Siddharth Balachandran

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. pmc Interferon-γ-induced necrosis: an antitumor biotherapeutic perspective
    Siddharth Balachandran
    Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Interferon Cytokine Res 33:171-80. 2013
  2. pmc NF-κB inhibition by bortezomib permits IFN-γ-activated RIP1 kinase-dependent necrosis in renal cell carcinoma
    Roshan J Thapa
    Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, PA, USA
    Mol Cancer Ther 12:1568-78. 2013
  3. pmc NF-kappaB protects cells from gamma interferon-induced RIP1-dependent necroptosis
    Roshan J Thapa
    Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Cell Biol 31:2934-46. 2011
  4. pmc Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases
    Roshan J Thapa
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 110:E3109-18. 2013
  5. pmc Requirement of FADD, NEMO, and BAX/BAK for aberrant mitochondrial function in tumor necrosis factor alpha-induced necrosis
    Krishna M Irrinki
    Department of Biochemistry, Temple University, Philadelphia, PA 19140, USA
    Mol Cell Biol 31:3745-58. 2011
  6. pmc Anti-CD70 immunocytokines for exploitation of interferon-γ-induced RIP1-dependent necrosis in renal cell carcinoma
    Peirong Chen
    Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 8:e61446. 2013
  7. pmc Identification of STAT2 serine 287 as a novel regulatory phosphorylation site in type I interferon-induced cellular responses
    Håkan C Steen
    Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 288:747-58. 2013
  8. pmc STAT1-independent control of a neurotropic measles virus challenge in primary neurons and infected mice
    Lauren A O'Donnell
    Program in Immune Cell Development and Host Defense, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Immunol 188:1915-23. 2012
  9. pmc Interferon impedes an early step of hepatitis delta virus infection
    Ziying Han
    Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e22415. 2011
  10. pmc Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B
    Shuyun Rao
    Blood Cell Development and Cancer Keystone, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Blood 120:3764-73. 2012

Collaborators

  • Gregory P Adams
  • Joseph R Testa
  • Muniswamy Madesh
  • Steven G Kelsen
  • John Taylor
  • Roshan J Thapa
  • Shoko Nogusa
  • Suraj Peri
  • Peirong Chen
  • Suresh H Basagoudanavar
  • Daniel Rubio
  • Håkan C Steen
  • Glenn F Rall
  • Shuyun Rao
  • Lauren A O'Donnell
  • Emmanuelle Nicolas
  • Amer A Beg
  • Krishna M Irrinki
  • Ziying Han
  • Karthik Mallilankaraman
  • Mark Andrake
  • Dong Hua Yang
  • Luis J Sigal
  • Ana M Gamero
  • Carlos A Barrero
  • Mitchell Cheung
  • Ren Huan Xu
  • Anthony Lerro
  • Salim Merali
  • Heidi Simmons
  • Tracy E Krouse
  • Antonio Alcami
  • Mary Ellen Truckenmiller
  • Alexei Degterev
  • Amanda L Gill
  • Jenny L Maki
  • Christopher C Norbury
  • Karthik Devarajan
  • Alfred G Knudson
  • Jianming Pei
  • Sanda Remakus
  • Calvin Shaller
  • Tamas Oravecz
  • Stephen P Hunger
  • A Thomas Look
  • R Wesley Rose
  • David L Wiest
  • Michele Rhodes
  • Alejandro Gutierrez
  • John R Jeffers
  • Rugang Zhang
  • Stephen Conway
  • Roman A Timakhov
  • Gerard P Zambetti
  • Michael Slifker
  • Jacqueline Perrigoue
  • Zhigang Tu
  • Stephen Anderson
  • Sang Yun Lee
  • Junmei Wang
  • Frank J Smith
  • Steven R Houser
  • Michael J Slifker
  • Rajesh Kumar Gandhirajan
  • Neelakshi R Jog
  • Michael J May
  • Harish C Chandramoorthy
  • Krishna Irrinki

