P Whittaker

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi request reprint Genome-linked toxic responses to dietary iron overload
    P Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, D C 20204
    Toxicol Pathol 25:556-64. 1997
  2. ncbi request reprint Iron and zinc interactions in humans
    P Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA
    Am J Clin Nutr 68:442S-446S. 1998
  3. ncbi request reprint Genotoxicity of iron compounds in Salmonella typhimurium and L5178Y mouse lymphoma cells
    V C Dunkel
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA
    Environ Mol Mutagen 33:28-41. 1999
  4. ncbi request reprint Histopathological evaluation of liver, pancreas, spleen, and heart from iron-overloaded Sprague-Dawley rats
    P Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, D C 20204, USA
    Toxicol Pathol 24:558-63. 1996
  5. ncbi request reprint Effect of increasing iron supplementation on blood lipids in rats
    P Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street S W, HFS 236, Washington, DC 20204, USA
    Br J Nutr 86:587-92. 2001
  6. ncbi request reprint Iron and folate in fortified cereals
    P Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA
    J Am Coll Nutr 20:247-54. 2001
  7. ncbi request reprint Genotoxicity of iron chelators in L5178Y mouse lymphoma cells
    P Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA
    Environ Mol Mutagen 38:347-56. 2001
  8. ncbi request reprint Acute toxicity of carbonyl iron and sodium iron EDTA compared with ferrous sulfate in young rats
    P Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland 20740 3835, USA
    Regul Toxicol Pharmacol 36:280-6. 2002

Detail Information

Publications8

  1. ncbi request reprint Genome-linked toxic responses to dietary iron overload
    P Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, D C 20204
    Toxicol Pathol 25:556-64. 1997
    ..The rats also showed degeneration of the germinal epithelium of the testis, formation of multinucleated giant cells, and lack of mature sperm...
  2. ncbi request reprint Iron and zinc interactions in humans
    P Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA
    Am J Clin Nutr 68:442S-446S. 1998
    ..Twelve iron sources are listed as GRAS; elemental iron has become the source of choice because it is less expensive to produce and has fewer organoleptic problems. Use of ferrous fumarate is also increasing...
  3. ncbi request reprint Genotoxicity of iron compounds in Salmonella typhimurium and L5178Y mouse lymphoma cells
    V C Dunkel
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA
    Environ Mol Mutagen 33:28-41. 1999
    ..The LED ratio ranges from 1 for FeSO4 to 30 for carbonyl Fe, which are similar to oral LD50 values obtained in animal studies...
  4. ncbi request reprint Histopathological evaluation of liver, pancreas, spleen, and heart from iron-overloaded Sprague-Dawley rats
    P Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, D C 20204, USA
    Toxicol Pathol 24:558-63. 1996
    ....
  5. ncbi request reprint Effect of increasing iron supplementation on blood lipids in rats
    P Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street S W, HFS 236, Washington, DC 20204, USA
    Br J Nutr 86:587-92. 2001
    ....
  6. ncbi request reprint Iron and folate in fortified cereals
    P Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA
    J Am Coll Nutr 20:247-54. 2001
    ..However, with recent increases in fortification, public health officials in the US are concemed that excess intake of specific nutrients such as iron and folic acid may result in toxic manifestations...
  7. ncbi request reprint Genotoxicity of iron chelators in L5178Y mouse lymphoma cells
    P Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA
    Environ Mol Mutagen 38:347-56. 2001
    ..The other three chelators that were not mutagenic were Na2EDTA, phytic acid, and ferrozine...
  8. ncbi request reprint Acute toxicity of carbonyl iron and sodium iron EDTA compared with ferrous sulfate in young rats
    P Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland 20740 3835, USA
    Regul Toxicol Pharmacol 36:280-6. 2002
    ..1 g Fe/kg and was approximately 45 times more toxic than carbonyl Fe, which had an LD(50) greater then 50 g Fe/kg. NaFeEDTA had an LD(50) of 1.3 g Fe/kg and, when compared with FeSO(4), had approximately the same level of toxicity...