John F Young

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi request reprint Physiological "constants" for PBPK models for pregnancy
    J F Young
    Division of Reproductive and Development Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    J Toxicol Environ Health 52:385-401. 1997
  2. ncbi request reprint Database composition can affect the structure-activity relationship prediction
    John F Young
    Division of Biometry and Risk Assessment, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079 9502, USA
    J Toxicol Environ Health A 69:1527-40. 2006
  3. ncbi request reprint Building an organ-specific carcinogenic database for SAR analyses
    John Young
    Division of Biometry and Risk Assessment, Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas, USA
    J Toxicol Environ Health A 67:1363-89. 2004
  4. ncbi request reprint Analysis of methylmercury disposition in humans utilizing a PBPK model and animal pharmacokinetic data
    J F Young
    Division of Biometry and Risk Assessment, National Center for Toxicological Research, Jefferson, Arkansas 72079 9502, USA
    J Toxicol Environ Health A 63:19-52. 2001
  5. ncbi request reprint Correlation of blood cholinesterase levels with toxicity of sarin in rats
    J F Young
    National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079 9502, USA
    J Toxicol Environ Health A 62:161-74. 2001
  6. ncbi request reprint Physiologically-based pharmacokinetic model for pregnancy as a tool for investigation of developmental mechanisms
    J F Young
    Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Comput Biol Med 28:359-64. 1998
  7. ncbi request reprint Relationships between biomarkers of exposure and toxicokinetics in Fischer 344 rats and B6C3F1 mice administered single doses of acrylamide and glycidamide and multiple doses of acrylamide
    Eden Tareke
    National Center for Toxicological Research, Jefferson, AR 72079, USA
    Toxicol Appl Pharmacol 217:63-75. 2006
  8. ncbi request reprint Toxicokinetics of acrylamide and glycidamide in Fischer 344 rats
    Daniel R Doerge
    National Center for Toxicological Research, Jefferson, AR 72079, USA
    Toxicol Appl Pharmacol 208:199-209. 2005
  9. doi request reprint Using dietary exposure and physiologically based pharmacokinetic/pharmacodynamic modeling in human risk extrapolations for acrylamide toxicity
    Daniel R Doerge
    National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
    J Agric Food Chem 56:6031-8. 2008
  10. ncbi request reprint Physiologically based pharmacokinetic/pharmacodynamic model for acrylamide and its metabolites in mice, rats, and humans
    John F Young
    Division of Biometry and Risk Assessment, National Center for Toxicological Research Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Chem Res Toxicol 20:388-99. 2007

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Physiological "constants" for PBPK models for pregnancy
    J F Young
    Division of Reproductive and Development Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    J Toxicol Environ Health 52:385-401. 1997
    ..These exposures provide fundamentally important data to help design and interpret molecular probe investigations into mechanisms of teratogenesis...
  2. ncbi request reprint Database composition can affect the structure-activity relationship prediction
    John F Young
    Division of Biometry and Risk Assessment, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079 9502, USA
    J Toxicol Environ Health A 69:1527-40. 2006
    ..The numbers of chemicals in the various data sets ranged from 187 to 999 and appeared to have no affect on any of the 3 predictors of sensitivity, specificity, or concordance...
  3. ncbi request reprint Building an organ-specific carcinogenic database for SAR analyses
    John Young
    Division of Biometry and Risk Assessment, Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas, USA
    J Toxicol Environ Health A 67:1363-89. 2004
    ..These preliminary analyses all yielded approximately the same results with an overall predictability of about 63%, which was comprised of a sensitivity of about 30% and a specificity of about 77%...
  4. ncbi request reprint Analysis of methylmercury disposition in humans utilizing a PBPK model and animal pharmacokinetic data
    J F Young
    Division of Biometry and Risk Assessment, National Center for Toxicological Research, Jefferson, Arkansas 72079 9502, USA
    J Toxicol Environ Health A 63:19-52. 2001
    ..The resulting human model, in accord with the animal models, predicts relatively high inorganic mercury levels in the kidneys long after the disappearance of methylmercury from the blood...
  5. ncbi request reprint Correlation of blood cholinesterase levels with toxicity of sarin in rats
    J F Young
    National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079 9502, USA
    J Toxicol Environ Health A 62:161-74. 2001
    ..Neither plasma or erythrocyte baseline cholinesterase levels nor relative or absolute cholinesterase decline values could be used as predictors of mortality from sarin administration in rats...
  6. ncbi request reprint Physiologically-based pharmacokinetic model for pregnancy as a tool for investigation of developmental mechanisms
    J F Young
    Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Comput Biol Med 28:359-64. 1998
    ..In this context pregnancy requires special considerations in that the PBPK model must represent the dynamic growth of both the maternal and embryo/fetal systems...
  7. ncbi request reprint Relationships between biomarkers of exposure and toxicokinetics in Fischer 344 rats and B6C3F1 mice administered single doses of acrylamide and glycidamide and multiple doses of acrylamide
    Eden Tareke
    National Center for Toxicological Research, Jefferson, AR 72079, USA
    Toxicol Appl Pharmacol 217:63-75. 2006
    ..06-0.3 adducts/10(8) nucleotides. This approach may prove useful in extrapolating human cancer risks from findings in rodent bioassays...