Detail Information

Publications13

  1. pmc Interferon-γ-induced necrosis: an antitumor biotherapeutic perspective
    Siddharth Balachandran
    Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Interferon Cytokine Res 33:171-80. 2013
    ..Although this review will focus on exploiting IFN-γ-induced necrosis for treatment of renal cell carcinoma, these approaches are also directly applicable to several human cancers in which IFNs have shown therapeutic potential...
  2. pmc NF-κB inhibition by bortezomib permits IFN-γ-activated RIP1 kinase-dependent necrosis in renal cell carcinoma
    Roshan J Thapa
    Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, PA, USA
    Mol Cancer Ther 12:1568-78. 2013
    ..When taken together with the observation that NF-κB signaling is elevated in RCCs, these results provide rationale for the combined use of IFN-γ and bortezomib in the treatment of metastatic RCCs...
  3. pmc NF-kappaB protects cells from gamma interferon-induced RIP1-dependent necroptosis
    Roshan J Thapa
    Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Cell Biol 31:2934-46. 2011
    ..Together, these studies demonstrate that NF-κB protects cells from IFN-γ-mediated necroptosis by transcriptionally activating a survival response that quenches ROS to preserve mitochondrial integrity...
  4. pmc Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases
    Roshan J Thapa
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 110:E3109-18. 2013
    ..Collectively, these findings outline a mechanism of IFN-induced RIP kinase-dependent necrotic cell death and identify FADD and caspases as negative regulators of this process. ..
  5. pmc Requirement of FADD, NEMO, and BAX/BAK for aberrant mitochondrial function in tumor necrosis factor alpha-induced necrosis
    Krishna M Irrinki
    Department of Biochemistry, Temple University, Philadelphia, PA 19140, USA
    Mol Cell Biol 31:3745-58. 2011
    ..Finally, elimination of BAX and BAK or overexpression of Bcl-x(L) protects cells from necroptosis at a later step. These findings provide evidence that mitochondria play an amplifying role in inflammation-induced necroptosis...
  6. pmc Anti-CD70 immunocytokines for exploitation of interferon-γ-induced RIP1-dependent necrosis in renal cell carcinoma
    Peirong Chen
    Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 8:e61446. 2013
    ..These results provide a foundation for the in vivo exploitation of IFN-γ-driven tumoricidal activity in RCC...
  7. pmc Identification of STAT2 serine 287 as a novel regulatory phosphorylation site in type I interferon-induced cellular responses
    Håkan C Steen
    Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 288:747-58. 2013
    ..Altogether, we have uncovered that in response to type I IFN, STAT2 is serine phosphorylated in the coiled-coil domain that when phosphorylated can negatively regulate the biological activities of type I IFNs...
  8. pmc STAT1-independent control of a neurotropic measles virus challenge in primary neurons and infected mice
    Lauren A O'Donnell
    Program in Immune Cell Development and Host Defense, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Immunol 188:1915-23. 2012
    ..Moreover, the canonical IFN-γ-triggered STAT1 gene expression profile was not induced in STAT1-deficient neurons, suggesting that IFN-γ regulates neuronal STAT1-independent pathways to control viral replication...
  9. pmc Interferon impedes an early step of hepatitis delta virus infection
    Ziying Han
    Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e22415. 2011
    ..Thus in vivo, the success of long-term interferon therapy for chronic HDV, may likewise involve blocking HDV spread by interfering with the initiation of productive infection of naïve hepatocytes...
  10. pmc Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B
    Shuyun Rao
    Blood Cell Development and Cancer Keystone, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Blood 120:3764-73. 2012
    ..Our finding that Rpl22 inactivation promotes transformation by inducing expression of Lin28B provides the first insight into the mechanistic basis by which mutations in Rpl22, and perhaps some other RP genes, increases cancer risk...
  11. pmc Meta-analysis identifies NF-κB as a therapeutic target in renal cancer
    Suraj Peri
    Department of Biostatistics and Bioinformatics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 8:e76746. 2013
    ..To determine the expression patterns of NF-κB regulators and target genes in clear cell renal cell carcinoma (ccRCC), their correlation with von Hippel Lindau (VHL) mutational status, and their association with survival outcomes...
  12. pmc Crosstalk between the type 1 interferon and nuclear factor kappa B pathways confers resistance to a lethal virus infection
    Daniel Rubio
    Immune Cell Development and Host Defense Program, Research Institute of Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Cell Host Microbe 13:701-10. 2013
    ..These findings may also explain why some pathogens target both pathways to cause disease...
  13. pmc Distinct roles for the NF-kappa B RelA subunit during antiviral innate immune responses
    Suresh H Basagoudanavar
    Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Room 224, Reimann Building, 333 Cottman Ave, Philadelphia, PA 19111, USA
    J Virol 85:2599-610. 2011
    ....