Li Yu

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. pmc Specific requirements for elements of the 5' and 3' terminal regions in flavivirus RNA synthesis and viral replication
    Li Yu
    Laboratory of Vector Borne Virus Diseases, Division of Viral Products, Office of Vaccines Research and Review, CBER, FDA, Bethesda, Maryland, USA
    Virology 374:170-85. 2008
  2. doi request reprint Protein-protein interactions among West Nile non-structural proteins and transmembrane complex formation in mammalian cells
    Li Yu
    Laboratory of Vector Borne Virus Diseases, Division of Viral Products, Office of Vaccines Research and Review, Microscopy and Imaging Core Facility, CBER, FDA, Bethesda, MD, USA Electronic address
    Virology 446:365-77. 2013
  3. pmc The open reading frame 3a protein of severe acute respiratory syndrome-associated coronavirus promotes membrane rearrangement and cell death
    Eric C Freundt
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 84:1097-109. 2010
  4. pmc The topology of bulges in the long stem of the flavivirus 3' stem-loop is a major determinant of RNA replication competence
    Li Yu
    Laboratory Vector Borne Viruse Disease, Division of Viral Products, FDA, Bethesda, MD 20892, USA
    J Virol 79:2309-24. 2005
  5. pmc Termination of autophagy and reformation of lysosomes regulated by mTOR
    Li Yu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 465:942-6. 2010
  6. doi request reprint Attenuated West Nile viruses bearing 3'SL and envelope gene substitution mutations
    Li Yu
    Laboratory of Vector Borne Virus Diseases, Division of Viral Products, FDA, Bethesda, MD 20892, USA
    Vaccine 26:5981-8. 2008
  7. pmc Molecular determinants for subcellular localization of the severe acute respiratory syndrome coronavirus open reading frame 3b protein
    Eric C Freundt
    Laboratory of Immunology, Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 83:6631-40. 2009
  8. pmc Autophagic cell death
    Michael J Lenardo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Methods Enzymol 453:17-31. 2009
  9. ncbi request reprint Requirements for West Nile virus (-)- and (+)-strand subgenomic RNA synthesis in vitro by the viral RNA-dependent RNA polymerase expressed in Escherichia coli
    Masako Nomaguchi
    Department of Microbiology and Immunology, Georgetown University Medical Center, SW309 Med Dent Building, 3900 Reservoir Road, Washington, D C 20057, USA
    J Biol Chem 279:12141-51. 2004
  10. ncbi request reprint Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1
    Frank Rosenbauer
    Harvard Institutes of Medicine and Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA
    Nat Genet 38:27-37. 2006

Collaborators

Detail Information

Publications10

  1. pmc Specific requirements for elements of the 5' and 3' terminal regions in flavivirus RNA synthesis and viral replication
    Li Yu
    Laboratory of Vector Borne Virus Diseases, Division of Viral Products, Office of Vaccines Research and Review, CBER, FDA, Bethesda, Maryland, USA
    Virology 374:170-85. 2008
    ..Combined results suggested that replication was not dependent upon species homology between the 3'SL and NS5...
  2. doi request reprint Protein-protein interactions among West Nile non-structural proteins and transmembrane complex formation in mammalian cells
    Li Yu
    Laboratory of Vector Borne Virus Diseases, Division of Viral Products, Office of Vaccines Research and Review, Microscopy and Imaging Core Facility, CBER, FDA, Bethesda, MD, USA Electronic address
    Virology 446:365-77. 2013
    ..NS2B protein seems to play a key role in bringing the TPs together on the ER membrane and in bridging the TPs with non-membrane-associated proteins (NS3 and NS5). ..
  3. pmc The open reading frame 3a protein of severe acute respiratory syndrome-associated coronavirus promotes membrane rearrangement and cell death
    Eric C Freundt
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 84:1097-109. 2010
    ..These results establish an important role for ORF 3a in SARS-CoV-induced cell death, Golgi fragmentation, and the accumulation of intracellular vesicles...
  4. pmc The topology of bulges in the long stem of the flavivirus 3' stem-loop is a major determinant of RNA replication competence
    Li Yu
    Laboratory Vector Borne Viruse Disease, Division of Viral Products, FDA, Bethesda, MD 20892, USA
    J Virol 79:2309-24. 2005
    ..Results suggested that bulges and their topological location within the long stem of the 3'SL are primary determinants of replication competence for flavivirus genomes...
  5. pmc Termination of autophagy and reformation of lysosomes regulated by mTOR
    Li Yu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 465:942-6. 2010
    ..Thus, an evolutionarily conserved cycle in autophagy governs nutrient sensing and lysosome homeostasis during starvation...
  6. doi request reprint Attenuated West Nile viruses bearing 3'SL and envelope gene substitution mutations
    Li Yu
    Laboratory of Vector Borne Virus Diseases, Division of Viral Products, FDA, Bethesda, MD 20892, USA
    Vaccine 26:5981-8. 2008
    ..The env gene mutations had an attenuating effect in the context of the wt WNV genome but only a marginal enhancing effect on the attenuation of WNmutE virus...
  7. pmc Molecular determinants for subcellular localization of the severe acute respiratory syndrome coronavirus open reading frame 3b protein
    Eric C Freundt
    Laboratory of Immunology, Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 83:6631-40. 2009
    ..The findings reported here reveal that for multilocalized proteins, consideration of the spatiotemporal distribution may be crucial for understanding viral protein behavior and function...
  8. pmc Autophagic cell death
    Michael J Lenardo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Methods Enzymol 453:17-31. 2009
    ..Finally, we discuss methods to genetically or chemically perturb autophagy to test whether autophagy is required for cell death. Together, these approaches provide a guide to investigate the relationship between autophagy and cell death...
  9. ncbi request reprint Requirements for West Nile virus (-)- and (+)-strand subgenomic RNA synthesis in vitro by the viral RNA-dependent RNA polymerase expressed in Escherichia coli
    Masako Nomaguchi
    Department of Microbiology and Immunology, Georgetown University Medical Center, SW309 Med Dent Building, 3900 Reservoir Road, Washington, D C 20057, USA
    J Biol Chem 279:12141-51. 2004
    ..These results support a model that "cyclization" of the viral RNA play a role for (-)-strand RNA synthesis but not for (+)-strand RNA synthesis...
  10. ncbi request reprint Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1
    Frank Rosenbauer
    Harvard Institutes of Medicine and Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA
    Nat Genet 38:27-37. 2006
    ..These results elucidate how a single transcription factor, PU.1, through the cell context-specific activity of a key cis-regulatory element, affects the development of multiple cell lineages and can induce cancer...