P Whittaker

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi request reprint Genotoxicity of iron chelators in L5178Y mouse lymphoma cells
    P Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA
    Environ Mol Mutagen 38:347-56. 2001
  2. ncbi request reprint Mutagenicity of chromium picolinate and its components in Salmonella typhimurium and L5178Y mouse lymphoma cells
    Paul Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD 20740 3835, United States
    Food Chem Toxicol 43:1619-25. 2005
  3. ncbi request reprint Iron and folate in fortified cereals
    P Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA
    J Am Coll Nutr 20:247-54. 2001
  4. ncbi request reprint Effect of increasing iron supplementation on blood lipids in rats
    P Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street S W, HFS 236, Washington, DC 20204, USA
    Br J Nutr 86:587-92. 2001
  5. ncbi request reprint Acute toxicity of carbonyl iron and sodium iron EDTA compared with ferrous sulfate in young rats
    P Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland 20740 3835, USA
    Regul Toxicol Pharmacol 36:280-6. 2002
  6. ncbi request reprint Genotoxicity of iron compounds in Salmonella typhimurium and L5178Y mouse lymphoma cells
    V C Dunkel
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA
    Environ Mol Mutagen 33:28-41. 1999
  7. ncbi request reprint Genome-linked toxic responses to dietary iron overload
    P Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, D C 20204
    Toxicol Pathol 25:556-64. 1997
  8. ncbi request reprint Histopathological evaluation of liver, pancreas, spleen, and heart from iron-overloaded Sprague-Dawley rats
    P Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, D C 20204, USA
    Toxicol Pathol 24:558-63. 1996
  9. ncbi request reprint Enhancement of acute myocardial lesions by asthma drugs in rats
    V E Whitehurst
    Center for Drug Evaluation and Research, Food and Drug Administration, Washington, D C 20204
    Toxicol Pathol 22:72-6. 1994
  10. ncbi request reprint Iron and zinc interactions in humans
    P Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA
    Am J Clin Nutr 68:442S-446S. 1998

Detail Information

Publications15

  1. ncbi request reprint Genotoxicity of iron chelators in L5178Y mouse lymphoma cells
    P Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA
    Environ Mol Mutagen 38:347-56. 2001
    ..The other three chelators that were not mutagenic were Na2EDTA, phytic acid, and ferrozine...
  2. ncbi request reprint Mutagenicity of chromium picolinate and its components in Salmonella typhimurium and L5178Y mouse lymphoma cells
    Paul Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD 20740 3835, United States
    Food Chem Toxicol 43:1619-25. 2005
    ..Neither chromium picolinate nor chromium chloride induced a mutagenic response in S. typhimurium. However, in the L5178Y mouse lymphoma mutation assay, chromium picolinate induced mutagenic responses without and with the addition of S9...
  3. ncbi request reprint Iron and folate in fortified cereals
    P Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA
    J Am Coll Nutr 20:247-54. 2001
    ..However, with recent increases in fortification, public health officials in the US are concemed that excess intake of specific nutrients such as iron and folic acid may result in toxic manifestations...
  4. ncbi request reprint Effect of increasing iron supplementation on blood lipids in rats
    P Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street S W, HFS 236, Washington, DC 20204, USA
    Br J Nutr 86:587-92. 2001
    ....
  5. ncbi request reprint Acute toxicity of carbonyl iron and sodium iron EDTA compared with ferrous sulfate in young rats
    P Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland 20740 3835, USA
    Regul Toxicol Pharmacol 36:280-6. 2002
    ..1 g Fe/kg and was approximately 45 times more toxic than carbonyl Fe, which had an LD(50) greater then 50 g Fe/kg. NaFeEDTA had an LD(50) of 1.3 g Fe/kg and, when compared with FeSO(4), had approximately the same level of toxicity...
  6. ncbi request reprint Genotoxicity of iron compounds in Salmonella typhimurium and L5178Y mouse lymphoma cells
    V C Dunkel
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA
    Environ Mol Mutagen 33:28-41. 1999
    ..The LED ratio ranges from 1 for FeSO4 to 30 for carbonyl Fe, which are similar to oral LD50 values obtained in animal studies...
  7. ncbi request reprint Genome-linked toxic responses to dietary iron overload
    P Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, D C 20204
    Toxicol Pathol 25:556-64. 1997
    ..The rats also showed degeneration of the germinal epithelium of the testis, formation of multinucleated giant cells, and lack of mature sperm...
  8. ncbi request reprint Histopathological evaluation of liver, pancreas, spleen, and heart from iron-overloaded Sprague-Dawley rats
    P Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, D C 20204, USA
    Toxicol Pathol 24:558-63. 1996
    ....
  9. ncbi request reprint Enhancement of acute myocardial lesions by asthma drugs in rats
    V E Whitehurst
    Center for Drug Evaluation and Research, Food and Drug Administration, Washington, D C 20204
    Toxicol Pathol 22:72-6. 1994
    ..A decrease in serum iron levels was observed in rats of all beta-agonist and/or methylxanthine-treated groups...
  10. ncbi request reprint Iron and zinc interactions in humans
    P Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA
    Am J Clin Nutr 68:442S-446S. 1998
    ..Twelve iron sources are listed as GRAS; elemental iron has become the source of choice because it is less expensive to produce and has fewer organoleptic problems. Use of ferrous fumarate is also increasing...
  11. ncbi request reprint Identification of foodborne bacteria by infrared spectroscopy using cellular fatty acid methyl esters
    P Whittaker
    Division of Research and Applied Technology, ONPLDS, Food and Drug Administration FDA, Center for Food Safety and Applied Nutrition CFSAN, 5100 Paint Branch Parkway, College Park, MD 20740 3835, USA
    J Microbiol Methods 55:709-16. 2003
    ..A series of bacterial FAME test samples were prepared and analyzed for accuracy of identification, and all were correctly identified. Our results suggest that this infrared strategy could be used to identify foodborne pathogens...
  12. ncbi request reprint Variation of analytical results for peanuts in energy bars and milk chocolate
    Mary W Trucksess
    U S Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD 20740, USA
    J AOAC Int 87:943-9. 2004
    ..This study serves as a template for application to other foods, and for extrapolation to different sizes of samples and subsamples as well as numbers of analyses...
  13. ncbi request reprint Evaluation of commercial kava extracts and kavalactone standards for mutagenicity and toxicity using the mammalian cell gene mutation assay in L5178Y mouse lymphoma cells
    Paul Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, HFS 717, College Park, MD 20740 3835, USA
    Food Chem Toxicol 46:168-74. 2008
    ..Neither the kava samples nor the kavalactones induced a mutagenic response in the L5178Y mouse lymphoma mutation assay with the addition of human liver S9 activation...
  14. doi request reprint Evaluation of the butter flavoring chemical diacetyl and a fluorochemical paper additive for mutagenicity and toxicity using the mammalian cell gene mutation assay in L5178Y mouse lymphoma cells
    Paul Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, HFS 717, College Park, MD 20740 3835, United States
    Food Chem Toxicol 46:2928-33. 2008
    ..The increase in the frequency of small colonies in the assay with diacetyl indicates that diacetyl causes damage to multiple loci on chromosome 11 in addition to functional loss of the thymidine kinase locus...
  15. ncbi request reprint Dose-response effects of ectopic agouti protein on iron overload and age-associated aspects of the Avy/a obese mouse phenome
    George L Wolff
    Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079 9502, USA
    Peptides 26:1697-711. 2005
    ....