Jun Zhang

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. doi request reprint Biomarkers of endothelial cell activation: candidate markers for drug-induced vasculitis in patients or drug-induced vascular injury in animals
    Jun Zhang
    Division of Drug Safety Research, Center for Drug Evaluation and Research, U S Food and Drug Administration, Silver Spring, MD 20993, USA
    Vascul Pharmacol 56:14-25. 2012
  2. ncbi request reprint Mechanisms and biomarkers of cardiovascular injury induced by phosphodiesterase inhibitor III SK&F 95654 in the spontaneously hypertensive rat
    Jun Zhang
    Division of Applied Pharmacology Research HFD 910, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993, USA
    Toxicol Pathol 34:152-63. 2006
  3. pmc Immunolocalization of Kim-1, RPA-1, and RPA-2 in kidney of gentamicin-, mercury-, or chromium-treated rats: relationship to renal distributions of iNOS and nitrotyrosine
    Jun Zhang
    Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993, USA
    Toxicol Pathol 36:397-409. 2008
  4. doi request reprint Isoproterenol-induced cardiotoxicity in sprague-dawley rats: correlation of reversible and irreversible myocardial injury with release of cardiac troponin T and roles of iNOS in myocardial injury
    Jun Zhang
    Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, United States Food and Drug Administration, Silver Spring, Maryland 20993 0002, USA
    Toxicol Pathol 36:277-8. 2008
  5. pmc Differences in immunolocalization of Kim-1, RPA-1, and RPA-2 in kidneys of gentamicin-, cisplatin-, and valproic acid-treated rats: potential role of iNOS and nitrotyrosine
    Jun Zhang
    Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993 0002, USA
    Toxicol Pathol 37:629-43. 2009
  6. doi request reprint Biomarkers of endothelial cell activation serve as potential surrogate markers for drug-induced vascular injury
    Jun Zhang
    Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA
    Toxicol Pathol 38:856-71. 2010
  7. doi request reprint Histopathology of vascular injury in Sprague-Dawley rats treated with phosphodiesterase IV inhibitor SCH 351591 or SCH 534385
    Jun Zhang
    Division of Applied Pharmacology Research HFD 910, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993 0002, USA
    Toxicol Pathol 36:827-39. 2008
  8. doi request reprint Comparison of the diagnostic accuracy of di-22:6-bis(monoacylglycerol)phosphate and other urinary phospholipids for drug-induced phospholipidosis or tissue injury in the rat
    Karol L Thompson
    Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Building 64, Room 2036, Silver Spring, MD 20993, USA
    Int J Toxicol 31:14-24. 2012
  9. pmc Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium
    Yuzhao Zhou
    Center for Devices and Radiological Health, U S Food and Drug Administration, White Oak Life Sciences Laboratory, Silver Spring, MD 20993, USA
    Toxicol Sci 101:159-70. 2008
  10. doi request reprint Biomarkers in peripheral blood associated with vascular injury in Sprague-Dawley rats treated with the phosphodiesterase IV inhibitors SCH 351591 or SCH 534385
    James L Weaver
    Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993 0002, USA
    Toxicol Pathol 36:840-9. 2008

Detail Information

Publications80

  1. doi request reprint Biomarkers of endothelial cell activation: candidate markers for drug-induced vasculitis in patients or drug-induced vascular injury in animals
    Jun Zhang
    Division of Drug Safety Research, Center for Drug Evaluation and Research, U S Food and Drug Administration, Silver Spring, MD 20993, USA
    Vascul Pharmacol 56:14-25. 2012
    ..Further investigation, however, is needed to assess their potential utility...
  2. ncbi request reprint Mechanisms and biomarkers of cardiovascular injury induced by phosphodiesterase inhibitor III SK&F 95654 in the spontaneously hypertensive rat
    Jun Zhang
    Division of Applied Pharmacology Research HFD 910, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993, USA
    Toxicol Pathol 34:152-63. 2006
    ....
  3. pmc Immunolocalization of Kim-1, RPA-1, and RPA-2 in kidney of gentamicin-, mercury-, or chromium-treated rats: relationship to renal distributions of iNOS and nitrotyrosine
    Jun Zhang
    Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993, USA
    Toxicol Pathol 36:397-409. 2008
    ..It is possible that iNOS activation with nitrotyrosine production in injured nephron segments may be involved in the induction of Kim-1, RPA-1, and RPA-2 following exposure to nephrotoxicants...
