Affiliation: Food and Drug Administration
Xie H, Liu T, Lu X, Wu Z, Belser J, Katz J, et al
. A live attenuated H1N1 M1 mutant provides broad cross-protection against influenza A viruses, including highly pathogenic A/Vietnam/1203/2004, in mice. J Infect Dis. 2009;200:1874-83 pubmed publisher
..Our study suggests an alternative approach to attenuate wt influenza viruses for the development of a pandemic vaccine with broad cross-protection. ..
Plant E, Eick Cost A, Ezzeldin H, Sanchez J, Ye Z, Cooper M. The Effects of Birth Year, Age and Sex on Hemagglutination Inhibition Antibody Responses to Influenza Vaccination. Vaccines (Basel). 2018;6: pubmed publisher
..The magnitude of this antibody response is associated with, among other factors, the influenza strain that circulated following birth. ..
Wang X, Tan J, Biswas S, Zhao J, Devadas K, Ye Z, et al
. Pandemic Influenza A (H1N1) Virus Infection Increases Apoptosis and HIV-1 Replication in HIV-1 Infected Jurkat Cells. Viruses. 2016;8: pubmed publisher
..These data indicate that HIV-1 replication can be activated by pH1N1 virus in HIV-1-infected cells resulting in induction of cell death through apoptotic pathways. ..
Plant E, Ilyushina N, Sheikh F, Donnelly R, Ye Z. Influenza virus NS1 protein mutations at position 171 impact innate interferon responses by respiratory epithelial cells. Virus Res. 2017;240:81-86 pubmed publisher
..Consequently, these viruses may be more virulent than the parental strains that do not contain mutations at position 171 in the NS1 protein. ..