Li Yu

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. doi request reprint Protein-protein interactions among West Nile non-structural proteins and transmembrane complex formation in mammalian cells
    Li Yu
    Laboratory of Vector Borne Virus Diseases, Division of Viral Products, Office of Vaccines Research and Review, Microscopy and Imaging Core Facility, CBER, FDA, Bethesda, MD, USA Electronic address
    Virology 446:365-77. 2013
  2. doi request reprint Attenuated West Nile viruses bearing 3'SL and envelope gene substitution mutations
    Li Yu
    Laboratory of Vector Borne Virus Diseases, Division of Viral Products, FDA, Bethesda, MD 20892, USA
    Vaccine 26:5981-8. 2008
  3. pmc Specific requirements for elements of the 5' and 3' terminal regions in flavivirus RNA synthesis and viral replication
    Li Yu
    Laboratory of Vector Borne Virus Diseases, Division of Viral Products, Office of Vaccines Research and Review, CBER, FDA, Bethesda, Maryland, USA
    Virology 374:170-85. 2008
  4. pmc The open reading frame 3a protein of severe acute respiratory syndrome-associated coronavirus promotes membrane rearrangement and cell death
    Eric C Freundt
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 84:1097-109. 2010
  5. pmc Termination of autophagy and reformation of lysosomes regulated by mTOR
    Li Yu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 465:942-6. 2010
  6. pmc Molecular determinants for subcellular localization of the severe acute respiratory syndrome coronavirus open reading frame 3b protein
    Eric C Freundt
    Laboratory of Immunology, Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 83:6631-40. 2009
  7. pmc The topology of bulges in the long stem of the flavivirus 3' stem-loop is a major determinant of RNA replication competence
    Li Yu
    Laboratory Vector Borne Viruse Disease, Division of Viral Products, FDA, Bethesda, MD 20892, USA
    J Virol 79:2309-24. 2005
  8. pmc Autophagic cell death
    Michael J Lenardo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Methods Enzymol 453:17-31. 2009

Collaborators

Detail Information

Publications8

  1. doi request reprint Protein-protein interactions among West Nile non-structural proteins and transmembrane complex formation in mammalian cells
    Li Yu
    Laboratory of Vector Borne Virus Diseases, Division of Viral Products, Office of Vaccines Research and Review, Microscopy and Imaging Core Facility, CBER, FDA, Bethesda, MD, USA Electronic address
    Virology 446:365-77. 2013
    ..NS2B protein seems to play a key role in bringing the TPs together on the ER membrane and in bridging the TPs with non-membrane-associated proteins (NS3 and NS5). ..
  2. doi request reprint Attenuated West Nile viruses bearing 3'SL and envelope gene substitution mutations
    Li Yu
    Laboratory of Vector Borne Virus Diseases, Division of Viral Products, FDA, Bethesda, MD 20892, USA
    Vaccine 26:5981-8. 2008
    ..The env gene mutations had an attenuating effect in the context of the wt WNV genome but only a marginal enhancing effect on the attenuation of WNmutE virus...
  3. pmc Specific requirements for elements of the 5' and 3' terminal regions in flavivirus RNA synthesis and viral replication
    Li Yu
    Laboratory of Vector Borne Virus Diseases, Division of Viral Products, Office of Vaccines Research and Review, CBER, FDA, Bethesda, Maryland, USA
    Virology 374:170-85. 2008
    ..Combined results suggested that replication was not dependent upon species homology between the 3'SL and NS5...
  4. pmc The open reading frame 3a protein of severe acute respiratory syndrome-associated coronavirus promotes membrane rearrangement and cell death
    Eric C Freundt
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 84:1097-109. 2010
    ..These results establish an important role for ORF 3a in SARS-CoV-induced cell death, Golgi fragmentation, and the accumulation of intracellular vesicles...
  5. pmc Termination of autophagy and reformation of lysosomes regulated by mTOR
    Li Yu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 465:942-6. 2010
    ..Thus, an evolutionarily conserved cycle in autophagy governs nutrient sensing and lysosome homeostasis during starvation...
  6. pmc Molecular determinants for subcellular localization of the severe acute respiratory syndrome coronavirus open reading frame 3b protein
    Eric C Freundt
    Laboratory of Immunology, Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 83:6631-40. 2009
    ..The findings reported here reveal that for multilocalized proteins, consideration of the spatiotemporal distribution may be crucial for understanding viral protein behavior and function...
  7. pmc The topology of bulges in the long stem of the flavivirus 3' stem-loop is a major determinant of RNA replication competence
    Li Yu
    Laboratory Vector Borne Viruse Disease, Division of Viral Products, FDA, Bethesda, MD 20892, USA
    J Virol 79:2309-24. 2005
    ..Results suggested that bulges and their topological location within the long stem of the 3'SL are primary determinants of replication competence for flavivirus genomes...
  8. pmc Autophagic cell death
    Michael J Lenardo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Methods Enzymol 453:17-31. 2009
    ..Finally, we discuss methods to genetically or chemically perturb autophagy to test whether autophagy is required for cell death. Together, these approaches provide a guide to investigate the relationship between autophagy and cell death...