  4. doi request reprint Isoproterenol-induced cardiotoxicity in sprague-dawley rats: correlation of reversible and irreversible myocardial injury with release of cardiac troponin T and roles of iNOS in myocardial injury
    Jun Zhang
    Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, United States Food and Drug Administration, Silver Spring, Maryland 20993 0002, USA
    Toxicol Pathol 36:277-8. 2008
    ..These findings suggest that low doses of Iso exert complex effects on the myocardium and that the generation of NO through increased expression of iNOS could be an important factor in the pathogenesis of myocyte injury...
  5. pmc Differences in immunolocalization of Kim-1, RPA-1, and RPA-2 in kidneys of gentamicin-, cisplatin-, and valproic acid-treated rats: potential role of iNOS and nitrotyrosine
    Jun Zhang
    Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993 0002, USA
    Toxicol Pathol 37:629-43. 2009
    ..These findings suggest that peroxynitrite formation may be involved in the pathogenesis of Gen and Cis nephrotoxicity and that Kim-1, RPA-1, and RPA-2 have the potential to serve as site-specific biomarkers for Gen or Cis AKI...
  6. doi request reprint Biomarkers of endothelial cell activation serve as potential surrogate markers for drug-induced vascular injury
    Jun Zhang
    Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA
    Toxicol Pathol 38:856-71. 2010
    ..This review alerts pharmaceutical companies, research institutions, and regulatory agencies to the continuing need for reliable biomarkers of EC activation in drug development...
  7. doi request reprint Histopathology of vascular injury in Sprague-Dawley rats treated with phosphodiesterase IV inhibitor SCH 351591 or SCH 534385
    Jun Zhang
    Division of Applied Pharmacology Research HFD 910, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993 0002, USA
    Toxicol Pathol 36:827-39. 2008
    ..The present study also provides a morphological and cellular basis for evaluating candidate biomarkers of drug-induced vascular injury...
  8. doi request reprint Comparison of the diagnostic accuracy of di-22:6-bis(monoacylglycerol)phosphate and other urinary phospholipids for drug-induced phospholipidosis or tissue injury in the rat
    Karol L Thompson
    Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Building 64, Room 2036, Silver Spring, MD 20993, USA
    Int J Toxicol 31:14-24. 2012
    ..The data provide evidence supporting the use of di-22:6-BMP as a urinary biomarker of PLD in rats...
  9. pmc Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium
    Yuzhao Zhou
    Center for Devices and Radiological Health, U S Food and Drug Administration, White Oak Life Sciences Laboratory, Silver Spring, MD 20993, USA
    Toxicol Sci 101:159-70. 2008
    ..Urinary Kim-1 and kidney Kim-1/Havcr1 expression appear to be sensitive and tissue-specific biomarkers that will improve detection of early acute kidney injury following exposure to nephrotoxic chemicals and drugs...
  10. doi request reprint Biomarkers in peripheral blood associated with vascular injury in Sprague-Dawley rats treated with the phosphodiesterase IV inhibitors SCH 351591 or SCH 534385
    James L Weaver
    Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993 0002, USA
    Toxicol Pathol 36:840-9. 2008
    ..The changes in these parameters showed both a dose- and time-dependent association with histopathologic changes. These biomarkers could provide an additional tool for the nonclinical and clinical evaluation of investigational compounds...
  11. doi request reprint Early alterations in heart gene expression profiles associated with doxorubicin cardiotoxicity in rats
    Karol L Thompson
    Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA
    Cancer Chemother Pharmacol 66:303-14. 2010
    ..To identify potential additional cardioprotective treatment strategies, we investigated early doxorubicin-induced changes in cardiac gene expression...
  12. doi request reprint A multifaceted evaluation of imatinib-induced cardiotoxicity in the rat
    Eugene H Herman
    Food and Drug Administration, Division of Applied Pharmacology Research, Silver Spring, Maryland, USA
    Toxicol Pathol 39:1091-106. 2011
    ..The authors conclude that Imb exerts cardiotoxic effects that are manifest through a complex pattern of cellular alterations, the severity of which can be influenced by arterial blood pressure...
  13. doi request reprint Early events in vascular injury in the rat induced by the phosphodiesterase IV inhibitor SCH 351591
    James L Weaver
    Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993 0002, USA
    Toxicol Pathol 38:738-44. 2010
    ..At fifteen minutes, histopathology showed activation of mast cells, but not degranulation. Increases in endothelial activation and perivascular inflammatory cells were first apparent at thirty minutes and increased through 240 minutes...
