Pei Zhang

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi Depletion of interfering antibodies in chronic hepatitis C patients and vaccinated chimpanzees reveals broad cross-genotype neutralizing activity
    Pei Zhang
    Division of Hematology and Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:7537-41. 2009
  2. ncbi Neutralization epitope responsible for the hepatitis B virus subtype-specific protection in chimpanzees
    Pei Zhang
    Division of Hematology and Laboratory of Biophysics, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:9214-9. 2006
  3. ncbi Hepatitis C virus epitope-specific neutralizing antibodies in Igs prepared from human plasma
    Pei Zhang
    Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:8449-54. 2007
  4. ncbi Amino acid residue-specific neutralization and nonneutralization of hepatitis C virus by monoclonal antibodies to the E2 protein
    Hongying Duan
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    J Virol 86:12686-94. 2012
  5. ncbi Hepatitis C virus with a naturally occurring single amino-acid substitution in the E2 envelope protein escapes neutralization by naturally-induced and vaccine-induced antibodies
    Hongying Duan
    Division of Viral Products, Center for Biologics Evaluation and Research, FDA, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Vaccine 28:4138-44. 2010
  6. ncbi Antibody-mediated synergy and interference in the neutralization of SARS-CoV at an epitope cluster on the spike protein
    Lilin Zhong
    Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 390:1056-60. 2009
  7. ncbi Human antibodies can cross guinea pig placenta and bind its neonatal Fc Receptor: implications for studying immune prophylaxis and therapy during pregnancy
    Evi Budo Struble
    Laboratory of Plasma Derivatives, Division of Hematology, OBRR, FDA, Bethesda, MD 20892, USA
    Clin Dev Immunol 2012:538701. 2012
  8. ncbi Neutralizing antibodies to hepatitis C virus (HCV) in immune globulins derived from anti-HCV-positive plasma
    Mei Ying W Yu
    Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:7705-10. 2004
  9. ncbi Peptides panned from a phage-displayed random peptide library are useful for the detection of Bacillus anthracis surrogates B. cereus 4342 and B. anthracis Sterne
    Shilpakala Sainath Rao
    Section of Cell Biology, Laboratory of Cellular Hematology, Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 395:93-8. 2010
  10. ncbi Expression of immunoglobulin gene with classical V-(D)-J rearrangement in mouse brain neurons
    Jing Huang
    Center for Human Disease Genomics, Institution of Basic Medical Science, Peking University, 38 Xue Yuan Road, 100083 Beijing, China
    Int J Biochem Cell Biol 40:1604-15. 2008

Collaborators

  • Lilin Zhong
  • Evi Budo Struble
  • Mei Ying W Yu
  • Birke Bartosch
  • Francois Loic Cosset
  • Hongying Duan
  • Jing Huang
  • Marian Major
  • Stephen Feinstone
  • Shilpakala Sainath Rao
  • Yu-qing Deng
  • Alla Kachko
  • Hailing Yan
  • Shivani Pandey
  • Maria Luisa Virata-Theimer
  • Lu Deng
  • Christine Harman
  • Zhong Zhao
  • Dino Feigelstock
  • Chintamani D Atreya
  • Nga Nguyen
  • Galina Abdouleva
  • Kathleen Mihalik
  • Bindu Abraham
  • Ketha V K Mohan
  • Yuntao Mao
  • Jin Du
  • Xiaohui Zhu
  • Xiaoyan Qiu
  • Xin Sun
  • Li Zhang
  • Xiao-yan Qiu
  • Xiao-hui Zhu
  • Guo-Hui Li
  • Ying-mei Zhang
  • Zhi-Xin Li
  • Jie Zheng