  8. ncbi request reprint Toxicokinetics of acrylamide and glycidamide in Fischer 344 rats
    Daniel R Doerge
    National Center for Toxicological Research, Jefferson, AR 72079, USA
    Toxicol Appl Pharmacol 208:199-209. 2005
    ..These findings provide additional information needed to assess genotoxic risks from the low levels of AA that are pervasive in the food supply...
  9. doi request reprint Using dietary exposure and physiologically based pharmacokinetic/pharmacodynamic modeling in human risk extrapolations for acrylamide toxicity
    Daniel R Doerge
    National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
    J Agric Food Chem 56:6031-8. 2008
    ..These results suggest that a more holistic analysis of dietary cancer risks may be appropriate, by which potential risks from AA should be considered in conjunction with other risks and benefits from foods...
  10. ncbi request reprint Physiologically based pharmacokinetic/pharmacodynamic model for acrylamide and its metabolites in mice, rats, and humans
    John F Young
    Division of Biometry and Risk Assessment, National Center for Toxicological Research Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Chem Res Toxicol 20:388-99. 2007
    ..The steady-state human liver GA-DNA adduct level from exposure to background levels of AA in the diet was predicted to be between 0.06 and 0.26 adducts per 10(8) nucleotides...
  11. doi request reprint Human organ/tissue growth algorithms that include obese individuals and black/white population organ weight similarities from autopsy data
    John F Young
    Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    J Toxicol Environ Health A 72:527-40. 2009
    ..In contrast to other black/white anthropomorphic measurements, the data demonstrated no observable or statistical difference in weights for any organ/tissue between individuals identified as black or white in the autopsy reports...
  12. ncbi request reprint Plasma levels of parent compound and metabolites after doses of either d-fenfluramine or d-3,4-methylenedioxymethamphetamine (MDMA) that produce long-term serotonergic alterations
    John F Bowyer
    Division of Neurotoxicology and Biometry and Risk Assessment, National Center for Toxicological Research FDA, 72079 9502, Jefferson, AR, USA
    Neurotoxicology 24:379-90. 2003
    ..There were 80% reductions in the plasma membrane-associated 5-HT transporters 6 months after either the FEN or MDMA dosing regimen indicating that both treatments produced long-term serotonergic effects...
  13. ncbi request reprint Discriminant function analyses of liver-specific carcinogens
    Richard D Beger
    Division of Chemistry, Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA
    J Chem Inf Comput Sci 44:1107-10. 2004
    ..50 for liver cancer and 0.5 for noncancer, yielded an overall predictability of 61.0% which was comprised of a liver cancer sensitivity of 50.5% and a noncancer specificity of 65.3%...
  14. ncbi request reprint Toxicokinetics of acrylamide and glycidamide in B6C3F1 mice
    Daniel R Doerge
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Toxicol Appl Pharmacol 202:258-67. 2005
    ..These findings are critical to the assessment of genotoxicity of AA at low doses in the food supply, which appears to depend on total exposure to GA...
  15. ncbi request reprint Improving predictive modeling in pediatric drug development: pharmacokinetics, pharmacodynamics, and mechanistic modeling
    William Slikker
    Office of Research, National Center for Toxicological Research FDA, 3900 NCTR Road, Jefferson, Arkansas 72079 9502, USA
    Ann N Y Acad Sci 1053:505-18. 2005
    ..Issues addressed in this workshop should be considered in the development of new predictive and mechanistic models of drug kinetics and dynamics in the developing human...
  16. ncbi request reprint Toxicokinetics of riddelliine, a carcinogenic pyrrolizidine alkaloid, and metabolites in rats and mice
    Lee Williams
    National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Toxicol Appl Pharmacol 182:98-104. 2002
    ..It is concluded that factors other than toxicokinetics are responsible for the observed species/sex specificity of gross toxicity or liver tumor induction in rats and mice...
  17. ncbi request reprint Steady state pharmacokinetics of oral treatment with 13-cis-retinoic acid or all-trans-retinoic acid in male and female adult rats
    Sherry A Ferguson
    Division of Neurotoxicology, National Center for Toxicological Research FDA, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
    Basic Clin Pharmacol Toxicol 98:582-7. 2006
    ..There were no sex differences for any parameter. Serum levels resulting from the 7.5 mg/kg 13-cis-retinoic acid were similar to those of human Accutane users...
  18. ncbi request reprint Use of the 'STRATIFY' falls risk assessment in patients recovering from acute stroke
    Jane Smith
    Stroke United Network Yorkshire SUNY, Academic Unit of Elderly Care and Rehabilitation, St Luke s Hospital, University of Leeds
    Age Ageing 35:138-43. 2006
    ..To investigate the predictive validity and reliability of the STRATIFY falls risk assessment tool as applied to patients recovering from acute stroke...
  19. ncbi request reprint Combined analysis of two randomized trials of community physiotherapy for patients more than one year post stroke
    John Green
    Department of Health Care for the Elderly, St Luke s Hospital, Bradford, W Yorkshire, UK
    Clin Rehabil 18:249-52. 2004
    ....
  20. ncbi request reprint Determinants of plasminogen activator inhibitor-1 in South Asians with ischaemic stroke
    Kirti Kain
    Academic Unit of Molecular Vascular Medicine University of Leeds, Leeds General Infirmary, Leeds, UK
    Cerebrovasc Dis 14:77-83. 2002
    ..Regression analysis with significant correlates in the model demonstrated age, gender and triglycerides in patients and fasting insulin and HDL cholesterol in reference subjects as independent predictors of PAI-1 antigen...