  14. ncbi request reprint Age-related differences in susceptibility to toxic effects of valproic acid in rats
    Parvaneh Espandiari
    FDA, Center for Drug Evaluation and Research, Silver Spring, MD 20993, USA
    J Appl Toxicol 28:628-37. 2008
    ..In conclusion, this study showed that the vulnerability profile of each age group was different indicating that a multi-age pediatric animal model is appropriate to assess more completely age-dependent changes in drug toxicity...
  15. ncbi request reprint SK&F 95654-induced acute cardiovascular toxicity in Sprague-Dawley rats--histopathologic, electron microscopic, and immunohistochemical studies
    Jun Zhang
    Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, Food and Drug Administration, Laurel, Maryland 20708, USA
    Toxicol Pathol 30:28-40. 2002
    ....
  16. doi request reprint Kidney injury biomarkers in hypertensive, diabetic, and nephropathy rat models treated with contrast media
    Rodney L Rouse
    Division of Drug Safety Research, Office of Testing and Research, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U S Food and Drug Administration, Silver Spring, Maryland, USA
    Toxicol Pathol 41:662-80. 2013
    ..2m, Lcn-2, and BUN were the best predictors of histopathology defined kidney injury...
  17. doi request reprint Comparison of urinary and serum levels of di-22:6-bis(monoacylglycerol)phosphate as noninvasive biomarkers of phospholipidosis in rats
    Karol L Thompson
    Division of Drug Safety Research, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993, USA
    Toxicol Lett 213:285-91. 2012
    ..These data help define the potential context-of-use of serum di-22:6-BMP as a non-clinical biomarker of PLD...
  18. pmc The utility of a rodent model in detecting pediatric drug-induced nephrotoxicity
    Parvaneh Espandiari
    Center for Drug Evaluation and Research, Silver Spring, Maryland 20993, USA
    Toxicol Sci 99:637-48. 2007
    ....
  19. ncbi request reprint Serum cardiac troponin T as a biomarker for acute myocardial injury induced by low doses of isoproterenol in rats
    Eugene Herman
    Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, FDA, Silver Spring, MD 20993, USA
    Cardiovasc Toxicol 6:211-22. 2006
    ....
  20. doi request reprint The iron chelator Dp44mT inhibits the proliferation of cancer cells but fails to protect from doxorubicin-induced cardiotoxicity in spontaneously hypertensive rats
    V Ashutosh Rao
    Laboratory of Biochemistry, Center for Drug Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Building 29A, Room 2A 11, Bethesda, MD 20892, USA
    Cancer Chemother Pharmacol 68:1125-34. 2011
    ..We tested the hypothesis that Dp44mT can improve clinical outcomes of treatment with Dox by alleviating cardiotoxicity...
  21. ncbi request reprint High fat diet and GLP-1 drugs induce pancreatic injury in mice
    Rodney Rouse
    Division of Applied Regulatory Science, Center for Drug Evaluation and Research, U S Food and Drug Administration, Silver Spring, MD 20993, USA Electronic address
    Toxicol Appl Pharmacol 276:104-14. 2014
    ..These findings support HFD as a risk factor to increased susceptibility/severity for acute pancreatitis and indicate that GLP-1 drugs cause pancreatic injury that can be exacerbated in a HFD environment. ..
  22. doi request reprint Comparative profile of commercially available urinary biomarkers in preclinical drug-induced kidney injury and recovery in rats
    Rodney L Rouse
    Division of Applied Pharmacology Research, Office of Testing and Research, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA
    Kidney Int 79:1186-97. 2011
    ..Thus, these biomarkers performed with different effectiveness when evaluated by individual pathological processes such as necrosis, apoptosis, and regeneration...
  23. doi request reprint Baseline serum cardiac troponin I concentrations in Sprague-Dawley, spontaneous hypertensive, Wistar, Wistar-Kyoto, and Fisher rats as determined with an ultrasensitive immunoassay
    Eugene Herman
    Division of Applied Pharmacology Research, Food and Drug Administration, Silver Spring, Maryland 20993 0002, USA
    Toxicol Pathol 39:653-63. 2011
    ....
  24. doi request reprint Sex-related differences in mast cell activity and doxorubicin toxicity: a study in spontaneously hypertensive rats
    Jun Zhang
    1Division of Drug Safety Research, Center for Drug Evaluation and Research Food and Drug Administration, Silver Spring, Maryland, USA
    Toxicol Pathol 42:361-75. 2014
    ....
