Lilin Zhong

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. doi request reprint Antibody-mediated synergy and interference in the neutralization of SARS-CoV at an epitope cluster on the spike protein
    Lilin Zhong
    Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 390:1056-60. 2009
  2. pmc Structural evidence for a bifurcated mode of action in the antibody-mediated neutralization of hepatitis C virus
    Lu Deng
    Division of Hematology, Office of Blood Research and Review, and Division of Viral Products, Office of Vaccine Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 110:7418-22. 2013
  3. pmc Amino acid residue-specific neutralization and nonneutralization of hepatitis C virus by monoclonal antibodies to the E2 protein
    Hongying Duan
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    J Virol 86:12686-94. 2012
  4. doi request reprint Hepatitis C virus with a naturally occurring single amino-acid substitution in the E2 envelope protein escapes neutralization by naturally-induced and vaccine-induced antibodies
    Hongying Duan
    Division of Viral Products, Center for Biologics Evaluation and Research, FDA, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Vaccine 28:4138-44. 2010
  5. pmc Depletion of interfering antibodies in chronic hepatitis C patients and vaccinated chimpanzees reveals broad cross-genotype neutralizing activity
    Pei Zhang
    Division of Hematology and Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:7537-41. 2009
  6. pmc Human antibodies can cross guinea pig placenta and bind its neonatal Fc Receptor: implications for studying immune prophylaxis and therapy during pregnancy
    Evi Budo Struble
    Laboratory of Plasma Derivatives, Division of Hematology, OBRR, FDA, Bethesda, MD 20892, USA
    Clin Dev Immunol 2012:538701. 2012

Collaborators

  • Pei Zhang
  • Evi Budo Struble
  • Li Ma
  • Harvey Alter
  • Hongying Duan
  • Lu Deng
  • Stephen Feinstone
  • Christine Harman
  • Maria Luisa Virata-Theimer
  • Hailing Yan
  • Zhong Zhao
  • Marian Major
  • Alla Kachko
  • Shivani Pandey
  • Dino Feigelstock
  • Kathleen Mihalik

Detail Information

Publications6

  1. doi request reprint Antibody-mediated synergy and interference in the neutralization of SARS-CoV at an epitope cluster on the spike protein
    Lilin Zhong
    Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 390:1056-60. 2009
    ....
  2. pmc Structural evidence for a bifurcated mode of action in the antibody-mediated neutralization of hepatitis C virus
    Lu Deng
    Division of Hematology, Office of Blood Research and Review, and Division of Viral Products, Office of Vaccine Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 110:7418-22. 2013
    ..Our structural insights into the key determinants for the antibody-mediated neutralization may contribute to the immune prophylaxis of HCV infection and the development of an effective HCV vaccine...
  3. pmc Amino acid residue-specific neutralization and nonneutralization of hepatitis C virus by monoclonal antibodies to the E2 protein
    Hongying Duan
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    J Virol 86:12686-94. 2012
    ..Further understanding of the molecular mechanisms of antibody-mediated neutralization and nonneutralization should provide insights for designing a vaccine to control HCV infection in vivo...
  4. doi request reprint Hepatitis C virus with a naturally occurring single amino-acid substitution in the E2 envelope protein escapes neutralization by naturally-induced and vaccine-induced antibodies
    Hongying Duan
    Division of Viral Products, Center for Biologics Evaluation and Research, FDA, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Vaccine 28:4138-44. 2010
    ..Thus, mutation Q412H found in naturally occurring variants could represent an antibody escape mutation. These data may have important implications for vaccine design...
  5. pmc Depletion of interfering antibodies in chronic hepatitis C patients and vaccinated chimpanzees reveals broad cross-genotype neutralizing activity
    Pei Zhang
    Division of Hematology and Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:7537-41. 2009
    ..Our studies contribute to understanding the mechanisms of antibody-mediated neutralization and interference and provide a practical approach to the development of more potent and broadly reactive hepatitis C immune globulins...
  6. pmc Human antibodies can cross guinea pig placenta and bind its neonatal Fc Receptor: implications for studying immune prophylaxis and therapy during pregnancy
    Evi Budo Struble
    Laboratory of Plasma Derivatives, Division of Hematology, OBRR, FDA, Bethesda, MD 20892, USA
    Clin Dev Immunol 2012:538701. 2012
    ..These preliminary data lay the groundwork for introducing pregnant guinea pigs as an appropriate model for the evaluation of antibody therapies and advancing the health of women and neonates...