Joshua M Costin
Affiliation: Fort Myers
- Neutralizing and non-neutralizing monoclonal antibodies against dengue virus E protein derived from a naturally infected patientJohn S Schieffelin
Section of Pediatric Infectious Disease, Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA, USA
Virol J 7:28. 2010..Naturally occurring human monoclonal antibodies can help us understand the protective and pathogenic roles of the humoral immune system in dengue virus infection...
- Cytopathic mechanisms of HIV-1Joshua M Costin
Biotechnology Research Group, Department of Biology, Florida Gulf Coast University, 10501 FGCU Blvd, S, Fort Myers, FL 33965, USA
Virol J 4:100. 2007..This review gathers information on TM in an attempt to shed some light on the functional regions of this protein...
- Viroporin potential of the lentivirus lytic peptide (LLP) domains of the HIV-1 gp41 proteinJoshua M Costin
Biotechnology Research Group, Department of Biology, Florida Gulf Coast University, 10501 FGCU Blvd S, Fort Myers, FL 33965, USA
Virol J 4:123. 2007..These sequences have been dubbed lentiviral lytic peptides (LLP) -1, -2, and -3...
- Mechanistic study of broadly neutralizing human monoclonal antibodies against dengue virus that target the fusion loopJoshua M Costin
Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, Florida, USA
J Virol 87:52-66. 2013..Characterization of hMAbs targeting this region may provide new insights into DENV vaccine and therapeutic strategies...
- Viral entry inhibitors block dengue antibody-dependent enhancement in vitroCindo O Nicholson
Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, FL 33965, USA
Antiviral Res 89:71-4. 2011..Both peptides were able to inhibit ADE, showing that entry inhibitors are possible candidates for the development of specific treatment for severe DENV infection...
- In vitro inhibition of dengue virus entry by p-sulfoxy-cinnamic acid and structurally related combinatorial chemistriesCraig R Rees
Biotechnology Research Group, Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, FL 33965, USA
Antiviral Res 80:135-42. 2008..These and other related chemistries may be useful as reagents for studying DENV entry, capturing and detecting DENV, and development of pharmaceuticals...
- Structural optimization and de novo design of dengue virus entry inhibitory peptidesJoshua M Costin
Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, Florida, United States of America
PLoS Negl Trop Dis 4:e721. 2010..These peptides may be useful for characterization of intermediate states in the membrane fusion process, investigation of DENV receptor molecules, and as lead compounds for drug discovery...