  25. doi request reprint Autophagy in pancreatic acinar cells in caerulein-treated mice: immunolocalization of related proteins and their potential as markers of pancreatitis
    Leshuai Zhang
    1Division of Drug Safety Research, Center for Drug Evaluation and Research, U S Food and Drug Administration, Silver Spring, Maryland, USA
    Toxicol Pathol 42:435-57. 2014
    ..This finding supports Reg3γ as a candidate biomarker for pancreatic injury. ..
  26. ncbi request reprint Evaluation of the Tg.AC assay: specificity testing with three noncarcinogenic pharmaceuticals that induce selected stress gene promoters in vitro and the inhibitory effects of solvent components
    Karol L Thompson
    Division of Applied Pharmacology Research, Office of Testing and Research, Office of Pharmaceutical Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Laurel, Maryland 20708, USA
    Toxicol Sci 74:271-8. 2003
    ..However, vehicle composition must be carefully selected because the outcome of this assay can be confounded by certain commonly used solvents...
  27. ncbi request reprint A new inducible adenoviral expression system that responds to inflammatory stimuli in vivo
    Gang Cai
    Department of Laboratory Diagnosis, Changhai Hospital, The Second Military Medical University, Shanghai, PR China
    J Gene Med 8:1369-78. 2006
    ..In this study, we tried to achieve an inducible adenoviral expression system for physiologically responsive gene therapy of autoimmune or inflammatory diseases...
  28. ncbi request reprint Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR
    Jun Zhang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Science 298:422-4. 2002
    ..These results suggest an innovative therapeutic approach for treating the adverse effects of acetaminophen and potentially other hepatotoxic agents...
  29. ncbi request reprint Analysis of apoptosis and cell proliferation after high intensity-focused ultrasound ablation combined with microbubbles in rabbit livers
    Wen Luo
    Department of Ultrasound in Xijing Hospital, Fourth Military Medical University, 17th Changle Xilu, Xi an, China
    Eur J Gastroenterol Hepatol 19:962-8. 2007
    ..To analyze apoptosis and expression of proliferating cell nuclear antigen (PCNA) sequentially in the rabbit liver tissue after high-intensity focused ultrasound (HIFU) ablation combined with microbubbles...
  30. ncbi request reprint Quantitative analysis of FMO gene mRNA levels in human tissues
    Jun Zhang
    Human BioMolecular Research Institute, 5310 Eastgate Mall, San Diego, CA 92121, USA
    Drug Metab Dispos 34:19-26. 2006
    ..e., FMO1 in kidney, FMO2 in lung, FMO3 and FMO5 in adult liver), FMO4 mRNA was observed more broadly at relatively comparable levels in liver, kidney, lung, and small intestine...
  31. ncbi request reprint Death decoy receptor TR6/DcR3 inhibits T cell chemotaxis in vitro and in vivo
    Guixiu Shi
    Laboratory of Transplantation Immunology and Nephrology Service of Notre Dame Hospital, Centre Hospitalier de l Universite de Montreal, Universite de Montreal, Montreal, Quebec, Canada
    J Immunol 171:3407-14. 2003
    ..This study revealed a previously unknown function of TR6 in immune regulation, and such an effect could conceivably be explored for therapeutic use in controlling undesirable immune responses...
  32. ncbi request reprint Effect of pharmacologic preconditioning with tetrandrine on subsequent ischemia/reperfusion injury in rat liver
    Zhongmin Liu
    Department of General Surgery and Organ Transplantation, The Second Affiliated Hospital, Shantou University Medical College, Dongxiabeilu, Shantou, 515041 Guangdong, People s Republic of China
    World J Surg 28:620-4. 2004
    ..The simultaneous decrease of both lipid peroxide generation and polymorphonuclear neutrophil infiltration in the ischemic liver may explain the acquisition of tolerance following administration of TET...
  33. ncbi request reprint Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor
    Wendong Huang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 19:1646-53. 2005
    ....
  34. ncbi request reprint Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism
    Mohammed Qatanani
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Endocrinology 146:995-1002. 2005
    ..The increase in serum TSH levels resulted in the stimulation of thyroid-follicular cell proliferation. These results highlight the central role of the xenosensor CAR in drug-hormone interactions...
  35. doi request reprint Placental characteristics and birthweight
    Carolyn M Salafia
    Department of Epidemiology, Mailman School of Public Health, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Paediatr Perinat Epidemiol 22:229-39. 2008
    ..Analysis suggested that the impact of all maternal characteristics except smoking was consistent with mediation by placental characteristics...
