Joan E Roberts
Affiliation: Fordham University
- The role of A2E in prevention or enhancement of light damage in human retinal pigment epithelial cellsJoan E Roberts
Department of Natural Sciences, Fordham University, New York, NY 10023, USA
Photochem Photobiol 75:184-90. 2002..These results imply that the role of A2E is not simple and may change over the course of a lifetime. A2E itself may play a protective role in the young eye but a toxic role in older eyes...
- Screening for ocular phototoxicityJoan E Roberts
Department of Natural Sciences, Fordham University, New York, New York 10003, USA
Int J Toxicol 21:491-500. 2002..Preclinical safety testing may prevent ocular side effects that can range from mild, reversible blurred vision to permanent blindness...
- Effects of melatonin and its receptor antagonist on retinal pigment epithelial cells against hydrogen peroxide damageRichard B Rosen
Department of Ophthalmology, New York Eye and Ear Infirmary, New York Medical College, New York, NY, USA
Mol Vis 18:1640-8. 2012....
- Simulated microgravity induced damage in human retinal pigment epithelial cellsJoan E Roberts
Department of Natural Sciences, Fordham University, New York, NY 10023, USA
Mol Vis 12:633-8. 2006..The goal of this study was to determine the potential damage to the human retina that may occur from weightlessness during space flight using simulated microgravity...
- Phototoxicity and cytotoxicity of fullerol in human lens epithelial cellsJoan E Roberts
Department of Natural Sciences, Fordham University, 113 West 60th Street, New York City, NY 10023, USA
Toxicol Appl Pharmacol 228:49-58. 2008..Before fullerols are used to deliver drugs to the eye, they should be tested for photo- and cytotoxicity in vivo...
- Ocular phototoxicityJ E Roberts
Department of Natural Sciences, Fordham University, 113 West 60th Street, New York, NY 10023, USA
J Photochem Photobiol B 64:136-43. 2001..We now know many of the reasons for these effects, and with this knowledge methods are being developed to interfere with these damaging processes...
- Ultraviolet radiation as a risk factor for cataract and macular degenerationJoan E Roberts
Department of Natural Sciences, Fordham University, New York City, NY 10023, USA
Eye Contact Lens 37:246-9. 2011..For those over 50 years old, it would be of value to remove these wavelengths of light with specially designed sunglasses or contact lenses to reduce the risk of age-related macular degeneration...
- Light and immunomodulationJ E Roberts
Department of Natural Sciences, Fordham University, 113 West 60th Street, New York, New York 10023, USA
Ann N Y Acad Sci 917:435-45. 2000..It is therefore important, when reporting neuroendocrine immune findings, to control the intensity, timing and wavelength of ambient light...
- Photochemical studies on xanthurenic acid J E Roberts
Fordham University, New York City, NY 10023, USA
Photochem Photobiol 72:467-71. 2000....
- Update on the positive effects of light in humansJoan E Roberts
Fordham University, Department of Natural Sciences, 113 West 60th Street, New York, NY 10023, USA
Photochem Photobiol 81:490-2. 2005..Light that reaches the human eye has two fundamental biological functions: regulation of the visual cycle and of circadian rhythm. We report here the most recent developments in both of these areas...
- Photophysical studies on melatonin and its receptor agonistsJ E Roberts
Fordham University, New York, NY 10023, USA
J Pineal Res 29:94-9. 2000..It appears that the production of singlet oxygen by melatonin would not be sufficient to directly block the proliferation of melanoma cells, but may activate gene products that could contribute to the oncostatic effect...
- Melatonin receptors in human uveal melanocytes and melanoma cellsJ E Roberts
Department of Natural Sciences, Fordham University, New York, New York 10023, USA
J Pineal Res 28:165-71. 2000..Furthermore, the expression of RNA encoding melatonin receptors in normal uveal melanocytes suggests that melatonin may play a role in the function of these cells...
- Uveal melanocytes, ocular pigment epithelium, and Müller cells in culture: in vitro toxicologyDan Ning Hu
Tissue Culture Center, The New York Eye and Ear Infirmary, New York, New York 10003, USA
Int J Toxicol 21:465-72. 2002..Cultured uveal melanocytes, pigment epithelial cells, and Müller cells can be used to study the toxicology of these cells in vitro...
- Retinal photodamage by endogenous and xenobiotic agentsAlbert R Wielgus
Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA
Photochem Photobiol 88:1320-45. 2012..This article will review the underlying reasons why visible light in general and short blue visible light in particular dramatically raises the risk of photodamage to the human retina...
- Photooxidation of lens proteins with xanthurenic acid: a putative chromophore for cataractogenesisJ E Roberts
Fordham University, New York, NY, USA
Photochem Photobiol 74:740-4. 2001..Our results suggest that naturally occurring Xan is a chromophore capable of photosensitization and photooxidation of lens proteins. Furthermore, this compound could play a role in age-related cataractogenesis...
- Phototoxicity in human lens epithelial cells promoted by St. John's WortYu Ying He
Laboratory of Chemistry and Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 10023, USA
Photochem Photobiol 80:583-6. 2004..Thus, ingested SJW is potentially phototoxic to the eye and could contribute to early cataractogenesis. Precautions should be taken to protect the eye from intense sunlight while taking SJW...
- Influence of dietary melatonin on photoreceptor survival in the rat retina: an ocular toxicity studyAllan F Wiechmann
Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
Exp Eye Res 86:241-50. 2008..Chronic exposure to natural or artificial light and simultaneous intake of melatonin may potentially contribute to a significant loss of photoreceptor cells in the aging retina...
- Phototoxicity in human retinal pigment epithelial cells promoted by hypericin, a component of St. John's wortAlbert R Wielgus
Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
Photochem Photobiol 83:706-13. 2007..Thus, ingested SJW is potentially phototoxic to the retina and could contribute to retinal or early macular degeneration...
- Comparison of the aerobic photoreactivity of A2E with its precursor retinalAnna Pawlak
Department of Biophysics, Institute of Molecular Biology and Biotechnology, Jagiellonian University, Krakow, Poland
Photochem Photobiol 77:253-8. 2003..The collective data support the conclusion that A2E does not produce sufficient concentrations of ROI to be the primary phototoxic constituent of lipofuscin...
- Spectroscopic properties and reactivity of free radical forms of A2EAgnieszka Broniec
Department of Biophysics, Faculty of Biotechnology, Jagiellonian University, Gronostajowa 7, 30 387 Krakow, Poland
Free Radic Biol Med 38:1037-46. 2005..In benzene we observed an efficient oxidation of zeaxanthin to its radical cation by the A2E radical cation; this may be relevant to a detrimental effect of A2E in vision...
- Time-resolved microspectrofluorimetry and fluorescence lifetime imaging of hypericin in human retinal pigment epithelial cellsPaola Taroni
INFM Department of Physics and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milan, Italy
Photochem Photobiol 81:524-8. 2005..The latter change is observed also when high concentrations are reached locally, due to more efficient localization within the cell...