Research Topics
| Mark K BuyyounouskiSummaryAffiliation: Fox Chase Cancer Center Country: USA Publications
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Detail Information
Publications
A survey of current clinical practice in permanent and temporary prostate brachytherapy: 2010 updateMark K Buyyounouski
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Brachytherapy 11:299-305. 2012....
Validating the interval to biochemical failure for the identification of potentially lethal prostate cancerMark K Buyyounouski
Fox Chase Cancer Center, Philadelphia, PA 19111, USA
J Clin Oncol 30:1857-63. 2012..To validate the interval to biochemical failure (IBF) as a prognostic factor at the time of biochemical failure for prostate cancer mortality (PCM) following radiotherapy (RT)...
Interval to biochemical failure highly prognostic for distant metastasis and prostate cancer-specific mortality after radiotherapyMark K Buyyounouski
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Int J Radiat Oncol Biol Phys 70:59-66. 2008..The present study examined the clinical utility of the interval to biochemical failure (IBF) as a prognostic factor for distant metastasis (DM) and prostate cancer-specific mortality (PCSM) after radiotherapy...
Radiotherapy: PSA nadir predicts long-term mortalityMark K Buyyounouski
Clinical Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
Nat Rev Clin Oncol 7:188-90. 2010..5 ng/ml within 2 years of radiotherapy treatment predicts distant metastases and death from prostate cancer...
Defining biochemical failure after radiotherapy with and without androgen deprivation for prostate cancerMark K Buyyounouski
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Int J Radiat Oncol Biol Phys 63:1455-62. 2005..To compare several characteristics of alternative definitions of biochemical failure (BF) in men with extended follow-up after radiotherapy (RT) with or with androgen deprivation therapy (ADT) for prostate cancer...
Prostate bed motion during intensity-modulated radiotherapy treatmentTracy Klayton
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
Int J Radiat Oncol Biol Phys 84:130-6. 2012..In this series, we report prostate bed localization and motion characteristics, using data collected from implanted radiofrequency transponders...
A comparison of acute and chronic toxicity for men with low-risk prostate cancer treated with intensity-modulated radiation therapy or (125)I permanent implantThomas N Eade
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
Int J Radiat Oncol Biol Phys 71:338-45. 2008..To compare the toxicity and biochemical outcomes of intensity-modulated radiation therapy (IMRT) and (125)I transperineal permanent prostate seed implant ((125)I) for patients with low-risk prostate cancer...
Intensity-modulated radiotherapy reduces gastrointestinal toxicity in patients treated with androgen deprivation therapy for prostate cancerNavesh K Sharma
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Int J Radiat Oncol Biol Phys 80:437-44. 2011..The present study compared the genitourinary and gastrointestinal (GI) toxicity in men treated with 3D-CRT+AD vs. IMRT+AD...
Timing of biochemical failure and distant metastatic disease for low-, intermediate-, and high-risk prostate cancer after radiotherapyPeter B Morgan
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 2497, USA
Cancer 110:68-80. 2007..The authors hypothesized that early failures due to subclinical micrometastasis at presentation could be differentiated from late failures due to local persistence...
The radiation doses to erectile tissues defined with magnetic resonance imaging after intensity-modulated radiation therapy or iodine-125 brachytherapyMark K Buyyounouski
Department of Radiation Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
Int J Radiat Oncol Biol Phys 59:1383-91. 2004..Intensity-modulated radiation therapy may offer further reductions in the doses received by the PB and CB; however, at what cost to prostate coverage and normal tissue sparing will be the subject of a follow-up study...
Radiotherapy doses of 80 Gy and higher are associated with lower mortality in men with Gleason score 8 to 10 prostate cancerNiraj Pahlajani
Department of Radiation Oncology, Cooper University Hospital, Camden, NJ, USA
Int J Radiat Oncol Biol Phys 82:1949-56. 2012..However, local failure is also a major problem. We sought to establish the importance of more aggressive local radiotherapy (RT) to ≥80 Gy...
Hypoxic prostate/muscle PO2 ratio predicts for outcome in patients with localized prostate cancer: long-term resultsAruna Turaka
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Int J Radiat Oncol Biol Phys 82:e433-9. 2012..To correlate tumor oxygenation status with long-term biochemical outcome after prostate brachytherapy...
Radiation dose and late failures in prostate cancerPeter B Morgan
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
Int J Radiat Oncol Biol Phys 67:1074-81. 2007..To quantify the impact of radiation dose escalation on the timing of biochemical failure (BF) and distant metastasis (DM) for prostate cancer treated with radiotherapy (RT) alone...
