Mingjie Zhang

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi Anti-West Nile virus activity of in vitro expanded human primary natural killer cells
    Mingjie Zhang
    Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20892, USA
    BMC Immunol 11:3. 2010
  2. ncbi MicroRNA regulation of STAT4 protein expression: rapid and sensitive modulation of IL-12 signaling in human natural killer cells
    Yong Huang
    Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20892, USA
    Blood 118:6793-802. 2011
  3. ncbi beta-Estradiol attenuates the anti-HIV-1 efficacy of Stavudine (D4T) in primary PBL
    Mingjie Zhang
    Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA
    Retrovirology 5:82. 2008
  4. ncbi Functional interaction between cellular p100 and the dengue virus 3' UTR
    Yingfeng Lei
    Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA
    J Gen Virol 92:796-806. 2011
  5. ncbi Interleukin-12 treatment down-regulates STAT4 and induces apoptosis with increasing ROS production in human natural killer cells
    Yong Huang
    Center for Biologics Evaluation and Research, U S Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20892, USA
    J Leukoc Biol 90:87-97. 2011
  6. ncbi Role of interleukin-18 in human natural killer cell is associated with interleukin-2
    Yong Huang
    Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20892, USA
    Mol Immunol 47:2604-10. 2010
  7. ncbi Bcl-2 upregulation by HIV-1 Tat during infection of primary human macrophages in culture
    Mingjie Zhang
    Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Rockville, MD 20852 1448, USA
    J Biomed Sci 9:133-9. 2002
  8. ncbi HIV regulation of the IL-7R: a viral mechanism for enhancing HIV-1 replication in human macrophages in vitro
    Mingjie Zhang
    Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, FDA, 1401 Rockville Pike, Rockville, MD 20852 1448, USA
    J Leukoc Biol 79:1328-38. 2006

Collaborators

Detail Information

Publications8

  1. ncbi Anti-West Nile virus activity of in vitro expanded human primary natural killer cells
    Mingjie Zhang
    Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20892, USA
    BMC Immunol 11:3. 2010
    ..The expanded NK cells were tested for their ability to inhibit WNV infection in vitro...
  2. ncbi MicroRNA regulation of STAT4 protein expression: rapid and sensitive modulation of IL-12 signaling in human natural killer cells
    Yong Huang
    Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20892, USA
    Blood 118:6793-802. 2011
    ..These data suggest that miR-132, -212, and -200a up-regulation during prolonged IL-12 treatment, negatively regulates the IL-12 signaling pathway by reducing STAT4 expression in primary human NK cells...
  3. ncbi beta-Estradiol attenuates the anti-HIV-1 efficacy of Stavudine (D4T) in primary PBL
    Mingjie Zhang
    Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA
    Retrovirology 5:82. 2008
    ..Recent work suggests there are gender effects in HIV/AIDS progression. Here we ask whether the sex steroid hormone beta-estradiol affects the replication of HIV-1 or the efficacy of a common anti-retroviral drug, Stavudine (D4T)...
  4. ncbi Functional interaction between cellular p100 and the dengue virus 3' UTR
    Yingfeng Lei
    Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA
    J Gen Virol 92:796-806. 2011
    ..These results provide evidence that p100 interacts with the 3' UTR of DENV and is required for normal DENV replication...
  5. ncbi Interleukin-12 treatment down-regulates STAT4 and induces apoptosis with increasing ROS production in human natural killer cells
    Yong Huang
    Center for Biologics Evaluation and Research, U S Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20892, USA
    J Leukoc Biol 90:87-97. 2011
    ..These findings provide new insights into IL-12 regulation in human NK cells, where IL-12 initially promotes NK cell activation but subsequently limits this response through a negative-feedback mechanism...
  6. ncbi Role of interleukin-18 in human natural killer cell is associated with interleukin-2
    Yong Huang
    Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20892, USA
    Mol Immunol 47:2604-10. 2010
    ..These results reveal that the effects of IL-18 on human NK cell are associated with IL-2 concentration and suggest the importance of IL-2 level in cytokine immunotherapy...
  7. ncbi Bcl-2 upregulation by HIV-1 Tat during infection of primary human macrophages in culture
    Mingjie Zhang
    Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Rockville, MD 20852 1448, USA
    J Biomed Sci 9:133-9. 2002
    ..These results suggest that in infecting cells of the monocyte/macrophage lineage, HIV-1 may be benefiting from additional protection against apoptosis caused by specific upregulation of cellular anti-apoptotic genes...
  8. ncbi HIV regulation of the IL-7R: a viral mechanism for enhancing HIV-1 replication in human macrophages in vitro
    Mingjie Zhang
    Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, FDA, 1401 Rockville Pike, Rockville, MD 20852 1448, USA
    J Leukoc Biol 79:1328-38. 2006
    ..The results suggest that the effects of IL-7 on HIV replication in MDM should be considered when analyzing and designing clinical trials involving treatment of patients with IL-7 or Tat vaccines...