  36. ncbi request reprint Enhancing effects of SonoVue, a microbubble sonographic contrast agent, on high-intensity focused ultrasound ablation in rabbit livers in vivo
    Wen Luo
    Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi an, China
    J Ultrasound Med 26:469-76. 2007
    ..The purpose of this study was to explore the enhancing biological effects of SonoVue (Bracco SpA, Milan, Italy), a sulfur hexafluoride sonographic contrast agent, on high-intensity focused ultrasound (HIFU) ablation in vivo...
  37. ncbi request reprint A strategy for high-throughput analysis of levosimendan and its metabolites in human plasma samples using sequential negative and positive ionization liquid chromatography/tandem mass spectrometric detection
    Jun Zhang
    Department of Drug Analysis, Abbott Laboratories, Abbott Park, IL 60064, USA
    Rapid Commun Mass Spectrom 21:2169-76. 2007
    ..4% to 2.6% for OR-1855, and -0.3% to 4.5% for OR-1896. By using a single extraction approach coupled with sequential LC/MS/MS analysis for levosimendan and its metabolites, the assay maintained high throughput and low sample volume usage...
  38. pmc Hydrophobic core mutations in CI2 globally perturb fast side-chain dynamics similarly without regard to position
    Matthew J Whitley
    Department of Biochemistry and Biophysics, School of Medicine, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Biochemistry 47:8566-76. 2008
    ..Interestingly, mutation at folding nucleus positions led to widespread increases in backbone flexibility, whereas non-folding-nucleus positions led to increases in flexibility in the C-terminal half of the protein only...
  39. ncbi request reprint Past and present course of cardioprotection against ischemia-reperfusion injury
    David A Liem
    Department of Physiology, Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Appl Physiol 103:2129-36. 2007
    ..The present mini-review highlights a short summary of the historical and present course of research into cardioprotection against myocardial I/R injury...
  40. ncbi request reprint Functional activity of the mouse flavin-containing monooxygenase forms 1, 3, and 5
    Jun Zhang
    Human BioMolecular Research Institute, 5310 Eastgate Mall, San Diego, CA 92121, USA
    J Biochem Mol Toxicol 21:206-15. 2007
    ..The results revealed unique features for mFMO5, suggesting possible impact on the functional significance of this abundantly expressed FMO5 isoform in both human and mouse liver...
  41. ncbi request reprint Targeted inhibition of Sp1-mediated transcription for antiangiogenic therapy of metastatic human gastric cancer in orthotopic nude mouse models
    Liwei Wang
    The Key Laboratory of Antibody Technology of State Ministry of Health, Nanjing Medical University, Nanjing 210029, P R China
    Int J Oncol 33:161-7. 2008
    ....
  42. ncbi request reprint Acrolein consumption exacerbates myocardial ischemic injury and blocks nitric oxide-induced PKCepsilon signaling and cardioprotection
    Guang Wu Wang
    Department of Physiology and the Cardiovascular Research Laboratories, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    J Mol Cell Cardiol 44:1016-22. 2008
    ..Consumption of an aldehyde-rich diet could exacerbate cardiac IR injury and block NO donor-induced cardioprotection via mechanisms that disrupt PKCepsilon signaling...
  43. ncbi request reprint Vasorelaxant effect of taurine is diminished by tetraethylammonium in rat isolated arteries
    Long Gang Niu
    Department of Pharmacology, Shanxi Medical University, Xinjiannanlu 56, Taiyuan 030001, Shanxi Province, PR China
    Eur J Pharmacol 580:169-74. 2008
    ....
  44. ncbi request reprint Reshaping the folding energy landscape of human carbonic anhydrase II by a single point genetic mutation Pro237His
    Yan Jiang
    Sichuan University, Chengdu 610064, Sichuan, People s Republic of China
    Int J Biochem Cell Biol 40:776-88. 2008
    ..The results herein suggested that the correct positioning of the long loop around P237 might be crucial to the folding of HCA II, particularly the formation of the active site...
  45. ncbi request reprint Cardioprotection involves activation of NF-kappa B via PKC-dependent tyrosine and serine phosphorylation of I kappa B-alpha
    Jun Zhang
    Department of Physiology, Cardiovascular Research Laboratories, University of California Los Angeles, CA 90095, USA
    Am J Physiol Heart Circ Physiol 285:H1753-8. 2003
    ..Together, these data indicate that ischemic PC-induced activation of NF-kappa B occurs through both tyrosine and serine phosphorylation of I kappa B-alpha and is regulated by nonreceptor tyrosine kinases and PKC...
