T B Ledue

Summary

Affiliation: Foundation for Blood Research
Country: USA

Publications

  1. ncbi request reprint Analytical evaluation of particle-enhanced immunonephelometric assays for C-reactive protein, serum amyloid A and mannose-binding protein in human serum
    T B Ledue
    Foundation for Blood Research, Scarborough, Maine 04070 0190, USA
    Ann Clin Biochem 35:745-53. 1998
  2. pmc Evaluation of the recombinant VlsE-based liaison chemiluminescence immunoassay for detection of Borrelia burgdorferi and diagnosis of Lyme disease
    Thomas B Ledue
    Foundation for Blood Research, 8 Science Park Road, Scarborough, ME 04074, USA
    Clin Vaccine Immunol 15:1796-804. 2008
  3. ncbi request reprint Preanalytic and analytic sources of variations in C-reactive protein measurement: implications for cardiovascular disease risk assessment
    Thomas B Ledue
    Foundation for Blood Research, 69 U S Route One, Scarborough, ME 04070 0190, USA
    Clin Chem 49:1258-71. 2003
  4. doi request reprint Development and validation of 14 human serum protein assays on the Roche cobasĀ® c 501
    Thomas B Ledue
    Foundation for Blood Research, Scarborough, Maine 04074, USA
    J Clin Lab Anal 25:52-60. 2011
  5. ncbi request reprint Development of immunoturbidimetric assays for fourteen human serum proteins on the Hitachi 912
    Thomas B Ledue
    Foundation for Blood Research, Scarborough, ME 04070 0190, USA
    Clin Chem Lab Med 40:520-8. 2002
  6. ncbi request reprint High sensitivity immunoassays for C-reactive protein: promises and pitfalls
    T B Ledue
    Foundation for Blood Research, Scarborough, ME 04070 0190, USA
    Clin Chem Lab Med 39:1171-6. 2001
  7. ncbi request reprint Commutability of serum protein values: persisting bias among manufacturers using values assigned from the certified reference material 470 (CRM 470) in the United States
    T B Ledue
    Foundation for Blood Research, Scarborough, ME 04070 0190, USA
    Clin Chem Lab Med 39:1129-33. 2001
  8. ncbi request reprint Reference distributions for the negative acute-phase serum proteins, albumin, transferrin and transthyretin: a practical, simple and clinically relevant approach in a large cohort
    R F Ritchie
    Foundation for Blood Research, Scarborough, Maine 04074, USA
    J Clin Lab Anal 13:273-9. 1999
  9. ncbi request reprint Patient hydration: a major source of laboratory uncertainty
    Robert F Ritchie
    Foundation for Blood Research, Scarborough, ME 04070 0190, USA
    Clin Chem Lab Med 45:158-66. 2007
  10. ncbi request reprint Serologic associations of anti-cytoplasmic antibodies identified during anti-nuclear antibody testing
    Wendy Y Craig
    Foundation for Blood Research, Scarborough, ME 04070 0190, USA
    Clin Chem Lab Med 44:1283-6. 2006

