Mark D Andrake

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. pmc Nuclear import of Avian Sarcoma Virus integrase is facilitated by host cell factors
    Mark D Andrake
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Retrovirology 5:73. 2008
  2. doi request reprint Retroviral Integrase: Then and Now
    Mark D Andrake
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 email
    Annu Rev Virol 2:241-64. 2015
  3. pmc Mode of inhibition of HIV-1 Integrase by a C-terminal domain-specific monoclonal antibody
    Joseph Ramcharan
    The Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Retrovirology 3:34. 2006
  4. pmc Comparison of metal-dependent catalysis by HIV-1 and ASV integrase proteins using a new and rapid, moderate throughput assay for joining activity in solution
    Mark D Andrake
    Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    AIDS Res Ther 6:14. 2009
  5. pmc Architecture and assembly of HIV integrase multimers in the absence of DNA substrates
    Ravi Shankar Bojja
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 288:7373-86. 2013
  6. pmc Retroviral integrases promote fraying of viral DNA ends
    Richard A Katz
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 286:25710-8. 2011
  7. doi request reprint Systematic evaluation of underlying defects in DNA repair as an approach to case-only assessment of familial prostate cancer
    Emmanuelle Nicolas
    Programs in Genomics, Fox Chase Cancer Center, Philadelphia, PA, USA
    Oncotarget 6:39614-33. 2015
  8. pmc A modified HSP70 inhibitor shows broad activity as an anticancer agent
    Gregor M Balaburski
    Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, PA 19104, USA
    Mol Cancer Res 11:219-29. 2013
  9. doi request reprint Defects in DNA Repair Genes Predict Response to Neoadjuvant Cisplatin-based Chemotherapy in Muscle-invasive Bladder Cancer
    Elizabeth R Plimack
    Fox Chase Cancer Center, Philadelphia, PA, USA Electronic address
    Eur Urol 68:959-67. 2015
  10. pmc Architecture of a full-length retroviral integrase monomer and dimer, revealed by small angle X-ray scattering and chemical cross-linking
    Ravi S Bojja
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 286:17047-59. 2011

Collaborators

  • Ilya G Serebriiskii
  • Yan Zhou
  • Yu Ning Wong
  • Brian L Egleston
  • Alexander Kutikov
  • Neil Beeharry
  • Maureen E Murphy
  • Roland L Dunbrack
  • George Merkel
  • Anna Marie Skalka
  • Erica A Golemis
  • Elizabeth R Plimack
  • Eric A Ross
  • Emmanuelle Nicolas
  • Ravi Shankar Bojja
  • Gregor M Balaburski
  • Steven Weigand
  • Ravi S Bojja
  • Richard A Katz
  • Joseph Ramcharan
  • Costas D Lallas
  • David Y T Chen
  • Mary B Daly
  • Norma Palma
  • Dale L Bodian
  • David J McConkey
  • Katherine Alpaugh
  • Roman Yelensky
  • Veda N Giri
  • Richard E Greenberg
  • Elizabeth D Handorf
  • Joseph G Vockley
  • Marijo Bilusic
  • Michael Slifker
  • Edouard J Trabulsi
  • Vincent A Miller
  • Rosalia Viterbo
  • Sanjeevani Arora
  • Jean Hoffman-Censits
  • Essel Dulaimi
  • Michael J Hall
  • Timothy A Brennan
  • Seth Hayik
  • Jessie Villanueva
  • Julia I Ju Leu
  • Tim Yen
  • Donna L George
  • Gao Zhang
  • Meenhard Herlyn
  • Adam Henderson
  • Marissa Kummerling
  • Heinrich Roder
  • Olya Yarychkivska
  • Diana M Colleluori

Detail Information

Publications10

  1. pmc Nuclear import of Avian Sarcoma Virus integrase is facilitated by host cell factors
    Mark D Andrake
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Retrovirology 5:73. 2008
    ..The sequence is distinct from all known NLSs but, like many, contains basic residues that are essential for activity...
  2. doi request reprint Retroviral Integrase: Then and Now
    Mark D Andrake
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 email
    Annu Rev Virol 2:241-64. 2015
    ..A more detailed account of recent analyses of integrase structure follows, as they have provided valuable insights into enzyme function and raised important new questions. ..
  3. pmc Mode of inhibition of HIV-1 Integrase by a C-terminal domain-specific monoclonal antibody
    Joseph Ramcharan
    The Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Retrovirology 3:34. 2006
    ..To gain additional insight into the mode of inhibition we also measured the DNA binding capacity and enzymatic activities of the Ala substituted proteins...
  4. pmc Comparison of metal-dependent catalysis by HIV-1 and ASV integrase proteins using a new and rapid, moderate throughput assay for joining activity in solution
    Mark D Andrake
    Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    AIDS Res Ther 6:14. 2009
    ..The assay is validated, and its utility demonstrated in a comparison of the metal-dependent activities of HIV-1 and ASV IN proteins...
  5. pmc Architecture and assembly of HIV integrase multimers in the absence of DNA substrates
    Ravi Shankar Bojja
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 288:7373-86. 2013
    ..These models of full-length HIV IN provide new insight into multimer assembly and suggest additional approaches for enzyme inhibition...
  6. pmc Retroviral integrases promote fraying of viral DNA ends
    Richard A Katz
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 286:25710-8. 2011
    ..We conclude that frayed ends represent a functional intermediate in which DNA termini can be sampled for suitability for endonucleolytic processing...
  7. doi request reprint Systematic evaluation of underlying defects in DNA repair as an approach to case-only assessment of familial prostate cancer
    Emmanuelle Nicolas
    Programs in Genomics, Fox Chase Cancer Center, Philadelphia, PA, USA
    Oncotarget 6:39614-33. 2015
    ..This work suggests the value of focusing on underlying defects in DNA damage in familial prostate cancer risk assessment and demonstrates an operational framework for exome sequencing in case-only prostate cancer genetic evaluation. ..
  8. pmc A modified HSP70 inhibitor shows broad activity as an anticancer agent
    Gregor M Balaburski
    Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, PA 19104, USA
    Mol Cancer Res 11:219-29. 2013
    ..PES-Cl is thus a promising new anticancer compound with several notable mechanisms of action...
  9. doi request reprint Defects in DNA Repair Genes Predict Response to Neoadjuvant Cisplatin-based Chemotherapy in Muscle-invasive Bladder Cancer
    Elizabeth R Plimack
    Fox Chase Cancer Center, Philadelphia, PA, USA Electronic address
    Eur Urol 68:959-67. 2015
    ..Validated biomarkers predictive of response are currently lacking...
  10. pmc Architecture of a full-length retroviral integrase monomer and dimer, revealed by small angle X-ray scattering and chemical cross-linking
    Ravi S Bojja
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 286:17047-59. 2011
    ..These results suggest a pathway for formation of functional IN-DNA complexes that has not previously been considered and possible strategies for preventing such assembly...