Jeff Boyd

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. pmc Genetic analysis of the early natural history of epithelial ovarian carcinoma
    Bhavana Pothuri
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    PLoS ONE 5:e10358. 2010
  2. ncbi request reprint Whole exome sequence analysis of serous borderline tumors of the ovary
    Jeff Boyd
    Cancer Genome Institute, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA
    Gynecol Oncol 130:560-4. 2013
  3. ncbi request reprint Heterogenic loss of the wild-type BRCA allele in human breast tumorigenesis
    Tari A King
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Ann Surg Oncol 14:2510-8. 2007
  4. ncbi request reprint BRCA1 and BRCA2 germline mutations in lymphoma patients
    Orit Yossepowitch
    Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Leuk Lymphoma 44:127-31. 2003
  5. ncbi request reprint Clinicopathologic significance of defective DNA mismatch repair in endometrial carcinoma
    Destin Black
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 24:1745-53. 2006
  6. ncbi request reprint BRCA mutations in women with ductal carcinoma in situ
    Karen Lisa Smith
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 13:4306-10. 2007
  7. ncbi request reprint Increased progesterone receptor expression in benign epithelium of BRCA1-related breast cancers
    Tari A King
    Departments of Surgery, Pathology, Epidemiology and Biostatistics, and Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Cancer Res 64:5051-3. 2004
  8. ncbi request reprint Fallopian tube and primary peritoneal carcinomas associated with BRCA mutations
    Douglas A Levine
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 21:4222-7. 2003
  9. ncbi request reprint Stratification of intermediate-risk endometrial cancer patients into groups at high risk or low risk for recurrence based on tumor gene expression profiles
    Sarah E Ferguson
    Departments of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Clin Cancer Res 11:2252-7. 2005
  10. ncbi request reprint Frequent mutation of the PIK3CA gene in ovarian and breast cancers
    Douglas A Levine
    Gynecology and Breast Research Laboratory, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 11:2875-8. 2005