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Analytical evaluation of particle-enhanced immunonephelometric assays for C-reactive protein, serum amyloid A and mannose-binding protein in human serum
    T B Ledue
    Foundation for Blood Research, Scarborough, Maine 04070 0190, USA
    Ann Clin Biochem 35:745-53. 1998
    ..We observed no relationship with CRP concentration and age; however, SAA levels increased with age while MBP levels decreased. The BNII provides a simple, rapid and sensitive system for measuring CRP, SAA and MBP in human serum...
  2. pmc Evaluation of the recombinant VlsE-based liaison chemiluminescence immunoassay for detection of Borrelia burgdorferi and diagnosis of Lyme disease
    Thomas B Ledue
    Foundation for Blood Research, 8 Science Park Road, Scarborough, ME 04074, USA
    Clin Vaccine Immunol 15:1796-804. 2008
    ..1%, and an overall agreement of 97.1% between the DiaSorin recombinant VlsE chemiluminescence immunoassay and the Immunetics peptide-based C6 enzyme-linked immunosorbent assay...
  3. ncbi request reprint Preanalytic and analytic sources of variations in C-reactive protein measurement: implications for cardiovascular disease risk assessment
    Thomas B Ledue
    Foundation for Blood Research, 69 U S Route One, Scarborough, ME 04070 0190, USA
    Clin Chem 49:1258-71. 2003
    ..Nevertheless, there remains considerable work to optimize the utility of this marker for risk assessment...
  4. doi request reprint Development and validation of 14 human serum protein assays on the Roche cobasĀ® c 501
    Thomas B Ledue
    Foundation for Blood Research, Scarborough, Maine 04074, USA
    J Clin Lab Anal 25:52-60. 2011
    ..These newly developed assays provide precise and accurate results with high throughput, but without the associated cost of a dedicated instrument...
  5. ncbi request reprint Development of immunoturbidimetric assays for fourteen human serum proteins on the Hitachi 912
    Thomas B Ledue
    Foundation for Blood Research, Scarborough, ME 04070 0190, USA
    Clin Chem Lab Med 40:520-8. 2002
    ..In conclusion, the newly developed assays on the Hitachi 912 offer high throughput (>250 tests per hour) without the associated cost of a dedicated instrument for protein assays...
  6. ncbi request reprint High sensitivity immunoassays for C-reactive protein: promises and pitfalls
    T B Ledue
    Foundation for Blood Research, Scarborough, ME 04070 0190, USA
    Clin Chem Lab Med 39:1171-6. 2001
    ..Factors such as assay precision, sensitivity, matrix effects, calibration, and standardization need to be addressed adequately by the in vitro diagnostic industry and the clinical laboratory...
  7. ncbi request reprint Commutability of serum protein values: persisting bias among manufacturers using values assigned from the certified reference material 470 (CRM 470) in the United States
    T B Ledue
    Foundation for Blood Research, Scarborough, ME 04070 0190, USA
    Clin Chem Lab Med 39:1129-33. 2001
    ..Further efforts at standardization are needed in order to improve commutability of results among laboratories and are essential if universal reference intervals are to be developed...
  8. ncbi request reprint Reference distributions for the negative acute-phase serum proteins, albumin, transferrin and transthyretin: a practical, simple and clinically relevant approach in a large cohort
    R F Ritchie
    Foundation for Blood Research, Scarborough, Maine 04074, USA
    J Clin Lab Anal 13:273-9. 1999
    ..The ultimate interpretation of an individual's measurement relies upon the clinical setting...
  9. ncbi request reprint Patient hydration: a major source of laboratory uncertainty
    Robert F Ritchie
    Foundation for Blood Research, Scarborough, ME 04070 0190, USA
    Clin Chem Lab Med 45:158-66. 2007
    ....
  10. ncbi request reprint Serologic associations of anti-cytoplasmic antibodies identified during anti-nuclear antibody testing
    Wendy Y Craig
    Foundation for Blood Research, Scarborough, ME 04070 0190, USA
    Clin Chem Lab Med 44:1283-6. 2006
    ..Moreover, few data are available that address this laboratory situation...
  11. ncbi request reprint Reference distributions for apolipoproteins AI and B and B/AI ratios: comparison of a large cohort to the world's literature
    Robert F Ritchie
    Foundation for Blood Research, Scarborough, Maine
    J Clin Lab Anal 20:218-26. 2006
    ..This meta-analysis provides support and reassurance that many of the smaller reference intervals published previously fall within reasonable limits of out large population...
  12. ncbi request reprint Reference distributions for apolipoproteins AI and B and the apolipoprotein B/AI ratios: a practical and clinically relevant approach in a large cohort
    Robert F Ritchie
    Foundation for Blood Research, Scarborough, Maine
    J Clin Lab Anal 20:209-17. 2006
    ....
  13. ncbi request reprint Reference distributions for alpha2-macroglobulin: a practical, simple and clinically relevant approach in a large cohort
    Robert F Ritchie
    Foundation for Blood Research, Scarborough, Maine, USA
    J Clin Lab Anal 18:139-47. 2004
    ..When patient data are normalized in this manner, the distribution parameters can be used to assign a centile corresponding to an individual's measurement thus simplifying interpretation...
  14. ncbi request reprint Reference distributions for complement proteins C3 and C4: a practical, simple and clinically relevant approach in a large cohort
    Robert F Ritchie
    Foundation for Blood Research, Scarborough, Maine 04074, USA
    J Clin Lab Anal 18:1-8. 2004
    ..When patient data are normalized in this manner, the distribution parameters can be used to assign a centile corresponding to an individual's measurement, thus simplifying interpretation...
  15. ncbi request reprint Reference distributions for serum iron and transferrin saturation: a comparison of a large cohort to the world's literature
    Robert F Ritchie
    Foundation for Blood Research, Scarborough, Maine 04070 0190, USA
    J Clin Lab Anal 16:246-52. 2002
    ..Our 95% reference ranges are somewhat broader than those of the smaller studies, but they agree well with those of the larger ones...
  16. ncbi request reprint Reference distributions for serum iron and transferrin saturation: a practical, simple, and clinically relevant approach in a large cohort
    Robert F Ritchie
    Foundation for Blood Research, Scarborough, Maine 04070 0190, USA
    J Clin Lab Anal 16:237-45. 2002
    ..After normalization, the Gaussian parameters can be used to assign a corresponding centile to an individual's measurement, simplifying interpretation. These data provide new and more detailed reference ranges for serum iron and TSAT...
  17. ncbi request reprint Laboratory assessment of the acute phase response: using CRP as a model
    Robert F Ritchie
    Foundation for Blood Research, Scarborough, ME, USA
    Methods Mol Biol 225:343-52. 2003
  18. ncbi request reprint Reference distributions for immunoglobulins A, G, and M: a practical, simple, and clinically relevant approach in a large cohort
    R F Ritchie
    Foundation for Blood Research, Scarborough, Maine 04074, USA
    J Clin Lab Anal 12:363-70. 1998
    ..Insights gained from this study can help improve and simplify the interpretation of immunoglobulin measurements...
  19. ncbi request reprint Commutability of the CRM 470 C-reactive protein value in the Dade Behring N High Sensitivity CRP assay
    A Myron Johnson
    University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Clin Chem Lab Med 41:177-82. 2003
    ..An alternative approach is suggested...