Alfonso Bellacosa

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. pmc Altered gene expression in morphologically normal epithelial cells from heterozygous carriers of BRCA1 or BRCA2 mutations
    Alfonso Bellacosa
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cancer Prev Res (Phila) 3:48-61. 2010
  2. ncbi request reprint A portrait of AKT kinases: human cancer and animal models depict a family with strong individualities
    Alfonso Bellacosa
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Cancer Biol Ther 3:268-75. 2004
  3. pmc APC +/- alters colonic fibroblast proteome in FAP
    Bhavinkumar B Patel
    Developmental Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Oncotarget 2:197-208. 2011
  4. ncbi request reprint Optimized procedures for microarray analysis of histological specimens processed by laser capture microdissection
    John J Upson
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Cell Physiol 201:366-73. 2004
  5. ncbi request reprint Altered gene expression in phenotypically normal renal cells from carriers of tumor suppressor gene mutations
    Radka Stoyanova
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Biol Ther 3:1313-21. 2004
  6. ncbi request reprint Comparison of RNA amplification methods and chip platforms for microarray analysis of samples processed by laser capture microdissection
    Elena Caretti
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    J Cell Biochem 103:556-63. 2008
  7. pmc Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4
    Salvatore Cortellino
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Dev Biol 325:225-37. 2009
  8. pmc Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair
    Salvatore Cortellino
    Cancer Biology Program and Epigenetics and Progenitor Cells Keystone Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cell 146:67-79. 2011
  9. ncbi request reprint The DNA N-glycosylase MED1 exhibits preference for halogenated pyrimidines and is involved in the cytotoxicity of 5-iododeoxyuridine
    David P Turner
    Human Genetics Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Cancer Res 66:7686-93. 2006
  10. pmc DNA demethylation by TDG
    Shannon R Dalton
    Cancer Biology Program, Epigenetics and Progenitor Cells Program, Fox Chase Cancer Center, PA 19111, USA
    Epigenomics 4:459-67. 2012