How can men destined for biochemical failure after androgen deprivation and radiotherapy be identified earlier?David J D'Ambrosio
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
Int J Radiat Oncol Biol Phys 70:1487-91. 2008..This study sought to determine whether the initial PSA increase from undetectable after completion of all treatment predicts for eventual biochemical failure (BF)...
The proportion of prostate biopsy tissue with Gleason pattern 4 or 5 predicts for biochemical and clinical outcome after radiotherapy for prostate cancerAlexandra L Hanlon
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Int J Radiat Oncol Biol Phys 67:1082-7. 2007..To investigate the prognostic utility of the proportion of prostate biopsy tissue containing Gleason pattern 4 or 5 (GP4/5) after definitive radiotherapy (RT) for prostate cancer...
Biochemical failure and the temporal kinetics of prostate-specific antigen after radiation therapy with androgen deprivationMark K Buyyounouski
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
Int J Radiat Oncol Biol Phys 61:1291-8. 2005..The American Society of Therapeutic Radiation Oncology definition for biochemical failure overestimates BF in 20-30% after RT+AD compared to 5% after RT alone...
Role of radiotherapy in ductal (endometrioid) carcinoma of the prostateThomas N Eade
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Cancer 109:2011-5. 2007..This case series of 6 patients is the first to report the outcome of ductal carcinoma treated with external beam radiotherapy...
Does treatment duration affect outcome after radiotherapy for prostate cancer?David J D'Ambrosio
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
Int J Radiat Oncol Biol Phys 72:1402-7. 2008..In prostate cancer, the overall treatment time can be considerable, as can the potential for treatment breaks. We evaluated the effect of elapsed treatment time on outcome after RT for prostate cancer...
Gains from real-time tracking of prostate motion during external beam radiation therapyJin sheng Li
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
Int J Radiat Oncol Biol Phys 75:1613-20. 2009..To study the gains from real-time tracking of prostate motion and threshold-based intervention and the feasibility of margin reduction for external beam radiation therapy of prostate cancer...
The impact of dose-escalated radiotherapy plus androgen deprivation for prostate cancer using 2 linked nomogramsRadka Stoyanova
Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Cancer 119:1080-8. 2013..The authors designed a model to estimate the results of various doses of radiotherapy (RT) combined with various durations of ADT...
Assessment of the American Joint Committee on Cancer staging (sixth and seventh editions) for clinically localized prostate cancer treated with external beam radiotherapy and comparison with the National Comprehensive Cancer Network risk-stratification meNicholas G Zaorsky
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
Cancer 118:5535-43. 2012....
Aspirin and statin nonuse associated with early biochemical failure after prostate radiation therapyNicholas G Zaorsky
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
Int J Radiat Oncol Biol Phys 84:e13-7. 2012..To present the largest retrospective series investigating the effect of aspirin and statins, which are hypothesized to have antineoplastic properties, on biochemical failure (nadir plus 2 ng/mL) after prostate radiation therapy (RT)...
What dose of external-beam radiation is high enough for prostate cancer?Thomas N Eade
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Int J Radiat Oncol Biol Phys 68:682-9. 2007..To quantify the radiotherapy dose-response of prostate cancer, adjusted for prognostic factors in a mature cohort of men treated relatively uniformly at a single institution...
Does transurethral resection of prostate (TURP) affect outcome in patients who subsequently develop prostate cancer?David J D'Ambrosio
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Urology 71:938-41. 2008..The purpose of this study was to determine whether a history of TURP is associated with increased biochemical failure (BF) after definitive radiotherapy for prostate cancer...
The Phoenix definition of biochemical failure predicts for overall survival in patients with prostate cancerMatthew C Abramowitz
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 2497, USA
Cancer 112:55-60. 2008..The objective of the current study was to compare ASTRO and Phoenix BF estimates as determinants of distant metastasis (DM), cause-specific mortality (CSM), and overall mortality (OM)...
Residual prostate cancer after radiotherapy: a study of radical cystoprostatectomy specimensDavid J Kaplan
Department of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Urology 72:654-8. 2008..We investigated the relationship between prostate-specific antigen (PSA) and histologically residual CaP after definitive RT in patients undergoing radical cystoprostatectomy (RCP) for unrelated indications...
Evaluation of the Prostate Cancer Prevention Trial Risk calculator in a high-risk screening populationDavid J Kaplan
Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, USA
BJU Int 105:334-7. 2010..Study Type - Diagnostic (exploratory cohort) Level of Evidence 2b...
Young age under 60 years is not a contraindication to treatment with definitive dose escalated radiotherapy for prostate cancerTracy L Klayton
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia 19111, United States
Radiother Oncol 101:508-12. 2011..It is widely believed that younger prostate cancer patients are at greater risk of recurrence following radiotherapy (RT)...
