. ncbi request reprint The genetics of renal oncocytosis: a possible model for neoplastic progression
    Tahseen Al-Saleem
    Department of Pathology, Medical Science Division, Human Genetics Program, Populations Sciences Division, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Cancer Genet Cytogenet 152:23-8. 2004
    ..To our knowledge, this is the first report of the genetic and cytogenetic findings in oncocytosis not related to BDH syndrome and may suggest a possible model of progression from oncocytoma to chromophobe renal cell carcinoma...
  15. pmc Genome-wide promoter methylome of small renal masses
    Ilsiya Ibragimova
    Cancer Epigenetics Program and Kidney Keystone Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 8:e77309. 2013
    ..The differential methylation signatures may have utility in early detection and particularly differential diagnosis for prognostic stratification as well as identify novel gene and pathway targets for therapeutic intervention...
  16. pmc Assays for hypermethylation of the BRCA1 gene promoter in tumor cells to predict sensitivity to PARP-inhibitor therapy
    Ilsiya Ibragimova
    Department of Surgical Oncolog, Fox Chase Cancer Center, Philadelphia, PA, USA
    Methods Mol Biol 780:277-91. 2011
    ..Here, we describe the four optimal technologies for assaying the promoter methylation status of BRCA1 and/or other genes...
  17. pmc VILIP-1 downregulation in non-small cell lung carcinomas: mechanisms and prediction of survival
    Jian Fu
    Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    PLoS ONE 3:e1698. 2008
    ....
  18. pmc Epigenetics of kidney cancer and bladder cancer
    Amanda M Hoffman
    Departments of Surgical Oncology and Pathology, W350, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Epigenomics 3:19-34. 2011
    ..These clinical problems are the basis for the translational application of gene hypermethylation in the diagnosis and prognosis of kidney and bladder cancer...
  19. ncbi request reprint Detection of promoter hypermethylation of tumor suppressor genes in urine from kidney cancer patients
    Paul Cairns
    Fox Chase Cancer Center, Surgical Oncology and Pathology, Philadelphia, Pennsylvania 19111, USA
    Ann N Y Acad Sci 1022:40-3. 2004
    ..We conclude that promoter hypermethylation is a common and early event in kidney tumorigenesis and can be detected in the urine DNA from patients with organ-confined renal cancer of all histologic types...
  20. ncbi request reprint Promoter hypermethylation of tumor suppressor genes in urine from kidney cancer patients
    Cristina Battagli
    Departments of Surgical Oncology and Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 63:8695-9. 2003
    ..Methylation-specific PCR may enhance early detection of renal cancer using a noninvasive urine test...
  21. pmc Renal cell carcinoma
    Paul Cairns
    Departments of Surgical Oncology and Pathology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Cancer Biomark 9:461-73. 2010
    ..The use of molecular markers for early detection and prognosis merits more attention with ongoing advances in omics technologies. This review focuses on early RCC, that is disease confined within the renal capsule...
  22. pmc Wnt5a suppresses epithelial ovarian cancer by promoting cellular senescence
    Benjamin G Bitler
    Women s Cancer Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 71:6184-94. 2011
    ..We suggest that strategies to drive senescence in EOC cells by reconstituting Wnt5a signaling may offer an effective new strategy for EOC therapy...
  23. ncbi request reprint Telomerase is frequently activated in tumors with microsatellite instability
    Inmaculada Ibanez de Caceres
    Department of Surgical Oncology, Philadelphia, Pennsylvania, USA
    Cancer Biol Ther 3:289-92. 2004
    ..We found similarly frequent activation of telomerase in tumors with and without MMR mutation, suggesting that human tumors with MMR mutation may respond favorably to treatment with telomerase inhibitors...
  24. pmc Translational application of epigenetic alterations: ovarian cancer as a model
    Marie E Maradeo
    SPORE in Ovarian Cancer Program, Fox Chase Cancer Center, Philadelphia, USA
    FEBS Lett 585:2112-20. 2011
    ..In this review, we discuss the rationale, studies to date, and issues in the translational application of epigenetics using epithelial ovarian cancer as a specific example of all types of cancer...
  25. ncbi request reprint LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancer
    Abbas Abdollahi
    Ovarian Cancer Program, Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 278:6041-9. 2003
    ....
  26. ncbi request reprint The basic biology and immunobiology of renal cell carcinoma: considerations for the clinician
    Robert G Uzzo
    Department of Surgical Oncology, Division of Urology, Fox Chase Cancer Center, Temple University School of Medicine, 7701 Burholme Avenue, Room C308, Philadelphia, PA 19111, USA
    Urol Clin North Am 30:423-36. 2003
    ..These studies must be correlated in a rigorous fashion to clinical parameters and outcomes. Progress against this elusive tumor will require a continuous translational dialogue between laboratory and clinical investigators...
  27. pmc Signaling pathways in renal cell carcinoma
    Gowrishankar Banumathy
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Cancer Biol Ther 10:658-64. 2010
    ..This review summarizes the state of knowledge about signaling pathways in RCC and discusses the known genetic and epigenetic alterations that underlie dysregulation of these pathways...
  28. ncbi request reprint Induction of the estrogen receptor by ablation of DNMT1 in ER-negative breast cancer cells
    Peter D Adams
    Fox Chase Cancer Center Philadelphia, Pennsylvania USA
    Cancer Biol Ther 2:557-8. 2003
  29. ncbi request reprint Towards Clinical Application of Methylated DNA Sequences as Cancer Biomarkers: A Joint NCI's EDRN and NIST Workshop on Standards, Methods, Assays, Reagents and Tools
    Jacob Kagan
    Cancer Biomarkers Research Group, Division of Cancer Prevention, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Res 67:4545-9. 2007
    ....
  30. ncbi request reprint Molecular genetics and histopathologic features of adult distal nephron tumors
    Thomas J Polascik
    Division of Urologic Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    Urology 60:941-6. 2002
  31. ncbi request reprint Genome-wide genetic characterization of bladder cancer: a comparison of high-density single-nucleotide polymorphism arrays and PCR-based microsatellite analysis
    Mohammad Obaidul Hoque
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205 2196, USA
    Cancer Res 63:2216-22. 2003
    ..Moreover, SNP analysis raises the possibility of individual tumor genome-wide allelotyping with potential prognostic and diagnostic applications...
  32. ncbi request reprint Reduction of Pax9 gene dosage in an allelic series of mouse mutants causes hypodontia and oligodontia
    Ralf Kist
    Institute of Human Genetics, University of Newcastle upon Tyne, International Centre for Life, UK
    Hum Mol Genet 14:3605-17. 2005
    ....

Research Grants3

  1. Methylation & Proteomics-Based Detection of Renal Cancer
    Paul Cairns; Fiscal Year: 2007
    ..We have preliminary evidence which indicates that a sensitive and specific molecular test providing diagnosis of early renal cancer is feasible from a simple urine specimen. We will test this further. ..
  2. Molecular Detection of Prostate Cancer in Urine
    Paul Cairns; Fiscal Year: 2005
    ..We will test this further in two clinically problematic populations in need of better diagnosis. ..