  46. ncbi request reprint Synthesis of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase (CYP51)
    Qing Yan Sun
    Department of Organic Chemistry, College of Pharmacy, Second Military Medical University, Guohe Road 325, Shanghai 200433, People s Republic of China
    Eur J Med Chem 42:1226-33. 2007
    ..albicans as voriconazole (with the MIC value of 0.0152microg/mL). Compounds 3, 6, and 7 showed higher activity against C. parapsilosis than all five positive controls...
  47. ncbi request reprint The antiandrogenic activity of the fungicide N-(3, 5-dichlorophenyl) succinimide in in vivo and in vitro assays
    Jun Zhang
    Department of Toxicology, School of Medicine, Zhejiang University, P R China
    J Reprod Dev 53:535-43. 2007
    ..05) the expression of PBP C3 and had no effect on the level of TRPM-2 (P>0.05). In conclusion, NDPS is a moderate antiandrogen that elicits antiandrogenic effects at least partly by antagonizing AR and increasing the expression of PBP C3...
  48. ncbi request reprint The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity
    Jun Zhang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 279:49517-22. 2004
    ..These results define a central role for CAR in LCA detoxification and show that CAR and PXR function coordinately to regulate both xenobiotic and bile acid metabolism...
  49. ncbi request reprint A new anthraquinone and cytotoxic curvularins of a Penicillium sp. from the rhizosphere of Fallugia paradoxa of the Sonoran desert
    Jixun Zhan
    Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, University of Arizona, 250 E Valencia Road, Tucson, Arizona 85706 6800, USA
    J Antibiot (Tokyo) 57:341-4. 2004
  50. ncbi request reprint PIASy represses TRIF-induced ISRE and NF-kappaB activation but not apoptosis
    Jun Zhang
    National Jewish Medical and Research Center, 1400 Jackson Street, K516c, Denver, CO 80206, USA
    FEBS Lett 570:97-101. 2004
    ..Furthermore, PIASy also inhibits IRF-3, IRF-7 and Sendai virus-induced ISRE activation. Our results suggest that PIASy is an inhibitor of TRIF-induced ISRE and NF-kappaB activation but not apoptosis...
  51. ncbi request reprint [Effects of chronic alcohol administration on the activities of the key glycolytic enzymes of rats]
    Hong Pang
    Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Wei Sheng Yan Jiu 33:195-7. 2004
    ..They can also be one of the mechanisms of diabetes mellitus relating to alcohol because of the high blood sugar and the disturbed blood sugar regulation...
  52. ncbi request reprint Bmx, a member of the Tec family of nonreceptor tyrosine kinases, is a novel participant in pharmacological cardioprotection
    Jun Zhang
    Department of Physiology, Cardiovascular Research Laboratories, Suite 1619 MRL Bldg, 675 Charles E Young Dr, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Am J Physiol Heart Circ Physiol 287:H2364-6. 2004
    ..These findings indicate that a novel type of PKC-tyrosine kinase module (involving Bmx) is formed in the heart and may be involved in pharmacological cardioprotection by NO donors...
  53. ncbi request reprint [Effects of intravenous and inhalational anesthetics on short-latency somatosensory evoked potentials]
    Wei min Liang
    Deportment of Anesthesia, Huashan Hospital, Fudan University, Shanghai 200040, China
    Zhonghua Yi Xue Za Zhi 84:460-3. 2004
    ..To choose suitable general anesthetics dosages when short-latency somatosensory evoked potentials (SLSEP) is monitored during operation...
  54. ncbi request reprint [Effects of high-volume hemofiltration on serum levels of tumor necrosis factor and its receptors in patients with multiple organ dysfunction syndromes]
    Jun Zhang
    Department of Nephrology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 16:81-4. 2004
    ..To investigate whether serum tumor necrosis factor-alpha (TNF-alpha) and its receptors can be removed by high-volume hemofiltration (HVHF) or continuous veno-venous hemofiltration (CVVH)...
  55. ncbi request reprint [Evaluation of the reliability of three different hepatitis E diagnosis reagents on the clinical acute hepatitis E]
    Ying jie Zheng
    The Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, Xiamen University, Xiamen 361005, China
    Zhonghua Gan Zang Bing Za Zhi 12:16-7. 2004
    ..To evaluate the reliability of different hepatitis E diagnosis reagent tests on the acute hepatitis E...
  56. ncbi request reprint [Significance of serological markers and virological marker for hepatitis E in rhesus monkey model]
    Jun Zhang
    The Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, Xiamen University, Xiamen 361005, China
    Zhonghua Gan Zang Bing Za Zhi 12:7-10. 2004
    ..To evaluate the serological markers and biological marker in the diagnosis of hepatitis E infection in a rhesus monkey model...
