Pei Zhang

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. pmc A neutralization epitope in the hepatitis C virus E2 glycoprotein interacts with host entry factor CD81
    Zhong Zhao
    Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
    PLoS ONE 9:e84346. 2014
  2. pmc Depletion of interfering antibodies in chronic hepatitis C patients and vaccinated chimpanzees reveals broad cross-genotype neutralizing activity
    Pei Zhang
    Division of Hematology and Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:7537-41. 2009
  3. pmc Hepatitis C virus epitope-specific neutralizing antibodies in Igs prepared from human plasma
    Pei Zhang
    Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:8449-54. 2007
  4. pmc Neutralization epitope responsible for the hepatitis B virus subtype-specific protection in chimpanzees
    Pei Zhang
    Division of Hematology and Laboratory of Biophysics, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:9214-9. 2006
  5. pmc Structural evidence for a bifurcated mode of action in the antibody-mediated neutralization of hepatitis C virus
    Lu Deng
    Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 110:7418-22. 2013
  6. pmc Amino acid residue-specific neutralization and nonneutralization of hepatitis C virus by monoclonal antibodies to the E2 protein
    Hongying Duan
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    J Virol 86:12686-94. 2012
  7. doi request reprint Hepatitis C virus with a naturally occurring single amino-acid substitution in the E2 envelope protein escapes neutralization by naturally-induced and vaccine-induced antibodies
    Hongying Duan
    Division of Viral Products, Center for Biologics Evaluation and Research, FDA, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Vaccine 28:4138-44. 2010
  8. doi request reprint Antibody-mediated synergy and interference in the neutralization of SARS-CoV at an epitope cluster on the spike protein
    Lilin Zhong
    Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 390:1056-60. 2009
  9. pmc Human antibodies can cross guinea pig placenta and bind its neonatal Fc Receptor: implications for studying immune prophylaxis and therapy during pregnancy
    Evi Budo Struble
    Laboratory of Plasma Derivatives, Division of Hematology, OBRR, FDA, Bethesda, MD 20892, USA
    Clin Dev Immunol 2012:538701. 2012
  10. pmc Epitope mapping by random peptide phage display reveals essential residues for vaccinia extracellular enveloped virion spread
    Yong He
    Laboratory of Plasma Derivatives, Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, FDA CBER OBRR DH LPD, HFM 345, 1401 Rockville Pike, Rockville, MD 20852, USA
    Virol J 9:217. 2012

