Mark D Andrake

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. pmc Nuclear import of Avian Sarcoma Virus integrase is facilitated by host cell factors
    Mark D Andrake
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Retrovirology 5:73. 2008
  2. pmc Mode of inhibition of HIV-1 Integrase by a C-terminal domain-specific monoclonal antibody
    Joseph Ramcharan
    The Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Retrovirology 3:34. 2006
  3. pmc Comparison of metal-dependent catalysis by HIV-1 and ASV integrase proteins using a new and rapid, moderate throughput assay for joining activity in solution
    Mark D Andrake
    Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    AIDS Res Ther 6:14. 2009
  4. pmc Architecture and assembly of HIV integrase multimers in the absence of DNA substrates
    Ravi Shankar Bojja
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 288:7373-86. 2013
  5. pmc Retroviral integrases promote fraying of viral DNA ends
    Richard A Katz
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 286:25710-8. 2011
  6. pmc A modified HSP70 inhibitor shows broad activity as an anticancer agent
    Gregor M Balaburski
    Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, PA 19104, USA
    Mol Cancer Res 11:219-29. 2013
  7. pmc Architecture of a full-length retroviral integrase monomer and dimer, revealed by small angle X-ray scattering and chemical cross-linking
    Ravi S Bojja
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 286:17047-59. 2011

Collaborators

  • Maureen E Murphy
  • Anna Marie Skalka
  • George Merkel
  • Roland L Dunbrack
  • Ravi Shankar Bojja
  • Gregor M Balaburski
  • Steven Weigand
  • Richard A Katz
  • Ravi S Bojja
  • Joseph Ramcharan
  • Julia I Ju Leu
  • Jessie Villanueva
  • Meenhard Herlyn
  • Gao Zhang
  • Neil Beeharry
  • Donna L George
  • Tim Yen
  • Seth Hayik
  • Marissa Kummerling
  • Olya Yarychkivska
  • Adam Henderson
  • Heinrich Roder
  • Diana M Colleluori

Detail Information

Publications7

  1. pmc Nuclear import of Avian Sarcoma Virus integrase is facilitated by host cell factors
    Mark D Andrake
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Retrovirology 5:73. 2008
    ..The sequence is distinct from all known NLSs but, like many, contains basic residues that are essential for activity...
  2. pmc Mode of inhibition of HIV-1 Integrase by a C-terminal domain-specific monoclonal antibody
    Joseph Ramcharan
    The Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Retrovirology 3:34. 2006
    ..To gain additional insight into the mode of inhibition we also measured the DNA binding capacity and enzymatic activities of the Ala substituted proteins...
  3. pmc Comparison of metal-dependent catalysis by HIV-1 and ASV integrase proteins using a new and rapid, moderate throughput assay for joining activity in solution
    Mark D Andrake
    Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    AIDS Res Ther 6:14. 2009
    ..The assay is validated, and its utility demonstrated in a comparison of the metal-dependent activities of HIV-1 and ASV IN proteins...
  4. pmc Architecture and assembly of HIV integrase multimers in the absence of DNA substrates
    Ravi Shankar Bojja
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 288:7373-86. 2013
    ..These models of full-length HIV IN provide new insight into multimer assembly and suggest additional approaches for enzyme inhibition...
  5. pmc Retroviral integrases promote fraying of viral DNA ends
    Richard A Katz
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 286:25710-8. 2011
    ..We conclude that frayed ends represent a functional intermediate in which DNA termini can be sampled for suitability for endonucleolytic processing...
  6. pmc A modified HSP70 inhibitor shows broad activity as an anticancer agent
    Gregor M Balaburski
    Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, PA 19104, USA
    Mol Cancer Res 11:219-29. 2013
    ..PES-Cl is thus a promising new anticancer compound with several notable mechanisms of action...
  7. pmc Architecture of a full-length retroviral integrase monomer and dimer, revealed by small angle X-ray scattering and chemical cross-linking
    Ravi S Bojja
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 286:17047-59. 2011
    ..These results suggest a pathway for formation of functional IN-DNA complexes that has not previously been considered and possible strategies for preventing such assembly...