Collaborators

Detail Information

Publications24

  1. pmc Altered gene expression in morphologically normal epithelial cells from heterozygous carriers of BRCA1 or BRCA2 mutations
    Alfonso Bellacosa
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cancer Prev Res (Phila) 3:48-61. 2010
    ....
  2. ncbi request reprint A portrait of AKT kinases: human cancer and animal models depict a family with strong individualities
    Alfonso Bellacosa
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Cancer Biol Ther 3:268-75. 2004
    ....
  3. pmc APC +/- alters colonic fibroblast proteome in FAP
    Bhavinkumar B Patel
    Developmental Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Oncotarget 2:197-208. 2011
    ..The results indicate that heterozygosity for a mutant APC tumor suppressor gene alters the proteomes of both colon-derived normal fibroblasts in a gene-specific manner, consistent with a "one-hit" effect...
  4. ncbi request reprint Optimized procedures for microarray analysis of histological specimens processed by laser capture microdissection
    John J Upson
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Cell Physiol 201:366-73. 2004
    ..Taken together, these results demonstrate that LCM-derived tissue from histological specimens can generate abundant amounts of high-quality aRNA for subsequent microarray analysis...
  5. ncbi request reprint Altered gene expression in phenotypically normal renal cells from carriers of tumor suppressor gene mutations
    Radka Stoyanova
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Biol Ther 3:1313-21. 2004
    ..The inherently complex signaling networks of tumors result from genetic and epigenetic alterations that occur during cancer initiation and progression...
  6. ncbi request reprint Comparison of RNA amplification methods and chip platforms for microarray analysis of samples processed by laser capture microdissection
    Elena Caretti
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    J Cell Biochem 103:556-63. 2008
    ..986. The quicker NuGEN procedure, when coupled with X3P arrays, also yielded excellent results (correlation of 0.951). These observations will be useful for planning large-scale analyses of LCM-dissected clinical samples...
  7. pmc Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4
    Salvatore Cortellino
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Dev Biol 325:225-37. 2009
    ..We conclude that complex A and complex B factors play similar but distinct roles in ciliogenesis and Shh/Gli3 signaling...
  8. pmc Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair
    Salvatore Cortellino
    Cancer Biology Program and Epigenetics and Progenitor Cells Keystone Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cell 146:67-79. 2011
    ....
  9. ncbi request reprint The DNA N-glycosylase MED1 exhibits preference for halogenated pyrimidines and is involved in the cytotoxicity of 5-iododeoxyuridine
    David P Turner
    Human Genetics Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Cancer Res 66:7686-93. 2006
    ..These findings establish MED1 as a bona fide repair activity for the removal of halogenated bases and indicate that MED1 may play a significant role in 5IdU cytotoxicity...
  10. pmc DNA demethylation by TDG
    Shannon R Dalton
    Cancer Biology Program, Epigenetics and Progenitor Cells Program, Fox Chase Cancer Center, PA 19111, USA
    Epigenomics 4:459-67. 2012
    ..In this article, we review the recent literature highlighting the prominent role played in active DNA demethylation by base excision repair and especially by TDG...
  11. pmc One-hit effects in cancer: altered proteome of morphologically normal colon crypts in familial adenomatous polyposis
    Anthony T Yeung
    Division of Basic Science, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    Cancer Res 68:7579-86. 2008
    ..These changes may represent the earliest biomarkers of colorectal cancer development, potentially leading to the identification of molecular targets for cancer prevention...
  12. ncbi request reprint Induction of deoxyribonucleic acid damage by alkylating agents
    Salvatore Cortellino
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, PA, USA
    Methods Mol Biol 285:121-5. 2004
  13. ncbi request reprint RNA repair: damage control
    Alfonso Bellacosa
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Curr Biol 13:R482-4. 2003
    ..RNA damage can induce apoptosis and may be exploited for anti-cancer chemotherapy. It is a surprise, however, to learn that cells may repair RNA damage, suggesting a far greater significance of RNA in genotoxic stress...
  14. ncbi request reprint Genetic hits and mutation rate in colorectal tumorigenesis: versatility of Knudson's theory and implications for cancer prevention
    Alfonso Bellacosa
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Genes Chromosomes Cancer 38:382-8. 2003
    ..The beauty of Knudson's two-hit theory is its ability to explain diverse experimental situations and guide specific predictions, including some directly relevant to cancer prevention...
  15. pmc Dose dependent effects on cell cycle checkpoints and DNA repair by bendamustine
    Neil Beeharry
    Basic Science Division, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e40342. 2012
    ..Sensitizing cells to killing by BDM can be achieved by inhibiting base-excision repair or disrupting the DNA damage checkpoint pathway...
  16. ncbi request reprint Activation of AKT kinases in cancer: implications for therapeutic targeting
    Alfonso Bellacosa
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Adv Cancer Res 94:29-86. 2005
    ....
  17. ncbi request reprint Induction of deoxyribonucleic acid damage by gamma irradiation
    Salvatore Cortellino
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, PA, USA
    Methods Mol Biol 285:127-32. 2004
  18. pmc VILIP-1 downregulation in non-small cell lung carcinomas: mechanisms and prediction of survival
    Jian Fu
    Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    PLoS ONE 3:e1698. 2008
    ....
  19. pmc Recombinant nucleases CEL I from celery and SP I from spinach for mutation detection
    Maxim Pimkin
    Basic Science, Fox Chase Cancer Center, Philadelphia, PA, USA
    BMC Biotechnol 7:29. 2007
    ..Previously, CEL I-like activities were described only in a variety of plants and could not be expressed in an active form in bacteria...
  20. pmc The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity
    Salvatore Cortellino
    Program in Human Genetics, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 100:15071-6. 2003
    ..MED1 defects (much like MMR defects) may impair cell cycle arrest and apoptosis induced by DNA damage...
  21. ncbi request reprint Use of RNA amplification in the optimal characterization of global gene expression using cDNA microarrays
    Radka Stoyanova
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    J Cell Physiol 201:359-65. 2004
    ..This study indicates that high quality microarray data can be generated from small amounts of RNA, including those extracted from limiting clinical samples and microdissected histological specimens...
  22. ncbi request reprint Ultraviolet irradiation of cells
    David P Turner
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, PA, USA
    Methods Mol Biol 285:133-7. 2004
  23. pmc Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice
    Gianluigi Condorelli
    Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 99:12333-8. 2002
    ..In summary, our results not only demonstrate that Akt regulates cardiomyocyte cell size in vivo, but, importantly, show that Akt modulates cardiac contractility in vivo without directly affecting beta-AR signaling capacity...
  24. ncbi request reprint Searchable high-resolution 2D gel proteome of the human colon crypt
    Bhavinkumar B Patel
    Division of Basic Science, Medical Science, and Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Proteome Res 6:2232-8. 2007
    ..These interactive, searchable, hyperlink-enabled proteome maps and gene ontology analyses will facilitate future studies to discover the earliest markers and intervention targets during progression to colon cancer...