Development of RTOG consensus guidelines for the definition of the clinical target volume for postoperative conformal radiation therapy for prostate cancerJeff M Michalski
Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
Int J Radiat Oncol Biol Phys 76:361-8. 2010..To define a prostate fossa clinical target volume (PF-CTV) for Radiation Therapy Oncology Group (RTOG) trials using postoperative radiotherapy for prostate cancer...
An intraoperative real-time sleeved seed technique for permanent prostate brachytherapyNavesh K Sharma
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Brachytherapy 9:126-30. 2010....
Intensity-modulated radiotherapy with MRI simulation to reduce doses received by erectile tissue during prostate cancer treatmentMark K Buyyounouski
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
Int J Radiat Oncol Biol Phys 58:743-9. 2004..A Phase III randomized trial has been designed to test the clinical significance of the erectile tissue-sparing technique described here...
Positive prostate biopsy laterality and implications for stagingMark K Buyyounouski
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Urology 62:298-303. 2003..04). CONCLUSIONS: Inclusion of positive biopsy laterality status into clinical staging causes stage migration without reflecting a change in outcome and should not be used...
Radiotherapy treatment planning for testicular seminomaRichard B Wilder
Department of Radiation Oncology, Moffitt Cancer Center, Tampa, FL, USA
Int J Radiat Oncol Biol Phys 83:e445-52. 2012..g., if they have a horseshoe kidney, inflammatory bowel disease, or a history of radiotherapy)...
Dosimetry and preliminary acute toxicity in the first 100 men treated for prostate cancer on a randomized hypofractionation dose escalation trialAlan Pollack
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Int J Radiat Oncol Biol Phys 64:518-26. 2006..The dosimetry and acute toxicity are described in the first 100 men enrolled in a randomized trial...
Prostate-specific antigen nadir within 12 months of prostate cancer radiotherapy predicts metastasis and deathPino Alcantara
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
Cancer 109:41-7. 2007..0001).CONCLUSIONS.nPSA12 is a strong independent predictor of outcome after RT alone for prostate cancer and should be useful in identifying patients at high risk for progression to metastasis and death...
Stamp test delivers message on erectile dysfunction after high-dose intensity-modulated radiotherapy for prostate cancerLanea M M Keller
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
Urology 80:337-42. 2012..To evaluate erectile function after high-dose radiotherapy for prostate cancer using the International Index of Erectile Function, Expanded Prostate Cancer Index Composite, and stamp test...
Radiation therapy for pituitary metastasis: report of four casesAruna Turaka
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Tumori 98:e1-6. 2012..To report the clinical outcomes of four patients with pituitary metastases treated with radiotherapy...
Effect of gold marker seeds on magnetic resonance spectroscopy of the prostateMurshed Hossain
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
Int J Radiat Oncol Biol Phys 83:451-8. 2012..The purpose of this study was to quantify the effects of gold seeds on the quality of MRSI data acquired in phantom experiments...
Dosimetric comparison of stereotactic body radiotherapy using 4D CT and multiphase CT images for treatment planning of lung cancer: evaluation of the impact on daily dose coverageLu Wang
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Radiother Oncol 91:314-24. 2009..To investigate the dosimetric impact of using 4D CT and multiphase (helical) CT images for treatment planning target definition and the daily target coverage in hypofractionated stereotactic body radiotherapy (SBRT) of lung cancer...
Unexpected dementia following prophylactic cranial irradiation for small cell lung cancer: case reportDavid J D'Ambrosio
Department of Radiation Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
J Neurooncol 85:77-9. 2007..Prophylactic cranial irradiation (PCI) is commonly offered to patients with limited stage primary small cell lung cancer following a complete response...
Percentage of biopsy cores positive for malignancy and biochemical failure following prostate cancer radiotherapy in 3,264 men: statistical significance without predictive performanceScott G Williams
Peter MacCallum Cancer Centre and University of Melbourne, Melbourne, Australia
Int J Radiat Oncol Biol Phys 70:1169-75. 2008..To define and incorporate the impact of the percentage of positive biopsy cores (PPC) into a predictive model of prostate cancer radiotherapy biochemical outcome...
In regard to Selek et al. erectile dysfunction and radiation dose to penile base structures: a lack of correlation. IJROBP 2004;59:1039-1046Mark K Buyyounouski
Int J Radiat Oncol Biol Phys 60:1664-5; author reply 1666. 2004
Re: improved clinical staging system combining biopsy laterality and TNM stage for men with T1c and T2 prostate cancer: results from the search databaseMark K Buyyounouski
J Urol 171:1246-7; author reply 1247. 2004
