Lilin Zhong

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi Antibody-mediated synergy and interference in the neutralization of SARS-CoV at an epitope cluster on the spike protein
    Lilin Zhong
    Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 390:1056-60. 2009
  2. ncbi Hepatitis C virus with a naturally occurring single amino-acid substitution in the E2 envelope protein escapes neutralization by naturally-induced and vaccine-induced antibodies
    Hongying Duan
    Division of Viral Products, Center for Biologics Evaluation and Research, FDA, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Vaccine 28:4138-44. 2010
  3. ncbi Depletion of interfering antibodies in chronic hepatitis C patients and vaccinated chimpanzees reveals broad cross-genotype neutralizing activity
    Pei Zhang
    Division of Hematology and Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:7537-41. 2009
  4. ncbi Human antibodies can cross guinea pig placenta and bind its neonatal Fc Receptor: implications for studying immune prophylaxis and therapy during pregnancy
    Evi Budo Struble
    Laboratory of Plasma Derivatives, Division of Hematology, OBRR, FDA, Bethesda, MD 20892, USA
    Clin Dev Immunol 2012:538701. 2012

Collaborators

  • Pei Zhang
  • Evi Budo Struble
  • Hongying Duan
  • A Lesher
  • JOEL BEREN
  • Li Ma
  • Marian Major
  • Stephen Feinstone
  • Evi Struble
  • Dino Feigelstock
  • Kathleen Mihalik

Detail Information

Publications4

  1. ncbi Antibody-mediated synergy and interference in the neutralization of SARS-CoV at an epitope cluster on the spike protein
    Lilin Zhong
    Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 390:1056-60. 2009
    ....
  2. ncbi Hepatitis C virus with a naturally occurring single amino-acid substitution in the E2 envelope protein escapes neutralization by naturally-induced and vaccine-induced antibodies
    Hongying Duan
    Division of Viral Products, Center for Biologics Evaluation and Research, FDA, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Vaccine 28:4138-44. 2010
    ..Thus, mutation Q412H found in naturally occurring variants could represent an antibody escape mutation. These data may have important implications for vaccine design...
  3. ncbi Depletion of interfering antibodies in chronic hepatitis C patients and vaccinated chimpanzees reveals broad cross-genotype neutralizing activity
    Pei Zhang
    Division of Hematology and Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:7537-41. 2009
    ..Our studies contribute to understanding the mechanisms of antibody-mediated neutralization and interference and provide a practical approach to the development of more potent and broadly reactive hepatitis C immune globulins...
  4. ncbi Human antibodies can cross guinea pig placenta and bind its neonatal Fc Receptor: implications for studying immune prophylaxis and therapy during pregnancy
    Evi Budo Struble
    Laboratory of Plasma Derivatives, Division of Hematology, OBRR, FDA, Bethesda, MD 20892, USA
    Clin Dev Immunol 2012:538701. 2012
    ..These preliminary data lay the groundwork for introducing pregnant guinea pigs as an appropriate model for the evaluation of antibody therapies and advancing the health of women and neonates...