  57. ncbi request reprint [Acute aging model induced by gamma-ray irradiation]
    Yun Li
    School of Public Health, West China University of Medical Sciences, Chengdu 610041, China
    Wei Sheng Yan Jiu 31:290-1. 2002
    ..The results from this investigation indicate that an acute aging model can be induced by gamma-ray irradiating on rats...
  58. ncbi request reprint A TNF family member LIGHT transduces costimulatory signals into human T cells
    Xiaochun Wan
    Laboratory of Transplantation Immunology, Center Hospitalier de l Universite de Montreal, University of Montreal, Montreal, Quebec, Canada
    J Immunol 169:6813-21. 2002
    ..These data suggest that TR6 delivers costimulation through its ligand(s) on the T cell surface, and at least the major part of such costimulation is via LIGHT...
  59. ncbi request reprint BLyS and B cell autoimmunity
    Tong Zhou
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Ala, USA
    Curr Dir Autoimmun 6:21-37. 2003
  60. ncbi request reprint Mouse T cells receive costimulatory signals from LIGHT, a TNF family member
    Guixiu Shi
    Laboratory of Transplantation Immunology, Research Center, Centre hospitalier de l Universite de Montreal CHUM Notre Dame Hospital, Pavilion DeSeve, 1560 Sherbrooke Street E, Montreal, Quebec H2L 4M21, Canada
    Blood 100:3279-86. 2002
    ..Indeed, LIGHT cross-linking enhanced p44/42 mitogen-activated protein kinase activation after TCR ligation. This study reveals a new function and signaling event of LIGHT...
  61. ncbi request reprint Predictors of herbicide exposure in farm applicators
    Tye E Arbuckle
    Health Surveillance and Epidemiology Division, Population and Public Health Branch, Health Canada, A L 0701D, Ottawa, Ontario, K1A 0L2, Canada
    Int Arch Occup Environ Health 75:406-14. 2002
    ....
  62. ncbi request reprint TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator
    Thi Sau Migone
    Human Genome Sciences, Inc, Rockville, MD 20850, USA
    Immunity 16:479-92. 2002
    ..Our data suggest that interaction of TL1A with DR3 promotes T cell expansion during an immune response, whereas TR6 has an opposing effect...
  63. ncbi request reprint Functional proteomic analysis of a three-tier PKCepsilon-Akt-eNOS signaling module in cardiac protection
    Jun Zhang
    Division of Cardiology, Departments of Physiology and Medicine, University of California at Los Angeles, Los Angeles, California, USA
    Am J Physiol Heart Circ Physiol 288:H954-61. 2005
    ....
  64. ncbi request reprint [Correlation between sensitivity to TRAIL and expression level of DR5 on surface of tumor cells]
    Yuan Fang Ma
    Institute of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Zhonghua Zhong Liu Za Zhi 26:528-30. 2004
    ..To investigate the correlation between sensitivity to tumor necrosis factor-related apoptosis inducing ligand (TRAIL) and expression level of death receptor 5 (DR5) on tumor cell surface...
  65. ncbi request reprint Placental growth patterns affect birth weight for given placental weight
    Carolyn M Salafia
    Department of Epidemiology, Mailman School of Public Health, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Birth Defects Res A Clin Mol Teratol 79:281-8. 2007
    ....
  66. ncbi request reprint Proteomics-based development of biomarkers in cardiovascular disease: mechanistic, clinical, and therapeutic insights
    Manuel Mayr
    Cardiovascular Division, King s College, University of London, London SE59 NU, United Kingdom
    Mol Cell Proteomics 5:1853-64. 2006
  67. ncbi request reprint Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration
    Wendong Huang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Science 312:233-6. 2006
    ..FXR, and possibly other nuclear receptors, may promote homeostasis not only by regulating expression of appropriate metabolic target genes but also by driving homeotrophic liver growth...
  68. ncbi request reprint Serum level of homocysteine is correlated to carotid artery atherosclerosis in Chinese with ischemic stroke
    Hongli Wang
    Department of Neurology, Peking University Third Hospital, Beijing 100083, China
    Neurol Res 28:25-30. 2006
    ..To investigate the relationship between serum level of homocysteine (Hcy) and carotid artery atheroscleosis (CAA)...
