Chihae Yang

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi request reprint Computational toxicology approaches at the US Food and Drug Administration
    Chihae Yang
    Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD, USA
    Altern Lab Anim 37:523-31. 2009
  2. doi request reprint A structural feature-based computational approach for toxicology predictions
    Luis G Valerio
    Informatics and Computational Safety Analysis Staff, Science and Research Staff, US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, 10903 New Hampshire Avenue, Silver Spring, MD 20993 0002, USA
    Expert Opin Drug Metab Toxicol 6:505-18. 2010
  3. ncbi request reprint Combined Use of MC4PC, MDL-QSAR, BioEpisteme, Leadscope PDM, and Derek for Windows Software to Achieve High-Performance, High-Confidence, Mode of Action-Based Predictions of Chemical Carcinogenesis in Rodents
    Edwin J Matthews
    Informatics and Computational Safety Analysis Staff, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U S Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD, 20993 0002, USA
    Toxicol Mech Methods 18:189-206. 2008
  4. ncbi request reprint Identification of structure-activity relationships for adverse effects of pharmaceuticals in humans: Part B. Use of (Q)SAR systems for early detection of drug-induced hepatobiliary and urinary tract toxicities
    Edwin J Matthews
    US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, Informatics and Computational Safety Analysis Staff ICSAS, Silver Spring, MD 20993, USA
    Regul Toxicol Pharmacol 54:23-42. 2009

Detail Information

Publications4

  1. ncbi request reprint Computational toxicology approaches at the US Food and Drug Administration
    Chihae Yang
    Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD, USA
    Altern Lab Anim 37:523-31. 2009
    ....
  2. doi request reprint A structural feature-based computational approach for toxicology predictions
    Luis G Valerio
    Informatics and Computational Safety Analysis Staff, Science and Research Staff, US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, 10903 New Hampshire Avenue, Silver Spring, MD 20993 0002, USA
    Expert Opin Drug Metab Toxicol 6:505-18. 2010
    ..These in silico tools are of interest in supporting regulatory review processes, and priority setting in research and product development...
  3. ncbi request reprint Combined Use of MC4PC, MDL-QSAR, BioEpisteme, Leadscope PDM, and Derek for Windows Software to Achieve High-Performance, High-Confidence, Mode of Action-Based Predictions of Chemical Carcinogenesis in Rodents
    Edwin J Matthews
    Informatics and Computational Safety Analysis Staff, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U S Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD, 20993 0002, USA
    Toxicol Mech Methods 18:189-206. 2008
    ..7% of the carcinogens linked in this study to Derek for Windows defined modes of action...
  4. ncbi request reprint Identification of structure-activity relationships for adverse effects of pharmaceuticals in humans: Part B. Use of (Q)SAR systems for early detection of drug-induced hepatobiliary and urinary tract toxicities
    Edwin J Matthews
    US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, Informatics and Computational Safety Analysis Staff ICSAS, Silver Spring, MD 20993, USA
    Regul Toxicol Pharmacol 54:23-42. 2009
    ..4% specificity, 56.2% sensitivity). Consensus predictions resulted in better performance as judged by both internal and external validation experiments...