Marina Zaitseva

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. pmc Effects of postchallenge administration of ST-246 on dissemination of IHD-J-Luc vaccinia virus in normal mice and in immune-deficient mice reconstituted with T cells
    Marina Zaitseva
    Division of Viral Products, Food and Drug Administration, Bethesda, Maryland, USA
    J Virol 87:5564-76. 2013
  2. doi request reprint Use of human MonoMac6 cells for development of in vitro assay predictive of adjuvant safety in vivo
    Marina Zaitseva
    Divisions of Viral Products, Veterinary Services, and Biostatistics, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Vaccine 30:4859-65. 2012
  3. pmc Polyclonal antibody cocktails generated using DNA vaccine technology protect in murine models of orthopoxvirus disease
    Joseph W Golden
    Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA
    Virol J 8:441. 2011
  4. pmc Passive immunotherapies protect WRvFire and IHD-J-Luc vaccinia virus-infected mice from lethality by reducing viral loads in the upper respiratory tract and internal organs
    Marina Zaitseva
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29B, Room 4NN06, 8800 Rockville Pike, Bethesda, MD 20892, USA
    J Virol 85:9147-58. 2011
  5. pmc Application of bioluminescence imaging to the prediction of lethality in vaccinia virus-infected mice
    Marina Zaitseva
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Virol 83:10437-47. 2009
  6. ncbi request reprint Regeneration of the adult thymus is preceded by the expansion of K5+K8+ epithelial cell progenitors and by increased expression of Trp63, cMyc and Tcf3 transcription factors in the thymic stroma
    Ileana Popa
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA
    Int Immunol 19:1249-60. 2007
  7. doi request reprint Measurements of vaccinia virus dissemination using whole body imaging: approaches for predicting of lethality in challenge models and testing of vaccines and antiviral treatments
    Marina Zaitseva
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
    Methods Mol Biol 890:161-76. 2012
  8. ncbi request reprint Increased CXCR4-dependent HIV-1 fusion in activated T cells: role of CD4/CXCR4 association
    Marina Zaitseva
    Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29B, Room 4NN06, 8800 Rockville Pike, Bethesda, MD 20892, USA
    J Leukoc Biol 78:1306-17. 2005
  9. ncbi request reprint HIV coreceptors: role of structure, posttranslational modifications, and internalization in viral-cell fusion and as targets for entry inhibitors
    Marina Zaitseva
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1614:51-61. 2003
  10. pmc Peptides trap the human immunodeficiency virus type 1 envelope glycoprotein fusion intermediate at two sites
    Yong He
    Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 77:1666-71. 2003

Collaborators

Detail Information

Publications13

  1. pmc Effects of postchallenge administration of ST-246 on dissemination of IHD-J-Luc vaccinia virus in normal mice and in immune-deficient mice reconstituted with T cells
    Marina Zaitseva
    Division of Viral Products, Food and Drug Administration, Bethesda, Maryland, USA
    J Virol 87:5564-76. 2013
    ..Furthermore, immune-deficient animals with partial T cell reconstitution can control virus replication after a course of ST-246 and survive lethal vaccinia virus challenge...
  2. doi request reprint Use of human MonoMac6 cells for development of in vitro assay predictive of adjuvant safety in vivo
    Marina Zaitseva
    Divisions of Viral Products, Veterinary Services, and Biostatistics, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Vaccine 30:4859-65. 2012
    ..The developed human cell based assays could provide an important tool for early screening of new molecular moieties and adjuvant formulations and may assist in selection of safer products...
  3. pmc Polyclonal antibody cocktails generated using DNA vaccine technology protect in murine models of orthopoxvirus disease
    Joseph W Golden
    Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA
    Virol J 8:441. 2011
    ..The L1 and A27 components of this vaccine target the mature virion (MV) whereas A33 and B5 target the enveloped virion (EV)...
  4. pmc Passive immunotherapies protect WRvFire and IHD-J-Luc vaccinia virus-infected mice from lethality by reducing viral loads in the upper respiratory tract and internal organs
    Marina Zaitseva
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29B, Room 4NN06, 8800 Rockville Pike, Bethesda, MD 20892, USA
    J Virol 85:9147-58. 2011
    ....
  5. pmc Application of bioluminescence imaging to the prediction of lethality in vaccinia virus-infected mice
    Marina Zaitseva
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Virol 83:10437-47. 2009
    ..Collectively, our data support the use of bioimaging for lethality prediction following vaccinia virus challenge and for gaining insight into protective mechanisms conferred by vaccines and therapeutics...
  6. ncbi request reprint Regeneration of the adult thymus is preceded by the expansion of K5+K8+ epithelial cell progenitors and by increased expression of Trp63, cMyc and Tcf3 transcription factors in the thymic stroma
    Ileana Popa
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA
    Int Immunol 19:1249-60. 2007
    ..These results suggest that TEC progenitors could be reactivated in the adult thymus and, therefore, reactivation of TEC progenitors could provide a new approach for thymic reconstitution...
  7. doi request reprint Measurements of vaccinia virus dissemination using whole body imaging: approaches for predicting of lethality in challenge models and testing of vaccines and antiviral treatments
    Marina Zaitseva
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
    Methods Mol Biol 890:161-76. 2012
    ....
  8. ncbi request reprint Increased CXCR4-dependent HIV-1 fusion in activated T cells: role of CD4/CXCR4 association
    Marina Zaitseva
    Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29B, Room 4NN06, 8800 Rockville Pike, Bethesda, MD 20892, USA
    J Leukoc Biol 78:1306-17. 2005
    ..The CD4-CXCR4 complexes may shuttle between late endosomes and the cell surface...
  9. ncbi request reprint HIV coreceptors: role of structure, posttranslational modifications, and internalization in viral-cell fusion and as targets for entry inhibitors
    Marina Zaitseva
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1614:51-61. 2003
    ..We also summarize the classes of coreceptor inhibitors under development...
  10. pmc Peptides trap the human immunodeficiency virus type 1 envelope glycoprotein fusion intermediate at two sites
    Yong He
    Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 77:1666-71. 2003
    ..These results indicate that there are two distinct sites in receptor-activated Env that are potential targets for drug or vaccine development...
  11. ncbi request reprint Differences in PGE2 production between primary human monocytes and differentiated macrophages: role of IL-1β and TRIF/IRF3
    Yukinori Endo
    Center for Biologics Evaluation and Research CBER, Food and Drug Administration FDA, Bethesda, Maryland, United States of America
    PLoS ONE 9:e98517. 2014
    ..These findings suggest a key role for blood monocytes in the rapid onset of fever in animals and humans exposed to bacterial products and some novel adjuvants. ..
  12. pmc Dissection of human immunodeficiency virus type 1 entry with neutralizing antibodies to gp41 fusion intermediates
    Hana Golding
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg 29A Room 1A21, 8800 Rockville Pike, Bethesda, MD 20892, USA
    J Virol 76:6780-90. 2002
    ..They also indicate that six-helix bundles can form prior to fusion and that the lag time before fusion occurs may include the time needed to accumulate preformed six-helix bundles at the fusion site...
  13. ncbi request reprint Up-regulation of IL-7, stromal-derived factor-1 alpha, thymus-expressed chemokine, and secondary lymphoid tissue chemokine gene expression in the stromal cells in response to thymocyte depletion: implication for thymus reconstitution
    Iryna Zubkova
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Immunol 175:2321-30. 2005
    ..Thus, our data showed for the first time that expression of IL-7, SDF-1alpha, TECK, and SLC mRNA is induced in the thymic stroma during T cell depletion and may play an important role in the reconstitution of the adult thymus...