  69. ncbi request reprint Direct targeting of genetically modified tumour cells to Fc gammaRI triggers potent tumour cytotoxicity
    Lisette Bevaart
    Immunotherapy Laboratory, Department of Immunology, University Medical Centre Utrecht, Lundlaan, Utrecht, The Netherlands
    Br J Haematol 132:317-25. 2006
    ..These results demonstrated that tumour cells can be readily modified to activate cell effector mechanisms, a strategy that may be useful for in vivo targeting in patients...
  70. ncbi request reprint Noninvasive imaging of oral premalignancy and malignancy
    Petra Wilder-Smith
    University of California, Beckman Laser Institute, Irvine, California 92612, USA
    J Biomed Opt 10:051601. 2005
    ..Our conclusions are that OCT/ODT and MPM/SHG are promising noninvasive in vivo diagnostic modalities for oral dysplasia and malignancy...
  71. ncbi request reprint Renal pedicle lymphatic disconnection for chyluria via retroperitoneoscopy and open surgery: report of 53 cases with followup
    Xu Zhang
    Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    J Urol 174:1828-31. 2005
    ..We present our experience with retroperitoneoscopic renal pedicle lymphatic disconnection. We compared the clinical efficacy of this treatment for chyluria with that of open surgery...
  72. ncbi request reprint [Organotypic cerebral slice culture and the course of neuronal development in it]
    Mei Zheng
    Department of Neurology, Peking University Third Hospital, Beijing 100083, China
    Beijing Da Xue Xue Bao 37:406-9. 2005
    ..To establish a method of organotypic cerebral culture. So as to pave the way for building some neurodegenerative disease models...
  73. ncbi request reprint Regenerative and therapeutic effects of heparin-binding epidermal growth factor-like growth factor on diabetes by gene transduction through retrograde pancreatic duct injection of adenovirus vector
    Junji Kozawa
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Pancreas 31:32-42. 2005
    ..A member of the epidermal growth factor (EGF) family, heparin binding (HB)-EGF, may promote this process. We examined whether HB-EGF gene transduction into duct cells could promote beta-cell regeneration...
  74. ncbi request reprint Cloning and characterization of mouse homolog of the CXC chemokine receptor CXCR1
    Wenxian Fu
    Department of Immunology, Peking University Health Science Center, Beijing 100083, China
    Cytokine 31:9-17. 2005
    ....
  75. ncbi request reprint Hepatocyte paraffin 1 immunoexpression in esophageal brush samples
    Jun Zhang
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Cancer 105:304-9. 2005
    ..A cytopathologic diagnosis of IM on esophageal brushings by morphology alone can be difficult. The authors investigated the role of hepatocyte paraffin 1 (Heppar-1) immunostaining as a possible marker of IM in cytologic samples of BE...
  76. ncbi request reprint Ethanol alters cellular activation and CD14 partitioning in lipid rafts
    Qun Dai
    Department of Cellular Biology and Anatomy, Louisiana State University Health Science Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Biochem Biophys Res Commun 332:37-42. 2005
    ..This membrane action of EtOH might be one of the mechanisms by which EtOH acts as a generalized suppressor for TLR signaling...
  77. ncbi request reprint Study of the effects of mild hypothermia on cerebral PO2, PCO2 and pH and body temperature in patients with acute severe head injury
    Jun Jia
    Department of Neurosurgery, Shenzhen Longgang Central Hospital, Shenzhen 518116, China
    Chin J Traumatol 8:138-41. 2005
    ..To study the effects of mild hypothermia on cerebral oxygen partial pressure, carbon dioxide partial pressure, pH and body temperature (PbrO2, PbrCO2, pHbr and BT) in patients with acute severe head injury...
  78. ncbi request reprint The effect of N-acetylcysteine on Clara cells and Clara cell 16 kDa protein in a murine model of allergen-induced airway inflammation
    Xiaomeng Nie
    Department of Respiratory Medicine, Changhai Hospital, Shanghai, China
    Respirology 10:157-63. 2005
    ....
  79. ncbi request reprint Drug-induced vascular injury--a quest for biomarkers
    William Kerns
    Pharma Consulting Inc
    Toxicol Appl Pharmacol 203:62-87. 2005
  80. ncbi request reprint Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection
    Christopher P Baines
    Department of Physiology, University of Louisville, and the Jewish Hospital Heart and Lung Institute, Louisville, KY 40202, USA
    Circ Res 90:390-7. 2002
    ..Furthermore, formation of mitochondrial PKCepsilon-ERK modules appears to play a role in PKCepsilon-mediated cardioprotection, in part by the phosphorylation and inactivation of Bad...