Detail Information

Publications11

  1. ncbi Depletion of interfering antibodies in chronic hepatitis C patients and vaccinated chimpanzees reveals broad cross-genotype neutralizing activity
    Pei Zhang
    Division of Hematology and Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:7537-41. 2009
    ..Our studies contribute to understanding the mechanisms of antibody-mediated neutralization and interference and provide a practical approach to the development of more potent and broadly reactive hepatitis C immune globulins...
  2. ncbi Neutralization epitope responsible for the hepatitis B virus subtype-specific protection in chimpanzees
    Pei Zhang
    Division of Hematology and Laboratory of Biophysics, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:9214-9. 2006
    ....
  3. ncbi Hepatitis C virus epitope-specific neutralizing antibodies in Igs prepared from human plasma
    Pei Zhang
    Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:8449-54. 2007
    ....
  4. ncbi Amino acid residue-specific neutralization and nonneutralization of hepatitis C virus by monoclonal antibodies to the E2 protein
    Hongying Duan
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    J Virol 86:12686-94. 2012
    ..Further understanding of the molecular mechanisms of antibody-mediated neutralization and nonneutralization should provide insights for designing a vaccine to control HCV infection in vivo...
  5. ncbi Hepatitis C virus with a naturally occurring single amino-acid substitution in the E2 envelope protein escapes neutralization by naturally-induced and vaccine-induced antibodies
    Hongying Duan
    Division of Viral Products, Center for Biologics Evaluation and Research, FDA, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Vaccine 28:4138-44. 2010
    ..Thus, mutation Q412H found in naturally occurring variants could represent an antibody escape mutation. These data may have important implications for vaccine design...
  6. ncbi Antibody-mediated synergy and interference in the neutralization of SARS-CoV at an epitope cluster on the spike protein
    Lilin Zhong
    Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 390:1056-60. 2009
    ....
  7. ncbi Human antibodies can cross guinea pig placenta and bind its neonatal Fc Receptor: implications for studying immune prophylaxis and therapy during pregnancy
    Evi Budo Struble
    Laboratory of Plasma Derivatives, Division of Hematology, OBRR, FDA, Bethesda, MD 20892, USA
    Clin Dev Immunol 2012:538701. 2012
    ..These preliminary data lay the groundwork for introducing pregnant guinea pigs as an appropriate model for the evaluation of antibody therapies and advancing the health of women and neonates...
  8. ncbi Neutralizing antibodies to hepatitis C virus (HCV) in immune globulins derived from anti-HCV-positive plasma
    Mei Ying W Yu
    Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:7705-10. 2004
    ..Immune globulins made from anti-HCV-positive plasma and containing broadly reactive neutralizing antibodies may provide a method of preventing HCV infection...
  9. ncbi Peptides panned from a phage-displayed random peptide library are useful for the detection of Bacillus anthracis surrogates B. cereus 4342 and B. anthracis Sterne
    Shilpakala Sainath Rao
    Section of Cell Biology, Laboratory of Cellular Hematology, Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 395:93-8. 2010
    ..anthracis Sterne. Overall, our findings validate the usefulness of synthetic versions of phage-derived peptides in combination with Qdot-liquid nanocrystals as high sensitivity bioprobes for various microbial detection platforms...
  10. ncbi Expression of immunoglobulin gene with classical V-(D)-J rearrangement in mouse brain neurons
    Jing Huang
    Center for Human Disease Genomics, Institution of Basic Medical Science, Peking University, 38 Xue Yuan Road, 100083 Beijing, China
    Int J Biochem Cell Biol 40:1604-15. 2008
    ..Although the bioactivity of neuron-derived immunoglobulin G was not yet clear, we believed that immunoglobulin G might play an important role in neuronal development...
  11. ncbi [Immunoglobulin expression in colon cancer cell line HT-29 and its biological activities]
    Yu-qing Deng
    Peking University Center for Human Disease Genomics, Beijing 100083, China
    Zhonghua Zhong Liu Za Zhi 28:88-91. 2006
    ..05) and apoptosis (P < 0.01) were induced. CONCLUSION: These results suggest that tumor derived Ig could promote the survival and growth of tumor cells...