Collaborators

Detail Information

Publications26

  1. pmc Genetic analysis of the early natural history of epithelial ovarian carcinoma
    Bhavana Pothuri
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    PLoS ONE 5:e10358. 2010
    ....
  2. ncbi request reprint Whole exome sequence analysis of serous borderline tumors of the ovary
    Jeff Boyd
    Cancer Genome Institute, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA
    Gynecol Oncol 130:560-4. 2013
    ..Toward a more comprehensive understanding of the molecular genetic architecture of SBTs, we undertook whole exome sequencing of this tumor type...
  3. ncbi request reprint Heterogenic loss of the wild-type BRCA allele in human breast tumorigenesis
    Tari A King
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Ann Surg Oncol 14:2510-8. 2007
    ..However, several lines of evidence suggest that phenotypic effects may result from BRCA haploinsufficiency...
  4. ncbi request reprint BRCA1 and BRCA2 germline mutations in lymphoma patients
    Orit Yossepowitch
    Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Leuk Lymphoma 44:127-31. 2003
    ..This data indicate that germline BRCA mutations are not associated with an increased risk for lymphoid malignancies...
  5. ncbi request reprint Clinicopathologic significance of defective DNA mismatch repair in endometrial carcinoma
    Destin Black
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 24:1745-53. 2006
    ..The pathognomonic molecular manifestation of this repair defect is microsatellite instability (MSI). Here, we test the hypothesis that MSI predicts the clinicopathologic features of endometrial carcinoma...
  6. ncbi request reprint BRCA mutations in women with ductal carcinoma in situ
    Karen Lisa Smith
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 13:4306-10. 2007
    ..The strength of the association between ductal carcinoma in situ (DCIS) and BRCA mutations has not been defined...
  7. ncbi request reprint Increased progesterone receptor expression in benign epithelium of BRCA1-related breast cancers
    Tari A King
    Departments of Surgery, Pathology, Epidemiology and Biostatistics, and Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Cancer Res 64:5051-3. 2004
    ..We conclude that deregulation of progesterone receptor expression, as a result of BRCA1 haploinsufficiency, may represent an early event in BRCA1-linked breast tumorigenesis...
  8. ncbi request reprint Fallopian tube and primary peritoneal carcinomas associated with BRCA mutations
    Douglas A Levine
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 21:4222-7. 2003
    ....
  9. ncbi request reprint Stratification of intermediate-risk endometrial cancer patients into groups at high risk or low risk for recurrence based on tumor gene expression profiles
    Sarah E Ferguson
    Departments of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Clin Cancer Res 11:2252-7. 2005
    ..Here, we test whether global gene expression profiling can distinguish intermediate-risk tumors into high-risk and low-risk subgroups...
  10. ncbi request reprint Frequent mutation of the PIK3CA gene in ovarian and breast cancers
    Douglas A Levine
    Gynecology and Breast Research Laboratory, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 11:2875-8. 2005
    ..Here, we test whether PIK3CA is subject to mutation in ovarian and breast cancers...
  11. ncbi request reprint Evaluation of germline PTEN mutations in endometrial cancer patients
    Destin Black
    Gynecology and Breast Research Laboratory, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Gynecol Oncol 96:21-4. 2005
    ..The aim of this study was to test whether a substantial proportion of endometrial cancers are associated with germline mutations of the PTEN gene, not necessarily in association with clinically overt Cowden syndrome...
  12. ncbi request reprint Clinicopathologic analysis of early-stage sporadic ovarian carcinoma
    Mario M Leitao
    Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center New York, NY 10021, USA
    Am J Surg Pathol 28:147-59. 2004
    ..Clear cell histology does not confer a worse prognosis compared with other histologies. The presence of a TP53 mutation was an adverse prognostic indicator...
  13. ncbi request reprint Molecular profiling of endometrial cancers from African-American and Caucasian women
    Sarah E Ferguson
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Gynecol Oncol 101:209-13. 2006
    ..The purpose of this study was to test the hypothesis that African-American women with EC have a distinct gene expression profile compared to Caucasian women with EC...
  14. ncbi request reprint Mutation and expression of the TP53 gene in early stage epithelial ovarian carcinoma
    Mario M Leitao
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Gynecol Oncol 93:301-6. 2004
    ..The purpose of this study was to perform a comprehensive analysis of TP53 mutation and p53 expression status in early stage ovarian carcinomas...
  15. pmc Intraepithelial T cells and tumor proliferation: impact on the benefit from surgical cytoreduction in advanced serous ovarian cancer
    Sarah F Adams
    Department of Obstetrics and Gynecology, Ovarian Cancer Research Center, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Cancer 115:2891-902. 2009
    ....
  16. ncbi request reprint Routinely assessed morphological features correlate with microsatellite instability status in endometrial cancer
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Hum Pathol 39:116-25. 2008
    ..Therefore, morphological patterns encountered in endometrial carcinoma may prove useful in screening tumors under consideration for MSI testing and identifying appropriate patients for referral to a genetic counseling service...
  17. ncbi request reprint Gene expression profiling of tamoxifen-associated uterine cancers: evidence for two molecular classes of endometrial carcinoma
    Sarah E Ferguson
    Gynecology and Breast Research Laboratory, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Gynecol Oncol 92:719-25. 2004
    ..The purpose of this study was to test the hypothesis that tamoxifen-associated endometrial carcinomas have a distinct gene expression profile compared to matched cases not associated with this exposure...
  18. pmc Analysis of genetic variation in Ashkenazi Jews by high density SNP genotyping
    Adam B Olshen
    Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    BMC Genet 9:14. 2008
    ..435,632 SNPs overlapped and met annotation criteria in the two groups...
  19. ncbi request reprint Role of KRAS and BRAF gene mutations in mucinous ovarian carcinoma
    Mary L Gemignani
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Gynecol Oncol 90:378-81. 2003
    ....
  20. ncbi request reprint Mouse models of gynecologic pathology
    Jeff Boyd
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA
    N Engl J Med 352:2240-2. 2005
  21. ncbi request reprint Ovarian cancer risk in Ashkenazi Jewish carriers of BRCA1 and BRCA2 mutations
    Jaya M Satagopan
    Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 8:3776-81. 2002
    ..To address this, we have used a case-control design that does not involve familial aggregation to estimate the lifetime penetrance of ovarian cancer due to BRCA1 and BRCA2 mutations...
  22. pmc A phase II trial of erlotinib in combination with bevacizumab in patients with metastatic breast cancer
    Maura N Dickler
    Breast Cancer Medicine Service, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 14:7878-83. 2008
    ..To evaluate the efficacy and toxicity of erlotinib plus bevacizumab in patients with metastatic breast cancer (MBC), targeting the epidermal growth factor receptor (EGFR/HER1) and the vascular endothelial growth factor (VEGF) pathway...
  23. pmc A phase 2 trial of erlotinib in patients with previously treated squamous cell and adenocarcinoma of the esophagus
    David H Ilson
    Gastrointestinal Oncology Service Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer 117:1409-14. 2011
    ..Tyrosine kinase inhibitors (TKIs) of the epidermal growth factor receptor (EGFR) have activity in solid tumors. The authors evaluated an oral EGFR TKI, erlotinib, in patients with previously treated esophageal cancer...
  24. pmc Differential exoprotease activities confer tumor-specific serum peptidome patterns
    Josep Villanueva
    Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Clin Invest 116:271-84. 2006
    ..Our findings also have important implications for future peptide biomarker discovery efforts...
  25. ncbi request reprint Pediatric radical abdominal trachelectomy for cervical clear cell carcinoma: a novel surgical approach
    Nadeem R Abu-Rustum
    Gynecology Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Room C 1096, New York, NY 10021, USA
    Gynecol Oncol 97:296-300. 2005
    ..This novel approach is also pertinent to the pediatric patient and is described in this report. A molecular analysis is also performed to determine if these are DES-associated tumors...
  26. ncbi request reprint Cell proliferation and apoptosis in BRCA-associated hereditary ovarian cancer
    Douglas A Levine
    Gynecology and Breast Research Laboratory, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Gynecol Oncol 85:431-4. 2002
    ..The goal was to test the hypothesis that cellular growth properties differ between hereditary and sporadic ovarian cancers...