Collaborators

Detail Information

Publications14

  1. pmc A neutralization epitope in the hepatitis C virus E2 glycoprotein interacts with host entry factor CD81
    Zhong Zhao
    Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
    PLoS ONE 9:e84346. 2014
    ..The characterization of this neutralization epitope with a function in host entry factor CD81 interaction should enhance our understanding of antibody-mediated neutralization of HCV infections. ..
  2. pmc Depletion of interfering antibodies in chronic hepatitis C patients and vaccinated chimpanzees reveals broad cross-genotype neutralizing activity
    Pei Zhang
    Division of Hematology and Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:7537-41. 2009
    ..Our studies contribute to understanding the mechanisms of antibody-mediated neutralization and interference and provide a practical approach to the development of more potent and broadly reactive hepatitis C immune globulins...
  3. pmc Hepatitis C virus epitope-specific neutralizing antibodies in Igs prepared from human plasma
    Pei Zhang
    Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:8449-54. 2007
    ....
  4. pmc Neutralization epitope responsible for the hepatitis B virus subtype-specific protection in chimpanzees
    Pei Zhang
    Division of Hematology and Laboratory of Biophysics, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:9214-9. 2006
    ....
  5. pmc Structural evidence for a bifurcated mode of action in the antibody-mediated neutralization of hepatitis C virus
    Lu Deng
    Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 110:7418-22. 2013
    ..Our structural insights into the key determinants for the antibody-mediated neutralization may contribute to the immune prophylaxis of HCV infection and the development of an effective HCV vaccine...
  6. pmc Amino acid residue-specific neutralization and nonneutralization of hepatitis C virus by monoclonal antibodies to the E2 protein
    Hongying Duan
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    J Virol 86:12686-94. 2012
    ..Further understanding of the molecular mechanisms of antibody-mediated neutralization and nonneutralization should provide insights for designing a vaccine to control HCV infection in vivo...
  7. doi request reprint Hepatitis C virus with a naturally occurring single amino-acid substitution in the E2 envelope protein escapes neutralization by naturally-induced and vaccine-induced antibodies
    Hongying Duan
    Division of Viral Products, Center for Biologics Evaluation and Research, FDA, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Vaccine 28:4138-44. 2010
    ..Thus, mutation Q412H found in naturally occurring variants could represent an antibody escape mutation. These data may have important implications for vaccine design...
  8. doi request reprint Antibody-mediated synergy and interference in the neutralization of SARS-CoV at an epitope cluster on the spike protein
    Lilin Zhong
    Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 390:1056-60. 2009
    ....
  9. pmc Human antibodies can cross guinea pig placenta and bind its neonatal Fc Receptor: implications for studying immune prophylaxis and therapy during pregnancy
    Evi Budo Struble
    Laboratory of Plasma Derivatives, Division of Hematology, OBRR, FDA, Bethesda, MD 20892, USA
    Clin Dev Immunol 2012:538701. 2012
    ..These preliminary data lay the groundwork for introducing pregnant guinea pigs as an appropriate model for the evaluation of antibody therapies and advancing the health of women and neonates...
  10. pmc Epitope mapping by random peptide phage display reveals essential residues for vaccinia extracellular enveloped virion spread
    Yong He
    Laboratory of Plasma Derivatives, Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, FDA CBER OBRR DH LPD, HFM 345, 1401 Rockville Pike, Rockville, MD 20852, USA
    Virol J 9:217. 2012
    ..In this study, we utilized a random phage display library to investigate the epitope recognized by MAb-1G10 that is critical for facilitating cell-to-cell spread of the vaccinia virus...
  11. pmc Neutralizing antibodies to hepatitis C virus (HCV) in immune globulins derived from anti-HCV-positive plasma
    Mei Ying W Yu
    Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:7705-10. 2004
    ..Immune globulins made from anti-HCV-positive plasma and containing broadly reactive neutralizing antibodies may provide a method of preventing HCV infection...
  12. doi request reprint Peptides panned from a phage-displayed random peptide library are useful for the detection of Bacillus anthracis surrogates B. cereus 4342 and B. anthracis Sterne
    Shilpakala Sainath Rao
    Section of Cell Biology, Laboratory of Cellular Hematology, Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 395:93-8. 2010
    ..anthracis Sterne. Overall, our findings validate the usefulness of synthetic versions of phage-derived peptides in combination with Qdot-liquid nanocrystals as high sensitivity bioprobes for various microbial detection platforms...
  13. doi request reprint Expression of immunoglobulin gene with classical V-(D)-J rearrangement in mouse brain neurons
    Jing Huang
    Center for Human Disease Genomics, Institution of Basic Medical Science, Peking University, 38 Xue Yuan Road, 100083 Beijing, China
    Int J Biochem Cell Biol 40:1604-15. 2008
    ..Although the bioactivity of neuron-derived immunoglobulin G was not yet clear, we believed that immunoglobulin G might play an important role in neuronal development...
  14. ncbi request reprint [Immunoglobulin expression in colon cancer cell line HT-29 and its biological activities]
    Yu qing Deng
    Peking University Center for Human Disease Genomics, Beijing 100083, China
    Zhonghua Zhong Liu Za Zhi 28:88-91. 2006
    ..To determine the expression of immunoglobulins in HT-29 cells (an established colon cancer cell line, and explore their effect on the biological activities of the cancer cells.)..