Research Grants10

  1. Molecular Classification of Endometrial Carcinomas
    Jeff Boyd; Fiscal Year: 2005
    ....
  2. Molecular Classification of Endometrial Carcinomas
    Jeff Boyd; Fiscal Year: 2004
    ....
  3. GENETIC MECHANISM OF BRCA LINKED OVARIAN TUMORIGENESIS
    Jeff Boyd; Fiscal Year: 2004
    ..Data from these studies may lead to the development of more effective therapeutic strategies for genetically-defined subsets of ovarian cancer patients. ..
  4. GENETIC MECHANISM OF BRCA LINKED OVARIAN TUMORIGENESIS
    Jeff Boyd; Fiscal Year: 2003
    ..Data from these studies may lead to the development of more effective therapeutic strategies for genetically-defined subsets of ovarian cancer patients. ..
  5. GENETIC MECHANISM OF BRCA LINKED OVARIAN TUMORIGENESIS
    Jeff Boyd; Fiscal Year: 2002
    ..Data from these studies may lead to the development of more effective therapeutic strategies for genetically-defined subsets of ovarian cancer patients. ..
  6. GENETIC MECHANISM OF BRCA LINKED OVARIAN TUMORIGENESIS
    Jeff Boyd; Fiscal Year: 2001
    ..Data from these studies may lead to the development of more effective therapeutic strategies for genetically-defined subsets of ovarian cancer patients. ..
  7. Molecular Classification of Endometrial Carcinomas
    Jeff Boyd; Fiscal Year: 2006
    ....